46. High Homocysteine: Histamine, Methylation & Why You Might Not Tolerate Methylated B Vitamins

51. Methylation Optimisation: What The Biohacking Trend Gets Wrong

Methylation has become one of the hottest topics in functional medicine, biohacking, and wellness. From MTHFR testing to methylated supplements, many people are being told that boosting methylation is the key to better energy, mood, detoxification, hormone balance, and longevity. But what if more methylation isn't always better? In this episode, Joanne explores the science behind methylation, the roles of MTHFR and COMT, and why relying solely on genetic reports can lead to inappropriate supplementation. Joanne explains the difference between undermethylation and overmethylation, the symptoms of excess methyl groups, and why many people experience worsening anxiety, insomnia, irritability, and other adverse effects when taking methylated supplements. Whether you're a practitioner, student, or someone navigating histamine intolerance, hormone imbalances, or chronic health concerns, this episode provides a balanced, evidence-informed perspective on one of today's most talked-about health trends. In this episode, you'll learn: * What methylation is and why it's essential for health * How methylation affects neurotransmitters, hormones, detoxification, and gene expression * The difference between undermethylation and overmethylation * The role of MTHFR, COMT, folate, and vitamin B12 in methylation pathways * Common symptoms of excess methyl groups * Why genetic testing alone doesn't tell the whole story * The potential risks of methylated supplements * A more personalised approach to methylation support ✨ Want more? Follow on Instagram [https://www.instagram.com/joannekennedynaturopath/], Facebook [https://www.facebook.com/Joannekennedynaturopathy1], and YouTube [https://www.youtube.com/channel/UC_OVEwjTcNYfAg3_NrVK-xQ] for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance [https://joannekennedynaturopathy.com/the-ultimate-bundle-for-managing-histamine-intolerance-2/]—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! [https://joannekennedynaturopathy.com/methylation-test/] In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course [https://joanne-kennedy.mykajabi.com/hmc-application] starting early 2026! 📆 Work with us 1:1! Book a consultation [https://joannekennedynaturopathy.com/consultations/] and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here! [https://joannekennedynaturopathy.com/ask-a-question-or-suggest-a-topic/]

50. Is PMDD a Histamine Problem? H1 and H2 Blockers Explained

Could histamine be contributing to Premenstrual Dysphoric Disorder (PMDD)? In this episode of The Histamine Well Podcast, Joanne explores the growing interest in the connection between PMDD, histamine intolerance, mast cell activation, and hormonal fluctuations. As more women report improvements in PMDD symptoms with antihistamines, the question is gaining attention: could histamine be a missing piece of the PMDD puzzle? Joanne breaks down the science behind the estrogen-histamine feedback loop, explains how histamine interacts with estrogen and progesterone throughout the menstrual cycle, and discusses why some women experience worsening mood symptoms during the luteal phase. You'll learn about the role of mast cells, neurotransmitters, neuroinflammation, and hormone sensitivity in PMDD, as well as the potential benefits and limitations of H1 and H2 antihistamines. Joanne also shares her clinical observations on histamine-related hormone symptoms and why addressing underlying drivers of histamine excess may be essential for long-term symptom improvement. In This Episode You'll Learn: * What PMDD is and how it differs from PMS * The relationship between histamine and women's hormones * How estrogen can increase histamine levels * The role of progesterone in histamine regulation * Mast cell activation and hormone-related symptoms * Why histamine may worsen anxiety, irritability, and mood swings * The science behind H1 and H2 blockers * Potential risks of long-term antihistamine use * Histamine's effects on neurotransmitters including serotonin and dopamine * The connection between PMDD, MCAS, and histamine intolerance * Why methylation may play a role in PMDD symptoms * Common root causes of histamine excess, including SIBO, mold exposure, oxalates, and gut dysfunction * Natural strategies for addressing histamine-related hormone symptoms ✨ Want more? Follow on Instagram [https://www.instagram.com/joannekennedynaturopath/], Facebook [https://www.facebook.com/Joannekennedynaturopathy1], and YouTube [https://www.youtube.com/channel/UC_OVEwjTcNYfAg3_NrVK-xQ] for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance [https://joannekennedynaturopathy.com/the-ultimate-bundle-for-managing-histamine-intolerance-2/]—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! [https://joannekennedynaturopathy.com/methylation-test/] In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course [https://joanne-kennedy.mykajabi.com/hmc-application] starting early 2026! 📆 Work with us 1:1! Book a consultation [https://joannekennedynaturopathy.com/consultations/] and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here! [https://joannekennedynaturopathy.com/ask-a-question-or-suggest-a-topic/]

49. Mould & Mitochondria: Why You're Still Exhausted (and What's Really Driving It)

Persistent fatigue is one of the most common—and most frustrating—symptoms experienced by people with mould illness. Many find that despite sleeping more, resting, pacing themselves, and trying countless supplements, the exhaustion simply doesn't improve. In this episode of The Histamine Well Podcast, Joanne explores the hidden connection between mould illness and mitochondrial dysfunction, revealing why fatigue can persist long after mould exposure has been identified. You'll learn how three key factors often work together to impair cellular energy production: * Mycotoxins and their direct toxic effects on mitochondria * Sulfur depletion and reduced glutathione production * Oxalate accumulation and mitochondrial stress Joanne explains how these mechanisms can disrupt ATP production, increase oxidative stress, and contribute to symptoms such as chronic fatigue, brain fog, muscle weakness, exercise intolerance, post-exertional malaise, pain sensitivity, and temperature dysregulation. This episode also explores the important relationship between mould exposure, gut dysbiosis, SIBO, sulfur metabolism, and oxalate overload—factors that are frequently overlooked when addressing ongoing fatigue and recovery from mould illness. Whether you're a practitioner, student, or someone navigating chronic health challenges, this episode provides valuable insights into the biological processes driving fatigue and what may need to be addressed for meaningful recovery. In this episode, you'll discover: * How mould toxins damage mitochondrial function * Why fatigue often persists despite rest and sleep * The critical role of sulfur in energy production and detoxification * How oxalates can contribute to mitochondrial dysfunction * Common signs of mould-related mitochondrial impairment * Why addressing mould exposure alone may not be enough for recovery ✨ Want more? Follow on Instagram [https://www.instagram.com/joannekennedynaturopath/], Facebook [https://www.facebook.com/Joannekennedynaturopathy1], and YouTube [https://www.youtube.com/channel/UC_OVEwjTcNYfAg3_NrVK-xQ] for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance [https://joannekennedynaturopathy.com/the-ultimate-bundle-for-managing-histamine-intolerance-2/]—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! [https://joannekennedynaturopathy.com/methylation-test/] In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course [https://joanne-kennedy.mykajabi.com/hmc-application] starting early 2026! 📆 Work with us 1:1! Book a consultation [https://joannekennedynaturopathy.com/consultations/] and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here! [https://joannekennedynaturopathy.com/ask-a-question-or-suggest-a-topic/]

48. How Mould Mycotoxins Cause SIBO

In this episode of The Histamine Well Podcast, Joanne explores the hidden connection between mould mycotoxins and Small Intestinal Bacterial Overgrowth (SIBO) — and why so many people with chronic digestive symptoms may be missing the true root cause of their gut dysfunction. If you’ve been struggling with bloating, reflux, constipation, diarrhea, histamine intolerance, food sensitivities, nausea, fatigue, or recurring SIBO that never fully resolves, this episode explains how mould exposure may be contributing to ongoing nervous system and digestive dysfunction. Joanne breaks down the mechanisms behind mould-related gut issues, including how mycotoxins impact the vagus nerve, gut motility, stomach acid production, bile flow, pancreatic enzymes, inflammation, and the migrating motor complex. She also discusses why chronic SIBO cases are often difficult to treat when mould toxicity is not properly addressed. In this episode, you’ll learn: * Why mould illness and SIBO commonly occur together * How poor vagal tone affects digestion and bacterial overgrowth * The connection between mould, histamine intolerance, and mast cell activation * Why low stomach acid and sluggish bile flow can worsen gut symptoms * How chronic inflammation disrupts gut motility and digestive function * Why antibiotics and herbal antimicrobials may not fully resolve SIBO * The importance of mould testing in chronic gut health conditions #SIBO #MouldIllness #HistamineIntolerance #GutHealth #Mycotoxins #MCAS #FunctionalMedicine #DigestiveHealth #MoldToxicity #VagusNerve ✨ Want more? Follow on Instagram [https://www.instagram.com/joannekennedynaturopath/], Facebook [https://www.facebook.com/Joannekennedynaturopathy1], and YouTube [https://www.youtube.com/channel/UC_OVEwjTcNYfAg3_NrVK-xQ] for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance [https://joannekennedynaturopathy.com/the-ultimate-bundle-for-managing-histamine-intolerance-2/]—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! [https://joannekennedynaturopathy.com/methylation-test/] In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course [https://joanne-kennedy.mykajabi.com/hmc-application] starting early 2026! 📆 Work with us 1:1! Book a consultation [https://joannekennedynaturopathy.com/consultations/] and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here! [https://joannekennedynaturopathy.com/ask-a-question-or-suggest-a-topic/]

47. The Bile-Histamine Connection: SIBO, Estrogen, Mold & Oxalates Explained

What if your histamine symptoms aren’t just about food? In this episode of the The Histamine Well Podcast, Joanne explores the overlooked connection between bile flow, histamine intolerance, SIBO, estrogen dominance, mold exposure, oxalates, methylation, and chronic inflammation. Bile plays a critical role in digestion, detoxification, hormone clearance, and microbial balance in the gut. When bile flow becomes sluggish, it can contribute to bacterial overgrowth, poor fat digestion, impaired estrogen detoxification, oxalate accumulation, and worsening histamine symptoms. In this episode, Joanne explains: * How poor bile flow contributes to histamine intolerance * Why mold toxicity and mycotoxins affect the liver and gallbladder * The vicious cycle between SIBO and bile dysfunction * How estrogen dominance impacts bile flow and histamine * Why oxalates can worsen inflammation and histamine symptoms * The role of methylation and phosphatidylcholine in healthy bile production * How vagus nerve dysfunction affects digestion and bile release * Common signs and symptoms of poor bile flow This episode is essential listening for anyone struggling with histamine intolerance, MCAS, gut health issues, bloating, hormone imbalances, mold illness, chronic inflammation, food sensitivities, or unexplained digestive symptoms. 🎧 Subscribe to The Histamine Well Podcast for evidence-based conversations on histamine intolerance, methylation, SIBO, mold illness, women’s hormones, and functional medicine. #HistamineIntolerance #SIBO #GutHealth #MoldIllness #EstrogenDominance #Oxalates #Methylation #FunctionalMedicine #BileFlow ✨ Want more? Follow on Instagram [https://www.instagram.com/joannekennedynaturopath/], Facebook [https://www.facebook.com/Joannekennedynaturopathy1], and YouTube [https://www.youtube.com/channel/UC_OVEwjTcNYfAg3_NrVK-xQ] for updates and tips. 📘 New to this journey? Buy The Ultimate Bundle for Managing Histamine Intolerance [https://joannekennedynaturopathy.com/the-ultimate-bundle-for-managing-histamine-intolerance-2/]—your step-by-step guide to manage your histamine intolerance effectively.  🧪 Curious about your methylation status? Try our at-home Methylation Test! [https://joannekennedynaturopathy.com/methylation-test/] In just 15 minutes, discover if you're over-methylating or under-methylating and receive targeted supplement recommendations to help rebalance. Use code HISTAMINEWELL10 for 10% off. 🎓 Practitioner or student? Join the waitlist for the Histamine & Methylation Online Group Coaching Course [https://joanne-kennedy.mykajabi.com/hmc-application] starting early 2026! 📆 Work with us 1:1! Book a consultation [https://joannekennedynaturopathy.com/consultations/] and take your first step to real healing. 🎤 Have a topic suggestion? Submit it here! [https://joannekennedynaturopathy.com/ask-a-question-or-suggest-a-topic/]