The Two- and Three-Neuron Problem - OsteoSignal - Episode 005

Peptides & Brain Health - OsteoSignal Ep. 011

In this episode of OsteoSignal, Neal discusses the emerging research on peptides and their implications for brain health. He distinguishes between nutraceuticals and pharmaceuticals, emphasizing the role of AI in modern medicine. The conversation covers the importance of arginine, the impact of biofilms on health, and the connection to Alzheimer's disease. Neal also shares insights on osteopathic manual therapy techniques and the significance of proper nutrition and supplementation for overall well-being. Studies mentioned: "Arginine and Arginine-Rich Peptides as Modulators of Protein Aggregation and Cytotoxicity Associated With Alzheimer's Disease" https://pubmed.ncbi.nlm.nih.gov/34776866/ [https://pubmed.ncbi.nlm.nih.gov/34776866/] OsteoSignal with Neal D. O'Neal, PT is a podcast exploring how your body's natural design connects with osteopathic science - translating complex signals into practical insight so you can truly thrive. Disclaimer: The content of this podcast is for information purposes only and should not be considered medical advice. Discuss any medical procedure with your health care provider. For more information about the content of this episode, visit https://pursuitpt.com or https://pursuitperformancetraining.com. Copyright © 2026 Neal D. O'Neal, PT

Peptides & Healthcare: The FDA, Economics, and the Future of Healthcare - OsteoSignal Ep. 010

In this episode of OsteoSignal, we discuss the significance of peptides in healthcare, their functions, and the challenges posed by FDA regulations. We explore the therapeutic applications of peptides, including their role in healing and recovery, and the impact of osteopathic manual therapy on peptide efficacy. The discussion also delves into the economics of healthcare, the influence of pharmaceutical benefits managers, and the need for a shift from sick care to genuine health care. The conversation concludes with insights into the future of peptides in medicine and the importance of patient advocacy. For more information about Neal's classes, visit https://pursuitpt.com/classes [https://pursuitpt.com/classes] Key sites/people mentioned: Josh Woodger, manual therapist in the Salt Lake City area: https://bulldogmanualtherapy.com [https://bulldogmanualtherapy.com/] Brigham Buhler and Ways 2 Well: https://ways2well.com [https://ways2well.com/] Brigham Buhler on Joe Rogan: https://rumble.com/v6yrfh8-joe-rogan-experience-2376-brigham-buhler.html [https://rumble.com/v6yrfh8-joe-rogan-experience-2376-brigham-buhler.html] (EXPLICIT) Modern Medical Mafia Docuseries: https://youtu.be/k0bcWlI4ht4?si=g7p2RbuGzHQ6yNdj [https://youtu.be/k0bcWlI4ht4?si=g7p2RbuGzHQ6yNdj]

Pain is a Liar - OsteoSignal Ep. 009

In this OsteoSignal episode, Neal and guests discuss the concept of pain as an unreliable narrator and introduces the role of non-physician osteopathic manual therapy in modern healthcare. He emphasizes the importance of understanding the body's systems and how they interact, rather than just treating symptoms. The discussion covers various topics including biomechanical signaling, fascial tensegrity, interoceptive physiology, and the integration of osteopathic manual therapy with traditional healthcare practices. The conversation highlights the need to address underlying issues and the differences between regenerative and degenerative approaches in healthcare. OsteoSignal with Neal D. O'Neal, PT is a podcast exploring how your body's natural design connects with osteopathic science - translating complex signals into practical insight so you can truly thrive. Disclaimer: The content of this podcast is for information purposes only and should not be considered medical advice. Discuss any medical procedure with your health care provider. For more information about the content of this episode, visit https://pursuitpt.com or https://pursuitperformancetraining.com. Copyright © 2026 Neal D. O'Neal, PT

Hormones, Peptides, and the Gut: Rebuilding Health from the Inside Out with Manual Therapy - OsteoSignal Ep. 008

In this episode of OsteoSignal, we discuss some of the complexities of health, focusing on hormone replacement therapy, the role of peptides, and the importance of the gut microbiome. We talk about the differences in how hormone therapies are perceived and prescribed for men and women, the significance of manual therapy in conjunction with hormone treatments, and the necessity of maintaining a healthy gut environment for overall wellness. Our conversation emphasizes the interconnectedness of biomechanical, biochemical, and bioelectrical health signals. In this conversation, the speakers delve into the complexities of health, focusing on the interplay between developmental issues in children and aging in adults. We discuss the role of peptides and manual therapy in restoring health, emphasizing the importance of a holistic approach to treatment. Our conversation also covers the effects of hormones like testosterone and the emerging understanding of Sermorelin, highlighting potential side effects and the need for informed decision-making in healthcare. OsteoSignal with Neal D. O'Neal, PT is a podcast exploring how your body's natural design connects with osteopathic science - translating complex signals into practical insight so you can truly thrive. Disclaimer: The content of this podcast is for information purposes only and should not be considered medical advice. Discuss any medical procedure with your health care provider. For more information about the content of this episode, visit https://pursuitpt.com or https://pursuitperformancetraining.com. Copyright © 2026 Neal D. O'Neal, PT

Applied Manual Osteopathy: Recovery After Surgery, Pediatric Cranial Treatment - OsteoSignal - Episode 007

In this conversation, Neal O'Neal discusses the principles of osteopathy, focusing on manual therapy techniques for post-operative care and pediatric treatment. He emphasizes the importance of treating the whole body, managing inflammation, and understanding the body's responses to surgery. The discussion also covers cranial osteopathy's role in addressing developmental issues in children and how physical health can influence behavior. Neal shares insights on effective treatment strategies that enhance recovery and promote overall well-being. He also discusses various aspects of patient treatment, focusing on the importance of understanding visceral signaling, the need for thorough patient assessments, and the significance of adapting treatment plans based on individual patient needs. The dialogue emphasizes the role of communication between practitioners and patients, highlighting how effective treatment requires a collaborative approach. O'Neal also touches on advanced treatment techniques and the necessity of recognizing patterns in patient care to achieve lasting results. Takeaways Osteopathy focuses on treating the whole body, not just the injury. Immediate post-operative treatment can enhance recovery. Managing inflammation is crucial for restoring range of motion. Cranial osteopathy can address developmental issues in children. Behavioral changes in children can be linked to physical health. Fluid flow in the body is essential for healing. Manual therapy can help with lymphatic drainage post-surgery. Understanding the body's response to surgery is key for therapists. Children's thumb sucking may indicate deeper issues needing treatment. Holistic approaches can lead to better patient outcomes. Understanding visceral signaling is crucial for effective treatment. Patient assessments should guide treatment planning. Recognizing patterns in patient care helps in addressing recurring issues. Communication between practitioners and patients is essential for effective therapy. Treatment plans should adapt to the individual needs of patients. Practitioners should anticipate patient issues and address them proactively. It's important to explore advanced treatment techniques for better outcomes. Therapists should not rely on a one-size-fits-all approach. Patients should feel empowered to communicate their needs to their therapists. Effective treatment requires a collaborative effort between patients and practitioners. OsteoSignal with Neal D. O'Neal, PT is a podcast exploring how your body's natural design connects with osteopathic science - translating complex signals into practical insight so you can truly thrive. Disclaimer: The content of this podcast is for information purposes only and should not be considered medical advice. Discuss any medical procedure with your health care provider. For more information about the content of this episode, visit https://pursuitpt.com or https://pursuitperformancetraining.com. Copyright 2026 Neal D. O'Neal, PT