Puppies, Pandemics, and Public Health

Animal Research: Bad Science, and A Broken System: A Former Lab Researcher Speaks Out | Ep18

51 min · 29 de abr de 2026
Portada del episodio Animal Research: Bad Science, and A Broken System: A Former Lab Researcher Speaks Out | Ep18

Descripción

What if the system we rely on to develop life-saving medicines is fundamentally flawed, causing immense animal suffering while failing to produce reliable results for humans? In this powerful episode of Puppies, Pandemics, and Public Health, Dr. Johnny Lieberman speaks with Dr. Emily Trunnell, Director of Science Advancement and Outreach at PETA. A former neuroscience researcher who conducted experiments on rats and mice during her PhD, Dr. Trunnell reveals the shocking realities of lab animal research  from dehydrated rats dying due to basic care failures and rats being forcibly intoxicated while lab workers joke about it, to Institutional Animal Care and Use Committees (IACUCs) acting as little more than rubber stamps. You’ll hear why more than 90% of drugs that pass animal tests still fail in human trials, the massive reproducibility crisis in animal research, species differences that make translation unreliable, and exciting non-animal methods (like organs-on-chips and AI modeling) that are already proving more human-relevant. This episode exposes a broken, self-regulated system and highlights the momentum toward modern, animal-free science that could accelerate medical progress while reducing harm. Top 3 Takeaways: * The Animal Research Oversight System Is Broken and Self-Regulatory IACUCs are dominated by animal researchers who “police themselves.” They check minimal boxes under the Animal Welfare Act (which excludes 95–99% of animals like mice and rats), rarely question justifications for pain or multiple surgeries, and provide almost no real protection. * Animal Experiments Are Poorly Reproducible and Rarely Translate to Humans Up to 89% of preclinical studies cannot be reproduced. 95% of drugs that succeed in animals fail in human clinical trials due to vast species differences, unnatural lab conditions, and publication bias that hides negative results. * Modern Non-Animal Methods Are Superior and Already Available Technologies like organs-on-chips, organoids, and AI-driven in silico modeling use human cells and biology, deliver faster and more accurate results, and can replace animal tests  with agencies like the FDA now actively working to make animal testing the exception rather than the rule. About the Guest: Dr. Emily Trunnell Dr. Emily Trunnell graduated Magna Cum Laude from the University of Georgia with a degree in Nutrition Science and earned her doctorate in Neuroscience from the University of Georgia in 2016. She is currently the Director of Science Advancement and Outreach at PETA, where she works to modernize science policy, scientific publishing practices, and university education to support the transition to animal-free research methods. A former animal researcher who conducted experiments on rats and mice during her PhD, Dr. Rinne lives with a passion for advancing human-relevant science that benefits both people and animals. 🔗 Learn more: scienceadvancement.org. [http://scienceadvancement.org] About the Show: Puppies, Pandemics, and Public Health explores the intersection of animal welfare, public policy, and human health. Hosted by Dr. Johnny Lieberman, each episode invites changemakers, legal experts, and health advocates to shed light on what really impacts our communities and what we can do about it. About the Host: Dr. Johnny Lieberman is a physician, public health advocate, and lifelong animal lover with a passion for connecting the dots between animal welfare, human behavior, and the systems that shape our lives. With a background in both medicine and public health policy, Johnny brings a unique lens to conversations about how our treatment of animals impacts human health, the environment, and social justice. In Puppies, Pandemics, and Public Health, Johnny brings warmth, curiosity, and a dash of wit to tough conversations that matter. From exposing the realities of factory farming to uncovering the links between zoonotic diseases and our food systems, his goal is to empower listeners to be informed, compassionate, and engaged citizens while still keeping it real (and sometimes bringing in puppies). Whether he's discussing legislative loopholes or snuggling his rescue dog between recordings, Dr. Lieberman believes that creating a healthier world starts with how we treat its most vulnerable beings. Email: John@johnliebermanmd.com

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24 episodios

episode Animal Testing: The Science Has Changed. Has the Public? | Ep23 artwork

Animal Testing: The Science Has Changed. Has the Public? | Ep23

EPISODE SUMMARY For 40 years, governments have quietly acknowledged that animal testing often fails to predict what medicines will do to humans. So why does the public still believe it's the gold standard? Jeffrey Brown, an epidemiologist who advises on animal-free testing methods, explains why the science has moved on, even if the narrative hasn't. IN THIS EPISODE - Why animal testing results often don't translate to human safety outcomes - The 1986 European Union directive that called for moving away from animal methods - How basic cell and molecular biology research differs from regulatory safety testing - The latest EU data showing animal use in research is declining - What the FDA and other regulatory agencies actually need from safety testing - How to evaluate conflicting messages from research institutions and advocacy groups - The gap between public perception of animal testing and what scientists know KEY TAKEAWAYS 1. Animal testing is not the reliable safety check most people assume it is, and scientists who work in regulatory affairs know this. 2. The European Union has tracked animal use in research for decades, and the numbers keep dropping as better methods take hold. 3. Moving away from animal testing is not just an ethical position. It is a scientific one, backed by 40 years of regulatory policy. 4. When governments and drug approval agencies push for non-animal methods, they are trying to get more accurate data, not less. 5. You do not have to be an expert to ask better questions about where safety data comes from. KEYWORDS Jeffrey Brown, animal testing, non-animal methods, FDA, drug safety, epidemiology, cell biology, medical device testing, European Union animal research policy, regulatory science, public health, animal-free research, toxicity testing, Science Consortium

8 de jul de 202639 min
episode Factory Farming Is Polluting America’s Water and Nobody’s Stopping It | Ep22 artwork

Factory Farming Is Polluting America’s Water and Nobody’s Stopping It | Ep22

EPISODE SUMMARY Factory farming produces 98% of the meat Americans eat, and its environmental damage runs far deeper than most people realize. Ken Swensen, founder of Inside Animal Ag, breaks down how industrial animal agriculture has become the primary driver of water pollution in the United States, contaminating drinking wells, killing aquatic life, and creating dead zones in our oceans. IN THIS EPISODE - Why 98% of animal products in the U.S. come from factory farms, despite misleading packaging - How concentrated manure and fertilizer runoff cause nutrient pollution in waterways - The link between factory farming and the Gulf of Mexico dead zone - Nitrate contamination in private wells and why 1.5 million Americans drink unsafe water - Health effects of nitrate exposure, including blue baby syndrome, cancer, and birth defects - Agricultural exceptionalism and why regulators look the other way - How meat labels deceive consumers into thinking they're buying humane products KEY TAKEAWAYS 1. Factory farming is the primary cause of water pollution in the United States, driven by excess manure and fertilizer from feed crops. 2. Even nitrate levels at half the EPA's legal limit can cause serious health problems, including cancer and birth defects. 3. Most consumers believe they're avoiding factory farm products, but deceptive labeling keeps them in the dark. 4. Aquatic species are the most threatened animals in the U.S., largely because of nutrient pollution from industrial agriculture. 5. The health and environmental costs of factory farming are quietly transferred from corporations to rural communities who never agreed to bear them. KEYWORDS Ken Swensen, Inside Animal Ag, factory farming, industrial animal agriculture, water pollution, nutrient pollution, nitrates in drinking water, Gulf of Mexico dead zone, manure runoff, feed crops, agricultural exceptionalism, food labeling, public health, environmental health, rural communities

24 de jun de 202648 min
episode Why Animal Testing Is a Broken System and What's Replacing It with Mackensey Alexander | Ep19 artwork

Why Animal Testing Is a Broken System and What's Replacing It with Mackensey Alexander | Ep19

What if the biggest obstacle to curing Alzheimer's, ALS, and cancer isn't funding or effort, but the model we've been using for 2,000 years? Mackensey Alexander, bioethicist and law student at Lewis & Clark, makes the case that animal testing isn't just ethically wrong, it's scientifically broken. With a 90% failure rate in translating results to humans and $23 billion in taxpayer dollars spent annually on animal models, Mackensey and Dr. Lieberman break down the growing field of New Approach Methods (NAMs), from tumor organoids to organ-on-a-chip technology, and why the science of the future is already here. Plus: what's happening right now in Washington D.C. that could change everything.

13 de may de 202635 min