The Human Upgrade: Biohacking for Longevity & Performance

Combine Creatine With THIS To Fight The Root Cause of Aging | Andrew Salzman : 1474

1 h 23 min · 28 de may de 2026
Portada del episodio Combine Creatine With THIS To Fight The Root Cause of Aging | Andrew Salzman : 1474

Descripción

How CD38, PARP, and Leaky Gut Are Destroying Your NAD Levels | Dr. Andrew Salzman  Your NAD is being drained by two hidden enzymes, your gut may be the starting point of every aging process in your body, and creatine does something to your mitochondria that has nothing to do with muscle. This episode rewrites what you thought you knew about longevity, anti-aging biology, and how your body actually produces and delivers energy at the cellular level.  -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR [https://www.youtube.com/@DaveAspreyBPR]  -Explore all of Wonderfeel’s products at: getwonderfeel.com/dave  [https://getwonderfeel.com/dave/?utm_source=Dave&utm_medium=podcast&utm_campaign=episode3] They are gifting a complimentary 7-day Youngr™ supply (mini pouch) with every order across any of their products. The code will be DAVE, and the campaign will be active through June 6th. Host Dave Asprey sits down with Dr. Andrew Salzman, a physician, inventor, and biomedical entrepreneur with more than 30 years of experience in drug discovery and development. An alumnus of Harvard Medical School, Yale University, and Columbia University, Dr. Salzman has authored more than 170 scientific publications and holds 50 patents. He invented the original clinical-stage PARP-1 inhibitor, leading to the world's first clinical treatment for raising NAD levels and fighting cancers caused by the BRCA1 and BRCA2 genes. Genentech licensed his breakthrough technology for $600 million. His research into gastrointestinal microbiota, autoimmune disease, oxidative stress, and mitochondrial ATP production now forms the foundation of how millions of patients get treated worldwide.     Dr. Salzman names the two biggest NAD drains in your body, CD38 and PARP, and explains why taking NMN or NR alone is like filling a bathtub with the drain wide open. He breaks down the formulation science behind pairing NAD precursors with CD38 blockers like hydroxytyrosol alongside PARP-reducing antioxidants like ergothioneine, and delivers a paradigm-shifting explanation of creatine as an energy distribution network inside your cells. Rather than a simple muscle supplement, creatine acts as a high-speed ATP shuttle that carries energy from your mitochondria to the precise location and moment your brain, gut, and heart need it most.  You'll Learn:  * Why NAD declines with age and which two enzymes are primarily responsible for draining it  * How CD38 rises with inflammation rather than NAD levels, and what that means for your supplement strategy  * Why creatine is one of the most underrated anti-aging and brain optimization supplements available  * How creatine functions as a spatial and temporal energy delivery network for your brain, gut, and heart  * Why the gut may be the origin point of the entire aging process and how that cascade unfolds decade by decade  * How leaky gut drives systemic inflammation, crashes NAD, and accelerates biological aging throughout the body  * What controls tight junction integrity and how ATP, butyrate, creatine, and fasting all play a role  * Why most creatine supplements fail to absorb properly and what to look for in a high-quality source  * How to rebuild your microbiome in three to four weeks through diet alone, without antibiotics  * Why walking immediately after a meal may be doing more harm than good to your gut lining     Thank you to our sponsors!       - Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave [https://www.screenfit.com/dave].  - KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/ [https://www.switchsupplements.com/]and use code DAVE for 20% off  - Pique | Go to Piquelife.com/dave [https://www.piquelife.com/collections/subs-collection?utm_source=superfiliate&utm_campaign=DAVE&utm_medium=pod&utm_content=eyJzZi1leHRlcm5hbC1zZXNzaW9uLXV1aWQiOiIzZTgwYTM4ZS0xYTk0LTQ0ZTgtYmRhMC1jMDc0ODhlODgyMDkifQ%3D%3D&ref=superfiliate-DAVE&attributes=%7B%22sf-external-session-uuid%22+%3D%3E+%227305ac2a-ad0b-4541-9519-de5c38d87d7b%22%2C+%22sf-origin%22+%3D%3E+%22organic--DAVE%22%7D] for 20% off.  - iRestore | Reverse hair loss at www.irestore.com/DAVE [http://www.irestore.com/DAVE] and get exclusive savings on the iRestore Elite, use code DAVE    Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: Dr. Andrew Salzman, NAD depletion, CD38 inhibition, PARP inhibition, NMN supplements, creatine ATP shuttle, leaky gut aging, tight junction integrity, inflammaging, lipopolysaccharide gut, flagellin toxin, butyrate gut healing, ergothioneine, hydroxytyrosol, peroxynitrite, superoxide mitochondria, creatine energy distribution, gut origin of aging, NAD bathtub analogy, BRCA PARP inhibitor, Wonderfeel, creatine monohydrate, intestinal permeability, microbiome butyrate, selective digestive decontamination, TMAO nitric oxide    Resources:    • Explore all of Wonderfeel’s products at: getwonderfeel.com/dave  [https://getwonderfeel.com/dave/?utm_source=Dave&utm_medium=podcast&utm_campaign=episode3] • Order Youngr™: getwonderfeel.com/dave [https://getwonderfeel.com/product/wonderfeel-youngr-nmn/?utm_source=Dave&utm_medium=podcast&utm_campaign=episode3 ] • Order ChocoCreatin™: getwonderfeel.com/dave [https://getwonderfeel.com/product/wonderfeel-chococreatin/?utm_source=Dave&utm_medium=podcast&utm_campaign=episode3 ] • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ [https://daveasprey.com/2026-clean-nicotine-roadmap/]  • Dave Asprey's Latest News | Go to https://daveasprey.com/ [https://daveasprey.com/] to join Inside Track today.   • Danger Coffee: https://dangercoffee.com/discount/dave15 [https://dangercoffee.com/discount/dave15]    • My Daily Supplements: SuppGrade Labs [https://www.shopsuppgradelabs.com/discount/DAVE15] (15% Off)    • Favorite Blue Light Blocking Glasses: TrueDark [https://truedark.com/?coupon-code=DAVEASPREY15&sc-page=shop] (15% Off)    • Dave Asprey’s BEYOND Conference: https://beyondconference.com [https://beyondconference.com/]    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated [https://daveasprey.com/heavily-meditated]   • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ [https://substack.daveasprey.com/]  • Upgrade Labs: https://upgradelabs.com [https://upgradelabs.com/]      Timestamps:   00:00 – Trailer  01:12 – Introduction & BRCA Background  02:19 – DNA Damage & PARP  04:38 – Free Radicals & Oxidative Stress  11:37 – NAD & Antioxidant Defense  12:34 – CD38 & NAD Depletion  23:31 – The Gut-Aging Hypothesis  30:05 – ATP, Creatine & Energy Distribution  36:41 – Creatine as Energy Shuttle  51:09 – Microbiome & Gut Repair  59:21 – TMAO & Nitric Oxide Interference  1:03:52 – Flagellin & Gut Inflammation Research  1:09:45 – FDA & Pharmaceutical Incentives  1:16:05 – Closing  See Privacy Policy at https://art19.com/privacy [https://art19.com/privacy] and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info [https://art19.com/privacy#do-not-sell-my-info].

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episode The Foods, Drinks, and Daily Habits Wrecking Your Brain (Surprising!) | David Perlmutter : 1498 artwork

The Foods, Drinks, and Daily Habits Wrecking Your Brain (Surprising!) | David Perlmutter : 1498

Neurologist Dr. David Perlmutter Explains Brain Inflammation and Alzheimer's Risk  Your brain has its own immune system, and when it turns against you, it becomes the hidden driver behind Alzheimer's, Parkinson's, depression, and even long COVID. This episode hands you the science to recognize it early and reverse it.    Get Dr. Perlmutter’s new book Brain Defenders: https://drperlmutter.com/books/brain-defenders/ [https://drperlmutter.com/books/brain-defenders/]    Host Dave Asprey sits down with Dr. David Perlmutter, a board-certified neurologist and six-time New York Times bestselling author whose work sits at the intersection of neurology, nutrition, and brain health. He is a Fellow of the American College of Nutrition, serves on its Board of Directors, and sits on the Editorial Board of the Journal of Alzheimer's Disease. His books, including the number one bestseller Grain Brain, span 32 languages and have sold over a million copies, and his upcoming release, Brain Defenders, explores the pivotal role of microglia, the brain's immune cells, in protecting, repairing, and reprogramming the brain for lifelong resilience.    Dave and Dr. Perlmutter break down how microglia, the brain's resident immune cells, shift from a supportive state into a destructive one called M1, and why this shift, not amyloid plaque, may be the real driver of Alzheimer's, Parkinson's, and other neurodegenerative conditions. They dig into why the leading amyloid-clearing drugs fail to improve cognition, what a landmark JAMA study revealed about reversing cognitive decline through lifestyle intervention alone, and why a single daily serving of ultra-processed food raised Alzheimer's risk by 13 percent in a 12.7 year study. They also cover new research on GLP-1 drugs and brain inflammation, the surprising role of gum disease and oral bacteria in dementia risk, and why 40 hertz light therapy is emerging as a low-cost tool for clearing brain plaque and calming neuroinflammation.    You'll Learn:  * Why the shift from supportive to destructive brain immune cells may be the true root cause of Alzheimer's and Parkinson's  * Why leading Alzheimer's drugs fail to improve cognition, and what the original research behind the amyloid hypothesis actually showed  * How one daily serving of ultra-processed food raises Alzheimer's risk, and what a landmark lifestyle intervention study found instead  * Whether GLP-1 drugs help or harm brain inflammation, based on new Parkinson's and Alzheimer's trial data  * How gum disease and oral bacteria are linked to dementia, and simple daily habits that reduce that risk  * Why 40 hertz light therapy is emerging as a tool to clear brain plaque and calm neuroinflammation  * How ketones, DHA, and metabolic health protect the brain after head injury    Thank you to our sponsors!       - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com [http://wonderlandconference.com/].  - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health [https://zenbud.health/] and use code DAVE15 at checkout for a discount.  - Pique | Head over to Piquelife.com/Dave [https://www.piquelife.com/collections/subs-collection?utm_source=superfiliate&utm_campaign=DAVE&utm_medium=pod&utm_content=eyJzZi1leHRlcm5hbC1zZXNzaW9uLXV1aWQiOiJmNTBiMTliMy1lMmIyLTRkMzctYmQyNS1hZTNmZDI5MDJhYmIifQ%3D%3D&ref=superfiliate-DAVE&attributes=%7B%22sf-external-session-uuid%22+%3D%3E+%222f8b41c4-f6cc-4749-99ff-3ab73c696ed6%22%2C+%22sf-origin%22+%3D%3E+%22organic--DAVE%22%7D] to get 20% off your order. That's P-I-Q-U-E life dot com slash DAVE  - PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave [http://predictivemind.io/dave] and use code DAVE for 10% off.    Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.    Keywords: microglia, brain inflammation, Alzheimer's prevention, Parkinson's disease, amyloid hypothesis, neurodegeneration, GLP-1 drugs, semaglutide, ultra-processed food, gum disease and dementia, oral microbiome, 40 hertz light therapy, ketones, DHA, mitochondria, brain fog, long COVID, David Perlmutter, Brain Defenders, Grain Brain, functional medicine, biohacking, longevity, neuroplasticity    Resources:    • Get Dr. Perlmutter’s New Book Brain Defenders: https://drperlmutter.com/books/brain-defenders/ [https://drperlmutter.com/books/brain-defenders/]  • Learn More About Dr. Perlmutter’s Work At: https://drperlmutter.com/ [https://drperlmutter.com/]  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ [https://daveasprey.com/2026-clean-nicotine-roadmap/]   • Dave Asprey's Latest News | Go to https://daveasprey.com/ [https://daveasprey.com/] to join Inside Track today.    • Danger Coffee: https://dangercoffee.com/discount/dave15? [https://dangercoffee.com/discount/dave15?]  • My Daily Supplements: SuppGrade Labs [https://www.shopsuppgradelabs.com/discount/DAVE15] (15% Off)     • Favorite Blue Light Blocking Glasses: TrueDark [https://truedark.com/?coupon-code=DAVEASPREY15&sc-page=shop] (15% Off)     • Dave Asprey’s BEYOND Conference: https://beyondconference.com [https://beyondconference.com/]     • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated [https://daveasprey.com/heavily-meditated]    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ [https://substack.daveasprey.com/]   • Upgrade Labs: https://upgradelabs.com [https://upgradelabs.com/]        Timestamps:   00:00 – Trailer  00:40 – Intro  02:38 – Ultra-Processed Foods  06:34 – Are Carbs Bad?  08:48 – Alcohol & Brain Health  12:28 – Microglia & Inflammation  24:37 – Head Injury & Recovery  29:27 – Oral Bacteria & Dementia  34:08 – GLP-1s & Brain Inflammation  40:20 – 40 Hertz Light Therapy  48:35 – Air Pollution vs. Lead  50:27 – David's Closing Truth  See Privacy Policy at https://art19.com/privacy [https://art19.com/privacy] and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info [https://art19.com/privacy#do-not-sell-my-info].

9 de jul de 202653 min
episode The 1910 Secret: How Light Turns Water Into Medicine | Brain Richards : 1497 artwork

The 1910 Secret: How Light Turns Water Into Medicine | Brain Richards : 1497

Near-Infrared Light Therapy & EMF Shielding with SaunaSpace Founder Brian Richards  Your mitochondria are starving for a nutrient you've probably never tracked, and it's not a vitamin or a macro. This episode reveals how a forgotten 1910 therapy uses light to physically restructure water inside your cells, unlocking a mechanism for healing, detox, and mitochondria repair that most of biohacking has completely overlooked.  Go to https://sauna.space/ [https://sauna.space/] and use code ‘Dave’ for a 15% discount!  Host Dave Asprey sits down with Brian Richards, founder of SaunaSpace and a leading voice in incandescent light therapy and infrared sauna engineering. With a background in chemistry and organic synthesis, Brian spent over a decade building a science-backed alternative to LED-based light therapy rooted in full-spectrum incandescent light and deep radiant heat. After healing his own insomnia, adrenal fatigue, and brain fog through light and heat exposure, he developed the FireLight Spectrum, a technology engineered to restore what modern lighting strips away.  Dave and Brian trace incandescent light therapy back to Dr. John Harvey Kellogg's 1910 book on light therapeutics, and explain why the same institutional forces that suppressed chiropractic care and natural medicine buried this practice for over a century. They break down how near-infrared light penetrates the body to charge water into a more bioavailable state, boost glutathione and melatonin production, and repolarize cellular voltage for better metabolism and longevity. The conversation also covers why blue light from LEDs devastates hormones, testosterone, and fertility, how EMF exposure silently drains human performance, and why grounding and Faraday shielding matter more than most supplements on the market.  You'll Learn:  * Why near-infrared light functions as an essential nutrient your body cannot make without it  * How light physically restructures water to improve mitochondria function and cellular energy  * The suppressed history of Dr. Kellogg's incandescent light therapy and why it disappeared  * How blue light exposure crashes testosterone and disrupts fertility and hormone regulation  * Why EMF shielding and grounding are critical, overlooked tools for longevity and recovery  * How to use infrared light like a daily supplement instead of an occasional treatment  * Why carnivore-adjacent, nutrient-dense eating pairs naturally with light and heat therapy    Thank you to our sponsors!       - ELITE Performance Coaching | If you’d like to discover where you may be addicted to struggle, allergic to success, and what may be standing between you and your next breakthrough, visit FastestChange.com [https://fastestchange.com/]  - Longevity Farms | Go to getlongevityfarms.shop [http://getlongevityfarms.shop/]. Use code DAVE for 20% off your next order.  - Calroy | Go to calroy.com/dave [https://calroy.com/product/cartigenix-hp/?lp=dave] for the clinical research, your discount, and a 45-day money-back guarantee.  - PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave [http://predictivemind.io/dave] and use code DAVE for 10% off.  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: Brian Richards, SaunaSpace, incandescent light therapy, near-infrared light, FireLight Spectrum, Dr. John Harvey Kellogg, Light Therapeutics, exclusion zone water, Gerald Pollack, EMF shielding, Faraday cage, grounding mat, earthing, redox potential, mitochondrial energy, glutathione, melatonin, blue light toxicity, circadian biology, red light therapy, heat shock proteins, vitamin D, sun callus, Danger Coffee, Flexner Report, testosterone, biophotons  Resources:    • Go to https://sauna.space/ [https://sauna.space/] and use code ‘Dave’ for a 15% discount!  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ [https://daveasprey.com/2026-clean-nicotine-roadmap/]   • Dave Asprey's Latest News | Go to https://daveasprey.com/ [https://daveasprey.com/] to join Inside Track today.    • Danger Coffee: https://dangercoffee.com/discount/dave15? [https://dangercoffee.com/discount/dave15?]  • My Daily Supplements: SuppGrade Labs [https://www.shopsuppgradelabs.com/discount/DAVE15] (15% Off)     • Favorite Blue Light Blocking Glasses: TrueDark [https://truedark.com/?coupon-code=DAVEASPREY15&sc-page=shop] (15% Off)     • Dave Asprey’s BEYOND Conference: https://beyondconference.com [https://beyondconference.com/]     • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated [https://daveasprey.com/heavily-meditated]    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ [https://substack.daveasprey.com/]   • Upgrade Labs: https://upgradelabs.com [https://upgradelabs.com/]      Timestamps:   00:00 – Trailer  00:46 – Meet Brian Richards  03:17 – Kellogg's Light Bath History  09:04 – Persecuted Light Pioneers  12:47 – Near-Infrared Science  16:07 – Blue Light Damage  19:26 – Sunscreen Myths  23:52 – Antidote & Melatonin  33:24 – Exclusion Zone Water  37:52 – Heart as a Vortex  41:47 – Fireplace & Infrared Deficiency  46:15 – FireLight Bulb Design  51:52 – EMF Shielding  55:16 – Faraday Cage & Grounding  1:05:51 – Sauna.Space Discount  See Privacy Policy at https://art19.com/privacy [https://art19.com/privacy] and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info [https://art19.com/privacy#do-not-sell-my-info].

7 de jul de 20261 h 0 min
episode I Tried EVERY Legal Focus Drug, Here’s What Actually Works : 1496 artwork

I Tried EVERY Legal Focus Drug, Here’s What Actually Works : 1496

Try Danger Creatine: https://dangercoffee.com/products/danger-creatine Try TrueDark glasses: https://truedark.com Try Danger Coffee: https://dangercoffee.com/ Try Suppgrade Labs: https://shopsuppgradelabs.com/ I have spent twenty years and millions of dollars testing every legal focus drug I could get my hands on. In this video, I break down which compounds actually work, which ones are a waste of money, and the exact stack that delivers hours of clean focus without the afternoon crash. The shift is simple: focus isn't a willpower problem. It's an energy production problem inside your brain. Once you fuel it at the cellular level, deep focus stops being a struggle and becomes the default state. Thank you to our sponsors! * ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health [http://zenbud.health/] and use code DAVE15 at checkout for a discount. * EMR-Tek | https://www.emr-tek.com/DAVE [https://www.emr-tek.com/DAVE] and use code DAVE for 40% off. * iRestore | Reverse hair loss at www.irestore.com/DAVE [http://www.irestore.com/DAVE] and get exclusive savings on the iRestore Elite, use code DAVE Timestamps: 0:00 – The Longevity Switch 0:47 – Why Mitochondria Matter 2:28 – What Mitophagy Is 2:46 – How Mitophagy Works 4:18 – What Shuts It Off 8:54 – The Damage Compounds 9:22 – How to Turn It Back On 10:31 – Signal 1: Fasting 11:48 – Signal 2: Exercise (REHIT) 12:30 – Signal 3: Cold Exposure 13:22 – Signal 4: NAD+ 14:29 – Signal 5: Urolithin A and Spermidine Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Danger Coffee: https://dangercoffee.com/DAVE15 Dave Asprey’s BEYOND Conference: https://beyondconference.com/ Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15 Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy [https://art19.com/privacy] and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info [https://art19.com/privacy#do-not-sell-my-info].

5 de jul de 202616 min
episode Organic Produce, Exercise vs Income, Cat Parasite, Thorne, Loss of Taste, and more... : 1495 artwork

Organic Produce, Exercise vs Income, Cat Parasite, Thorne, Loss of Taste, and more... : 1495

GLP-1 Side Effects, Gut Microbiome & Brain Health, Toxoplasmosis Risks, and the Dirty Dozen Explained  Plasma Acetate Emerges As Key Gut-Brain Messenger In Older Adults  A study published in Nature Communications examined how gut bacteria relate to plasma acetic acid, a short-chain fatty acid produced when gut microbes ferment fiber, and found that higher acetate levels tracked with lower triglycerides, higher HDL cholesterol, lower body fat, larger thalamic brain volume, and stronger performance on judgment-related cognitive tasks. Mediation analysis showed acetate acts as a direct link between specific gut bacteria, including Oscillibacter and Coprococcus, and these health outcomes. Host Dave Asprey breaks down why this elevates fiber fermentation, not fermented beverages, as the real lever for gut-brain health, and separates the evidence-backed mechanism from the kombucha-as-shortcut assumption.  Source:  https://www.nature.com/articles/s43856-026-01566-x [https://www.nature.com/articles/s43856-026-01566-x]  ~~  GLP-1 Drugs Linked To Sharp Rise In Smell And Taste Disturbances  A JAMA Otolaryngology cohort study tracking over 438,000 GLP-1 users against matched controls found a 48% higher risk of new smell or taste disturbances over two years, with smell disturbances up 81% and taste disturbances up 52%. Diagnoses included anosmia, parosmia, and parageusia, with researchers pointing to GLP-1 receptor activity in the olfactory bulb and other chemosensory pathways as a possible mechanism. Host Dave Asprey unpacks why this signal got buried under muscle loss and gut motility headlines, and what it means for anyone currently on or considering GLP-1 therapy.  Sources:  https://jamanetwork.com/journals/jamaotolaryngology/article-abstract/2850571 [https://jamanetwork.com/journals/jamaotolaryngology/article-abstract/2850571]  https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/10.1001/jamaoto.2026.1498 [https://jamanetwork.com/journals/jamaotolaryngology/fullarticle/10.1001/jamaoto.2026.1498]  https://trial.medpath.com/news/glp-1-receptor-agonists-linked-to-increased-risk-of-smell-and-taste-disturbances-study-finds [https://trial.medpath.com/news/glp-1-receptor-agonists-linked-to-increased-risk-of-smell-and-taste-disturbances-study-finds]  ~~  Scientists Push For Toxoplasmosis To Be Recognized As A Neglected Tropical Disease  A viewpoint paper in PLOS Neglected Tropical Diseases argues that toxoplasmosis, a parasitic infection carried by roughly one in three people globally, deserves WHO neglected tropical disease status given its outsized impact on vision and maternal-child health. Ocular toxoplasmosis is the most common intra-ocular infection worldwide, and an estimated 190,000 babies are born with congenital toxoplasmosis each year, concentrated in low-resource regions. Despite the scale, there is still no vaccine and no standard global treatment protocol. Host Dave Asprey explains why common, quiet health threats get chronically underfunded compared to dramatic outbreaks, and what pregnant listeners specifically should know about exposure risk.  Source:  https://www.sciencealert.com/parasite-affecting-1-in-3-people-is-a-serious-risk-to-human-health-scientists-warn [https://www.sciencealert.com/parasite-affecting-1-in-3-people-is-a-serious-risk-to-human-health-scientists-warn]  ~~  Yale-Oxford Data Shows Exercise May Boost Mental Health More Than A Raise  An analysis of CDC survey data from over 1.2 million U.S. adults found that people who exercise regularly report 1.5 to 2 fewer poor mental health days per month than non-exercisers, a benefit comparable to earning about $25,000 more per year. The data also revealed an inverted-U relationship, with optimal benefits at three to five sessions a week and diminishing or reversed returns at extreme volumes. Host Dave Asprey breaks down why moderate, consistent movement outperforms income as a mental health lever, and why overtraining carries its own psychological cost.  Sources:  https://www.weforum.org/stories/2019/04/exercise-officially-makes-you-happier-than-money-according-to-yale-and-oxford-research/ [https://www.weforum.org/stories/2019/04/exercise-officially-makes-you-happier-than-money-according-to-yale-and-oxford-research/]  https://medicine.yale.edu/news-article/exercise-linked-to-improved-mental-health-but-more-may-not-always-be-better/ [https://medicine.yale.edu/news-article/exercise-linked-to-improved-mental-health-but-more-may-not-always-be-better/]  ~~  Unilever Reportedly Exploring $4 Billion Bid For Supplement Brand Thorne  Unilever is said to be evaluating a bid for Thorne, the clinical-grade supplement brand currently owned by private equity firm L Catterton, in a deal that could value the company at up to $4 billion, with Haleon also reportedly circling. The move reflects a broader trend of major consumer-health conglomerates acquiring practitioner-trusted, lab-forward wellness brands. Host Dave Asprey weighs in on what happens to product quality and innovation when founder-led, science-first supplement companies get absorbed into shareholder-first parent corporations.  Source:  https://www.reuters.com/business/unilever-explores-bid-supplements-maker-thorne-ft-reports-2026-06-26/ [https://www.reuters.com/business/unilever-explores-bid-supplements-maker-thorne-ft-reports-2026-06-26/]  ~~  New Research Maps How Your Microbiome Processes Plant Compounds, And What It Means For Your Produce Aisle Choices  Researchers mapped 775 phytonutrients from over 1,100 edible plants against nearly 2,000 gut bacterial enzymes across thousands of human microbiomes, linking that enzyme activity to outcomes in IBD, colorectal cancer, and fatty liver disease. Individuals varied widely in how many of these compounds their gut could actually process, and in mouse studies, strawberries reduced colitis activity only in mice with an intact microbiome. Host Dave Asprey explains why the plant itself isn't the active ingredient, your bacteria are, and connects the findings to this year's Environmental Working Group Dirty Dozen and Clean Fifteen lists to help listeners decide where organic actually matters.  Sources:  https://pmc.ncbi.nlm.nih.gov/articles/PMC12768975/ [https://pmc.ncbi.nlm.nih.gov/articles/PMC12768975/]  https://www.eurekalert.org/news-releases/1108351 [https://www.eurekalert.org/news-releases/1108351]  https://www.nature.com/articles/s41564-025-02197-z [https://www.nature.com/articles/s41564-025-02197-z]  ~~  This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners who want mechanism-level insights into the gut-brain axis, an underreported GLP-1 side effect, a global parasite hiding in plain sight, the real ROI of exercise on mental health, consolidation in the supplement industry, and how your microbiome determines what your produce actually does for you. Host Dave Asprey connects clinical research, large cohort studies, mechanistic biology, and industry news into practical frameworks for improving gut health, brain performance, and long-term resilience.  New episodes every Tuesday, Thursday, Friday, and Sunday.  Keywords: plasma acetate gut brain axis, short chain fatty acids, gut microbiome cognition, GLP-1 smell taste disturbances, anosmia parosmia GLP-1, semaglutide side effects, toxoplasmosis neglected tropical disease, Toxoplasma gondii health risks, congenital toxoplasmosis, exercise mental health study, exercise versus income happiness, overtraining mental health, Unilever Thorne acquisition, supplement industry consolidation, phytonutrient gut bacteria enzymes, polyphenol metabolism microbiome, Dirty Dozen Clean Fifteen 2026, pesticide residue produce, biohacking news 2026, Dave Asprey, The Human Upgrade  Thank you to our sponsors!   - PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave [http://predictivemind.io/dave] and use code DAVE for 10% off.  - Viome | Check it out at viome.com [http://viome.com/] and use code 10DAVE for 10% off. It’s time to stop guessing and start knowing your body.  - iRestore | Reverse hair loss at www.irestore.com/DAVE [http://www.irestore.com/DAVE] and get exclusive savings on the iRestore Elite, use code DAVE  Resources:    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ [https://daveasprey.com/2026-clean-nicotine-roadmap/]  • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ [https://daveasprey.com/2026-biohacking-trends-report/]  • Dave Asprey's Latest News | Go to https://daveasprey.com/ [https://daveasprey.com/] to join Inside Track today.   • Danger Coffee: https://dangercoffee.com/discount/dave15 [https://dangercoffee.com/discount/dave15]    • My Daily Supplements: SuppGrade Labs [https://www.shopsuppgradelabs.com/discount/DAVE15] (15% Off)    • Favorite Blue Light Blocking Glasses: TrueDark [https://truedark.com/?coupon-code=DAVEASPREY15&sc-page=shop] (15% Off)    • Dave Asprey’s BEYOND Conference: https://beyondconference.com [https://beyondconference.com/]    • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated [https://daveasprey.com/heavily-meditated]   • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ [https://substack.daveasprey.com/]  • Upgrade Labs: https://upgradelabs.com [https://upgradelabs.com/]     Timestamps:  00:00 – Story #1: Acetate & Gut-Brain Health  01:57 – Story #2: GLP-1s & Smell/Taste Loss  03:22 – Story #3: Toxoplasmosis Risks  04:33 – Story #4: Exercise vs Income  05:53 – Story #5: Phytonutrients & Gut Enzymes  07:45 – Dirty Dozen & Clean Fifteen  08:46 – Story #6: Thorne Acquisition  09:49 – Takeaway  See Privacy Policy at https://art19.com/privacy [https://art19.com/privacy] and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info [https://art19.com/privacy#do-not-sell-my-info].

3 de jul de 202610 min
episode 90 Days of Full Carnivore: No Plants, No Fiber, Surprising Gut Results | Ben Azadi : 1494 artwork

90 Days of Full Carnivore: No Plants, No Fiber, Surprising Gut Results | Ben Azadi : 1494

Carnivore Diet, Cholesterol, Gut Bacteria, Microbiome, and Fasting Insulin Results from a 90-Day Self-Experiment  What if cutting out fiber entirely actually improved your gut bacteria? This episode breaks down a real 90-day carnivore self-experiment, complete with before and after blood work, stool testing, and continuous glucose data, that challenges everything you think you know about fiber, cholesterol, and metabolic health.    Watch this episode on YouTube for the full video experience:  https://www.youtube.com/@DaveAspreyBPR [https://www.youtube.com/@DaveAspreyBPR]    Host Dave Asprey sits down with Ben Azadi, founder of Keto Kamp and bestselling author of Metabolic Freedom. After overcoming obesity and severe health challenges, Ben has spent years educating millions of people on metabolic health, fasting, ketosis, and biohacking strategies through his podcast, books, and YouTube channel with over a million subscribers. He is known for turning complex science into practical tools anyone can use to burn fat, boost human performance, and support long-term longevity.  Ben walks through what happened when he ate nothing but meat, eggs, and dairy for 90 straight days, tracking everything from his microbiome diversity to his LDL particle size. His cholesterol numbers spiked, but the full lipid panel tells a very different story than most doctors would assume. They get into why ketosis works better when you cycle in and out of it, how sodium and electrolytes play a bigger role in insulin resistance than most people realize, and why eating 17 to 23 times a day might be quietly wrecking your metabolism.  The conversation also covers the real science behind creatine absorption, why Dave adds his to hot coffee for better brain uptake, the truth about cooking oils and smoke points, and why cold plunging is one of the most misunderstood biohacks in the wellness space. Dave and Ben dig into mitochondria, fasting protocols, sleep optimization, and the supplements that actually move the needle for energy, fat loss, and anti-aging.  This is essential listening for anyone serious about biohacking, functional medicine, brain optimization, and building a body that performs at a higher level for longer.  You'll Learn:  * What 90 days of zero fiber actually did to his gut bacteria and microbiome diversity  * Why his cholesterol went up but his cardiovascular risk markers stayed low  * The real reason cyclical ketosis works better than staying in ketosis full time  * How sodium and electrolyte intake affects insulin resistance and metabolism  * Why eating too frequently keeps your body stuck in glucose and insulin spikes  * The creatine hack that increases brain absorption using hot coffee  * Why cold plunging is overrated for most people who skip the hormesis basics    Thank you to our sponsors!       - PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave [http://predictivemind.io/dave] and use code DAVE for 10% off.  - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health [https://zenbud.health/] and use code DAVE15 at checkout for a discount.  - Timeline | Visit timeline.com/dave [http://timeline.com/dave] to learn more about Mitopure and get 20% off your first order for a limited time.  - ENERGYbits | If you want a simpler, smarter way to support your body… this is it. Head to ENERGYbits.com [http://energybits.com/] and use code ASPREY for 20% off your order.  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: Ben Azadi, Keto Kamp, carnivore diet, 90-day carnivore experiment, gut microbiome, gut bacteria diversity, fiber-free diet, LDL particle size, cyclical ketosis, fasting, autophagy, electrolytes, sodium intake, insulin resistance, fasting insulin, creatine, blood-brain barrier, melatonin, mitochondria, hormesis, cold plunge, dopamine receptors, olive oil polyphenols, smoke point, beef tallow, seed oils, HRV, sleep optimization, KetoFlex, Metabolic Freedom  Resources:    • See All Of Ben Azadi's Content At: https://benazadi.com/ [https://benazadi.com/]  • Check Out Ben’s YouTube Channel: https://www.youtube.com/@KetoKamp [https://www.youtube.com/@KetoKamp]  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ [https://daveasprey.com/2026-clean-nicotine-roadmap/]   • Dave Asprey's Latest News | Go to https://daveasprey.com/ [https://daveasprey.com/] to join Inside Track today.    • Danger Coffee: https://dangercoffee.com/discount/dave15 [https://dangercoffee.com/discount/dave15]     • My Daily Supplements: SuppGrade Labs [https://www.shopsuppgradelabs.com/discount/DAVE15] (15% Off)     • Favorite Blue Light Blocking Glasses: TrueDark [https://truedark.com/?coupon-code=DAVEASPREY15&sc-page=shop] (15% Off)     • Dave Asprey’s BEYOND Conference: https://beyondconference.com [https://beyondconference.com/]     • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated [https://daveasprey.com/heavily-meditated]    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ [https://substack.daveasprey.com/]   • Upgrade Labs: https://upgradelabs.com [https://upgradelabs.com/]      Timestamps:   00:00 – Trailer  01:15 – 90-Day Carnivore Experiment  04:43 – Cholesterol & Lipid Results  09:12 – Cyclical Keto Approach  20:19 – Reading Body Signals  26:36 – Danger Creatine Launch  31:55 – Calories vs. Hormones  33:53 – Root Cause of Insulin Resistance  35:37 – Sodium & Electrolytes  45:11 – Sleep Optimization  49:19 – Cold Plunging Overrated  51:17 – BICEP & Dopamine Reset  See Privacy Policy at https://art19.com/privacy [https://art19.com/privacy] and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info [https://art19.com/privacy#do-not-sell-my-info].

2 de jul de 20261 h 2 min