TSOT155: IgG-4 Massive Increase - Mechanism of Immune Response Suppression Generally, and Specifically After Covid-19 Jabs

A follow-up to QROT-197 (“Jabs Cause Huge Increase in IgG4. Which Massively Reduces Immune Responses"). A walk down of the scientific journal article "receipts." This proves beyond any doubt what any of their experts MUST have known through application of the most basic principles of their profession.  TLDL:  1. Massive exposure to an antigen (any molecule capable of inducing an immune response (to produce an antibody) in the host organism) results in IgG-4 increasing. This is such a known phenomena that we have "IgG-4 Related (Systemic) Disease."  2. IgG-4's effect is to slow down the immune response to the invader.  Where they happily admit it usually is when the result stops "allergic hypersensitivity" 3. mRNA Covid jabs have been shown to massively increase (by 500 TIMES) IgG-4 for the spike protein.  Not immediately, but after enough boosters. This does NOT occur with other types of vaccines (not that mRNA coding jab is a vaccine, but that's what they call it so they get immunity from lawsuits) 4. The reason, cited by the journals as well, is that since mRNA makes the body create the spike protein with no real limiting factor, you then eventually get too many created (and the literature has shown they persist in the body for a long time).  5. You now have the massive exposure required for your body to decide it needs to put the brakes on the immune response to the spike protein.  6. This results in the "vaccine" causing worse "breakthrough infections" from what it "protects" us from (infections that occur despite the vaccine having been administered.  ======================================================= EPISODE TIMELINE AND NOTES 0:00 Teaser Quotes 1:34 Intro * This regards the topic that I was introduced to via The Tenpenny Files. The guest Dr David Rasnick, worked with Peter Duesberg. Is an expert on the chromosomal imbalance (aneuploidy) theory of cancer.  Book “The Outsider: A Personal Odyssey into the Essence of Cancer [https://trineday.myshopify.com/products/the-outsider-a-personal-odyssey-into-the-essence-of-cancer].” *  What we’re covering here is more specific than his entire book. It’s his claim that an increase in IgG-4 (the unusual antibody that “puts the brakes on” the immune response) is increased as a result of multiple jabs, therefore allowing covid-19 infections rather than preventing it.  * Related is the idea of this increased IgG-4 and immune response suppression outside of the Covid-19 jab, and also then extending the logic to how cancers can be more serious since the immune system is also what protects us against cancer.  * I have not read his book, and this is not a recitation of it. Rather, it is me, as is my way, sometimes deep-diving to see if someone’s claim has a basis in published science, and laying out that proof and the logical sequence.  * That logical sequence, which is also how the rest of the episode is structured is as follows:  * What is IgG-4? * IgG-4 and its KNOWN application regarding reducing allergic reactions * IgG-4 and its general application to immune suppression * IgG-4 Related Disease, as a proof of the mechanism * IgG-4 increased by the jab * IgG-4 and increased cancer * The Jab and increased cancer 8:08 What is IgG-4?  Immunoglobulins are antibodies. IgG-4 a particular subclass of the IgG class of antibody.  13:34 IgG-4 and its known application regarding reducing allergic reactions * IgG-4 is the antibody that puts the brakes on the immune reaction, stopping allergic hypersensitivity.  * Often following large or chronic exposure to allergic antigens: "An important feature of IgG-4 production is the association with high-dose chronic antigen exposure."  * Known as “immune tolerance.”  * Also can DIRECTLY inhibit the activity of IgE (which is a REGULAR antibody, that is used to actually respond to the allergy antigens in the traditional antibody way.  * ASIDE: Decoding the use of “allergy” in the poison…errr. “drug” commercial warnings * Higher IgG-4 resulting in "Reduced effector function" (that is, reduced activity by the immune system to counter the antigen threat) 26:10 IgG-4 and its general application to immune suppression * Brave search question: Would a massive IGG-4 increase theoretically result in immune system being less active? Then backed up by the associated journal articles.  * A repetition from the basics as applied in allergen context, since allergens are antigens, and things that come into your body to effect “disease” are also antigens, subject to the  immune system response.  * “effectively dampening immune activation” 32:21 IgG-4 Related Disease as proof of the mechanism * Was called IgG-4 Related SYSTEMIC Disease. Then they decided they should bury that more clear title. * A chronic inflammatory condition, characterized by tissue infiltration with lymphocytes*, IgG4-secreting plasma cells, and various degrees of fibrosis (scarring). * *a type of white blood cell, and include t-cells, b-cells, innate lymphoid cells, of which natural killer cells are an important subtype. * An ASIDE emphasis on a journal article stating as plain background in a consensus statement on the pathology of IG-4 Related Disease, where it confirms that IgG-4 rises often 10 to 100 fold during successful allergen immunotherapy, the "increase correlates directly with the development of human tolerance, where the immune system stops overreacting to the allergen."  IT'S ALL RELATED 36:51 IgG-4 increased by the jab * IgG-4 antibodies can surpass all other IgG antibodies developed towards the spike protein, rising consistently from an average of 0.04% after the second immunization to 19.27% after the third one * CORRECTION: Note my verbal slip at 42:12.  * In discussing IgG-4 going from 0.04% to over 19% I talked through the math, but then instead of saying that that was almost a 500-fold increase, I accidentally said a 500% increase. That’d be wrong, in that 500% would only be a five-fold increase. Indeed the almost 500-fold increase is what is accurate.  * Per journal article, factors of this massive increase in IgG-4 are time since last jab, and whether you have continuous exposure to the spike protein  * (yet we know now that spike protein persists in the body for up to YEARS) * But this increase does not occur with traditional vaccines  * (LOGIC is SIMPLE – I explain it. The “code” makes your body CREATE a LOT of spike protein versus the small amount introduced by the other types of vaccines) * The increase also does not occur among those vaccinated after they’ve had actual Covid-19 * ASIDE: Plain and simple non-controversial statement as background that this covid vaccine and many others “do not produce sterilizing immunity, allowing people to suffer frequent re-infections.” * 65:50 ASIDE: Journal article stating plainly how the UK ONS findings entirely disagree with the US pat lying answer as to effectiveness, AND mentions all-cause mortality increase (versus pre-covid), for periods of time after vaccines had been introduced, in proportion to the level to which they were administered by country, in a study involving data from 31 countries. * 69:38 Construction of nanotubes (!!!   :-O )  71:17 IgG-4 and increased cancer * Increased IgG-4 found in either blood or tissues or both in esophageal cancer, melanoma, gastric cancer, colorectal cancer. * Also a larger % of IgG-4 is associated with worst clinical outcomes for the cancer.  79:42 Summarizing it all  ========================================= QUOTES USED AT BEGINNING OF EPISODES * IgG4 Antibodies Induced by Repeated Vaccination May Generate Immune Tolerance to the SARS-CoV-2 Spike Protein * In conclusion, these findings show that, like younger individuals, older adults produce antibodies with reduced functional capacity upon repeated COVID-19 mRNA vaccination * Repeated mRNA COVID-19 vaccinations cause a significant increase in SARS-CoV-2 spike-specific IgG4 antibodies, a subclass typically associated with immune tolerance rather than viral clearance.  While IgG4 is initially undetectable after primary doses, it rises extensively six months post-second dose and can become the dominant IgG subclass after the third or fourth mRNA booster, replacing IgG1 in some individuals. * [T]he possible link between the spike protein immunoglobulin G4 antibodies and cancer progression * Repeated inoculation with messenger RNA (mRNA) vaccines elicits immunoglobulin G4 (IgG4) antibody production. Such an increase in the concentration of specific and non-specific IgG4 antibodies allows the growth of some types of cancer by blocking the activation of effector immune cells. ================================================== References used in Podcast Episode ThermoFisher Scientific Introduction to Immunoglobulins [https://www.thermofisher.com/us/en/home/life-science/antibodies/antibodies-learning-center/antibodies-resource-library/antibody-methods/introduction-immunoglobulins.html]ThermoFisher Scientific Immunoglobulin IgG Class [https://www.thermofisher.com/us/en/home/life-science/antibodies/antibodies-learning-center/antibodies-resource-library/antibody-methods/immunoglobulin-igg-class.html] James, L.K., Till, S.J. Potential Mechanisms for IgG4 Inhibition of Immediate Hypersensitivity Reactions [https://link.springer.com/article/10.1007/s11882-016-0600-2]. Curr Allergy Asthma Rep 16, 23 (2016). https://doi.org/10.1007/s11882-016-0600-2 [https://doi.org/10.1007/s11882-016-0600-2] Shi LL, Xiong P, Yang M, Ardicli O, Schneider SR, Funch AB, Kiykim A, Lopez J, Akdis CA, Akdis M. Role of IgG4 Antibodies in Human Health and Disease [https://pmc.ncbi.nlm.nih.gov/articles/PMC12071442/]. Cells. 2025 Apr 25;14(9):639. doi: 10.3390/cells14090639. PMID: 40358163; PMCID: PMC12071442. https://en.wikipedia.org/wiki/IgG4-related_disease [https://en.wikipedia.org/wiki/IgG4-related_disease] Deshpande, Vikram, Yoh Zen, John KC Chan, Eunhee E Yi, Yasuharu Sato, Tadashi Yoshino, Günter Klöppel, et al. 2012. Consensus statement on the pathology of IgG4-related disease [https://dash.harvard.edu/entities/publication/73120378-cd15-6bd4-e053-0100007fdf3b]. Modern Pathology 25(9): 1181–1192. Gelderloos, A.T., Verheul, M.K., Middelhof, I. et al. Repeated COVID-19 mRNA vaccination results in IgG4 class switching and decreased NK cell activation by S1-specific antibodies in older adults. [https://link.springer.com/article/10.1186/s12979-024-00466-9] Immun Ageing 21, 63 (2024). https://doi.org/10.1186/s12979-024-00466-9 [https://doi.org/10.1186/s12979-024-00466-9] Raszek M, Cowley D, Redwan EM, Uversky VN, Rubio-Casillas A. Exploring the possible link between the spike protein immunoglobulin G4 antibodies and cancer progression [https://www.explorationpub.com/Journals/ei/Article/1003140]. Explor Immunol. 2024;4:267–84. https://doi.org/10.37349/ei.2024.00140 [https://doi.org/10.37349/ei.2024.00140]========================================= References mentioned but not quoted from during episode: Irrgang P, Gerling J, Kocher K, Lapuente D, Steininger P, Habenicht K, et al. Class switch toward noninflammatory, spike-specific IgG4 antibodies after repeated SARS-CoV-2 mRNA vaccination. Sci Immunol. 2023;8(79):eade2798. Kiszel P, Sik P, Miklos J, Kajdacsi E, Sinkovits G, Cervenak L, Prohaszka Z. Class switch towards spike protein-specific IgG4 antibodies after SARS-CoV-2 mRNA vaccination depends on prior infection history. Sci Rep. 2023;13(1):13166. Buhre JS, Pongracz T, Kunsting I, Lixenfeld AS, Wang W, Nouta J, et al. mRNA vaccines against SARS-CoV-2 induce comparably low long-term IgG Fc galactosylation and sialylation levels but increasing long-term IgG4 responses compared to an adenovirus-based vaccine. Front Immunol. 2022;13:1020844. Akhtar M, Islam MR, Khaton F, Soltana UH, Jafrin SA, Rahman SIA, et al. Appearance of tolerance-induction and non-inflammatory SARS-CoV-2 spike-specific IgG4 antibodies after COVID-19 booster vaccinations. Front Immunol. 2023;14:1309997. Yoshimura M, Sakamoto A, Ozuru R, Kurihara Y, Itoh R, Ishii K, et al. The appearance of anti-spike receptor binding domain immunoglobulin G4 responses after repetitive immunization with messenger RNA-based COVID-19 vaccines. Int J Infect Dis. 2024;139:1–5. Selva KJ, Ramanathan P, Haycroft ER, Reynaldi A, Cromer D, Tan CW, et al. Preexisting immunity restricts mucosal antibody recognition of SARS-CoV-2 and Fc profiles during breakthrough infections. JCI Insight. 2023;8(18):e172470. Kalkeri R, Zhu M, Cloney-Clark S, Plested JS, Parekh A, Gorinson D, et al. Altered IgG4 Antibody Response to Repeated mRNA versus Protein COVID Vaccines. medRxiv. 2024.