The Tim Ferriss Show

This episode is a solo Q&A session where I answer a bunch of questions. We covered a ton of ground, from personal health protocols to professional frameworks and creative projects.  This episode is brought to you by: Eight Sleep Pod Cover 5 [https://www.eightsleep.com/tim/] sleeping solution for dynamic cooling and heating: EightSleep.com/Tim [https://www.eightsleep.com/tim/] (use code TIM to get $350 off your very own Pod 5 Ultra.) Monarch Money [https://www.monarchmoney.com/tim] track, budget, plan, and do more with your money: MonarchMoney.com/Tim [https://www.monarchmoney.com/tim] (50% off your first year at monarchmoney.com with code TIM) Shopify [https://shopify.com/tim] global commerce platform, providing tools to start, grow, market, and manage a retail business: https://shopify.com/tim [https://shopify.com/tim] (one-dollar-per-month trial period) Timestamps: [00:00:00] Start [00:06:00] Coyote retail distribution challenges and data gathering. [00:09:12] Elbow surgery recovery: sequencing, decongestion, Marc Pro device, peptides, BFR training. [00:16:14] California vs. Austin for builders, mechanical engineers, and tech startups. [00:19:06] Using AI for medical advice workflow (and cross-referencing with professionals). [00:23:51] Current supplement regimen and PAGG/AGG status. [00:31:54] California vs. Texas considerations for aspiring parents. [00:32:48] Saying "No" to good things for "Hell, yes" moments. [00:34:34] Philanthropy lessons learned since starting Saisei Foundation. [00:37:45] Something I've changed my mind about recently: intermittent fasting. [00:42:44] Precious items from childhood I still keep: D&D relics and marine biology books. [00:43:03] Bucket list hike: Glacier National Park. [00:43:42] How the catalytic chaos of publishing The 4-Hour Chef led to launching this podcast. [00:45:52] Bringing delight vs. sixth-gear, high-performance focus. [00:49:05] Thoughts on extended human fasting research from the Soviet era. [00:52:58] Most magical New Mexico experience: Mountain Cloud Zen Center meditation retreat. [00:53:22] Meta skills for the AI era: Hyper-adaptability and world-class learning. [00:54:01] The (real and ideal) future of CØCKPUNCH/Legends of Varlata. [00:59:47] Competitive chess training enhancement: glucose management, intermittent fasting, MCT oil. [01:06:31] Behind-the-scenes projects: Fusion, algae feed additives, meat alternatives. [01:08:32] Countries I wish I had visited earlier, and places I'd still like to see. [01:11:06] "Not yet" vs. "No" in early growth phases. [01:14:14] Post Coyote, do I have any future games in the works? [01:14:46] Over-ear vs. in-ear headphones for podcasting. [01:15:16] What's the uncrowded channel right now? [01:16:17] Recommendations for Dr. Mindy Pelz. [01:16:58] Robert Rodriguez and project juggling. [01:17:24] Fast neutron reactors and the Bugatti of ketones. [01:19:05] Extended family outings and Mahonk Mountain House. [01:20:31] NO BOOK meetup plans? [01:20:54] Parting thoughts. * For show notes and past guests on The Tim Ferriss Show [https://tim.blog/podcast], please visit tim.blog/podcast [https://tim.blog/podcast/?utm_source=podcast&utm_medium=podcast&utm_campaign=podcast-description]. For deals from sponsors of The Tim Ferriss Show [https://tim.blog/podcast], please visit tim.blog/podcast-sponsors [https://tim.blog/podcast-sponsors] Sign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday [https://go.tim.blog/5-bullet-friday-1/]. For transcripts of episodes, go to tim.blog/transcripts [https://tim.blog/transcripts]. Discover Tim’s books: tim.blog/books [https://tim.blog/books]. Follow Tim: Twitter: twitter.com/tferriss [https://twitter.com/tferriss]  Instagram: instagram.com/timferriss [https://instagram.com/timferriss/] YouTube: youtube.com/timferriss [https://www.youtube.com/timferriss] Facebook: facebook.com/timferriss [https://www.facebook.com/TimFerriss/]  LinkedIn: linkedin.com/in/timferriss [http://linkedin.com/in/timferriss] Past guests on The Tim Ferriss Show [http://tim.blog/podcast] include Jerry Seinfeld [https://tim.blog/2020/12/08/jerry-seinfeld/], Hugh Jackman [https://tim.blog/2020/06/26/hugh-jackman/], Dr. Jane Goodall [https://tim.blog/2020/04/16/jane-goodall/], LeBron James [https://tim.blog/2018/11/27/lebron-james-mike-mancias/], Kevin Hart [https://tim.blog/2020/05/20/kevin-hart/], Doris Kearns Goodwin [https://tim.blog/2018/09/07/doris-kearns-goodwin-leadership/], Jamie Foxx [https://tim.blog/2015/12/06/jamie-foxx/], Matthew McConaughey [https://tim.blog/2020/10/19/matthew-mcconaughey/], Esther Perel [https://tim.blog/2017/05/21/esther-perel/], Elizabeth Gilbert [https://tim.blog/2020/05/08/elizabeth-gilbert/], Terry Crews [https://tim.blog/2017/12/20/terry-crews-how-to-have-do-and-be-all-you-want/], Sia [https://tim.blog/2020/08/12/sia/], Yuval Noah Harari [https://tim.blog/2020/10/27/yuval-noah-harari/], Malcolm Gladwell [https://tim.blog/2016/06/21/malcolm-gladwell/], Madeleine Albright [https://tim.blog/2020/05/27/secretary-madeleine-albright/], Cheryl Strayed [https://tim.blog/2017/03/30/cheryl-strayed/], Jim Collins [https://tim.blog/2019/02/18/jim-collins/], Mary Karr, [https://tim.blog/2020/11/11/mary-karr/] Maria Popova [https://tim.blog/2014/10/21/brain-pickings/], Sam Harris [https://tim.blog/2020/05/15/sam-harris-2/], Michael Phelps [https://tim.blog/2021/01/21/michael-phelps-grant-hackett/], Bob Iger [https://tim.blog/2020/01/16/bob-iger/], Edward Norton [https://tim.blog/2019/10/31/edward-norton-motherless-brooklyn/], Arnold Schwarzenegger [https://tim.blog/2015/02/02/arnold-schwarzenegger/], Neil Strauss [https://tim.blog/2014/06/24/neil-strauss/], Ken Burns [https://tim.blog/2019/09/12/ken-burns/], Maria Sharapova [https://tim.blog/2017/08/26/maria-sharapova/], Marc Andreessen [https://tim.blog/2016/05/29/marc-andreessen/], Neil Gaiman [https://tim.blog/2019/03/28/neil-gaiman/], Neil de Grasse Tyson [https://tim.blog/2019/10/03/neil-degrasse-tyson/], Jocko Willink [https://tim.blog/2016/09/21/jocko-willink-on-discipline-leadership-and-overcoming-doubt/], Daniel Ek [https://tim.blog/2020/12/03/daniel-ek/], Kelly Slater [https://tim.blog/2020/09/08/kelly-slater/], Dr. Peter Attia [https://tim.blog/2019/11/27/peter-attia-fasting-metformin-longevity/], Seth Godin [https://tim.blog/2016/02/10/seth-godin/], Howard Marks [https://tim.blog/2018/09/25/howard-marks/], Dr. Brené Brown [https://tim.blog/2020/02/06/brene-brown-striving-self-acceptance-saving-marriages/], Eric Schmidt [https://tim.blog/2019/04/09/eric-schmidt/], Michael Lewis [https://tim.blog/2020/05/01/michael-lewis/], Joe Gebbia [https://tim.blog/2018/03/08/joe-gebbia-co-founder-of-airbnb/], Michael Pollan [https://tim.blog/2018/05/06/michael-pollan-how-to-change-your-mind/], Dr. Jordan Peterson [https://tim.blog/2021/03/01/jordan-peterson/], Vince Vaughn [https://tim.blog/2017/05/31/vince-vaughn/], Brian Koppelman [https://tim.blog/2020/04/23/brian-koppelman/], Ramit Sethi [https://tim.blog/2019/05/07/ramit-sethi/], Dax Shepard [https://tim.blog/2020/11/18/dax-shepard/], Tony Robbins [https://tim.blog/2014/10/15/money-master-the-game/], Jim Dethmer [https://tim.blog/2020/05/18/jim-dethmer/], Dan Harris [https://tim.blog/2020/11/19/dan-harris/], Ray Dalio [https://tim.blog/2017/09/13/ray-dalio/], Naval Ravikant [https://tim.blog/2015/08/18/the-evolutionary-angel-naval-ravikant/], Vitalik Buterin [https://tim.blog/2021/03/08/vitalik-buterin-naval-ravikant/], Elizabeth Lesser [https://tim.blog/2021/03/16/elizabeth-lesser/], Amanda Palmer [https://tim.blog/2019/04/18/amanda-palmer-2/], Katie Haun [https://tim.blog/2021/02/18/katie-haun/], Sir Richard Branson [https://tim.blog/2017/10/09/richard-branson/], Chuck Palahniuk [https://tim.blog/2020/09/02/chuck-palahniuk/], Arianna Huffington [https://tim.blog/2017/10/18/arianna-huffington/], Reid Hoffman [https://tim.blog/2015/08/31/the-oracle-of-silicon-valley-reid-hoffman-plus-michael-mccullough/], Bill Burr [https://tim.blog/2017/09/17/bill-burr/], Whitney Cummings [https://tim.blog/2015/06/26/whitney-cummings/], Rick Rubin [https://tim.blog/2015/05/15/rick-rubin/], Dr. Vivek Murthy [https://tim.blog/2020/03/26/vivek-murthy/], Darren Aronofsky [https://tim.blog/2017/09/09/darren-aronofsky/], Margaret Atwood [https://tim.blog/2022/02/22/margaret-atwood/], Mark Zuckerberg [https://tim.blog/2022/03/24/mark-zuckerberg/], Peter Thiel [https://tim.blog/2014/09/09/peter-thiel/], Dr. Gabor Maté [https://tim.blog/2018/02/20/gabor-mate/], Anne Lamott [https://tim.blog/2021/07/09/anne-lamott/], Sarah Silverman [https://tim.blog/2022/01/12/sarah-silverman/], Dr. Andrew Huberman [https://tim.blog/2021/07/06/andrew-huberman/], and many more. See Privacy Policy at https://art19.com/privacy [https://art19.com/privacy] and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info [https://art19.com/privacy#do-not-sell-my-info].

Dr. Dominic D’Agostino (@DominicDAgosti2 [https://x.com/DominicDAgosti2]) is a tenured associate professor in the Department of Molecular Pharmacology and Physiology at the University of South Florida Morsani College of Medicine and a Visiting Senior Research Scientist at the Institute for Human and Machine Cognition. This episode is brought to you by: Helix Sleep [https://helixsleep.com/tim] premium mattresses: https://HelixSleep.com/Tim [https://helixsleep.com/tim] (27% off all mattress orders) Momentous [https://livemomentous.com/tim] high-quality creatine: https://livemomentous.com/tim [https://livemomentous.com/tim] (code TIM for up to 35% off) AG1 [https://drinkag1.com/Tim] all-in-one nutritional supplement: https://DrinkAG1.com/Tim [https://drinkag1.com/Tim] (1-year supply of Vitamin D plus 5 free AG1 travel packs) Timestamps: [00:00:00] Start. [00:14:43] Why I'm interested in ketogenic strategies for neurodegenerative prevention. [00:16:18] Mary and Steve Newport's ketone-linked temporary cognitive improvements. [00:18:18] A mechanisms overview for Alzheimer's/dementia. [00:21:25] The immune system as longevity's "fifth horseman" — and why metabolic control is key. [00:22:04] How to measure ketones and GKI. [00:23:00] Fasting vs. ketogenic diet. [00:24:18] There's nothing fishy about sardine fasting. [00:28:32] My hiatal hernia discovery and increased cancer risk concerns. [00:30:04] HSCRP as a superior biomarker to LDL for cardiovascular risk. [00:31:57] Glucose tolerance testing revelations and CGM importance. [00:31:57] Upgrading the metabolic machinery through keto without getting bored. [00:42:07] What do do if you, like Dom and me, are among the 30% who suffer from cholesterol hyperabsorption. [00:43:42] Dom's day-to-day diet regimen. [00:45:56] How Dom optimizes his aging dogs with ketones, SARMs, and supplements. [00:51:30] Supplementing for sleep disruption while fasting. [00:55:41] Why Dom doesn't have misgivings about melatonin. [00:59:15] Shingles prevention through fasting protocols. [01:00:15] Immune system modulation: Innate vs. adaptive, vegan vs. ketogenic. [01:03:54] Dom at 50-something: Current meal timing and composition. [01:05:57] Blue zone observations: Greek and Sardinian longevity habits. [01:08:16] Ketogenic diet initiation tips: MCT, electrolytes, and fasted cardio. [01:15:18] Ketone metabolic therapy for cancer. [01:18:15] The metabolic psychiatry revolution. [01:22:10] The soothing effects of hyperbaric oxygen and ketosis on seizure sufferers. [01:28:27] Metformin vs. berberine. [01:31:43] The low-dose neuroprotective potential of GLP-1 drugs. [01:34:58] NAD research: MIB-626 and stabilized forms for mitochondrial health. [01:39:48] Idebenone, CoQ10, and the Deanna protocol for ALS. [01:42:05] Dom's supplement short list: CoQ10, creatine, ketones, vitamin D, melatonin. [01:44:43] KetoNutrition.org, Metabolic Health Summit, Audacious Nutrition, veteran-focused research protocols, and other parting thoughts. * Show notes for this episode: https://tim.blog/2025/09/03/dr-dominic-dagostino-all-things-ketones/ For show notes and past guests on The Tim Ferriss Show [https://tim.blog/podcast], please visit tim.blog/podcast [https://tim.blog/podcast/?utm_source=podcast&utm_medium=podcast&utm_campaign=podcast-description]. For deals from sponsors of The Tim Ferriss Show [https://tim.blog/podcast], please visit tim.blog/podcast-sponsors [https://tim.blog/podcast-sponsors] Sign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday [https://go.tim.blog/5-bullet-friday-1/]. For transcripts of episodes, go to tim.blog/transcripts [https://tim.blog/transcripts]. Discover Tim’s books: tim.blog/books [https://tim.blog/books]. Follow Tim: Twitter: twitter.com/tferriss [https://twitter.com/tferriss]  Instagram: instagram.com/timferriss [https://instagram.com/timferriss/] YouTube: youtube.com/timferriss [https://www.youtube.com/timferriss] Facebook: facebook.com/timferriss [https://www.facebook.com/TimFerriss/]  LinkedIn: linkedin.com/in/timferriss [http://linkedin.com/in/timferriss] See Privacy Policy at https://art19.com/privacy [https://art19.com/privacy] and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info [https://art19.com/privacy#do-not-sell-my-info].

Kevin J. Tracey, MD is president and CEO of the Feinstein Institutes for Medical Research at Northwell Health, a pioneer of vagus nerve research and author of the recent book, The Great Nerve: The New Science of the Vagus Nerve and How to Harness Its Healing Reflexes [https://www.amazon.com/gp/product/059371699X/?tag=offsitoftimfe-20]. This episode is brought to you by: Eight Sleep Pod Cover 5 [https://www.eightsleep.com/tim/] sleeping solution for dynamic cooling and heating: EightSleep.com/Tim [https://www.eightsleep.com/tim/] (use code TIM to get $350 off your very own Pod 5 Ultra.) AG1 [https://drinkag1.com/Tim] all-in-one nutritional supplement: https://DrinkAG1.com/Tim [https://drinkag1.com/Tim] (1-year supply of Vitamin D plus 5 free AG1 travel packs with your first subscription purchase.) Wealthfront [https://wealthfront.com/Tim] high-yield cash account: https://Wealthfront.com/Tim [https://wealthfront.com/Tim] (Start earning 4.00% APY on your short-term cash until you’re ready to invest. And when new clients open an account today, you can get an extra fifty-dollar bonus [https://wealthfront.com/Tim] with a deposit of five hundred dollars or more.) Terms apply. Tim Ferriss receives cash compensation from Wealthfront Brokerage, LLC for advertising and holds a non-controlling equity interest in the corporate parent of Wealthfront Brokerage. See full disclosures here [https://wealthfront.com/Tim]. Timestamps: 00:00 Tim’s intro: why he dismissed vagus-nerve hype 06:34 What the vagus nerve actually is, plus common myths 11:31 Breaking news: FDA approval for SetPoint’s RA implant + Kelly Owens’s turnaround 21:11 Inflammation 101: when healing turns harmful 31:37 Bioelectronic medicine: from lab insight to real devices 55:26 TNF, IL-1, and IL-6: immune drivers and what VNS modulates 56:06 Exercise & recovery: vagal signals, IL-6, and adaptation 56:30 Cold exposure & breathwork: sympathetic spike, parasympathetic payoff 59:04 Chronic inflammation today: prevalence, diagnostics, and uncertainty 59:53 Autoimmunity: genes, environment, infections 01:01:08 Stress hormones, personality traits, and metabolic fallout 01:05:41 VNS tech landscape: implants, focused ultrasound, and what’s just TENS 01:11:14 Ear maps, revisited: the real science behind auricular stimulation 01:27:52 Ulf Andersson: auricular TENS, famotidine, and a depression turnaround 01:36:48 Depression & inflammation: where VNS helps (and where it doesn’t) 01:41:38 Body-brain loop: how inflammation signals ride the vagus nerve 01:42:56 Why VNS can lift mood: a working theory 01:43:22 Ulf’s setup: electrode placement and twice-daily routine 01:44:37 Acupuncture, fertility, and plausible vagal links 01:47:23 Chronic pain through an inflammation lens 01:48:34 Neural “engrams”: how the brain can store inflammatory memories 02:02:35 Cervical TENS vs. true VNS: mechanisms and open questions 02:12:15 On stage with the Dalai Lama: blue energy and two vagus nerves 02:16:55 Closing thoughts: self-care vs. medical devices, and what’s next * For show notes and past guests on The Tim Ferriss Show [https://tim.blog/podcast], please visit tim.blog/podcast [https://tim.blog/podcast/?utm_source=podcast&utm_medium=podcast&utm_campaign=podcast-description]. For deals from sponsors of The Tim Ferriss Show [https://tim.blog/podcast], please visit tim.blog/podcast-sponsors [https://tim.blog/podcast-sponsors] Sign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday [https://go.tim.blog/5-bullet-friday-1/]. For transcripts of episodes, go to tim.blog/transcripts [https://tim.blog/transcripts]. Discover Tim’s books: tim.blog/books [https://tim.blog/books]. Follow Tim: Twitter: twitter.com/tferriss [https://twitter.com/tferriss]  Instagram: instagram.com/timferriss [https://instagram.com/timferriss/] YouTube: youtube.com/timferriss [https://www.youtube.com/timferriss] Facebook: facebook.com/timferriss [https://www.facebook.com/TimFerriss/]  LinkedIn: linkedin.com/in/timferriss [http://linkedin.com/in/timferriss] Past guests on The Tim Ferriss Show [http://tim.blog/podcast] include Jerry Seinfeld [https://tim.blog/2020/12/08/jerry-seinfeld/], Hugh Jackman [https://tim.blog/2020/06/26/hugh-jackman/], Dr. Jane Goodall [https://tim.blog/2020/04/16/jane-goodall/], LeBron James [https://tim.blog/2018/11/27/lebron-james-mike-mancias/], Kevin Hart [https://tim.blog/2020/05/20/kevin-hart/], Doris Kearns Goodwin [https://tim.blog/2018/09/07/doris-kearns-goodwin-leadership/], Jamie Foxx [https://tim.blog/2015/12/06/jamie-foxx/], Matthew McConaughey [https://tim.blog/2020/10/19/matthew-mcconaughey/], Esther Perel [https://tim.blog/2017/05/21/esther-perel/], Elizabeth Gilbert [https://tim.blog/2020/05/08/elizabeth-gilbert/], Terry Crews [https://tim.blog/2017/12/20/terry-crews-how-to-have-do-and-be-all-you-want/], Sia [https://tim.blog/2020/08/12/sia/], Yuval Noah Harari [https://tim.blog/2020/10/27/yuval-noah-harari/], Malcolm Gladwell [https://tim.blog/2016/06/21/malcolm-gladwell/], Madeleine Albright [https://tim.blog/2020/05/27/secretary-madeleine-albright/], Cheryl Strayed [https://tim.blog/2017/03/30/cheryl-strayed/], Jim Collins [https://tim.blog/2019/02/18/jim-collins/], Mary Karr, [https://tim.blog/2020/11/11/mary-karr/] Maria Popova [https://tim.blog/2014/10/21/brain-pickings/], Sam Harris [https://tim.blog/2020/05/15/sam-harris-2/], Michael Phelps [https://tim.blog/2021/01/21/michael-phelps-grant-hackett/], Bob Iger [https://tim.blog/2020/01/16/bob-iger/], Edward Norton [https://tim.blog/2019/10/31/edward-norton-motherless-brooklyn/], Arnold Schwarzenegger [https://tim.blog/2015/02/02/arnold-schwarzenegger/], Neil Strauss [https://tim.blog/2014/06/24/neil-strauss/], Ken Burns [https://tim.blog/2019/09/12/ken-burns/], Maria Sharapova [https://tim.blog/2017/08/26/maria-sharapova/], Marc Andreessen [https://tim.blog/2016/05/29/marc-andreessen/], Neil Gaiman [https://tim.blog/2019/03/28/neil-gaiman/], Neil de Grasse Tyson [https://tim.blog/2019/10/03/neil-degrasse-tyson/], Jocko Willink [https://tim.blog/2016/09/21/jocko-willink-on-discipline-leadership-and-overcoming-doubt/], Daniel Ek [https://tim.blog/2020/12/03/daniel-ek/], Kelly Slater [https://tim.blog/2020/09/08/kelly-slater/], Dr. Peter Attia [https://tim.blog/2019/11/27/peter-attia-fasting-metformin-longevity/], Seth Godin [https://tim.blog/2016/02/10/seth-godin/], Howard Marks [https://tim.blog/2018/09/25/howard-marks/], Dr. Brené Brown [https://tim.blog/2020/02/06/brene-brown-striving-self-acceptance-saving-marriages/], Eric Schmidt [https://tim.blog/2019/04/09/eric-schmidt/], Michael Lewis [https://tim.blog/2020/05/01/michael-lewis/], Joe Gebbia [https://tim.blog/2018/03/08/joe-gebbia-co-founder-of-airbnb/], Michael Pollan [https://tim.blog/2018/05/06/michael-pollan-how-to-change-your-mind/], Dr. Jordan Peterson [https://tim.blog/2021/03/01/jordan-peterson/], Vince Vaughn [https://tim.blog/2017/05/31/vince-vaughn/], Brian Koppelman [https://tim.blog/2020/04/23/brian-koppelman/], Ramit Sethi [https://tim.blog/2019/05/07/ramit-sethi/], Dax Shepard [https://tim.blog/2020/11/18/dax-shepard/], Tony Robbins [https://tim.blog/2014/10/15/money-master-the-game/], Jim Dethmer [https://tim.blog/2020/05/18/jim-dethmer/], Dan Harris [https://tim.blog/2020/11/19/dan-harris/], Ray Dalio [https://tim.blog/2017/09/13/ray-dalio/], Naval Ravikant [https://tim.blog/2015/08/18/the-evolutionary-angel-naval-ravikant/], Vitalik Buterin [https://tim.blog/2021/03/08/vitalik-buterin-naval-ravikant/], Elizabeth Lesser [https://tim.blog/2021/03/16/elizabeth-lesser/], Amanda Palmer [https://tim.blog/2019/04/18/amanda-palmer-2/], Katie Haun [https://tim.blog/2021/02/18/katie-haun/], Sir Richard Branson [https://tim.blog/2017/10/09/richard-branson/], Chuck Palahniuk [https://tim.blog/2020/09/02/chuck-palahniuk/], Arianna Huffington [https://tim.blog/2017/10/18/arianna-huffington/], Reid Hoffman [https://tim.blog/2015/08/31/the-oracle-of-silicon-valley-reid-hoffman-plus-michael-mccullough/], Bill Burr [https://tim.blog/2017/09/17/bill-burr/], Whitney Cummings [https://tim.blog/2015/06/26/whitney-cummings/], Rick Rubin [https://tim.blog/2015/05/15/rick-rubin/], Dr. Vivek Murthy [https://tim.blog/2020/03/26/vivek-murthy/], Darren Aronofsky [https://tim.blog/2017/09/09/darren-aronofsky/], Margaret Atwood [https://tim.blog/2022/02/22/margaret-atwood/], Mark Zuckerberg [https://tim.blog/2022/03/24/mark-zuckerberg/], Peter Thiel [https://tim.blog/2014/09/09/peter-thiel/], Dr. Gabor Maté [https://tim.blog/2018/02/20/gabor-mate/], Anne Lamott [https://tim.blog/2021/07/09/anne-lamott/], Sarah Silverman [https://tim.blog/2022/01/12/sarah-silverman/], Dr. Andrew Huberman [https://tim.blog/2021/07/06/andrew-huberman/], and many more. See Privacy Policy at https://art19.com/privacy [https://art19.com/privacy] and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info [https://art19.com/privacy#do-not-sell-my-info].

Dr. Jeffrey Goldberg is Professor and Chair of Ophthalmology and Director of the Byers Eye Institute at Stanford University, a leading scientist in the development and degeneration of the visual system from eye to brain, and a practicing ophthalmologist and surgeon. This episode is brought to you by: Gamma [https://gamma.app/] AI design partner for effortless presentations, websites, social media posts, and more: https://gamma.app [https://gamma.app/] (Use code TIM at checkout for 30% off any plan.) Helix Sleep [https://helixsleep.com/tim] premium mattresses: https://HelixSleep.com/Tim [https://helixsleep.com/tim] (27% off on all mattress orders.) AG1 [https://drinkag1.com/Tim] all-in-one nutritional supplement: https://DrinkAG1.com/Tim [https://drinkag1.com/Tim] (1-year supply of Vitamin D plus 5 free AG1 travel packs with your first subscription purchase.) Timestamps: [00:00:00] Start. [00:05:30] How do you solve a problem like presbyopia? [00:08:34] The athletic benefits of training supranormal (better than 20/20) vision. [00:11:49] Indigenous eye drops and FDA-approved pilocarpine for presbyopia. [00:14:05] Understanding basic eye anatomy. [00:17:27] Exploring AREDS 2, CoQ10, ginkgo, vitamin B3, and other supplements for vision. [00:23:00] Visual training devices and psychedelic-prompted brain plasticity. [00:25:12] Thoughts on visual training effectiveness and motor action requirements. [00:28:29] Concussion rehabilitation and visual perception exercises. [00:32:36] Red light and violet light therapy for myopia and mitochondrial health. [00:36:07] Vision loss correlation with cognitive decline and depression. [00:39:36] Presbyopia progression and psychological dependence on readers. [00:41:15] Cognito Therapeutics headset for Alzheimer's treatment. [00:46:46] Glaucoma basics: neurodegenerative disease and risk factors. [00:48:53] Eye pressure variability and diurnal cycles. [00:50:02] Cannabis effects on eye pressure and compound isolation. [00:51:47] Stem cell research for vision restoration. [00:53:09] Anti-inflammatory effects and immune system role in eye diseases. [00:55:15] Gut microbiome connection to glaucoma in animal models. [00:58:43] Metabolic syndrome and GLP-1 receptor agonists. [01:00:50] Microbiome sharing and future therapeutic possibilities. [01:03:31] Dry eye treatment: preservative-free tears and serum drops. [01:08:43] Vision screening recommendations and UV protection. [01:11:22] Full-spectrum light benefits vs. UV exposure. [01:13:27] Paradigm shifts: irreversible vision loss becoming reversible. [01:17:18] Convergence of neuroscience advances and biotech investment. [01:21:58] Miraculous mitochondria: health, transplants, and three-parent babies. [01:26:24] My family history concerns and metabolic health screening. [01:29:26] Exercise's biggest gain: going from none to some. [01:33:03] Clinical trial participation resources and parting thoughts. * For show notes and past guests on The Tim Ferriss Show [https://tim.blog/podcast], please visit tim.blog/podcast [https://tim.blog/podcast/?utm_source=podcast&utm_medium=podcast&utm_campaign=podcast-description]. For deals from sponsors of The Tim Ferriss Show [https://tim.blog/podcast], please visit tim.blog/podcast-sponsors [https://tim.blog/podcast-sponsors] Sign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday [https://go.tim.blog/5-bullet-friday-1/]. For transcripts of episodes, go to tim.blog/transcripts [https://tim.blog/transcripts]. Discover Tim’s books: tim.blog/books [https://tim.blog/books]. 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Welcome to another wide-ranging "Random Show" episode that I recorded with my close friend Kevin Rose [https://www.kevinrose.com/] (digg.com [https://digg.com/])! We cover Kevin's sobriety journey and marking 100 days without alcohol, my results with the ketogenic diet and intermittent fasting, GLP-1 agonists, home security, the future of Venture Capital, AI, authenticating yourself online in a world of deepfakes and anonymity, the cultural shift toward human-to-human connection, Roblox, and more. Enjoy! This episode is brought to you by: Momentous [https://livemomentous.com/Tim] high-quality creatine for cognitive and muscular support: https://livemomentous.com/Tim (Code TIM for up to 35% off.) David Protein Bars [https://davidprotein.com/Tim] with 28g of protein, 150 calories, and 0g of sugar: https://davidprotein.com/Tim (Buy 4 cartons, get the 5th free.) AG1 [https://DrinkAG1.com/Tim] all-in-one nutritional supplement: https://DrinkAG1.com/Tim (1-year supply of Vitamin D plus 5 free AG1 travel packs with your first subscription purchase.) Timestamps: [00:00:00] Start. [00:06:54] Kevin celebrates 100 days sober! Why and how? [00:15:16] Nanoblocks: Kevin's new Japanese micro-building hobby. [00:18:16] The Slow TV movement and Craig Mod's ambient recordings. [00:20:58] Craving analog experiences and wilderness trekking. [00:22:24] Writing with background movies. [00:23:42] High hopes for The Naked Gun reboot. [00:24:35] Kevin's improved communication since quitting alcohol. [00:26:28] My health interventions for cognitive protection. [00:29:00] How ketogenic diet and 16/8 intermittent fasting led to my best lab results in 10+ years. [00:33:35] Weight control regimens we don't recommend. [00:39:51] Exogenous ketones: Qitone vs. premium options. [00:50:32] How glucose tolerance tests work. [00:51:58] Microdosing GLP-1 (tirzepatide) for glucose control. [00:54:12] DORA sleep medications and neuroprotective effects. [00:56:55] Belsomra trial and cost considerations. [00:57:52] Sauna temperature optimization based on Rhonda Patrick's research. [01:00:28] There are no biological free lunches. [01:03:27] The time Kevin found a homeless person in his closet. [01:06:11] Modern home security and privacy measures. [01:19:42] Pondering how we survived childhood. [01:24:23] AI-driven venture capital landscape changes. See Privacy Policy at https://art19.com/privacy [https://art19.com/privacy] and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info [https://art19.com/privacy#do-not-sell-my-info].