BioTalk Unzipped

BioTalk Unzipped

Podcast door BioTalk Unzipped

Unzipping the Stories Behind Medical Progress by sharing the latest and greatest advances in biopharmaceuticals and medical technologies in a fun, ent...

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episode Digital Twins: The Future of Drug Discovery with Dr. Tomáš Helikar artwork
Digital Twins: The Future of Drug Discovery with Dr. Tomáš Helikar

BioTalk Unzipped, hosts Gregory Austin and Chad Briscoe engage with Dr. Tomas Helikar in an exciting discussion on the future of AI, digital twins, and personalized medicine. From mathematical models and immune system simulations to groundbreaking collaborations with the Department of Defense, this episode uncovers how digital twins have the potential to transform drug discovery and clinical trials. Don’t miss insights on the ethical challenges of data privacy, the promise of animal digital twins, and the latest AI breakthroughs like MIT’s Sparrow algorithm! Chapters 01:00 How the mathematical models work. Normalization and Scaling in Computational Biology 07:55 Focus on the Immune System and Organ Models 09:05 Collaboration with the Department of Defense 11:03 Drug Discovery and Digital Twins 13:43 NEW NEWS! - AI in Drug Discovery: The MIT Sparrow Algorithm 17:51 Future of Digital Twins in Clinical Trials 18:59 Personalized Medicine and Individualized Treatments 23:33 The Potential of Animal Digital Twins 24:59 Building a Research Infrastructure for Digital Twins 26:03 Privacy and Ownership of Digital Twin Data 30:14 Encouraging Publication and Literature Engagement How to reach us: Tomas Helikar  https://www.linkedin.com/in/tomashelikar/ [https://www.linkedin.com/in/tomashelikar/]  X - https://x.com/tomashelikar [https://x.com/tomashelikar]  Dr. Chad Briscoe https://www.linkedin.com/in/chadbriscoe/ [https://www.linkedin.com/in/chadbriscoe/]  Celerion - https://www.celerion.com/ [https://www.celerion.com/]   Gregory Austin https://www.linkedin.com/in/gregoryaustin1/ [https://www.linkedin.com/in/gregoryaustin1/]  ECI - https://eci-rx.com [https://eci-rx.com] /  Sound Bites "Publications are the currency in academia." New News Story:  * MIT’s SPARROW Redefines Drug Discovery With Smart Synthesis * https://scitechdaily.com/mits-sparrow-redefines-drug-discovery-with-smart-synthesis/ [https://scitechdaily.com/mits-sparrow-redefines-drug-discovery-with-smart-synthesis/] Image Credits * MIT Molecule, https://news.mit.edu/topic/algorithms?page=2 [https://news.mit.edu/topic/algorithms?page=2]

16 dec 2024 - 37 min
episode Transforming Immunology: The Promise of Digital Twins with Dr. Tomáš Helikar artwork
Transforming Immunology: The Promise of Digital Twins with Dr. Tomáš Helikar

Dr. Tomas Helikar, a leading researcher in bioinformatics and systems biology, delves into groundbreaking work on developing a personalized immune digital twin, which aims to revolutionize the understanding and treatment of immune-related diseases.  Chapters 00:00 Introduction to BioTalk Unzipped 01:50 Meet Dr. Tomas Helikar 04:34 The Journey into Systems Biology 10:03 Understanding Digital Twins in Immunology 14:19 The Importance of Personalized Medicine 17:20 Digital Twin Research Funding and Its Impact 18:38 The Role of Digital Twins in Disease Management 21:11 Digital Twin Efforts for Organ Transplants 24:05 Computational Challenges in Modeling 26:36 Mathematical Models in Biological Research 28:11 - NEW NEWS! - Twist Joins Absci in AI Antibody Collaboration How to reach us: Tomas Helikar  https://www.linkedin.com/in/tomashelikar/ [https://www.linkedin.com/in/tomashelikar/]  X - https://x.com/tomashelikar [https://x.com/tomashelikar]  Dr. Chad Briscoe https://www.linkedin.com/in/chadbriscoe/ [https://www.linkedin.com/in/chadbriscoe/]  Celerion - https://www.celerion.com/ [https://www.celerion.com/]   Gregory Austin https://www.linkedin.com/in/gregoryaustin1/ [https://www.linkedin.com/in/gregoryaustin1/]  ECI - https://eci-rx.com [https://eci-rx.com] /  Charity Mentioned: https://saintpeterlincoln.com/school [https://saintpeterlincoln.com/school]  FOLLOW ► LinkedIn: https://www.linkedin.com/company/biotalk-unzipped [https://www.linkedin.com/company/biotalk-unzipped] Twitter: https://x.com/BiotalkUnzipped [https://x.com/BiotalkUnzipped] Instagram: https://www.instagram.com/biotalkunzipped/ [https://www.instagram.com/biotalkunzipped/]  Takeaways * Dr. Helikar's research focuses on the immune system's network and disease. * Systems biology integrates computer science and biology for better understanding. * Digital twins can provide personalized models for immune system analysis. * Your digital twin model could tell you how you might respond to a particular disease and if you really need to go to the hospital. * The immune digital twin reflects an individual's unique immune baseline. * Research funding is crucial for advancing innovative medical technologies. * Personalized medicine can improve public health outcomes significantly. * Computational power is essential for processing complex biological data. * Mathematical models are vital for simulating biological processes. * Digital twins can enhance drug discovery and clinical trial efficiency. Sound Bites "The immune system is a network of networks." “Each of our immune system baselines are different.” "We need to build out this multi-scale model." New News Story:  * Supplier-Turned-Partner: Twist Joins Absci in AI Antibody Collaboration * https://www.genengnews.com/topics/drug-discovery/supplier-turned-partner-twist-joins-absci-in-ai-antibody-collaboration/ [https://www.genengnews.com/topics/drug-discovery/supplier-turned-partner-twist-joins-absci-in-ai-antibody-collaboration/] Image Credits * Signal Transduction, www.scientificanimations.com - http://www.scientificanimations.com/wiki-images/ [http://www.scientificanimations.com/wiki-images/] * Computational Model, https://computationstructures.org/notes/models/notes.html [https://computationstructures.org/notes/models/notes.html]  * Holland computer center, https://newsroom.unl.edu/announce/cse/16380/90600 [https://newsroom.unl.edu/announce/cse/16380/90600]  * https://news.unl.edu/article/husker-football-game-day-information-announced-for-2023 [https://news.unl.edu/article/husker-football-game-day-information-announced-for-2023] * https://hcc.unl.edu/office-locations [https://hcc.unl.edu/office-locations]

02 dec 2024 - 32 min
episode How AI is Transforming Drug Development: Reflections from AAPS - PharmSci 360 with Mark Arnold artwork
How AI is Transforming Drug Development: Reflections from AAPS - PharmSci 360 with Mark Arnold

Dr. Mark Arnold, a distinguished bioanalytical thought leader with an impressive track record in supporting drug development programs. Mark is the Owner and Principal at Bioanalytical Solution Integration, where he provides strategic counsel on complex bioanalytical assays and regulatory compliance. With over 35  years of experience, including leadership roles at BMS and Labcorp, Mark has become a key figure in the biotech and pharma industries. He is also an AAPS Fellow and a founder of the Global Bioanalysis Consortium.  01:05 - Career Reflections and Contributions to Drug Development 05:28 - Understanding the Integration of Drug Development 09:30 - What Would You Change? Embracing Career Risks in Pharma 11:32 - Navigating Career Paths: Small vs. Large Companies 16:09 - NEW NEWS! - Can Electrical Fields Disrupt Cancer? 23:28 - The Role of AI in Drug Development 31:13 - Encouraging Innovation in a Regulated Industry Follow Mark, Chad and Gregory: Please donate to: Samaritan’s Purse https://www.samaritanspurse.org/ [https://www.samaritanspurse.org/]  Mark Arnold - https://www.linkedin.com/in/markearnoldphd/ [https://www.linkedin.com/in/markearnoldphd/]  Blog - https://bioanalysisandbiomarkers.blogspot.com/ [https://bioanalysisandbiomarkers.blogspot.com/]    Dr. Chad Briscoe - https://www.linkedin.com/in/chadbriscoe/ [https://www.linkedin.com/in/chadbriscoe/]  Celerion - https://www.celerion.com/ [https://www.celerion.com/]   Gregory Austin - https://www.linkedin.com/in/gregoryaustin1/ [https://www.linkedin.com/in/gregoryaustin1/]  ECI - https://eci-rx.com [https://eci-rx.com] /  BioTalk Unzipped on LinkedIn - https://www.linkedin.com/company/biotalk-unzipped/ [https://www.linkedin.com/company/biotalk-unzipped/]  New News Story:  * Novocure wins FDA approval for electric field device in lung cancer * https://www.biopharmadive.com/news/novocure-fda-lung-cancer-approval-optune-lua-tumor-treating-field/729997 [https://www.biopharmadive.com/news/novocure-fda-lung-cancer-approval-optune-lua-tumor-treating-field/729997] Two articles on finding 1000’s of dark matter RNA viruses:   * https://www.fiercebiotech.com/research/deep-learning-ai-model-scans-dark-matter-genomic-data-and-finds-70000-never-seen-rna [https://www.fiercebiotech.com/research/deep-learning-ai-model-scans-dark-matter-genomic-data-and-finds-70000-never-seen-rna] * https://www.nature.com/articles/d41586-024-03320-6 [https://www.nature.com/articles/d41586-024-03320-6] Image Credits * Novocure images courtesy of Novocure: www.novocure.com [http://www.novocure.com]

18 nov 2024 - 36 min
episode Insights from AAPS PharmSci 360 Live with Mark Arnold artwork
Insights from AAPS PharmSci 360 Live with Mark Arnold

In this episode of BioTalk Unzipped, host Gregory Austin and co-host Chad Briscoe engage with Dr. Mark Arnold, a distinguished bioanalytical thought leader. They discuss the impact of recent FDA regulations on drug development, the importance of community support through the Samaritan Purse charity, especially on recent hurricane victims, and the exciting advancements in RNA editing technologies. The conversation highlights the collaborative nature of the pharmaceutical industry and the drive behind bioanalytical work, emphasizing the ultimate goal of delivering effective therapies to patients.  Chapters 00:00 Introduction to BioTalk Unzipped at AAPS PharmSci 360 03:45 Samaritan's Purse Charity and Community Impact 05:16 Most impactful talk at AAPS? 11:50 Comparative Analysis of FDA and EU Regulations 17:37 The Drive Behind Bioanalytical Work 22:24 NEW NEWS! - Innovations in RNA Editing and Bioanalysis Takeaways * The FDA's new rules on lab-developed tests could delay biomarker utilization in clinical trials. * Community support through charities like Samaritan's Purse is crucial during crises. * The importance of collaboration in advancing drug development and bioanalytical methods. * Innovations in RNA editing present new bioanalytical challenges. * The drive to help patients is a key motivator for professionals in the field. * Sound Bites * "I worked on that drug and there's a clear benefit." * "It's getting that new therapy to a patient." * "This is going to change and potentially delay biomarkers." * New News Story:  * Wave sees RNA editing validation in early trial results ◦https://www.biopharmadive.com/news/wave-rna-editing-aatd-first-trial-data/729981/ [https://www.biopharmadive.com/news/wave-rna-editing-aatd-first-trial-data/729981/]  How to reach us: Please donate to: Samaritan’s Purse https://www.samaritanspurse.org/ [https://www.samaritanspurse.org/]  Mark Arnold https://www.linkedin.com/in/markearnoldphd/ [https://www.linkedin.com/in/markearnoldphd/]  Blog - https://bioanalysisandbiomarkers.blogspot.com/ [https://bioanalysisandbiomarkers.blogspot.com/]    Dr. Chad Briscoe https://www.linkedin.com/in/chadbriscoe/ [https://www.linkedin.com/in/chadbriscoe/]  Celerion - https://www.celerion.com/ [https://www.celerion.com/]   Gregory Austin https://www.linkedin.com/in/gregoryaustin1/ [https://www.linkedin.com/in/gregoryaustin1/]  ECI - https://eci-rx.com [https://eci-rx.com/] /  Image Credits * AAPS

01 nov 2024 - 29 min
episode Biotech Funding Trends and the Rise of Digital Twinning with CEO Scott Ogle artwork
Biotech Funding Trends and the Rise of Digital Twinning with CEO Scott Ogle

EP-23. In the second half of this compelling conversation on BioTalk Unzipped, Gregory Austin and Dr. Chad Briscoe continue their deep dive with Scott Ogle, CEO of TruLab. They explore the surprising parallels between the banking and pharma industries, the game-changing role of digital twinning in clinical trials, and the biotech funding landscape. Scott also shares his thoughts on leadership, mentorship, and the impact of the Inflation Reduction Act on pharma innovation. This episode offers listeners valuable insights into the future of drug development and the challenges of balancing professional and personal life in a fast-paced industry. Chapters 1:09 - Comparison of the Banking Industry to the Pharma Industry 5:18 - Data Integrity, Same For Decentralized Trials? 8:33 - Biotech Funding Trends 11:18 - NEW NEWS! – Digital Twinning in Clinical Trials 16:15 - What Advice Would You Give to Your Younger Self? 20:57 - Mentorship and Its Impact, How it Shaped Scott 23:45 - Balancing Work and Personal Life 24:32 - The Inflation Reduction Act and Innovation Takeaways * The regulatory environment in pharma can slow down innovation. * Digital twinning in clinical trials could revolutionize drug development. * Family influences play a significant role in shaping business perspectives. * The need for a strong company culture to maintain values during growth. * Biotech funding trends are influenced by macroeconomic factors like interest rates. * The importance of mentorship in professional development. Sound Bites * “The similarities between the banking industry and the pharma industry is eerily similar.” * “Quality is really what we do.” * “Being quality is core to software.” * “It’s really clear people care more about their money than they do their healthcare.” * “Biotech and large pharma seem to balance each other out.” * “The career for you is at the intersection of what you are good at and what you like to do.”  * “If you’re good at something and you like to do it, it fuels your energy to keep getting better.” * “Enjoy the impact in what you’re doing and accomplishing!” New News Story:  * Digital “Twinning”: Clinical Trials Powered by AI * https://www.sanofi.com/en/magazine/our-science/digital-twinning-clinical-trials-ai [https://www.sanofi.com/en/magazine/our-science/digital-twinning-clinical-trials-ai]   How to reach us: Scott Ogle https://www.linkedin.com/in/scott-ogle/ [https://www.linkedin.com/in/scott-ogle/]  TruLab - https://trulab.com/ [https://trulab.com/]    Dr. Chad Briscoe https://www.linkedin.com/in/chadbriscoe/ [https://www.linkedin.com/in/chadbriscoe/]  Celerion - https://www.celerion.com/ [https://www.celerion.com/]   Gregory Austin https://www.linkedin.com/in/gregoryaustin1/ [https://www.linkedin.com/in/gregoryaustin1/]  ECI - https://eci-rx.com [https://eci-rx.com] /  Image Credits Digital Twinning - Credit Getty Images Simulation - Credit: andrush / Adobe Stock Tomáš Helikar - https://www.linkedin.com/in/tomashelikar/ [https://www.linkedin.com/in/tomashelikar/]  Nebraska Swan computer - https://newsroom.unl.edu/announce/cse/16380/90600 [https://newsroom.unl.edu/announce/cse/16380/90600] Brian Hamilton - https://inmatestoentrepreneurs.org/board/brian-hamilton/ [https://inmatestoentrepreneurs.org/board/brian-hamilton/]

21 okt 2024 - 29 min
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