Freely Filtered, a NephJC Podcast

FF91 Liberate-D

The Filtrate Joel Topf kidneyboy.bsky.social [https://bsky.app/profile/kidneyboy.bsky.social] Pedro Teixeira @nephcrit.bsky.social [https://bsky.app/profile/nephcrit.bsky.social] Nayan Arora @captainchloride.bsky.social [https://bsky.app/profile/captainchloride.bsky.social] Anna Gaddy @annagaddy.bsky.social [https://bsky.app/profile/annagaddy.bsky.social] Swapnil Hiremath @hswapnil.medsky.social [https://bsky.app/profile/hswapnil.medsky.social] and on LinkedIn [https://www.linkedin.com/in/swapnilhiremath/] Special Guests Ian McCoy, MD @NephroNinja [https://x.com/NephroNinja] study author and UCSF [https://www.ucsfhealth.org/providers/ian-mccoy] Chi-yuan Hsu Senior author and Chief of the Division of Nephrology at UCSF [https://profiles.ucsf.edu/chi-yuan.hsu] Samuel Silver Associate Professor [https://deptmed.queensu.ca/people/samuel-silver] at Queens University in Canada Editing Vipin Verghese and Joel Topf Show Notes NephJC Discusion: Dialyze Less, Recover More? AKI’s Chance to Get LIBERATE-D [https://www.nephjc.com/news/liberated-aki] Manuscript: A Conservative Dialysis Strategy and Kidney Function Recovery in Dialysis-Requiring Acute Kidney InjuryThe Liberation From Acute Dialysis (LIBERATE-D) Randomized Clinical Trial JAMA [https://jamanetwork.com/journals/jama/fullarticle/2841171] | PubMed [https://pubmed.ncbi.nlm.nih.gov/41201895/] Ben’s pilot study: RAD-AKI Pilot study: Recovery After Dialysis-Requiring Acute Kidney Injury (RAD-AKI) (ClinicalTrials.gov [https://clinicaltrials.gov/study/NCT03305549]) STARRT-AKI NephJC [https://www.nephjc.com/news/starrt-aki] Editorial in JAMA: A-E-I-O-U and Sometimes Why—Dialysis in Acute Kidney Injury (JAMA [https://jamanetwork.com/journals/jama/fullarticle/2841172]) What Is Dialytrauma? (Nephrology Times [https://www.docwirenews.com/post/what-is-dialytrauma]) How Fragile Are the Results of a Trial? The Fragility Index (PubMedCentral [https://pmc.ncbi.nlm.nih.gov/articles/PMC7485073/]) Shiffl Trial: Daily Hemodialysis and the Outcome of Acute Renal Failure (NEJM [https://www.nejm.org/doi/full/10.1056/NEJMoa010877]) AKIKI: Initiation Strategies for Renal-Replacement Therapy in the Intensive Care Unit (NEJM [https://www.nejm.org/doi/full/10.1056/NEJMoa1603017]) AKIKI2: How Late it was, How Late! (NephJC [https://www.nephjc.com/news/akiki-2]) Sam Silver’s study: Promoting Kidney Recovery After Acute Kidney Injury Receiving Dialysis (Recover-AKI) (ClinicalTrial.Gov [https://clinicaltrials.gov/study/NCT04948476]) Marie Kondo (Wikipedia [https://en.wikipedia.org/wiki/Marie_Kondo]) Tubular Secretions Swap: The smutty dragon novels of novels of Rebecca Yarros (Wikipedia [https://en.wikipedia.org/wiki/Rebecca_Yarros]) Specifically The Empyrean series Anna: Brisket recipes Pedro: The Naked Gun (Wikipedia [https://en.wikipedia.org/wiki/The_Naked_Gun_(2025_film)]) with Liam Neeson Ian: ASN Kidney Health Guidance on the Outpatient Management of Patients with Dialysis-Requiring Acute Kidney Injury (PubMed [https://pubmed.ncbi.nlm.nih.gov/40014384/]) he really doesn’t get Tubular Secretions. Nayan: Tilt: A Novel by Emma Pattee (Amazon [https://www.amazon.com/Tilt-Novel-Emma-Pattee/dp/1668055481/ref=sr_1_1?adgrpid=185786214865&dib=eyJ2IjoiMSJ9.vsouq55-48aeD20KyEaGRh-V4mVrG2E-zppeL44EmLEAexCxA5T8C0NbEiTJtsFepey3KqkHncNAX2msW9UVrFg5wi3437SyRE7Lp2ij_mON-6rPV7fgJuqCtAnIz2dJK6ZlvlT41MnTLESZM22fszTYak-EjtTBVzFDHXGZdY04wftQ0OQmmI17w0qyNwRCn-istzOQOTwbme5LGHDAt7-V3lBCZ5rsjIME7F5DFWU.0RE0glXxUdl97m0ACr36NPnUvcBs8-CHvGtufBOmxc4&dib_tag=se&hvadid=779541324606&hvdev=c&hvexpln=0&hvlocphy=9016826&hvnetw=g&hvocijid=3426977299259243241--&hvqmt=e&hvrand=3426977299259243241&hvtargid=kwd-2552187199392&hydadcr=23203_13755239_2458124&keywords=tilt%20emma%20pattee&mcid=b5dd7b672b163e819fc2b95b8ed12f4b&qid=1774913320&sr=8-1]) Chi: The Year of Magical Thinking by Joan Didion (Wikipedia [https://en.wikipedia.org/wiki/The_Year_of_Magical_Thinking]) and Innovations in Nephrology (Springer Nature [https://link.springer.com/book/10.1007/978-3-031-11570-7]) Sam: Monopoly Super Electronic Banking Board Game (Amazon [https://www.amazon.com/Hasbro-Games-Monopoly-Electronic-Banking/dp/B083YKFYN3]) Joel: Song Sung Blue (Wikipedia [https://en.wikipedia.org/wiki/Song_Sung_Blue_(2025_film)])

FF90 NephMadness 2026: Animal House

The Filtrate Joel Topf (kidneyboy.bsky.social [https://bsky.app/profile/kidneyboy.bsky.social]) AC (@medpeedskidneys.bsky.social [https://bsky.app/profile/medpeedskidneys.bsky.social])NephMadness [https://ajkdblog.org/2026/01/14/nephmadness-2026-meet-the-gamemakers/] Anna Gaddy (@AnnaGaddy [https://x.com/AnnaGaddy]) Vipin Verghese (@vipvargh.bsky.social [https://bsky.app/profile/vipvargh.bsky.social]) Natalie Freidin Program director [https://medicine.musc.edu/departments/medicine/divisions/nephrology/fellowship/leadership] at Medical University of South Carolina Special Guests Anna Vinnikova (@kidneywars.bsky.social [https://bsky.app/profile/kidneywars.bsky.social]) Long time game maker for NephMadness [https://ajkdblog.org/2026/01/14/nephmadness-2026-meet-the-gamemakers/] and Associate Professor at Virginia Commonwealth University [https://medschool.vcu.edu/about/portfolio/details/avinniko/] Autumn Harris Associate Professor of Veterinary Medicine at NC State [https://cvm.ncsu.edu/people/anharr25/] Sarah Street MD PhD Assistant Professor of Medicine at Virginia Commonwealth University [https://www.vcuhealth.org/find-a-provider/profile/sarah-street] Editing Joel Topf Show Notes Animal House scouting report [https://ajkdblog.org/2026/03/01/nephmadness-2026-animal-house-region/] Autumn Harris on Team Cat [https://ajkdblog.org/2026/03/12/nephmadness-2025-animal-house-cats-kidneys-and-the-art-of-surviving-on-almost-no-water/] Cheese!

FF 89 Top Stories of 2025

I know 2026 feels like it ihas been here for months, but only a few weeks ago we were celebrating the nephrology accomplishments of 2025. The New Filtrate came together to review the year. The Filtrate Joel Topf‍ ‍@kidneyboy.bsky.social‬ [https://bsky.app/profile/kidneyboy.bsky.social] (COI [https://pbfluids.com/about/]) Swapnil Hiremath @hswapnil.medsky.social [https://bsky.app/profile/hswapnil.medsky.social] and on LinkedIn [https://www.linkedin.com/in/swapnilhiremath/] Editor in Chief of Kidney International Case Reports [https://www.sciencedirect.com/journal/kidney-international-case-reports] Anna Gaddy (@AnnaGaddy [https://x.com/AnnaGaddy]) Winner of NephJC Rookie of the Year 2020 Nayan Arora (@CaptainChloride.bsky.social [https://bsky.app/profile/captainchloride.bsky.social]) AC (@medpeedskidneys.bsky.social [https://bsky.app/profile/medpeedskidneys.bsky.social]) Vipin Verghese (@vipvargh.bsky.social [https://bsky.app/profile/vipvargh.bsky.social]) co-winner of NephJC Engaged Scientist of the Year in 2021 Brian Rifkin (@brianrifkin.bsky.social [https://bsky.app/profile/brianrifkin.bsky.social]) Co-Editor in Chief NephJC. Winner of NephJC Rookie of the Year 2021 Cristina Popa (@NephroSeeker [https://x.com/NephroSeeker]) Co-Editor in Chief NephJC. Wwinner of NephJC Rookie of the Year 2022 and MVP 2023 Editing and Show Notes by Anna Gaddy and Joel Topf The Kidney Connection written and performed by Tim Yau Show Notes Top Stories in Nephrology 2025 (NephJC [https://www.nephjc.com/news/2025/1/3/top-stories-in-nephrology-2025]) First Top sories in Nephrology 2010! (Renal Fellow Network [https://www.renalfellow.org/2010/12/25/top-nephrology-related-stories-of-2010/]) Links to all of the Top Stories in Nephrology, hosted on NephJC since 2017 (NephJC [https://www.nephjc.com/news/tag/Top+Stories]) 1. IgA Nephropathy VISIONARY: Sibeprenlimab in IgA Nephropathy — Interim Analysis of a Phase 3 Trial (NEJM [https://www.nejm.org/doi/abs/10.1056/NEJMoa2512133]) ORIGIN 3: A Phase 3 Trial of Atacicept in Patients with IgA Nephropathy (NEJM [https://www.nejm.org/doi/full/10.1056/NEJMoa2510198]) APPLAUSE-IgA Alternative Complement Pathway Inhibition with Iptacopan in IgA Nephropathy (NEJM [https://www.nejm.org/doi/abs/10.1056/NEJMoa2410316]) Aliza M. Thompson, MD, MS (ASN [https://www.asn-online.org/about/bio.aspx?ID=999640]) 2. Lupus Nephritis REGENCY: Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis (NEJM [https://www.nejm.org/doi/abs/10.1056/NEJMoa2410965]) 3. Nobel prize winner and peripheral immune tolerance 4. Xenotransplantation 5. GLP1ra Revolution Remodel REMODELing mechanistic trials for kidney disease: a multimodal, tissue-centered approach to understand the renal mechanism of action of semaglutide (Kidney International [https://www.sciencedirect.com/science/article/pii/S0085253825008610]) SURPASS-CVOT Tirzepatide vs. Dulaglutide Is Associated with Reduced Major Kidney Events in Patients with Type 2 Diabetes, CVD, and Very High-Risk Kidney Diseases (Kidney Week abstract in JASN [https://journals.lww.com/jasn/fulltext/2025/10001/tirzepatide_vs__dulaglutide_is_associated_with.4279.aspx#:~:text=In%20SURPASS%2DCVOT%2C%20among%20patients,compared%20with%20dulaglutide%20(DULA).]) Poll: 1 in 8 Adults Say They Are Currently Taking a GLP-1 Drug for Weight Loss, Diabetes or Another Condition, Even as Half Say the Drugs Are Difficult to Afford (KFF survey [https://www.kff.org/public-opinion/poll-1-in-8-adults-say-they-are-currently-taking-a-glp-1-drug-for-weight-loss-diabetes-or-another-condition-even-as-half-say-the-drugs-are-difficult-to-afford/]) 6. GDMT implementation in CKD: lessons learnt from CONFIDENCE and MIRO-CKD Confidence Finerenone with Empagliflozin in Chronic Kidney Disease and Type 2 Diabetes (NEJM [https://www.nejm.org/doi/10.1056/NEJMoa2410659]) MIRO-CKD Balcinrenone in combination with dapagliflozin compared with dapagliflozin alone in patients with chronic kidney disease and albuminuria: a randomised, active-controlled double-blind, phase 2b clinical trial (The Lancet [https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(25)02014-8/abstract]) 7. Flozin Meta analysis SMART-C. SGLT2 Inhibitors and Kidney Outcomes by Glomerular Filtration Rate and Albuminuria. A Meta-Analysis (JAMA [https://jamanetwork.com/journals/jama/fullarticle/2841163]) SMART-C. Effects of Sodium Glucose Cotransporter 2 Inhibitors by Diabetes Status and Level of Albuminuria. A Meta-Analysis (JAMA [https://jamanetwork.com/journals/jama/fullarticle/2841163]) 8. Paradigm Shift: Aiming for CKD Remission 9. Fish Oil and Dialysis PISCES Fish-Oil Supplementation and Cardiovascular Events in Patients Receiving Hemodialysis (NEJM [https://www.nejm.org/doi/full/10.1056/NEJMoa2513032?query=RP&cid=NEJM%20Recently%20Published,%20November%207,%202025%20DM2425285_NEJM_Non_Subscriber&bid=-1080630646]) 10. Decline in Dialysis Patients in the United States USRD 2025 Annual Data Report (USRDS [https://usrds-adr.niddk.nih.gov/2025/end-stage-renal-disease/1-incidence-and-prevalence]) Tubular Secretion Swapnil Hiremath Alien Earth on FX Hulu (Wikipedia [https://en.wikipedia.org/wiki/Alien:_Earth]) AC A Christmas Carol by Charles Dickens (Wikipedia [https://en.wikipedia.org/wiki/A_Christmas_Carol]) and The Muppet Christmas Carol (Wikipedia [https://en.wikipedia.org/wiki/The_Muppet_Christmas_Carol]) Anna Monty Don (Wikipedia [https://en.wikipedia.org/wiki/Monty_Don]) Nayan Back Street Boys at The Sphere (Wikipedia [https://en.wikipedia.org/wiki/Sphere_(venue)]) Brian Marty Supreme (Wikipedia [https://en.wikipedia.org/wiki/Marty_Supreme]) Cristina The Yellow Tie (Wikipedia [https://en.wikipedia.org/wiki/The_Yellow_Tie]) Vipin Stranger Things, good for a four year old? (Wikipedia [https://en.wikipedia.org/wiki/Stranger_Things]) Joel Crash Course: The Universe with Katie Mack and John Green (Apple PodCasts [https://podcasts.apple.com/us/podcast/crash-course-pods-the-universe/id1740594155])

FF 86 Atacicept for IgAN. Third attempt

The Filtrate Joel Topf‍ ‍@kidneyboy.bsky.social‬ [https://bsky.app/profile/kidneyboy.bsky.social] (COI [https://pbfluids.com/about/]) Sophia Ambruso @sophia-kidney.bsky.social [https://bsky.app/profile/sophia-kidney.bsky.social] Swapnil Hiremath @hswapnil.medsky.social [https://bsky.app/profile/hswapnil.medsky.social] and on LinkedIn [https://www.linkedin.com/in/swapnilhiremath/] Special Guests Jonathan Barratt Professor of Renal Medicine, University of Leicester Google Scholar [https://scholar.google.com/citations?hl=en&user=SJ2eaN8AAAAJ] (COI: all the companies) Editing and Show Notes by Nayan Arora @captainchloride.bsky.social [https://bsky.app/profile/captainchloride.bsky.social] The Kidney Connection written and performed by Tim Yau Show Notes Proteinuria Reduction as a Surrogate End Point in Trials of IgA Nephropathy (Aliza Thompson, 2019 PubMed [https://pmc.ncbi.nlm.nih.gov/articles/PMC6419287/]) The number, quality, and coverage of randomized controlled trials in nephrology (PubMed 2004 [https://pubmed.ncbi.nlm.nih.gov/14747388/]) A Randomized, Controlled Trial of Rituximab in IgA Nephropathy with Proteinuria and Renal Dysfunction (PubMed [https://pubmed.ncbi.nlm.nih.gov/27821627/] 2017) [https://pubmed.ncbi.nlm.nih.gov/41196369/] BLISS Be [https://pubmed.ncbi.nlm.nih.gov/27821627/]limumab in lupus nephritis (Neph [https://www.nephjc.com/news/bliss-ln]JC | P [https://www.nephjc.com/news/atacicept-origin3-gtfb36]ubMed [https://pubmed.ncbi.nlm.nih.gov/32937045/]) The Phase 2 trial of atacicept A phase 2b, randomized, double [https://pubmed.ncbi.nlm.nih.gov/41196369/]-blind, pl [https://pubmed.ncbi.nlm.nih.gov/27821627/]acebo-controlled, clinical trial of at [https://www.nephjc.com/news/atacicept-origin3-gtfb36]acicep [https://pubmed.ncbi.nlm.nih.gov/41196369/]t for trea [https://pubmed.ncbi.nlm.nih.gov/27821627/]tment of IgA nephropathy (PubMed [https://pubmed.ncbi.nlm.nih.gov/38552841/]) [https://www.nephjc.com/news/atacicept-origin3-gtfb36] The [https://www.nephjc.com/news/atacicept-origin3-gtfb36] phase 3 trial of atacicept, the subject of this podcast A Phase 3 Trial of Atacicept in Patients with IgA Nephr [https://pubmed.ncbi.nlm.nih.gov/41196369/]opathy (Pu [https://pubmed.ncbi.nlm.nih.gov/27821627/]bMed [https://pubmed.ncbi.nlm.nih.gov/41196369/] | NephJC [https://www.nephjc.com/news/atacicept-origin3-gtfb36]) The use of Gd-IgA1 in [https://www.nephjc.com/news/atacicept-origin3-gtfb36]the Testing Trial Role of Systemic Glucocorticoids in Reducing IgA and Galactose-Deficient IgA1 Levels in IgA Nephropathy (PubMed [https://pubmed.ncbi.nlm.nih.gov/40924482/]) If you can’t get enough Jon Barratt, take a look at his grand rounds at The University of Ottawa. Updates to the KDIGO Guidelines for the treatment of IgA nephropathy, with Prof Jonathan Barratt (YouTube [https://www.youtube.com/watch?v=OChs5BcTEGE]) Tubular Secretion Swapnil Hiremath Pluribus on Apple TV (Wikipedia [https://en.wikipedia.org/wiki/Pluribus_(TV_series)]) Jon Barratt Lynyrd Skynyrd (Wikipedia [https://en.wikipedia.org/wiki/Lynyrd_Skynyrd]) Slow Horses (Wikipedia [https://en.wikipedia.org/wiki/Slow_Horses]) on AppleTV Joel Topf the new ASN

FF 88 BICARICU-2, Bicarbonate in the ICU, still not helpful?

The Filtrate Joel Topf‍ ‍@kidneyboy.bsky.social‬ [https://bsky.app/profile/kidneyboy.bsky.social] (COI [https://pbfluids.com/about/]) Pedro Teixeira @nephcrit.bsky.social [https://bsky.app/profile/nephcrit.bsky.social] Ana Gaddy @AnnaGaddy [https://x.com/AnnaGaddy] Nayan Arora @captainchloride.bsky.social [https://bsky.app/profile/captainchloride.bsky.social] Special Guests David Goldfarb Professor of Medicene, NYU [https://nyulangone.org/doctors/1629018908/david-s-goldfarb] (COI [https://moonstonenutrition.com]) Editing by Pedro Teixeira The Kidney Connection written and performed by Tim Yau Show Notes BICARBICU 2018 (Lancet [https://www.thelancet.com/article/S0140-6736(18)31080-8/fulltext?__cf_chl_tk=6Gx2o04bwjwKdcioooaTuYAlXa3cqDnEZyJb2pDlfQA-1766810657-1.0.1.1-XNKehJDXR_bLMZmKr8KGA5_L.RD1clWP8OgWxB6jQf0]) BICARBICU-2 2025 (JAMA [https://jamanetwork.com/journals/jama/fullarticle/2840824]) SOFA score (Wikipedia [https://en.wikipedia.org/wiki/SOFA_score]) Sodium bicarbonate administration for metabolic acidosis in the intensive care unit: a target trial emulation (PubMed [https://pubmed.ncbi.nlm.nih.gov/40493225/]) Effect of sodium bicarbonate on intracellular pH under different buffering conditions (PubMed [https://pubmed.ncbi.nlm.nih.gov/8731089/]) Evaluating the clinical and cost-effectiveness of Sodium Bicarbonate administration for critically ill patients with Acute Kidney Injury (MOSAICC) (ICNARC Site [https://www.icnarc.org/research-studies/mosaicc/]) SODium BICarbonate for Metabolic Acidosis in the ICU (SODa-BIC) (ClinicalTrials.gov [https://clinicaltrials.gov/study/NCT05697770]) Surviving Sepsis Campaign Guidelines 2021 (Website [https://www.sccm.org/clinical-resources/guidelines/guidelines/surviving-sepsis-guidelines-2021]) Tubular Secretions Nayan: Louise Penny, The Black Wolf (Amazon [https://www.amazon.com/s?k=the+black+wolf+a+novel&adgrpid=187375749018&hvadid=779554479816&hvdev=c&hvexpln=0&hvlocphy=9016826&hvnetw=g&hvocijid=18241889278672633619--&hvqmt=e&hvrand=18241889278672633619&hvtargid=kwd-2419654292602&hydadcr=10022_13483915_10819&mcid=557d93471c02304180e3785be8dc9452&tag=googhydr-20&ref=pd_sl_4w1pg92uc1_e]) Anna: Broom Gate: A Curling Scandle (CBC [https://www.cbc.ca/listen/cbc-podcasts/1427-broomgate-a-curling-scandal]) Pedro: One Battle After Another! (Wikipedia [https://en.wikipedia.org/wiki/One_Battle_After_Another]) David: Patti Smith (Wikipedia [https://en.wikipedia.org/wiki/Patti_Smith]) Bonus pick: Kids Rarely Read Whole Books Anymore. Even in English Class. (NYT [https://www.nytimes.com/2025/12/12/us/high-school-english-teachers-assigning-books.html]) Joel: Boys in the Boat by Daniel James Brown (Film Wikipedia [https://en.wikipedia.org/wiki/The_Boys_in_the_Boat_(film)] | Book Wikipedia [https://en.wikipedia.org/wiki/The_Boys_in_the_Boat])