Heal Thy Self with Dr. G

The Most Powerful Peptide You've Never Heard Of (Affects 4,000 Genes) | Heal Thy Self w/ Dr. G #498

17 min · 2 jul 2026
aflevering The Most Powerful Peptide You've Never Heard Of (Affects 4,000 Genes) | Heal Thy Self w/ Dr. G #498 artwork

Beschrijving

Ebook: https://drive.google.com/file/d/1AUsxg05dXkKFeAa64kC0u16XynnSx68o/view?usp=drive_link Episode Description: Every peptide conversation right now is about GLP-1 drugs, BPC-157, and TB-500. Nobody is talking about the one with 50 years of published research that your body is already making and losing as you age. GHK-Cu is a naturally occurring tripeptide that declines by 60% between the ages of 20 and 60. That decline tracks directly with the loss of skin elasticity, slower wound healing, thinning hair, reduced collagen production, and rising inflammation. In randomized controlled trials it has outperformed Rogaine for hair growth, shown a 55% reduction in visible wrinkles, and been documented to positively affect the expression of over 4,000 human genes. Dr. G calls it his favorite peptide, and his partner uses it on her face every day. In this episode, you will learn:  • How GHK-Cu works as a copper delivery vehicle at the cellular level, why it modulates gene expression across 31% of the human genome, and what that means for tissue repair, inflammation, and biological aging  • The head to head randomized controlled trial where GHK-Cu outperformed minoxidil for hair count, follicle size, and the active growth phase of the hair cycle  • Exactly what to look for when buying GHK-Cu cream, why the peptide is chemically fragile, what packaging and pH range to require, and the red flags that tell you to walk away from a product Timestamps: 0:00 - Intro 1:44 - What GHK-CU Actually Is and How It Was First Discovered in 1973 3:10 - Why a 60% Decline in GHK-CU Between Ages 20 and 60 Tracks Directly With Aging 4:40 - What Makes GHK-CU Different From Every Other Popular Peptide 6:00 - How It Stimulates Collagen, Elastin & the Extracellular Matrix 7:15 - The Human Trial Showing a 51% Increase in Collagen Density From Topical Application 8:00 - The 4,000 Genes GHK-CU Affects (And What the Broad Institute Found) 9:30 - Anti-Inflammatory Effects: Why This Matters for Biological Aging 10:30 - Wound Healing, Angiogenesis & Tissue Repair Across Skin, Bone, Gut and Liver 11:30 - The 2022 RCT: 55.7% Reduction in Visible Wrinkles After 12 Weeks 12:30 - Hair Growth: Outperforming Minoxidil in a Head-to-Head Randomized Trial 14:30 - Why the Lower Dose (50mg/ml) Outperformed the Higher Dose 15:30 - Safety Profile, Contraindications & the "Copper Uglies" Explained 17:00 - How to Buy GHK-CU: Concentration, Packaging, pH & What to Avoid Learn more about your ad choices. Visit megaphone.fm/adchoices [https://megaphone.fm/adchoices]

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aflevering Scientist Found 5 Things That Boost Testosterone - Here’s What They Are | Heal Thy Self w/ Dr. G #498 artwork

Scientist Found 5 Things That Boost Testosterone - Here’s What They Are | Heal Thy Self w/ Dr. G #498

Episode Description: There are over 40 supplements on the market right now promising to raise your testosterone. The vast majority of them are a waste of your money. Some are doing nothing at all. Others may be doing damage. And this episode is not sponsored by a single one of them. After age 35, testosterone drops by 1% every year. For most men that starts to feel like lost recovery, vanishing drive, and stubborn fat around the midsection that will not budge. But low testosterone is not just a gym problem. It travels directly alongside insulin resistance, visceral fat accumulation, cardiovascular risk, depression, and cognitive decline. Out of 40 plus products making claims, only five have actual randomized controlled trial data behind them. Dr. G breaks all five down today, including the exact form and dose used in the research. In this episode, you'll learn:  •  Why KSM-66 ashwagandha is the most clinically validated of the group, how chronic stress is biologically competing with your testosterone production for the same raw materials, and why the form on the label matters more than the brand  •  How Tongkat Ali works by freeing up testosterone that is already in your body but locked away and unavailable, and why it produced a 90% normalization rate in men who were clinically low  •  Why most men with normal testosterone on paper still have low free testosterone, and how magnesium and zinc address the two different sides of that problem Plus where vitamin D actually fits in the stack, the one free intervention that matters more than all five supplements combined, and why deep sleep is where the majority of your testosterone is actually made. Product reviews assess both brand transparency and product quality. If a company doesn’t respond to our outreach, it doesn’t automatically mean their product is low quality but it does mean they’re failing their customers on transparency and communication. We reach out multiple times. No response isn’t an oversight, it's a choice. And consumers deserve better. Timestamps: 0:00 - Intro 1:30 - Why Low Testosterone Is Way More Dangerous Than Most Men Realize 3:00 - The Lifestyle Factors Destroying Your Testosterone Before Supplements Even Enter the Picture 4:15 - Supplement #1: The Most Clinically Validated Option in the Group 6:30 - Supplement #2: How This Herb Does Something Rare That Most Men Don't Know Is Possible 9:00 - Supplement #3: The Most Commonly Depleted Mineral for Testosterone (And Why) 11:30 - Supplement #4: Why Your Labs Can Look Normal and You Still Feel Like Garbage 13:30 - Supplement #5: The Foundation That Every Other Supplement Is Standing On 15:30 - Why Dr. G Says Test Before You Guess — And What to Actually Test For 17:00 - The One Free Thing That Matters More Than All Five Supplements Combined 18:00 - How to Stack All of This in the Right Order Learn more about your ad choices. Visit megaphone.fm/adchoices [https://megaphone.fm/adchoices]

9 jul 202616 min
aflevering The #1 Killer Women Never See Coming — and How to Beat It | ft. Dr. Mary Pardee HTS #499 artwork

The #1 Killer Women Never See Coming — and How to Beat It | ft. Dr. Mary Pardee HTS #499

→ Ora Organic | Real ingredients, planet-friendly packaging, easy to love. Head to https://ora.organic/pages/drg [https://ora.organic/pages/drg] and use my code HEALTHYSELF30 to enjoy 30% off your first Ora order today. → Puori | Go to https://puori.com/DRG [https://puori.com/DRG] and use the code DRG at checkout to get 32% off your first Puori Creatine+ subscription order. → Santa Barbara Chocolate | CocoaDynamics available at https://SantaBarbaraChocolate.com [https://santabarbarachocolate.com]. Use code DRG20 for 20% off. Episode Description: Social media has convinced women that they need to lower their cortisol to lose belly fat, sync their workouts to their menstrual cycle, eat differently depending on their cycle phase, avoid heavy lifting to stay lean, and take a stack of longevity supplements to live longer. Dr. Mary Pardee is here to call most of that what it is. Dr. Mary is a naturopathic and functional medicine doctor, one of Dr. G's closest friends, and one of the most evidence-based voices in the wellness space. This is her third time on Heal Thy Self and she is not holding back. From LDL cholesterol to VO2 max to the Mediterranean diet to cold plunge, she is cutting through the noise and giving women the clearest, most direct framework for actually living longer. In this episode, you'll discover:  •  Why LDL cholesterol is causative for heart disease the way smoking is causative for lung cancer, what numbers to actually target at different life stages, and why plaque formation begins in your 20s  •  The truth about cycle syncing workouts and food, why it is a marketing tactic designed to confuse a vulnerable population into buying something, and what the research actually says about training through your cycle  •  How to structure protein intake for muscle building, the exact grams per kilogram targets for different goals, and why women are still chronically under eating protein even in 2026 Plus the labs every woman should be running, what a DEXA scan actually reveals about body composition, and why cold plunge has no longevity evidence behind it while sauna does. Find Dr. Amy Pardee:  Website: https://www.modrnmed.com/ [https://www.modrnmed.com/] Instagram: https://www.instagram.com/dr.marypardee [https://www.instagram.com/dr.marypardee] https://www.instagram.com/catharinearnston Timestamps: 0:00 - Intro 2:07 - Rapid Fire: Cortisol, LDL, Heavy Lifting & Cycle Syncing — Myth or Fact? 5:30 - How Dr. Mary Became the Most Evidence-Based Naturopathic Doctor Dr. G Knows 9:10 - The Vulnerable Populations Being Targeted by Wellness Influencers 11:45 - The Truth About Cortisol and Belly Fat (And Who This Advice Is Actually Hurting) 15:00 - Calories vs. Whole Foods: Why "Just Eat Clean" Is Gaslighting a Lot of People 19:00 - DEXA Scans, Skinny Fat & Why Women Often Need to Add Muscle, Not Lose Weight 22:30 - How Much Protein Women Actually Need and Why Most Are Undereating It 26:00 - Animal Protein vs. Plant Protein: Has Dr. Mary Changed Her Mind? 28:30 - Heart Disease Is Still the #1 Killer — Here's Why That Hasn't Changed 31:00 - LDL Is Causative for Heart Disease, Full Stop (And Why the Nuance Is Misleading People) 35:00 - What LDL Numbers Should Actually Trigger Treatment 37:30 - Should People in Their 30s Be on Statins? Dr. Mary Says Yes 39:00 - How Much Can Diet Actually Lower Your LDL? The 20% Reality 42:00 - The Mediterranean Diet vs. Keto vs. Carnivore: What the Research Actually Supports 45:00 - VO2 Max: What It Measures, Why It Matters & Whether You Need to Test It 49:30 - Cycle Syncing Your Workouts and Diet: Social Media Trash 52:30 - Cold Plunge vs. Sauna for Longevity: What the Evidence Actually Shows 54:30 - The Labs Every Person Should Ask Their Doctor to Run 58:00 - One Thing Dr. Mary Wants Every Woman to Walk Away With Learn more about your ad choices. Visit megaphone.fm/adchoices [https://megaphone.fm/adchoices]

6 jul 20261 h 1 min
aflevering The Most Powerful Peptide You've Never Heard Of (Affects 4,000 Genes) | Heal Thy Self w/ Dr. G #498 artwork

The Most Powerful Peptide You've Never Heard Of (Affects 4,000 Genes) | Heal Thy Self w/ Dr. G #498

Ebook: https://drive.google.com/file/d/1AUsxg05dXkKFeAa64kC0u16XynnSx68o/view?usp=drive_link Episode Description: Every peptide conversation right now is about GLP-1 drugs, BPC-157, and TB-500. Nobody is talking about the one with 50 years of published research that your body is already making and losing as you age. GHK-Cu is a naturally occurring tripeptide that declines by 60% between the ages of 20 and 60. That decline tracks directly with the loss of skin elasticity, slower wound healing, thinning hair, reduced collagen production, and rising inflammation. In randomized controlled trials it has outperformed Rogaine for hair growth, shown a 55% reduction in visible wrinkles, and been documented to positively affect the expression of over 4,000 human genes. Dr. G calls it his favorite peptide, and his partner uses it on her face every day. In this episode, you will learn:  • How GHK-Cu works as a copper delivery vehicle at the cellular level, why it modulates gene expression across 31% of the human genome, and what that means for tissue repair, inflammation, and biological aging  • The head to head randomized controlled trial where GHK-Cu outperformed minoxidil for hair count, follicle size, and the active growth phase of the hair cycle  • Exactly what to look for when buying GHK-Cu cream, why the peptide is chemically fragile, what packaging and pH range to require, and the red flags that tell you to walk away from a product Timestamps: 0:00 - Intro 1:44 - What GHK-CU Actually Is and How It Was First Discovered in 1973 3:10 - Why a 60% Decline in GHK-CU Between Ages 20 and 60 Tracks Directly With Aging 4:40 - What Makes GHK-CU Different From Every Other Popular Peptide 6:00 - How It Stimulates Collagen, Elastin & the Extracellular Matrix 7:15 - The Human Trial Showing a 51% Increase in Collagen Density From Topical Application 8:00 - The 4,000 Genes GHK-CU Affects (And What the Broad Institute Found) 9:30 - Anti-Inflammatory Effects: Why This Matters for Biological Aging 10:30 - Wound Healing, Angiogenesis & Tissue Repair Across Skin, Bone, Gut and Liver 11:30 - The 2022 RCT: 55.7% Reduction in Visible Wrinkles After 12 Weeks 12:30 - Hair Growth: Outperforming Minoxidil in a Head-to-Head Randomized Trial 14:30 - Why the Lower Dose (50mg/ml) Outperformed the Higher Dose 15:30 - Safety Profile, Contraindications & the "Copper Uglies" Explained 17:00 - How to Buy GHK-CU: Concentration, Packaging, pH & What to Avoid Learn more about your ad choices. Visit megaphone.fm/adchoices [https://megaphone.fm/adchoices]

2 jul 202617 min
aflevering 100,000 Studies Prove This Works — So Why Has Nobody Told You | ft. Dr. Catharine Arnston HTS #497 artwork

100,000 Studies Prove This Works — So Why Has Nobody Told You | ft. Dr. Catharine Arnston HTS #497

→ ENERGYbits: Use code DRG for 20% off your order.  https://energybits.com/discount/DRG?rfsn=7969418.1fab15&utm_source=refersion&utm_medium=affiliate&utm_campaign=7969418.1fab15 [https://energybits.com/discount/DRG?rfsn=7969418.1fab15&utm_source=refersion&utm_medium=affiliate&utm_campaign=7969418.1fab15] Episode Description There is a food that has been on Earth for 4 billion years, is backed by over 100,000 scientific studies, is used by NASA, endorsed by the United Nations, and fuels Olympic and NFL athletes. And almost nobody is talking about it. Catharine Arnston is the founder of Energy Bits, a PhD holder, and the world's leading voice on spirulina and chlorella — the two algae she calls your nutritional and health insurance. She found this world trying to help her sister recover from breast cancer, spent 17 years going deeper into science than anyone else has, and is now nearly 70 years old with more energy, clarity, and vitality than most people half her age. The proof is in everything she says. In this episode, you'll discover:  • Why spirulina's amino acid profile is almost identical to mother's breast milk — and how it protects the mitochondria, clears brain fog, and rebuilds energy at a cellular level without stimulants or crashes  • What chlorella actually does inside the body: pulling out heavy metals, toxins, and excess iron while triggering serotonin production, improving mood, and getting your gut moving  • Why most algae on the market has had its most critical nutrients deactivated — and what to look for to make sure you're getting the real thing Aging is natural. Declining is not. Find Catharine:  Website: https://energybits.com [https://energybits.com] Personal Website: https://catharinearnston.com/ [https://catharinearnston.com/]Instagram: https://www.instagram.com/energybits [https://www.instagram.com/energybits]  Personal Instagram: https://www.instagram.com/catharinearnston [https://www.instagram.com/catharinearnston] Timestamps: 0:00 - Intro 2:07 - Meet Catherine Arnson: Nearly 70, More Energy Than Most 30-Year-Olds 3:50 - Rapid Fire: Exhaustion, Coffee Dependency & Why Algae Is a Food Not a Supplement 7:12 - Catherine's Origin Story: How a Sister's Breast Cancer Led to 100,000 Studies 10:18 - Why the Science on Spirulina and Chlorella Has Been Sitting in a Vault for Decades 12:40 - The Blue Pigment in Spirulina That Has Been Shown to Kill Cancer Cells 15:20 - Real Results: The 85-Year-Old Who Cleaned Her Garage After Starting Algae 18:00 - Why Women Over 40 Feel Like They Fell Off a Cliff (And What's Actually Happening) 22:10 - Chlorella's Highest Tryptophan Content in the World and What It Does for Mood 25:30 - Why Not All Algae Is Created Equal (And Why Most Brands Are Destroying the Nutrients) 29:45 - Spirulina vs. Chlorella: What Each One Does and Why You Need Both 34:00 - Spirulina Is the Second Most Nutritionally Complete Food After Breast Milk 37:10 - Skin, Hair, Nails & Brain Fog: What Spirulina Does Specifically for Women 42:00 - The Golf Umbrella Analogy: How SOD Protects Your Mitochondria 45:30 - Telomeres, Fertility & Heart Health: More of What These Algae Protect 50:15 - Why Men Die Earlier (The Iron Oxidation Connection) 54:20 - How to Take It, How Much, and When You'll Start Feeling a Difference 58:00 - Working With NHL, NFL & Olympic Athletes for Over a Decade 1:02:00 - Where to Find Energy Bits and What Sets Theirs Apart Learn more about your ad choices. Visit megaphone.fm/adchoices [https://megaphone.fm/adchoices]

29 jun 202655 min
aflevering Nature’s Ozempic Showed Metformin-Like Results in a Real Clinical Trial | Heal Thy Self w/ Dr. G #496 artwork

Nature’s Ozempic Showed Metformin-Like Results in a Real Clinical Trial | Heal Thy Self w/ Dr. G #496

Episode Description: Everyone is calling it nature's Ozempic. That is marketing. And it is doing a total disservice to what berberine actually does. Berberine is not a GLP-1 drug. It does not work the same way. The weight loss outcomes are not comparable. And if you are taking it expecting to drop 15% of your body weight, you are going to be disappointed. But here is what the research actually shows, and why Dr. G takes berberine every single day. The clinical evidence on berberine for blood sugar, cholesterol, insulin resistance, and gut health is genuinely compelling. A three month randomized controlled trial in newly diagnosed type two diabetics showed reductions in HbA1c, fasting blood glucose, and post-meal blood glucose that were comparable to metformin. A 2022 meta analysis confirmed it hits triglycerides, total cholesterol, LDL, blood pressure, and insulin resistance markers simultaneously. And the gut microbiome research is a piece almost nobody is talking about.In this episode, you will learn:  •  What berberine actually does in the body through the AMPK pathway, why it is not a GLP-1, and what to realistically expect from it  • Why standard berberine has a major absorption problem, what dihydroberberine is and why it may deliver 2 to 4 times more into circulation at a fraction of the dose  • Exactly how to buy berberine intelligently, what standardization means on a label, which forms to choose, and what to avoid. Timestamps: 0:00 - Intro 1:44 - How Berberine Works in the Body (And Why It's Not a GLP-1 Drug) 3:24 - The Weight Loss Reality: What Berberine Can and Can't Do 4:48 - Blood Sugar and Insulin Resistance: Where the Evidence Is Strongest 6:30 - Comparable to Metformin in Some Trials — What That Actually Means 7:42 - Cholesterol, Triglycerides & Cardiovascular Risk: Berberine's Strongest Evidence Base 9:44 - How Dr. G Uses Berberine in His Own Daily Routine 10:38 - Berberine's Underrated Effect on the Gut Microbiome 12:30 - The Big Absorption Problem With Standard Berberine (And the Solution) 14:22 - Dihydroberberine: 2-4x More Bioavailable in Human Trials 15:18 - How to Buy Berberine Intelligently: Standardization, Form & Third-Party Testing 17:00 - Who Should Take Berberine (And Who Shouldn't) Learn more about your ad choices. Visit megaphone.fm/adchoices [https://megaphone.fm/adchoices]

25 jun 202613 min