Lunch Hour Lectures - Spring 2008 - Audio

Toad meets T-Rex: The Evolution and Diversification of Frogs - Audio

40 min · 4 feb 201140 min
aflevering Toad meets T-Rex: The Evolution and Diversification of Frogs - Audio cover

Beschrijving

Love them or loathe them, frogs have a place in popular culture, from ‘Kermit’ to ‘Toad of Toad Hall’. The short, tailless body, large head, and long legs give a profile that is vaguely humanoid, but frogs are optimised for leaping rather than walking, a locomotor strategy that has been highly successful. Amongst amphibians, their body plan is unique, prompting questions as to its origin and evolutionary history. Some of the answers may be found in the fossil record of frogs, dating back 250 million years to the very beginning of the ‘Age of Dinosaurs’.

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aflevering The Yin and Yang of Cellular Communication - Audio artwork

The Yin and Yang of Cellular Communication - Audio

The lecture looks at how cells in emerging multicellular organisms have evolved ways of communicating with each other. The basic ‘yes’ and ‘no’ signalling was probably mediated by release into the extracellular space of substances which were available in abundance inside the cells – purine nucleotide ATP (molecule charged with energy – excitatory Yang) and its breakdown product adenosine (molecule devoid of energy – inhibitory Yin). The lecture will use examples from current research demonstrating how this dual system of conveying information from one cell to another has been preserved during evolution. Both substances are important modulators of cellular functions still playing often opposing roles in the peripheral tissues as well as in the central nervous system.

4 feb 201130 min