SHTG Digest — Tuesday June 23, 2026

SHTG Digest — Tuesday June 23, 2026

A fresh meta-analysis of 14 APOC3-inhibitor trials confirms 80% reduction in acute pancreatitis risk alongside a compelling indirect head-to-head of olezarsen versus volanesorsen in FCS, while the most important industry event this cycle is the looming June 30 FDA decision on Tryngolza for severe hypertriglyceridemia.

SHTG Digest — Friday June 19, 2026

A quiet breaking-news cycle on paper, but the lipid field is coiled for impact — a landmark Ionis FDA decision on olezarsen for severe hypertriglyceridemia is 11 days out, and fresh science clarifies who among heterozygous FCS-gene carriers will need APOC3-targeted therapy; on the bench, a novel SPP2–LPL axis offers a new handle on triglyceride homeostasis.

SHTG Digest — Tuesday June 16, 2026

A meta-analysis confirms olezarsen's strong efficacy across eight RCTs, a human kinetic study illuminates exactly how ANGPTL3 deficiency reshapes triglyceride-rich lipoprotein metabolism, and a JACC case report highlights the management challenges of severe HTG in pregnancy — while the industry stage is quiet mid-week but poised for major events: the FDA PDUFA date for Tryngolza in sHTG arrives June 30, and Arrowhead's SHASTA-3/4 phase 3 readout is expected this month.

SHTG Digest — Friday June 12, 2026

A quiet cycle on both fronts — no new top-tier lipid papers cleared the bar (the one journal hit, a Lancet D&E retrospective, was already covered Tuesday), and no fresh trade-press stories landed in the 5-day window, leaving the competitive backdrop dominated by the countdown to the FDA's June 30 decision on olezarsen in severe hypertriglyceridemia.

SHTG Digest — Tuesday June 9, 2026

A sweeping 25-year review of lipid medicine published today in *Lancet Diabetes & Endocrinology* maps the journey from statins to RNA/DNA-targeted therapies for APOC3 and ANGPTL3; on the industry side, it's a quiet news week, but the Ionis FDA clock for Tryngolza in severe hypertriglyceridemia is now ticking down to a June 30 decision.