Discovering Ketamine with Dr. Edward Domino

Discovering Ketamine with Dr. Edward Domino

In this episode I sit down the arylcyclohexylamine legend Dr. Edward F. Domino to discuss his pioneering research on ketamine, his subsequent research on NMDA antagonists, and his first encounter with a patient who reported antidepressant activity from using ketamine. _______________ 100s of unreleased episodes available at patreon.com/hamiltonmorris Merchandise available at hamiltonmorris.com _______________ A big thank you for supporting my content:  Amentara - https://www.amentara.com A source for Amanita muscaria, kanna, kava, akuamma, and all your other ethnobotanical needs. Use discount code "HAMILTON" for 22% off! MUD\WTR - Start your new morning ritual & get 20% off your subscription or one-time purchase at https://mudwtr.com/HAMILTONMORRIS  #sponsored #mudwtrpod Lucy Tobacco-Free Nicotine - https://www.lucy.co Lucy's mission is to reduce tobacco-related harm to zero! Use discount code "HAMILTON" Matcha.com - https://matcha.com Andrew Weil MD's matcha tea, it's delicious! Use discount code "HAMILTON" for up to 20% off + a FREE gift! _______________ 0:00 Introduction & context 2:45 The discovery of ketamine 8:30 Phencyclidine derivatives & Parke-Davis 14:15 First human administration of ketamine 19:30 The testicle compression experiment 23:45 Initial impressions & anesthetic potential 28:15 Collaboration with psychiatrists at Lafayette Clinic 32:00 Ketamine as a model for schizophrenia 36:30 The missed antidepressant discovery 42:15 The patient who knew better 46:45 Regret & listening to patients 51:00 FDA approval & antidepressant recognition 55:30 John C. Lilly & Marsha Moore 59:00 R-ketamine vs S-ketamine 63:45 The right-hand form & less dissociation 68:30 The Cal Stevens patent scandal 74:00 Cal Stevens the medicinal chemist 79:00 A missed opportunity to meet Cal Stevens 83:15 The endogenous ligand question 87:45 Complex mechanisms of ketamine action 92:00 Sigma receptors & research opportunities 96:30 R-ketamine as the future direction 101:00 Career advice & getting funded 105:30 The importance of permission from your boss 109:15 LSD-25 & other opportunities 112:45 Final reflections on legacy & family Support the show [https://www.patreon.com/HamiltonMorris]

Psychedelic-Induced False Memories w/ Dr. Manoj Doss

In this episode I sit down with Dr. Manoj Doss, an expert on the impact of psychoactive drugs on memory, to discuss the unfolding scandal regarding Amy Griffin's book The Tell, as well Jeffrey Epstein, AI, the illusory truth effect, and a skeptical analysis of psychedelic-associated insight. _______________ 100s of unreleased episodes available at patreon.com/hamiltonmorris Merchandise available at hamiltonmorris.com _______________ A big thank you for supporting my content:  Amentara - https://www.amentara.com A source for Amanita muscaria, kanna, kava, akuamma, and all your other ethnobotanical needs. Use discount code "HAMILTON" for 22% off! MUD\WTR - Start your new morning ritual & get 20% off your subscription or one-time purchase at https://mudwtr.com/HAMILTONMORRIS  #sponsored #mudwtrpod Lucy Tobacco-Free Nicotine - https://www.lucy.co Lucy's mission is to reduce tobacco-related harm to zero! Use discount code "HAMILTON" Matcha.com - https://matcha.com Andrew Weil MD's matcha tea, it's delicious! Use discount code "HAMILTON" for up to 20% off + a FREE gift! Support the show [https://www.patreon.com/HamiltonMorris]

A Hacker's 170 Million Dollar K-Hole

In this episode I spend three hours talking with the ex-hacker, anti-snitching activist, and NMDA-antagonist aficionado Stephen Watt about his experience writing computer code while high on ketamine that was used to steal millions of dollars from the cinnamon apple purveying buffet chain Boston Market, as well as T.J. Maxx and Dave & Buster's. Watt analyzes the benefits and dangers of ketamine, what dangers it might pose for users like Elon Musk, and the fringe possibility that ketamine medicalization could be used by foreign chaos agents. _______________ 100s of unreleased episodes available at patreon.com/hamiltonmorris Merchandise available at hamiltonmorris.com _______________ A big thank you for supporting my content:  Amentara - https://www.amentara.com A source for Amanita muscaria, kanna, kava, akuamma, and all your other ethnobotanical needs. Use discount code "HAMILTON" for 22% off! MUD\WTR - Start your new morning ritual & get 20% off your subscription or one-time purchase at https://mudwtr.com/HAMILTONMORRIS  #sponsored #mudwtrpod Lucy Tobacco-Free Nicotine - https://www.lucy.co Lucy's mission is to reduce tobacco-related harm to zero! Use discount code "HAMILTON" Matcha.com - https://matcha.com Andrew Weil MD's matcha tea, it's delicious! Use discount code "HAMILTON" for up to 20% off + a FREE gift! Support the show [https://www.patreon.com/HamiltonMorris]

Two years in an underground MDMA lab, a conversation with MethylMan

In this episode I sit down with a self-taught legend of underground MDMA synthesis and former Hive member named MethylMan. We discuss Wacker oxidation, reductive amination, aluminum amalgamation and the joys and dangers of underground chemistry. _______________ 100s of unreleased episodes available at patreon.com/hamiltonmorris Merchandise available at hamiltonmorris.com _______________ A big thank you for supporting my content: Kykeon Analytics - https://www.kykeonanalytics.com [https://www.youtube.com/redirect?event=video_description&redir_token=QUFFLUhqa3lOMUlaTTh0eXExeHFDVTcxNko4aTZMMGVuZ3xBQ3Jtc0tuX19CTkJ2WURhdjNUQ2NzTUJoWURGYXo0MGx2REJmeHRVbmVab3NhdzhYazJWbzh2M3dJbndLU2h6eUQyZGRJTDdQNGNaek1CM2NGVjNVM1BUZTVQZTdqdFJYa2tPaVNSU3hnUVZKUjZXa0VpVllFZw&q=https%3A%2F%2Fwww.kykeonanalytics.com%2F&v=owqLpbKWqw0] A fully anonymous mail-in drug checking lab service. MUD\WTR - Start your new morning ritual & get 20% off your subscription or one-time purchase at https://mudwtr.com/HAMILTONMORRIS [https://www.youtube.com/redirect?event=video_description&redir_token=QUFFLUhqbTRSRVY5ZHQ5Q2tESzZoUzJDOTc5ZTBta2hFUXxBQ3Jtc0tuWWN3Ym40ZDBkbFFzY3UwaVFwUUpvTWJHdGN2eVpsTURRN2dxWUFybjh2Ujd0a2t6OVc3WjlJaFpJTHpGbmRLc0Jyd0dpdTN5TXlkb2kxTHhKWS1QZlRiRlJ2Y3c3Ql85MzY5TnNsOENoc01OWXlTRQ&q=https%3A%2F%2Fmudwtr.com%2FHAMILTONMORRIS&v=owqLpbKWqw0] #sponsored [https://www.youtube.com/hashtag/sponsored] #mudwtrpod [https://www.youtube.com/hashtag/mudwtrpod] Lucy Tobacco-Free Nicotine - https://www.lucy.co [https://www.youtube.com/redirect?event=video_description&redir_token=QUFFLUhqbHFwUWdYaEpnbFVmcWUyS0V1N25Gbzc3NkJpd3xBQ3Jtc0ttbThyQ3lZcndzRW5YV1g0bWVoOUNFU25YQVEwZnZsTmhtTWYwRUJScXFCNWllY2Y4R1hDcUJZdmQwdlpwdV9Bc3pwQ1NFMFFWNjlXQ3NIN0hQNFl1cE5Jb0Z4UFBvdkNSM1BZd3AzckhoSU5JOV82Yw&q=https%3A%2F%2Fwww.lucy.co%2F&v=owqLpbKWqw0] Lucy's mission is to reduce tobacco-related harm to zero! Use discount code "HAMILTON" Matcha.com - https://matcha.com [https://www.youtube.com/redirect?event=video_description&redir_token=QUFFLUhqbVBmMVYtUEp0U1lOZUhqZkNLbjh1RXBIRVZJQXxBQ3Jtc0tteGJYdDBHV0VVMndnemw2eENNeS1ndnBzN01kY1c5bFo2RVo5WFUyNjYtSzQ0UmMzRkRPUGdEYm1Tbm9DZWRQWEpMRGRDSUtXZS0tNUxIbXpCMGZRTUw3d1dvZTBDUTBSSGpIellDemNndTdiZEdHTQ&q=https%3A%2F%2Fmatcha.com%2F&v=owqLpbKWqw0] Andrew Weil MD's matcha tea, it's delicious! Use discount code "HAMILTON" for up to 20% off + a FREE gift! Support the show [https://www.patreon.com/HamiltonMorris]

Lessons from Joel Stanley on Charlotte's Web

In this episode I speak with Joel Stanley, co-founder of Charlotte’s Web, about the political battles and innovative development of high-CBD, low-THC medical cannabis. Joel is now the founder and CEO of AJNA BioSciences, a clinical-stage biotech company developing FDA-approved botanical drugs from psychedelics and cannabinoids to treat mental health and neurological disorders. _______________ 100s of unreleased episodes available at patreon.com/hamiltonmorris Merchandise available at hamiltonmorris.com _______________ A big thank you for supporting my content: Kykeon Analytics - https://www.kykeonanalytics.com [https://www.youtube.com/redirect?event=video_description&redir_token=QUFFLUhqbG5od2FRTDNsNGJ1Rm82c1AtS1pLRUk0YTQzd3xBQ3Jtc0tuY0FjeXJuVUJDQlBmQW1hWDM5N2ZmUjB0SHUwbHBRQ0JDM2FZMFI5UndHWU96YmI5cVJ2a3lRbDBNVkhzZnpPOFhzVlZteXUyM2tmMzlRRVRxbmc4c3FGSHIzV3NvT19jTHJUNzFwM3lQSGtEbjdjSQ&q=https%3A%2F%2Fwww.kykeonanalytics.com%2F&v=m0PZ2Jrl61I] A fully anonymous mail-in drug checking lab service. Lucy Tobacco-Free Nicotine - https://www.lucy.co [https://www.youtube.com/redirect?event=video_description&redir_token=QUFFLUhqa2RmVklrOV8wWHdSU0ctSDU2TzMzbTFxNFI0d3xBQ3Jtc0tsQW9nc3NzdXpaWUdNSWo1NHJwTnZQdU9Zc1cyRVRzbjhfNk1iRUl1bHVEb0Ywa0JZak03NHBXN2tJclZKUmx5X1A5QlBTekUyT0VFTngxT1QzNllHTmxVTG83bk02ZFFyWVR6MTZmb1JNcWJXVG10VQ&q=https%3A%2F%2Fwww.lucy.co%2F&v=m0PZ2Jrl61I] Lucy's mission is to reduce tobacco-related harm to zero! Use discount code "HAMILTON" Matcha.com - https://matcha.com [https://www.youtube.com/redirect?event=video_description&redir_token=QUFFLUhqa21KOVFaOHdKSGpyRVg1V08weThhRGZfcHVmQXxBQ3Jtc0ttZkFTWVRnV2FnZ1V3YzA2VWIzRUpUWDdlMDdjWnd1dHdmQUFhNFIzT0VmNjZGdkxRQkJmVWk1UFJGMXdrR3puV2UwVFU1Z1lXSE5ZcVJTaE4yX2NqWXFDVGdadXlKM0pRdjhlZVRsQW85aU9zd0cxTQ&q=https%3A%2F%2Fmatcha.com%2F&v=m0PZ2Jrl61I] Andrew Weil MD's matcha tea, it's delicious! Use discount code "HAMILTON" for up to 20% off + a FREE gift! Support the show [https://www.patreon.com/HamiltonMorris]