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NSD2 targeting reverses plasticity and drug resistance in prostate cancer

4 min · 15. Dez. 2025
Episode NSD2 targeting reverses plasticity and drug resistance in prostate cancer Cover

Beschreibung

This article "NSD2 targeting reverses plasticity and drug resistance in prostate cancer" is published in Nature. Author: Jia J. Li Journal: Nature Year: 2025 Podcast type: Short The authors are: * Jia J. Li * Alessandro Vasciaveo * Dimitris Karagiannis * Zhen Sun * Kristjan H. Gretarsson * Xiao Chen * Ouathek Ouerfelli * Fabio Socciarelli * Ziv Frankenstein * Hanyang Dong * Min Zou * Wei Yuan * Guangli Yang * Gabriel M. Aizenman * Tania Pannellini * Xinjing Xu * Himisha Beltran * Yu Chen * Kevin Gardner * Brian D. Robinson * Johann de Bono * Or Gozani * Cory Abate-Shen * Mark A. Rubin * Massimo Loda * Charles L. Sawyers * Andrea Califano * Chao Lu * Michael M. Shen Affiliations: Jia J. Li, Cory Abate-Shen, Andrea Califano, Michael M. Shen, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA Jia J. Li, Alessandro Vasciaveo, Cory Abate-Shen, Andrea Califano, Michael M. Shen, Department of Systems Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA Jia J. Li, Dimitris Karagiannis, Kristjan H. Gretarsson, Xiao Chen, Chao Lu, Michael M. Shen, Department of Genetics and Development, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA Jia J. Li, Cory Abate-Shen, Michael M. Shen, Department of Urology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA Jia J. Li, Alessandro Vasciaveo, Dimitris Karagiannis, Kristjan H. Gretarsson, Xiao Chen, Ziv Frankenstein, Min Zou, Cory Abate-Shen, Andrea Califano, Chao Lu, Michael M. Shen, Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA Alessandro Vasciaveo, Gabriel M. Aizenman, Center for Data Science and Artificial Intelligence, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA Alessandro Vasciaveo, Gabriel M. Aizenman, Center for Therapeutics Discovery, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA Alessandro Vasciaveo, Gabriel M. Aizenman, Cancer Genome and Epigenetics Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA Zhen Sun, Yu Chen, Charles L. Sawyers, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA Ouathek Ouerfelli, Guangli Yang, Organic Synthesis Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA Fabio Socciarelli, Tania Pannellini, Brian D. Robinson, Massimo Loda, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA Ziv Frankenstein, Kevin Gardner, Cory Abate-Shen, Department of Pathology and Cell Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA Hanyang Dong, Or Gozani, Department of Biology, Stanford University, Stanford, CA, USA Min Zou, Cory Abate-Shen, Department of Molecular Pharmacology and Therapeutics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA Wei Yuan, Johann de Bono, Division of Clinical Studies, The Institute of Cancer Research, London, UK Himisha Beltran, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA Yu Chen, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA Mark A. Rubin, Department of Biomedical Research, Bern Center for Precision Medicine, University of Bern, Bern, Switzerland Massimo Loda, Nuffield Department of Surgical Sciences, Lincoln College, University of Oxford, Oxford, UK Charles L. Sawyers, Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA Andrea Califano, Department of Biomedical Informatics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA Andrea Califano, Department of Biochemistry and Molecular Biophysics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA

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Episode Universal transcriptomic hallmarks of mammalian ageing and mortality Cover

Universal transcriptomic hallmarks of mammalian ageing and mortality

This article "Universal transcriptomic hallmarks of mammalian ageing and mortality" is published in NATURE. Author: Alexander Tyshkovskiy Journal: NATURE Year: 2026 Podcast type: Short The authors are: * Alexander Tyshkovskiy * Daria Kholdina * Maria Davitadze * Adrian Molière * Alibek Moldakozhayev * Yoshiyasu Tongu * Tomoko Kasahara * Dmitrii Glubokov * Alec Eames * Leonid M. Kats * Anastasiya Vladimirova * Kejun Ying * Hanna Liu * Bohan Zhang * Uma Khasanova * Mahdi Moqri * Jeremy M. Van Raamsdonk * David E. Harrison * Randy Strong * Takaaki Abe * Sergey E. Dmitriev * Vadim N. Gladyshev Affiliations: Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Moscow State University, Moscow, Russia. ETH Zürich, Zurich, Switzerland. McGill University, Montreal, Quebec, Canada. Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada. Tohoku University, Sendai, Japan. Heidelberg University, Heidelberg, Germany. Harvard University, Boston, MA, USA. Massachusetts College of Pharmacy and Health Sciences, Boston, MA, USA. Stanford University, Stanford, CA, USA. The Jackson Laboratory, Bar Harbor, ME, USA. The University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. Broad Institute of Harvard and MIT, Cambridge, MA, USA.

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This article "Intestinal interoceptive dysfunction drives age-associated cognitive decline" is published in NATURE. Author: Timothy O. Cox Journal: NATURE Year: 2026 Podcast type: Short The authors are: * Timothy O. Cox * Ashwarya S. Devason * Alan de Araujo * Sydney Mason * Madhav Subramanian * Andrea F. M. Salvador * Hélène C. Descamps * Junwon Kim * Yixuan Zhu * Lev Litichevskiy * Sunhee Jung * Won-Suk Song * Adrián Cortés-Martín * Nathan T. Henderson * Kuei-Pin Huang * Thao Nguyen * Wisath Sae-Lee * Iboro C. Umana * Maria Sacta * Ryan J. Rahman * Stephen Wisser * J. Andrew D. Nelson * Ilona Golynker * Alana M. McSween * Eric F. Hohmann * Shaan Patel * Anna L. Bub * Clara Soekler * Niklas Blank * Kevt'her Hoxha * Lavinia Boccia * Andrea C. Wong * Klaas Bahnsen * Jihee Kim * Natalie Biderman * Dina Abbasian * Clarissa Shoffler * Christopher Petucci * Fiona E. McAllister * Amber L. Alhadeff * Marc V. Fuccillo * Colin Hill * Cholsoon Jang * J. Nicholas Betley * Guillaume de Lartigue * Virginia Y.-M. Lee * Maayan Levy * Christoph A. Thaiss Affiliations: University of Pennsylvania, Philadelphia, PA, USA. Monell Chemical Senses Center, Philadelphia, PA, USA. Arc Institute, Palo Alto, CA, USA. Stanford University, Stanford, CA, USA. University of California Irvine, Irvine, CA, USA. University College Cork, Cork, Ireland. Calico Life Sciences LLC, San Francisco, CA, USA. Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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