The Human Upgrade: Biohacking for Longevity & Performance

The Foods, Drinks, and Daily Habits Wrecking Your Brain (Surprising!) | David Perlmutter : 1498

53 min · 9. Juli 2026
Episode The Foods, Drinks, and Daily Habits Wrecking Your Brain (Surprising!) | David Perlmutter : 1498 Cover

Beschreibung

Neurologist Dr. David Perlmutter Explains Brain Inflammation and Alzheimer's Risk  Your brain has its own immune system, and when it turns against you, it becomes the hidden driver behind Alzheimer's, Parkinson's, depression, and even long COVID. This episode hands you the science to recognize it early and reverse it.    Get Dr. Perlmutter’s new book Brain Defenders: https://drperlmutter.com/books/brain-defenders/ [https://drperlmutter.com/books/brain-defenders/]    Host Dave Asprey sits down with Dr. David Perlmutter, a board-certified neurologist and six-time New York Times bestselling author whose work sits at the intersection of neurology, nutrition, and brain health. He is a Fellow of the American College of Nutrition, serves on its Board of Directors, and sits on the Editorial Board of the Journal of Alzheimer's Disease. His books, including the number one bestseller Grain Brain, span 32 languages and have sold over a million copies, and his upcoming release, Brain Defenders, explores the pivotal role of microglia, the brain's immune cells, in protecting, repairing, and reprogramming the brain for lifelong resilience.    Dave and Dr. Perlmutter break down how microglia, the brain's resident immune cells, shift from a supportive state into a destructive one called M1, and why this shift, not amyloid plaque, may be the real driver of Alzheimer's, Parkinson's, and other neurodegenerative conditions. They dig into why the leading amyloid-clearing drugs fail to improve cognition, what a landmark JAMA study revealed about reversing cognitive decline through lifestyle intervention alone, and why a single daily serving of ultra-processed food raised Alzheimer's risk by 13 percent in a 12.7 year study. They also cover new research on GLP-1 drugs and brain inflammation, the surprising role of gum disease and oral bacteria in dementia risk, and why 40 hertz light therapy is emerging as a low-cost tool for clearing brain plaque and calming neuroinflammation.    You'll Learn:  * Why the shift from supportive to destructive brain immune cells may be the true root cause of Alzheimer's and Parkinson's  * Why leading Alzheimer's drugs fail to improve cognition, and what the original research behind the amyloid hypothesis actually showed  * How one daily serving of ultra-processed food raises Alzheimer's risk, and what a landmark lifestyle intervention study found instead  * Whether GLP-1 drugs help or harm brain inflammation, based on new Parkinson's and Alzheimer's trial data  * How gum disease and oral bacteria are linked to dementia, and simple daily habits that reduce that risk  * Why 40 hertz light therapy is emerging as a tool to clear brain plaque and calm neuroinflammation  * How ketones, DHA, and metabolic health protect the brain after head injury    Thank you to our sponsors!       - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com [http://wonderlandconference.com/].  - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health [https://zenbud.health/] and use code DAVE15 at checkout for a discount.  - Pique | Head over to Piquelife.com/Dave [https://www.piquelife.com/collections/subs-collection?utm_source=superfiliate&utm_campaign=DAVE&utm_medium=pod&utm_content=eyJzZi1leHRlcm5hbC1zZXNzaW9uLXV1aWQiOiJmNTBiMTliMy1lMmIyLTRkMzctYmQyNS1hZTNmZDI5MDJhYmIifQ%3D%3D&ref=superfiliate-DAVE&attributes=%7B%22sf-external-session-uuid%22+%3D%3E+%222f8b41c4-f6cc-4749-99ff-3ab73c696ed6%22%2C+%22sf-origin%22+%3D%3E+%22organic--DAVE%22%7D] to get 20% off your order. That's P-I-Q-U-E life dot com slash DAVE  - PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave [http://predictivemind.io/dave] and use code DAVE for 10% off.    Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.    New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.    Keywords: microglia, brain inflammation, Alzheimer's prevention, Parkinson's disease, amyloid hypothesis, neurodegeneration, GLP-1 drugs, semaglutide, ultra-processed food, gum disease and dementia, oral microbiome, 40 hertz light therapy, ketones, DHA, mitochondria, brain fog, long COVID, David Perlmutter, Brain Defenders, Grain Brain, functional medicine, biohacking, longevity, neuroplasticity    Resources:    • Get Dr. Perlmutter’s New Book Brain Defenders: https://drperlmutter.com/books/brain-defenders/ [https://drperlmutter.com/books/brain-defenders/]  • Learn More About Dr. Perlmutter’s Work At: https://drperlmutter.com/ [https://drperlmutter.com/]  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ [https://daveasprey.com/2026-clean-nicotine-roadmap/]   • Dave Asprey's Latest News | Go to https://daveasprey.com/ [https://daveasprey.com/] to join Inside Track today.    • Danger Coffee: https://dangercoffee.com/discount/dave15? [https://dangercoffee.com/discount/dave15?]  • My Daily Supplements: SuppGrade Labs [https://www.shopsuppgradelabs.com/discount/DAVE15] (15% Off)     • Favorite Blue Light Blocking Glasses: TrueDark [https://truedark.com/?coupon-code=DAVEASPREY15&sc-page=shop] (15% Off)     • Dave Asprey’s BEYOND Conference: https://beyondconference.com [https://beyondconference.com/]     • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated [https://daveasprey.com/heavily-meditated]    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ [https://substack.daveasprey.com/]   • Upgrade Labs: https://upgradelabs.com [https://upgradelabs.com/]        Timestamps:   00:00 – Trailer  00:40 – Intro  02:38 – Ultra-Processed Foods  06:34 – Are Carbs Bad?  08:48 – Alcohol & Brain Health  12:28 – Microglia & Inflammation  24:37 – Head Injury & Recovery  29:27 – Oral Bacteria & Dementia  34:08 – GLP-1s & Brain Inflammation  40:20 – 40 Hertz Light Therapy  48:35 – Air Pollution vs. Lead  50:27 – David's Closing Truth  See Privacy Policy at https://art19.com/privacy [https://art19.com/privacy] and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info [https://art19.com/privacy#do-not-sell-my-info].

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Episode The Toxin In Your Gut That's Slowly Killing You (here's the fix) : 1506 Cover

The Toxin In Your Gut That's Slowly Killing You (here's the fix) : 1506

Fix Leaky Gut, Boost Testosterone & Slash Endotoxins with Spore-Based Probiotics | Kiran Krishnan Your bad gut bacteria might be the reason your testosterone, your immune system, and even your sperm count are struggling, and most probiotics never survive long enough to fix it. This episode reveals which strains actually make it through your stomach acid alive, and what happens once they do.    Go To JustThriveHealth.com/asprey [https://get.justthrivehealth.com/pages/asprey] for a free 90 day supply of bitters with your next subscription.  Host Dave Asprey sits down with research microbiologist Kiran Krishnan, co-founder of Microbiome Labs, the leading microbiome therapeutics brand among healthcare professionals. He has published multiple peer-reviewed studies, holds global patents, and has spent 20 years building companies focused on the science of the microbiome. His work centers on spore-based probiotics, the rare strains proven to survive the stomach's brutal acidity and actually rebuild the gut from the inside out.  Kiran and Dave break down why 98 percent of conventional probiotics die before they ever reach your gut, and why spore-forming bacteria are different. They dig into the "gelding effect," the well-documented pathway where endotoxins from bad gut bacteria shut down testosterone production and drive up cortisol, and how fixing your microbiome can reverse it. They cover the connection between endotoxemia and nearly every major marker of aging, metabolism, and inflammation, why butyrate acts like a natural GLP-1 for fat loss, how Akkermansia can upregulate mitochondria and improve blood sugar control, and the surprising role vitamin K2 plays in bone density and functional medicine. This is biohacking at the cellular level, using ancient biology, fasting-adjacent metabolic pathways, and precision supplementation to optimize human performance from the gut up.  You'll Learn:  * Why 98 percent of probiotics die in your stomach before they ever work  * What the "gelding effect" is and how gut bacteria can shut down testosterone  * How endotoxins drive inflammation, cortisol, and accelerated aging  * Why butyrate functions like a natural, low-cost alternative to GLP-1 drugs  * How Akkermansia improves mitochondrial function and blood sugar control  * The overlooked link between your microbiome and vitamin K2 production  * Why spore-based probiotics can survive gastric acid when most others cannot  * How 90 days of gut repair can measurably reduce circulating endotoxins    Keywords: best probiotics that survive stomach acid, spore based probiotics benefits, gelding effect testosterone, endotoxins and testosterone, how to lower endotoxins, LPS gut bacteria, Akkermansia GLP-1 natural, gut bacteria and belly fat, vitamin K2 bone density, Kiran Krishnan microbiologist, Just Thrive probiotic, leaky gut symptoms, microbiome and testosterone, fecal transplant benefits, Dave Asprey, biohacking, longevity  Resources:    • Go To JustThriveHealth.com/asprey [https://get.justthrivehealth.com/pages/asprey?utm_source=asprey&utm_medium=podcast&utm_campaign=asprey-podcast-host-read] for a free 90 day supply of bitters with your next subscription  • Learn More About All Of Just Thrive’s Offerings At: https://justthrivehealth.com/ [https://justthrivehealth.com/]  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ [https://daveasprey.com/2026-clean-nicotine-roadmap/]   • Dave Asprey's Latest News | Go to https://daveasprey.com/ [https://daveasprey.com/] to join Inside Track today.    • Danger Coffee: https://dangercoffee.com/discount/dave15? [https://dangercoffee.com/discount/dave15?]  • My Daily Supplements: SuppGrade Labs [https://www.shopsuppgradelabs.com/discount/DAVE15] (15% Off)     • Favorite Blue Light Blocking Glasses: TrueDark [https://truedark.com/?coupon-code=DAVEASPREY15&sc-page=shop] (15% Off)     • Dave Asprey’s BEYOND Conference: https://beyondconference.com [https://beyondconference.com/]     • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated [https://daveasprey.com/heavily-meditated]    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ [https://substack.daveasprey.com/]   • Upgrade Labs: https://upgradelabs.com [https://upgradelabs.com/]     Thank you to our sponsors!       - ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health [https://zenbud.health/] and use code DAVE15 at checkout for a discount.  - BodyHealth | Visit BodyHealth.com [https://bodyhealth.com/] and use code DAVE20 for 20% off your first purchase.  - Redmond Real - Leaf Toothpaste | Go to https://redmond.com/asprey [https://redmond.com/asprey] and use code ASPREY for 15% off your first order.  - Show notes - ELITE Performance Coaching | If you’d like to discover where you may be addicted to struggle, allergic to success, and what may be standing between you and your next breakthrough, visit FastestChange.com [https://fastestchange.com/]  Timestamps:   00:00 – Trailer  00:38 – Kiran Intro  02:01 – Stomach Acid & Probiotics  05:25 – Fauci & Spore Bacteria  13:58 – Losing Gut Diversity  19:01 – How Butyrate Is Made  22:11 – Dave's Personal Stack  24:00 – Quorum Sensing  31:26 – Endotoxins Explained  37:13 – Charcoal & Binders  39:41 – SIBO & Gut Bacteria  45:03 – Discovering Vitamin K2  49:33 – Gelding Effect & Testosterone  54:51 – Akkermansia & Weight Loss  01:02:17 – Role of Bitters  01:04:47 – Just Thrive Gift  See Privacy Policy at https://art19.com/privacy [https://art19.com/privacy] and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info [https://art19.com/privacy#do-not-sell-my-info].

23. Juli 20261 h 7 min
Episode The Truth About Visceral Fat vs Subcutaneous Fat | Dr. Sean O’Mara : 1505 Cover

The Truth About Visceral Fat vs Subcutaneous Fat | Dr. Sean O’Mara : 1505

Visceral fat, subcutaneous fat, Prenuvo MRI scans, and the truth about belly fat  Your gut and your face are telling on you. This episode reveals why the fat under your skin might be protecting you while the fat around your organs is quietly wrecking your metabolism, heart, and longevity, and exactly what to do about the difference.    Get $300 off your next Prenuvo MRI scan: https://prenuvo.com/?discount=Dave [https://prenuvo.com/?discount=Dave]  Host Dave Asprey sits down with Dr. Sean O'Mara, a former undercover narcotics agent, criminal prosecutor, emergency medicine physician, and retired U.S. Army Colonel who assisted the White House and Senior Executive Service, treating Vice President Dick Cheney, former President Bill Clinton, and Secretary of State Colin Powell. Today he's recognized as the world's most experienced physician in eliminating visceral fat and epicardial adipose tissue (EAT), the inflammatory fat now linked to nearly every major chronic disease and accelerated aging. He founded Influence Medicine, a specialty built around helping senators, heads of state, and top executives optimize their biology so they can perform and lead at the highest level.   Dave and Dr. O'Mara break down the real difference between visceral fat and subcutaneous fat, why a visible six-pack might signal hidden disease, and how MRI scans reveal what your mirror never will. They dig into the biohacking strategies that actually shift your body composition: fasting protocols that build beneficial fat instead of burning it away, microbiome optimization for fat metabolism, and the supplements and functional medicine tools Dr. O'Mara uses with his highest-performing clients. They also cover the gut-hormone connection driving modern metabolic dysfunction, why political leaders are quietly getting scanned, and what your face reveals about your visceral fat levels before you ever step on a scale.  You'll Learn:  * The real difference between visceral fat, subcutaneous fat, and why one protects you while the other kills you  * Why a six-pack might be hiding disease your MRI would catch  * How a 72-hour fasting protocol can build the good kind of fat through adiponectin signaling  * What your face reveals about your visceral fat and longevity risk  * The gut-hormone connection driving testosterone, metabolism, and inflammation  * Why senators and world leaders are getting scanned for hidden fat  * How microbiome health, fasting, and functional medicine work together for fat loss and longevity  Thank you to our sponsors!       - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com [http://wonderlandconference.com/].  - Suppgrade Labs | Get real restorative sleep with Quiet Mode. Use code DAVE15 at shopsuppgradelabs.com [http://shopsuppgradelabs.com/].  - Puori | Use code DAVE at puori.com/DAVE [https://puori.com/pages/dave?dt_id=1750934] to get 32% off your first Puori CP1 Pure Collagen. Order when you start a subscription. You save more than $26  - LMNT | Right now you can get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at drinkLMNT.com/dave [https://partners.drinklmnt.com/free-gift-with-purchase?rfsn=5182916.370beb&utm_medium=sponsor&utm_source=daveasprey&utm_campaign=agwp&utm_content=podcast&utm_term=&rfsn_cn=EXCLUSIVE+GIFT+FOR+DAVE+ASPREY%27S+COMMUNITY]  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: visceral fat vs subcutaneous fat, how to reduce visceral fat, best fat for longevity, MRI body scan benefits, Prenuvo full body scan, what is epicardial fat, skinny fat TOFI explained, why is my six pack unhealthy, 72 hour fasting benefits, fasting and testosterone, how to build subcutaneous fat, biohacking visceral fat, Sean O'Mara doctor, influence medicine, fecal microbiota transplant benefits, gut microbiome and fat loss, Dave Asprey, biohacking, longevity  Resources:    • Learn More About Dr. O’Mara’s Work At: https://drseanomara.com/ [https://drseanomara.com/]  • Get $300 Off Your Next Prenuvo MRI Scan: https://prenuvo.com/?discount=Dave [https://prenuvo.com/?discount=Dave]  • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ [https://daveasprey.com/2026-clean-nicotine-roadmap/]   • Dave Asprey's Latest News | Go to https://daveasprey.com/ [https://daveasprey.com/] to join Inside Track today.    • Danger Coffee: https://dangercoffee.com/discount/dave15? [https://dangercoffee.com/discount/dave15?]  • My Daily Supplements: SuppGrade Labs [https://www.shopsuppgradelabs.com/discount/DAVE15] (15% Off)     • Favorite Blue Light Blocking Glasses: TrueDark [https://truedark.com/?coupon-code=DAVEASPREY15&sc-page=shop] (15% Off)     • Dave Asprey’s BEYOND Conference: https://beyondconference.com [https://beyondconference.com/]     • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated [https://daveasprey.com/heavily-meditated]    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ [https://substack.daveasprey.com/]   • Upgrade Labs: https://upgradelabs.com [https://upgradelabs.com/]        Timestamps:   00:00 – Trailer  00:58 – Intro  02:38 – Fat Type Basics  04:19 – Reviewing Dave's Scan  08:04 – Good Fat vs. Bad Fat  16:49 – Fertility & Pregnancy  19:47 – Personality & Health  21:51 – Wealth & Health Neglect  30:32 – Insurance Incentives  39:29 – Microbiome & Disease  40:41 – FDA & Fecal Transplants  42:57 – Viome & Biomarker Data  45:40 – Skinny Fat & Appearance  49:44 – Building Subcutaneous Fat  52:57 – Fasting Protocol  58:37 – Closing  See Privacy Policy at https://art19.com/privacy [https://art19.com/privacy] and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info [https://art19.com/privacy#do-not-sell-my-info].

21. Juli 20261 h 0 min
Episode If I Only Had $200 to Reverse My Age... : 1504 Cover

If I Only Had $200 to Reverse My Age... : 1504

Most people think biohacking is only for billionaires with access to expensive machines, private clinics, and million-dollar anti-aging protocols. But the truth is, some of the most powerful upgrades in your biology start with the basic signals your body receives every single day. In this video, Dave Asprey breaks down how to start biohacking with around $200 by focusing on the foundations that control your sleep, energy, focus, and cellular repair. These are the simple changes that can create a massive difference before you ever spend money on advanced technology. If you’ve ever wanted to feel sharper, recover better, sleep deeper, and support your body’s natural repair systems without wasting money on random gadgets, this video shows you where to start. Try Danger Creatine: https://dangercoffee.com/products/danger-creatine [https://dangercoffee.com/products/danger-creatine] Try TrueDark glasses: https://truedark.com [https://truedark.com/] Try Danger Coffee: https://dangercoffee.com/discount/davetube [https://dangercoffee.com/discount/davetube] Try Suppgrade Labs: https://shopsuppgradelabs.com/ [https://shopsuppgradelabs.com/] I have spent twenty years and millions of dollars testing every legal focus drug I could get my hands on. In this video, I break down which compounds actually work, which ones are a waste of money, and the exact stack that delivers hours of clean focus without the afternoon crash. The shift is simple: focus isn't a willpower problem. It's an energy production problem inside your brain. Once you fuel it at the cellular level, deep focus stops being a struggle and becomes the default state. Thank you to our sponsors! *  ECHO Water | Go to http://echowater.com/dave [http://echowater.com/dave]and use code DAVE10 for 10% off your ECHO Flask. * The One Device | Use code DAVE for $10 off at theonedevice.com/dave [http://theonedevice.com/dave] * iRestore | Reverse hair loss at www.irestore.com/DAVE [http://www.irestore.com/DAVE] and get exclusive savings on the iRestore Elite, use code DAVE 00:00 – Trailer 00:53 – Sleep Environment Matters 03:44 – Red Light Bulbs 04:50 – Blackout Curtains 05:16 – Light-Blocking Glasses 07:16 – Morning Supplement Stack 07:41 – Creatine for the Brain 11:48 – MCT Oil Fuel 13:06 – Cellular Cleanup (Autophagy) 15:12 – Magnesium for Sleep 16:56 – Full Stack Recap 18:26 – Biohacking Is Accessibl Connect with Dave Asprey! Website: https://daveasprey.com TikTok: https://www.tiktok.com/@daveaspreyofficial Instagram: https://www.instagram.com/dave.asprey/ Facebook: https://www.facebook.com/Daveaspreyofficial/ X: https://x.com/daveasprey YouTube: https://www.youtube.com/c/daveaspreybpr The Human Upgrade Podcast: https://www.instagram.com/ TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/ Dave Asprey’s BEYOND Conference: https://beyondconference.com/ Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15 Upgrade Labs: https://upgradelabs.com 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy [https://art19.com/privacy] and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info [https://art19.com/privacy#do-not-sell-my-info].

19. Juli 202620 min
Episode The Science And Health Of Community Eating (How Many Times A Week?) : 1503 Cover

The Science And Health Of Community Eating (How Many Times A Week?) : 1503

Shawn Stevenson On The Science of Family Meals, Oxytocin, and Longevity Your dinner table might be the most overlooked biohack in your house. This episode reveals the exact minimum dose of family meals that lowers a child's risk of obesity, the hormone your body releases every time you eat with people you love, and why teaching your kids to cook may protect their metabolism for life. Host Dave Asprey sits down with Shawn Stevenson, founder of The Model Health Show and author of the bestselling Eat Smarter Family Cookbook series. Shawn spent over two decades studying nutritional science and functional medicine after recovering from advanced degenerative disc disease at age 20, and he has become one of the most trusted voices in health media for turning peer-reviewed research into real-world family habits. Shawn and Dave break down the science of community eating, including new research on oxytocin, nervous system regulation, and metabolism that shows why sitting down together beats eating alone every time. They cover the four biological drives running your behavior, the connection between family culture and longevity, and how simple shifts like humming, breathwork, and intentional meals can support brain optimization and anti-aging at a cellular level. This conversation also dives into the five love languages hidden inside food, a bio-photon DNA experiment that reframes how energy moves between people, and the exact number of meals per week that changes a child's health trajectory. You'll Learn: * The minimum effective dose of family meals per week that lowers childhood obesity and disordered eating * How oxytocin and a regulated nervous system change what happens at the dinner table * Why teaching kids to cook protects their metabolism and prevents dependence on ultra-processed food * How the five love languages show up in how you cook, serve, and share food * The bio-photon DNA experiment that shows how human energy fields affect the world around you * Why culture is something your family creates, not just something you inherit * How humming and breathwork practices can shift your nervous system and even change your voice Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Keywords: Shawn Stevenson, Dave Asprey, The Human Upgrade, biohacking, family dinner, family meals, community eating, longevity, functional medicine, oxytocin, nervous system regulation, childhood obesity, teaching kids to cook, five love languages, Model Health Show, Eat Smarter Family Cookbook, brain optimization, anti-aging, metabolism, nutrition science, mental health, family culture, healthy habits, minimum effective dose, human performance Thank you to our sponsors! -Gatlan | Book your free consultation at www.gatlan.com/DAVE [http://www.gatlan.com/DAVE] -Timeline | Visit timeline.com/dave [http://timeline.com/dave] to learn more about Mitopure and get 20% off your first order for a limited time -iRestore | Reverse hair loss at www.irestore.com/DAVE [http://www.irestore.com/DAVE] and get exclusive savings on the iRestore Elite, use code DAVE Resources:    • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ [https://daveasprey.com/2026-clean-nicotine-roadmap/]   • Dave Asprey's Latest News | Go to https://daveasprey.com/ [https://daveasprey.com/] to join Inside Track today.    • Danger Coffee: https://dangercoffee.com/discount/davetube [https://dangercoffee.com/discount/davetube]  • My Daily Supplements: SuppGrade Labs [https://www.shopsuppgradelabs.com/discount/DAVE15] (15% Off)     • Favorite Blue Light Blocking Glasses: TrueDark [https://truedark.com/?coupon-code=DAVEASPREY15&sc-page=shop] (15% Off)     • Dave Asprey’s BEYOND Conference: https://beyondconference.com [https://beyondconference.com/]     • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated [https://daveasprey.com/heavily-meditated]    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ [https://substack.daveasprey.com/]   • Upgrade Labs: https://upgradelabs.com [https://upgradelabs.com/]     See Privacy Policy at https://art19.com/privacy [https://art19.com/privacy] and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info [https://art19.com/privacy#do-not-sell-my-info].

17. Juli 20261 h 17 min
Episode Here's Why Your Supplements Don't Seem To Work | Nayan Patel : 1502 Cover

Here's Why Your Supplements Don't Seem To Work | Nayan Patel : 1502

Why Oral and IV Glutathione Never Actually Reach Your Cells (The Delivery Breakthrough Changing Everything)  Most of the supplements you're taking aren't failing you, they're failing to ever reach the cells that need them, and almost nobody selling them wants you to know that. This episode hands you the delivery breakthrough that actually gets it there.  Use code DAVE for a discount at aurowellness.com/dave [https://aurowellness.com/pages/dave]  Host Dave Asprey sits down with Dr. Nayan Patel, a pharmacist, researcher, and founder of Auro Wellness, whose work centers on solving one of biohacking's most stubborn problems: getting nutrients past the bloodstream and into the cells that actually need them. He holds 14 patents in delivery technology, partners in the high-end longevity clinic Unlimited Life, and has spent over two decades studying glutathione, the master antioxidant his own research helped bring into modern biohacking.  Dave and Dr. Patel break down a 2011 University of Texas study showing that oral and liposomal glutathione are completely broken down into raw amino acids before absorption, meaning none of it reaches the bloodstream as glutathione, a pattern that holds true even for IV administration. They dig into new brain-imaging research showing topical glutathione crossing into neural tissue within 20 minutes, why senescent "zombie cells" may be directly tied to glutathione shortfalls, and why NAD, despite its reputation as the ultimate longevity molecule, is actually dependent on glutathione to do its job. They also cover the real purity ceiling on GHK-copper peptides, safe upper limits for glycine and NAC before they start working against you, a topical alcohol protocol that clears acetaldehyde without triggering a breathalyzer, and why oxidative stress from GLP-1 use is quietly driving one of the drug class's least-discussed side effects.  You'll Learn:  * Why oral, liposomal, and even IV glutathione never actually reach your cells intact, and what a 2011 UT study proved about it  * How topical glutathione was shown to cross into brain tissue within 20 minutes, and what that means for neurological aging  * Why senescent "zombie cells" may be directly linked to glutathione shortfalls, and how one longevity clinic reversed markers by 70% in a year  * Why NAD isn't the "ultimate longevity drug" it's marketed as, and its actual dependent relationship with glutathione  * The real purity ceiling on GHK-copper peptides, and why 73% is currently the best available anywhere  * Safe upper limits for glycine and NAC, and the oxalate crystal and Parkinson's-like risks of overdoing either one  * A topical alcohol protocol that clears acetaldehyde fast enough to beat a breathalyzer  * Why GLP-1 drugs are quietly driving oxidative stress, and what most patients are missing to counter it    Thank you to our sponsors!       - PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave [http://predictivemind.io/dave] and use code DAVE for 10% off.  - OneSkin | Get 15% off OneSkin with the code DAVE at https://www.oneskin.co/DAVE [https://www.oneskin.co/DAVE] #oneskinpod  - Caldera + Lab | A small habit with big results. Go to CalderaLab.com [http://calderalab.com/]/DAVE and use code DAVE for 20% off your first order.  - Fatty15 is on a mission to support Healthy Aging for All, including all ages and stages of life. You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com [https://fatty15.com/] and using code DAVE at checkout  Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.  New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.  Keywords: glutathione, Nayan Patel, Ora Wellness, glutathione absorption, transdermal delivery, senescent cells, zombie cells, cellular aging, GHK-copper peptide, NAD, NAD supplements, NAC, glycine, GlyNAC, oxalate crystals, alcohol metabolism, acetaldehyde, GLP-1, semaglutide, oxidative stress, heavy metal detox, mercury toxicity, BPC-157, biohacking, longevity, functional medicine  Resources:    • Get A Discount On Auro Wellness Products - Use code DAVE: aurowellness.com/dave [https://aurowellness.com/pages/dave]  • Learn More About Dr. Patel’s work at: http://aurowellness.com/dave [http://aurowellness.com/dave] • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ [https://daveasprey.com/2026-clean-nicotine-roadmap/]   • Dave Asprey's Latest News | Go to https://daveasprey.com/ [https://daveasprey.com/] to join Inside Track today.    • Danger Coffee: https://dangercoffee.com/discount/davetube [https://dangercoffee.com/discount/davetube]  • My Daily Supplements: SuppGrade Labs [https://www.shopsuppgradelabs.com/discount/DAVE15] (15% Off)     • Favorite Blue Light Blocking Glasses: TrueDark [https://truedark.com/?coupon-code=DAVEASPREY15&sc-page=shop] (15% Off)     • Dave Asprey’s BEYOND Conference: https://beyondconference.com [https://beyondconference.com/]     • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated [https://daveasprey.com/heavily-meditated]    • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ [https://substack.daveasprey.com/]   • Upgrade Labs: https://upgradelabs.com [https://upgradelabs.com/]     Timestamps:   00:00 – Trailer  00:43 – Episode Intro  03:16 – Glutathione Basics  07:34 – Senescent Cells  11:07 – Cellular Delivery Science  14:20 – GlyNAC Precursors  21:37 – Amino Acid Ratios  25:18 – GHK Copper Peptide  28:41 – Purity & Manufacturing  31:34 – Glutathione vs. NAD  33:49 – Absorption Studies  37:51 – Heavy Metals & Toxins  42:35 – Alcohol & Glutathione  47:43 – Mortality & Reincarnation  49:54 – GLP-1s & Anhedonia  53:25 – Future of Peptides  See Privacy Policy at https://art19.com/privacy [https://art19.com/privacy] and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info [https://art19.com/privacy#do-not-sell-my-info].

16. Juli 202658 min