20VC: Why Now is the Time for the Application Layer | Why OpenAI & Anthropic Won't Win the App Layer | Why Startups Should be TokenMaxxing | Why VCs Should Reduce Weighting on Price & Ownership in an Age of AI with Mike Mignano, USV

20VC: Mercor CPO on Revenue Concentration from Frontier Labs | Why Large Enterprise is Scared to Partner with Frontier Labs | Why Small Specialised Models is the Future with Osvald Nitski

Osvald Nitski is the Chief Product Officer at Mercor, the AI-training and expert-data marketplace powering frontier-model development. Mercor last raised a $350 million Series C at a $10 billion valuation, and is reportedly in discussions for a new round at a $20 billion valuation. Mercor crossed $2BN in ARR in June; doubling from $1 billion in only four months. AGENDA: 00:04:00 Will open-source models kill the data-provider business? 00:07:00 Are enterprises still terrified of working with frontier model companies? 00:09:00 Does every company end up with its own specialised AI model? 00:10:00 Do enterprises actually have an AI ROI problem? 00:11:00 How should founders balance AI performance against exploding token bills? 00:14:00 Does AI mean product teams build 10x more—or ruthlessly simplify? 00:15:00 What does it now take to be a great product manager in an AI-native world? 00:20:00 Is the boom in AI services and forward-deployed engineers here to stay? 00:37:00 Can Mercor escape its dependence on a handful of frontier-model customers? 00:47:00 Are AI-generated code and agents creating a cybersecurity arms race? 00:56:00 When will robotics have its real "ChatGPT moment"?

20VC: OpenAI and Anthropic Threatened by Kimi? | Should the US Ban Chinese Open-Source Models | Should Openrouter Sell & Value in the Routing Layer? | Stripe Buying Paypal: What You Need to Know

AGENDA: 00:04 China's Kimi and Qwen Put Frontier AI on Notice00:08 Washington Debates Whether Chinese AI Models Should Be Banned 00:17 Can America Build a Profitable Open-Weight AI Champion? 00:21 OpenRouter's Moment: Is This the Perfect Time to Sell? 00:31 Fireworks' $1.5B Raise Signals the Real AI Money Is in Infrastructure 00:39 Why Every Great AI App May Need to Build Its Own Model 00:50 Stripe's Bold Play to Buy PayPal 01:01 The AI Funding Frenzy: Why Late-Stage Venture Is Winning 01:12 Nuclear Startups Go Wild While Databricks and Stripe Stay Private 01:15 The AI Supply Chain War: TSMC, ASML, DRAM—and Nvidia's Next Move

20VC: Are OpenAI and Anthropic Overvalued? The Open-Source AI Reality | How Token Costs Will Fall 10x And Usage Will Explode 100x | The Future Is Not One AGI; It's Millions of Specialised Models with Lin Qiao, Founder and CEO @ Fireworks

Lin Qiao is the Co-Founder and CEO of Fireworks AI, the leading specialized intelligence and AI inference platform that last week raised $1.5BN at a whopping $17BN valuation. With just 200 people, the company has hit $1BN in ARR and expects to hit $2BN before the end of the year. Prior to Fireworks, Lin spent several years at Meta including on the founding team of PyTorch. AGENDA: 00:07 — Why Did Fireworks Bet on Inference When Everyone Else Was Chasing Training? 00:13 — Can Open-Source Models Turn AI Infrastructure into a Commodity? 00:19 — Should Enterprises Trust Chinese Open Models With Their Most Sensitive Data? 00:25 — Will Model Progress Keep Moving This Fast—or Are We Nearing a Plateau? 00:28 — Will the Multi-Model World Create a $100BN Routing Layer? 00:37 — How Much Will AI Token Usage Explode Over the Next Two Years? 00:43 — Will Token Costs Fall 10x—and Unleash 100x More Demand? 00:49 — Does Fireworks Eventually Have to Build Its Own Data Centres? 01:02 — What Is the Real Bottleneck Holding Back the AI Economy?

20VC: $5BN in Revenue, 7 to 7,000 Employees in 9 Months, 206,000 Tests in a Single Day: The Craziest Story in Startups: Curative with Fred Turner

Fred Turner is the Founder and CEO @ Curative, one of the wildest stories in tech. Fred scaled a COVID testing business from $0 to $5BN in revenue and took the team from 7 to 7,000 employees in just 9 months. They did over 206,000 COVID tests in a single day and signed contracts in the 100s of $Ms with several of the largest states. Today, Curative is a unicorn health insurance business taking on the incumbents for one of the largest markets in healthcare. AGENDA: 00:00 How Did a Spare-Time COVID Test Become a $5BN Business? 07:00 How Do You Go From Testing Cows to STDs, Sepsis and COVID? 21:00 When Did Fred Realise COVID Was Massive—and How Did Curative Scale to $5BN? 36:00 Why Pivot Into Health Insurance—and What Is Broken About US Healthcare? 40:00 How Is AI Rebuilding Curative—and Which Departments Go to Zero? 45:00 Is SaaS Dead? Why Is Curative Cutting 80% of Its Software Spend? 48:00 Are Legacy Insurers Screwed? What Will Anthropic Be Worth in Three Years? 59:00 Will AI Make Companies Smaller? Which Jobs Will Survive? 1:10:00 Why Nuclear—and Could Subcritical Become Bigger Than Curative? 1:17:00 What Have Marriage and Fatherhood Taught Fred? What Has He Changed His Mind On?

20VC: Apple Sues OpenAI | Zuckerberg Back on X and Challenging Codex and Claude Code | SK Hynix's $26BN IPO | Is Seed Investing Dead: Jason Calacanis Departs Seed for Growth | Greylock Raises New $1.5BN Fund

AGENDA: * 00:00 – Apple SUES OpenAI: Did They Steal Apple's Biggest Secrets? * 05:10 – Is OpenAI's $6BN Hardware Bet Already Dead? * 12:50 – Zuckerberg Is Back: Meta Finally Takes On OpenAI * 18:05 – The AI Spending Bubble Nobody Is Talking About * 23:45 – Claude Is Coming for Designers, Product Managers & Figma * 27:15 – Anthropic's $50BN Explosion: Have We Already Hit AI's TAM? * 36:00 – The $26BN AI IPO Powering the Entire Industry * 40:00 – Seed Investing Is Dead? Jason Calacanis Changes Strategy * 57:00 – SaaS Is in Trouble: AI Is Accelerating Terminal Decay * 01:15:00 – Why Greylock Said No to Billions of Extra Dollars