Science in Real Time (ScienceIRT)

Spotlight: Imaging the Future — High-Content Screening, AI, and the Next Era of Phenotypic Discovery with Timothy P. Spicer, PhD

In this episode of Science in Real Time [https://www.aracelibio.com/science-irt-podcast-biology-big-data/], host Carli Reyes sits down with Dr. Timothy P. Spicer [https://wertheim.scripps.ufl.edu/profile/spicer-timothy/], Director of Assay Development & Screening at the The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology [https://wertheim.scripps.ufl.edu/], to explore how high-content screening, phenotypic discovery, and advanced imaging are reshaping modern drug discovery. Drawing on decades of experience at the forefront of translational science, Dr. Spicer shares how the field has evolved beyond traditional screening toward data-rich, image-driven approaches that unlock deeper biological understanding. What You’ll Hear: * From Screening to Systems-Level Insight – Dr. Spicer’s journey through the evolution of assay development and how high-content approaches have transformed discovery. * Defining High-Content Today – what “high-content screening” really means now—and how it’s changed over the last decade. * Phenotypes as Decision Drivers – why phenotypic screening is resurging and how imaging enables teams to embrace biological complexity. * AI, Automation & Reality vs Hype – where machine learning is truly impactful in imaging workflows—and where expectations still outpace reality. * Collaboration as a Catalyst – how partnerships between academia, biotech, and technology platforms accelerate innovation. * The Next Inflection Point – Dr. Spicer’s perspective on what the next 5–10 years of high-content screening will unlock. 🌐 Explore & Connect Learn more about Dr. Tim Spicer [https://wertheim.scripps.ufl.edu/profile/spicer-timothy/]’s work at UF Scripps [https://wertheim.scripps.ufl.edu/] and how advances in high-content screening and imaging are accelerating phenotypic discovery. Have an idea for a topic or guest you’d love to hear on Science in Real Time? We’d love to hear from you! Connect with us on the ScienceIRT website [https://www.aracelibio.com/science-irt-podcast-biology-big-data/] or on LinkedIn: Araceli Biosciences [https://www.linkedin.com/company/araceli-biosciences/]. If you enjoyed this episode, don’t forget to subscribe, leave a review, and share it with a colleague interested in the future of imaging, AI, and drug discovery. 🔗 Links * Science in Real Time: https://www.aracelibio.com/science-irt-podcast-biology-big-data/ [https://www.aracelibio.com/science-irt-podcast-biology-big-data/] * Araceli Biosciences LinkedIn: https://www.linkedin.com/company/araceli-biosciences/ [https://www.linkedin.com/company/araceli-biosciences/] * Dr. Tim Spicer’s LinkedIn: https://www.linkedin.com/in/timothy-spicer-5786943/  [https://www.linkedin.com/in/timothy-spicer-5786943/] * UF Scripps Institute: https://wertheim.scripps.ufl.edu/ [https://wertheim.scripps.ufl.edu/] * Dr. Tim Spicer's Contact Information: https://wertheim.scripps.ufl.edu/profile/spicer-timothy/  [https://wertheim.scripps.ufl.edu/profile/spicer-timothy/] * Dr. Tim Spicer's publications: https://pubmed.ncbi.nlm.nih.gov/?term=Spicer+TP&cauthor_id=39159824  [https://pubmed.ncbi.nlm.nih.gov/?term=Spicer+TP&cauthor_id=39159824] Copyright Music by: Scientific "How it Goes"

Spotlight: High-Content Discovery and the Future of Phenotypic Screening with Claudia McCown, PhD (UF Scripps)

In this episode of Science in Real Time [https://www.aracelibio.com/science-irt-podcast-biology-big-data/], host Carli Reyes sits down with Dr. Claudia McCown [https://www.linkedin.com/in/claudia-mccown-biochem/], a leader in high-content screening and phenotypic discovery, to explore how imaging, automation, and AI are transforming modern drug discovery. Drawing on her work at The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology [https://wertheim.scripps.ufl.edu/], Dr. McCown shares how the field is evolving from traditional high-throughput screening to data-rich, image-based approaches that reveal deeper biological insight. What You’ll Hear: * From Throughput to Insight – Dr. McCown’s journey from classical screening approaches to high-content, image-based discovery. * Phenotypes at Scale – how high-content screening captures complex cellular behaviors that traditional assays miss. * AI Meets Imaging – the role of automation and machine learning in accelerating and refining biological analysis. * Collaboration Across Disciplines – lessons from bridging academia, biotech, and technology platforms like Araceli’s Endeavor. * The Future of Discovery – how integrated workflows will reshape drug discovery and empower the next generation of scientists. 🌐 Explore & Connect Learn more about Dr. Claudia McCown [https://www.linkedin.com/in/claudia-mccown-biochem/]’s work in high-content screening at UF Scripps [https://wertheim.scripps.ufl.edu/] and how collaborations with Araceli Biosciences [https://www.aracelibio.com/] are advancing phenotypic discovery. Have an idea for a topic or guest you’d love to hear on Science in Real Time? We’d love to hear from you! Connect with us on the ScienceIRT website [https://www.aracelibio.com/science-irt-podcast-biology-big-data/] or on LinkedIn: Araceli Biosciences [https://www.linkedin.com/company/araceli-biosciences/]. If you enjoyed this episode, don’t forget to subscribe, leave a review, and share it with a colleague interested in the future of imaging, AI, and drug discovery. 🔗 Links * Science in Real Time: https://www.aracelibio.com/science-irt-podcast-biology-big-data/ [https://www.aracelibio.com/science-irt-podcast-biology-big-data/] * Araceli Biosciences LinkedIn: https://www.linkedin.com/company/araceli-biosciences/ [https://www.linkedin.com/company/araceli-biosciences/] * Victoria Arinella (UF Scripps Intern): https://www.linkedin.com/in/victoria-arinella/ [https://www.linkedin.com/in/victoria-arinella/] * Dr. Claudia McCown's LinkedIn: https://www.linkedin.com/in/claudia-mccown-biochem/  [https://www.linkedin.com/in/claudia-mccown-biochem/] * Dr. Claudia McCown's publications: https://pubmed.ncbi.nlm.nih.gov/?term=McCown+C&cauthor_id=40816642 [https://pubmed.ncbi.nlm.nih.gov/?term=McCown+C&cauthor_id=40816642] * UF Scripps Institute: https://www.scripps.edu/florida/ [https://www.scripps.edu/florida/] Copyright Music by: Scientific "How it Goes"

Spotlight: Can AI See What Scientists Can’t? How Machine Learning Is Unlocking Hidden Phenotypes in Cell Imaging with Reese Findley, PhD (ViQi)

In this episode of Science in Real Time [https://www.aracelibio.com/science-irt-podcast-biology-big-data/], host Carli Reyes sits down with Dr. Reese Findley [https://www.linkedin.com/in/teresa-findley15/], Senior Scientists at ViQi [https://www.viqiai.com/], to explore how machine learning is transforming the way we interpret complex biological systems. Drawing on her background in neuroscience and behavioral research, Dr. Findley shares how her work uncovering hidden behavioral states in animal models evolved into designing AI frameworks that detect subtle, high-dimensional cellular phenotypes in imaging data.  What You’ll Hear: * From Brains to Biology – Dr. Findley’s journey from neuroscience and behavior research into AI-driven cell imaging. * Hidden Phenotypes Revealed – how machine learning models uncover patterns in cellular data that traditional analysis may miss. * Making AI Interpretable – why transparency and collaboration are essential for building trust between computational and experimental teams. * Women in AI & Science – mentorship, resilience, and navigating interdisciplinary career paths. * The Future of AI in Discovery – opportunities, ethical responsibilities, and how emerging scientists can prepare for a data-driven era of biology. 🌐 Explore & Connect Learn more about Dr. Reese Findley [https://www.linkedin.com/in/teresa-findley15/] and her work at ViQi [https://www.viqiai.com/], and explore how AI-powered imaging is accelerating biological insight. Have an idea for a topic or guest you’d love to hear on Science in Real Time? We’d love to hear from you! Connect with us on the ScienceIRT website or on LinkedIn: Araceli Biosciences. If you enjoyed this episode, don’t forget to subscribe, leave a review, and share it with a colleague who’s curious about how AI is reshaping cell biology and drug discovery. 🔗 Links * Science in Real Time: https://www.aracelibio.com/science-irt-podcast-biology-big-data/ [https://www.aracelibio.com/science-irt-podcast-biology-big-data/] * Araceli Biosciences LinkedIn: https://www.linkedin.com/company/araceli-biosciences/ [https://www.linkedin.com/company/araceli-biosciences/] * ViQi, Inc.: https://www.linkedin.com/company/viqi-inc/   [https://www.linkedin.com/company/viqi-inc/] * Dr. Reese Findley LinkedIn: https://www.linkedin.com/in/teresa-findley15/ [https://www.linkedin.com/in/teresa-findley15/]  Copyright Music by: Scientific "How it Goes"

Spotlight: Reimagining Discovery — Leadership Lessons for a New Era of Biotech with Kirk Malloy, PhD

In this episode of Science in Real Time [https://www.aracelibio.com/science-irt-podcast-biology-big-data/], host Carli Reyes sits down with Dr. Kirk Malloy [https://www.linkedin.com/in/kirkmalloy], Founder and Principal of BioAdvisors, LLC [https://www.linkedin.com/in/kirkmalloy], to unpack what it truly takes to build, scale, and lead life science companies through periods of rapid innovation. Drawing on decades of leadership experience at companies like Illumina, Biosite, QIAGEN, and Verogen, Dr. Malloy shares hard-earned lessons on aligning scientific vision with strategic execution — and why leadership mindset matters more than ever in today’s data-driven discovery landscape. What You’ll Hear: * A Leadership Journey Across Biotech – Dr. Malloy’s path through some of the most transformative companies in life sciences. * Scaling with Intention – the strategic decisions that enable sustainable growth without losing scientific focus. * Aligning Vision and Strategy – how leaders can bridge R&D, commercial teams, and long-term company direction. * The Future of Discovery Workflows – where AI, imaging, and automation are creating real differentiation. * Leadership for the Next Era – advice for emerging leaders navigating complexity in modern biotech. 🌐 Explore & Connect Learn more about Dr. Kirk Malloy [https://www.linkedin.com/in/kirkmalloy] and his work at BioAdvisors, LLC [https://www.linkedin.com/in/kirkmalloy], and explore how leadership and strategy continue to shape innovation across the life sciences. Have an idea for a topic or guest you’d love to hear on Science in Real Time? We’d love to hear from you! Connect with us at the ScienceIRT website [https://www.aracelibio.com/science-irt-podcast-biology-big-data/] or on LinkedIn: Araceli Biosciences [https://www.linkedin.com/company/araceli-biosciences]. If you enjoyed this episode, don’t forget to subscribe, leave a review, and share it with a colleague who’s thinking about the future of discovery, leadership, and innovation in biotech! 🔗 Links * Science in Real Time: https://www.aracelibio.com/science-irt-podcast-biology-big-data/ [https://www.aracelibio.com/science-irt-podcast-biology-big-data/] * Araceli Biosciences LinkedIn: https://www.linkedin.com/company/araceli-biosciences/ [https://www.linkedin.com/company/araceli-biosciences/] * BioAdvisors, LLC: https://www.linkedin.com/in/kirkmalloy [https://www.linkedin.com/in/kirkmalloy] * Dr. Kirk Malloy LinkedIn: https://www.linkedin.com/in/kirkmalloy  [https://www.linkedin.com/in/kirkmalloy] * Dr. Kirk Malloy's email: kirk@bio-advisors.com  Copyright Music by: Scientific "How it Goes"

Special: Inside SBI2 2025 — How AI, Imaging, and Multi-Omics Are Transforming Discovery

In this episode of Science in Real Time [https://www.aracelibio.com/science-irt-podcast-biology-big-data/], host Carli Reyes brings listeners a behind-the-scenes recap of SBI2 2025 [https://sbi2.org/], the premier conference for quantitative imaging, high-content screening, and bioinformatics. Carli breaks down the biggest scientific trends shaping the future of imaging—from foundation models and AI-driven analysis to multi-omics integration and next-generation 3D model systems. This fast-paced, insight-rich episode dives into the keynotes, workshops, posters, and technology showcases that defined the meeting, while highlighting standout contributions from the Araceli Biosciences [https://www.aracelibio.com/] team. If you work in phenotypic screening, cell imaging, computational biology, or drug discovery, this recap distills what you need to know! 🎧 What You’ll Hear: * Why SBI2 matters for the future of quantitative imaging  * Top trends in Bioimaging: deep learning, reproducibility & cloud pipelines  * Araceli Biosciences highlights at SBI2, including: Victoria Arinella [https://www.linkedin.com/in/victoria-arinella] (UF Scripps) — improving assay reproducibility through automated image quality metrics. Dr. Claudia McCown [https://www.linkedin.com/in/claudia-mccown-biochem] (UF Scripps) — advancing collaborative imaging and multi-site data workflows. Conference reflections from Dr. Kristin Halfpenny [https://www.linkedin.com/in/kristin-halfpenny-ph-d-19096419], emphasizing the convergence of AI, 3D biology, imaging automation, and analytics. * Multi-omics + imaging = The next big leap * What makes SBI2 a unique scientific community * What’s next in imaging: AI integration, 3D models & automation 🌐 Explore & Connect: Learn more about SBI2, ScienceIRT and Araceli Biosciences at:  * Science in Real Time Podcast Webpage [https://www.aracelibio.com/science-irt-podcast-biology-big-data/] * Araceli Biosciences LinkedIn [https://www.linkedin.com/company/araceli-biosciences/] * Society of Biomolecular Imaging & Informatics (SBI2) Website [https://www.sbi2.org/]  Got an idea for a topic or a guest you’d love to hear on Science in Real Time? We’d love to hear from you! Connect with us at our ScienceIRT Website [https://www.aracelibio.com/science-irt-podcast-biology-big-data/] or on LinkedIn: Araceli Biosciences [https://www.linkedin.com/company/araceli-biosciences]. If you enjoyed this episode, don’t forget to subscribe, leave us a review, and share it with a colleague who’s just as passionate about shaping the future of biotech as you are! 🔗 Links:  * Science in Real Time: https://www.aracelibio.com/science-irt-podcast-biology-big-data/ [https://www.aracelibio.com/science-irt-podcast-biology-big-data/] * Araceli Biosciences LinkedIn: https://www.linkedin.com/company/araceli-biosciences/ [https://www.linkedin.com/company/araceli-biosciences/] * Society of Biomolecular Imaging & Informatics (SBI2): https://www.sbi2.org/ [https://www.sbi2.org/] Copyright Music by: Scientific "How it Goes"