Cardiology Today

Left Bundle Pacing Challenges BiVP for CRT 04/14/26

Welcome to Cardiology Today – Recorded April 14, 2026. This episode summarizes 5 key cardiology studies on topics like femoral venous puncture and catheter manipulation. Key takeaway: Left Bundle Pacing Challenges BiVP for CRT. Article Links: Article 1: Ultrasound-guided vs conventional venous puncture for atrial fibrillation ablation: the ULYSSES trial. [https://pubmed.ncbi.nlm.nih.gov/41979041] (European heart journal) Article 2: Left bundle branch area vs biventricular pacing for cardiac resynchronization therapy: the LEFT-BUNDLE-CRT trial. [https://pubmed.ncbi.nlm.nih.gov/41978340] (European heart journal) Article 3: Mavacamten Versus Alcohol Septal Ablation in Obstructive Hypertrophic Cardiomyopathy: An Echocardiography-Derived Pressure-Volume Analysis. [https://pubmed.ncbi.nlm.nih.gov/41969098] (Circulation. Heart failure) Article 4: Device-Related Adverse Events and Outcomes in Patients With Temporary Mechanical Circulatory Support Placed at Referral Centers Versus Cardiogenic Shock Hub Centers: An Observational Analysis. [https://pubmed.ncbi.nlm.nih.gov/41969084] (Circulation. Heart failure) Article 5: Characterization of a successful transseptal access with an electrified guidewire: An ex vivo ovine study. [https://pubmed.ncbi.nlm.nih.gov/41979555] (Heart rhythm) Full episode page: https://podcast.explainheart.com/podcast/left-bundle-pacing-challenges-bivp-for-crt-04-14-26/ [https://podcast.explainheart.com/podcast/left-bundle-pacing-challenges-bivp-for-crt-04-14-26/] FEATURED ARTICLES ARTICLE 1: ULTRASOUND-GUIDED VS CONVENTIONAL VENOUS PUNCTURE FOR ATRIAL FIBRILLATION ABLATION: THE ULYSSES TRIAL. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41979041 [https://pubmed.ncbi.nlm.nih.gov/41979041] Summary: The ULYSSES trial confirmed that vascular access site complications are the most common procedure-related adverse events during atrial fibrillation catheter ablation. This study directly compared an ultrasound-guided femoral venous puncture strategy with a conventional approach. The multicenter trial evaluated the efficacy of each technique in reducing complications in patients undergoing atrial fibrillation or left atrial tachycardia catheter ablation. The investigation’s findings provided a critical evidence base for optimizing patient safety during these procedures. ARTICLE 2: LEFT BUNDLE BRANCH AREA VS BIVENTRICULAR PACING FOR CARDIAC RESYNCHRONIZATION THERAPY: THE LEFT-BUNDLE-CRT TRIAL. Journal: European heart journal PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41978340 [https://pubmed.ncbi.nlm.nih.gov/41978340] Summary: Conduction system pacing has emerged as an alternative to biventricular pacing for cardiac resynchronization therapy. The LEFT-BUNDLE-CRT trial directly compared left-bundle branch area pacing to biventricular pacing. This multicenter, randomized, non-inferiority study provided a comprehensive evaluation of their comparative effectiveness in patients eligible for cardiac resynchronization therapy and left-bundle branch block. The study’s results established the non-inferiority profile of left-bundle branch area pacing against biventricular pacing for this patient population. ARTICLE 3: MAVACAMTEN VERSUS ALCOHOL SEPTAL ABLATION IN OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY: AN ECHOCARDIOGRAPHY-DERIVED PRESSURE-VOLUME ANALYSIS. Journal: Circulation. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41969098 [https://pubmed.ncbi.nlm.nih.gov/41969098] Summary: Obstructive hypertrophic cardiomyopathy is characterized by left ventricular outflow tract obstruction, which increases afterload and activates the Anrep response of hyperdynamic systole. This study directly compared the effects of the myosin inhibitor mavacamten to alcohol septal ablation. Researchers evaluated whether mavacamten reverses this hyperdynamic state, contrasting its impacts with the anatomic relief from alcohol septal ablation in 36 patients. The investigation’s echocardiography-derived pressure-volume analysis clarified the differential physiological effects of these two therapeutic approaches. ARTICLE 4: DEVICE-RELATED ADVERSE EVENTS AND OUTCOMES IN PATIENTS WITH TEMPORARY MECHANICAL CIRCULATORY SUPPORT PLACED AT REFERRAL CENTERS VERSUS CARDIOGENIC SHOCK HUB CENTERS: AN OBSERVATIONAL ANALYSIS. Journal: Circulation. Heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41969084 [https://pubmed.ncbi.nlm.nih.gov/41969084] Summary: Temporary mechanical circulatory support devices are often placed for cardiogenic shock at regional referral centers before transfer to hub centers. This observational analysis identified differences in device-related adverse events and patient outcomes based on the initial site of device placement. The study compared patients whose temporary mechanical circulatory support was initiated at a regional referral center prior to transfer versus those with initial placement at a cardiogenic shock hub center. Its findings clarified the safety and efficacy implications of different care pathways for cardiogenic shock patients. ARTICLE 5: CHARACTERIZATION OF A SUCCESSFUL TRANSSEPTAL ACCESS WITH AN ELECTRIFIED GUIDEWIRE: AN EX VIVO OVINE STUDY. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41979555 [https://pubmed.ncbi.nlm.nih.gov/41979555] Summary: This ex vivo ovine study characterized the determinants of successful transseptal puncture using an electrified guidewire, a technique previously unstudied in this context. Researchers utilized 25 fresh ovine hearts, creating an interatrial septum model from dissected right atrial tissue. The investigation involved fixing the sheath and guidewire to a jig to model clinical catheter manipulation. The study observed transseptal puncture dynamics across varying parameters, establishing key factors influencing success for electrified guidewire transseptal access. TRANSCRIPT Today’s date is April 14, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Ultrasound-guided vs conventional venous puncture for atrial fibrillation ablation: the ULYSSES trial. The ULYSSES trial confirmed that vascular access site complications are the most common procedure-related adverse events during atrial fibrillation catheter ablation. This study directly compared an ultrasound-guided femoral venous puncture strategy with a conventional approach. The multicenter trial evaluated the efficacy of each technique in reducing complications in patients undergoing atrial fibrillation or left atrial tachycardia catheter ablation. The investigation’s findings provided a critical evidence base for optimizing patient safety during these procedures. Article number two. Left bundle branch area vs biventricular pacing for cardiac resynchronization therapy: the LEFT-BUNDLE-CRT trial. Conduction system pacing has emerged as an alternative to biventricular pacing for cardiac resynchronization therapy. The LEFT-BUNDLE-CRT trial directly compared left-bundle branch area pacing to biventricular pacing. This multicenter, randomized, non-inferiority study provided a comprehensive evaluation of their comparative effectiveness in patients eligible for cardiac resynchronization therapy and left-bundle branch block. The study’s results established the non-inferiority profile of left-bundle branch area pacing against biventricular pacing for this patient population. Article number three. Mavacamten Versus Alcohol Septal Ablation in Obstructive Hypertrophic Cardiomyopathy: An Echocardiography-Derived Pressure-Volume Analysis. Obstructive hypertrophic cardiomyopathy is characterized by left ventricular outflow tract obstruction, which increases afterload and activates the Anrep response of hyperdynamic systole. This study directly compared the effects of the myosin inhibitor mavacamten to alcohol septal ablation. Researchers evaluated whether mavacamten reverses this hyperdynamic state, contrasting its impacts with the anatomic relief from alcohol septal ablation in 36 patients. The investigation’s echocardiography-derived pressure-volume analysis clarified the differential physiological effects of these two therapeutic approaches. Article number four. Device-Related Adverse Events and Outcomes in Patients With Temporary Mechanical Circulatory Support Placed at Referral Centers Versus Cardiogenic Shock Hub Centers: An Observational Analysis. Temporary mechanical circulatory support devices are often placed for cardiogenic shock at regional referral centers before transfer to hub centers. This observational analysis identified differences in device-related adverse events and patient outcomes based on the initial site of device placement. The study compared patients whose temporary mechanical circulatory support was initiated at a regional referral center prior to transfer versus those with initial placement at a cardiogenic shock hub center. Its findings clarified the safety and efficacy implications of different care pathways for cardiogenic shock patients. Article number five. Characterization of a successful transseptal access with an electrified guidewire: An ex vivo ovine study. This ex vivo ovine study characterized the determinants of successful transseptal puncture using an electrified guidewire, a technique previously unstudied in this context. Researchers utilized 25 fresh ovine hearts, creating an interatrial septum model from dissected right atrial tissue. The investigation involved fixing the sheath and guidewire to a jig to model clinical catheter manipulation. The study observed transseptal puncture dynamics across varying parameters, establishing key factors influencing success for electrified guidewire transseptal access. Thank you for listening. Don’t forget to subscribe. KEYWORDS femoral venous puncture, catheter manipulation, device-related adverse events, vascular access complications, cardiac resynchronization therapy, left ventricular outflow tract obstruction, temporary mechanical circulatory support, mavacamten, left atrial tachycardia, left-bundle branch block, cardiogenic shock, electrified guidewire, regional referral centers, ex vivo ovine model, ultrasound-guided puncture, interatrial septum, echocardiography, obstructive hypertrophic cardiomyopathy, transseptal puncture, alcohol septal ablation, hub centers, atrial fibrillation ablation, biventricular pacing, conduction system pacing, left-bundle branch area pacing. ABOUT Concise summaries of cardiovascular research for professionals. Subscribe • Share • Follow The post Left Bundle Pacing Challenges BiVP for CRT 04/14/26 [https://podcast.explainheart.com/podcast/left-bundle-pacing-challenges-bivp-for-crt-04-14-26/] first appeared on Cardiology Today [https://podcast.explainheart.com].

Time-Varying Data Boosts Transplant Risk Accuracy 04/14/26

Welcome to Cardiology Today – Recorded April 14, 2026. This episode summarizes 5 key cardiology studies on topics like aspirin and left bundle branch block. Key takeaway: Time-Varying Data Boosts Transplant Risk Accuracy. Article Links: Article 1: Endovascular Therapy for Post-Thrombotic Syndrome – A Randomized Trial. [https://pubmed.ncbi.nlm.nih.gov/41972998] (The New England journal of medicine) Article 2: Cell Type-Specific Targeting of Different Smooth Muscle Cell Populations by Intersectional Genetics. [https://pubmed.ncbi.nlm.nih.gov/41969103] (Circulation) Article 3: Timing is everything: Using time-varying binary indicators for evaluating post-transplant risk factors. [https://pubmed.ncbi.nlm.nih.gov/41974389] (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 4: Subclinical atrial fibrillation and the risk of heart failure: insights from ARTESiA. [https://pubmed.ncbi.nlm.nih.gov/41973801] (European journal of heart failure) Article 5: Dyssynchronous heart failure: mitochondrial distribution and functions mirror regional workload and energy demand in a large-animal model of ventricular desynchronization. [https://pubmed.ncbi.nlm.nih.gov/41968761] (European journal of heart failure) Full episode page: https://podcast.explainheart.com/podcast/time-varying-data-boosts-transplant-risk-accuracy-04-14-26/ [https://podcast.explainheart.com/podcast/time-varying-data-boosts-transplant-risk-accuracy-04-14-26/] FEATURED ARTICLES ARTICLE 1: ENDOVASCULAR THERAPY FOR POST-THROMBOTIC SYNDROME – A RANDOMIZED TRIAL. Journal: The New England journal of medicine PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41972998 [https://pubmed.ncbi.nlm.nih.gov/41972998] Summary: This randomized trial evaluated endovascular therapy, specifically iliac-vein stent placement, for patients with moderate or severe post-thrombotic syndrome linked to iliac-vein obstruction. The study included 225 patients who received either endovascular therapy or enhanced conventional management, addressing the critical clinical issue of improving quality of life. This trial focused on whether the intervention reduced symptom severity for patients severely affected by post-thrombotic syndrome. ARTICLE 2: CELL TYPE-SPECIFIC TARGETING OF DIFFERENT SMOOTH MUSCLE CELL POPULATIONS BY INTERSECTIONAL GENETICS. Journal: Circulation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41969103 [https://pubmed.ncbi.nlm.nih.gov/41969103] Summary: This study developed a new strategy using intersectional genetics for cell type-specific targeting of smooth muscle cell populations. This refined approach effectively overcomes limitations of existing Cre/loxP recombination systems that previously showed off-target activity outside the smooth muscle cell lineage. The new method precisely distinguishes among arterial smooth muscle cells, venous smooth muscle cells, and non-vascular smooth muscle cells. This capability is essential for characterizing the distinct roles of smooth muscle cells in various organs and diseases. ARTICLE 3: TIMING IS EVERYTHING: USING TIME-VARYING BINARY INDICATORS FOR EVALUATING POST-TRANSPLANT RISK FACTORS. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41974389 [https://pubmed.ncbi.nlm.nih.gov/41974389] Summary: This study demonstrated that incorporating a time-varying binary indicator in a Cox model correctly analyzes post-transplant risk factors. Traditional methods, which treat risk factors as fixed at the time of transplantation, produce inaccurate effect estimates due to immortal time bias. Using infection-related hospitalizations after heart transplantation as an example, this refined approach properly aligns the timing of exposure with survival follow-up. This methodology yields more credible and accurate effect estimates for risk factors emerging after transplantation. ARTICLE 4: SUBCLINICAL ATRIAL FIBRILLATION AND THE RISK OF HEART FAILURE: INSIGHTS FROM ARTESIA. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41973801 [https://pubmed.ncbi.nlm.nih.gov/41973801] Summary: The ARTESiA (Apixaban for the Reduction of Thromboembolism in Patients with Device-Detected Subclinical Atrial Fibrillation) trial, involving 3986 patients, compared apixaban with aspirin for reducing thromboembolism in individuals with device-detected subclinical atrial fibrillation. This study leveraged the ARTESiA patient cohort to investigate the connection between subclinical atrial fibrillation and the incidence of heart failure events. It established that while heart failure and clinical atrial fibrillation are closely related, the specific impact of device-detected subclinical atrial fibrillation on heart failure risk remained previously undefined. The research therefore identified a critical area for further clinical understanding regarding this patient population. ARTICLE 5: DYSSYNCHRONOUS HEART FAILURE: MITOCHONDRIAL DISTRIBUTION AND FUNCTIONS MIRROR REGIONAL WORKLOAD AND ENERGY DEMAND IN A LARGE-ANIMAL MODEL OF VENTRICULAR DESYNCHRONIZATION. Journal: European journal of heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41968761 [https://pubmed.ncbi.nlm.nih.gov/41968761] Summary: This study in an ovine model of dyssynchronous heart failure with left bundle branch block demonstrated that mitochondrial distribution and functions mirror regional workload and energy demand. Researchers established left bundle branch block-like activation in 11 sheep, observing them over eight weeks, alongside six control animals. The findings showed inhomogeneous left ventricular workload and systolic dysfunction in the dyssynchronous heart failure group. This research specifically linked metabolic remodeling, including glucose metabolism assessed by 18F-fluorodeoxyglucose tracers, to regional energetic stress in the diseased myocardium. TRANSCRIPT Today’s date is April 14, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Endovascular Therapy for Post-Thrombotic Syndrome – A Randomized Trial. This randomized trial evaluated endovascular therapy, specifically iliac-vein stent placement, for patients with moderate or severe post-thrombotic syndrome linked to iliac-vein obstruction. The study included 225 patients who received either endovascular therapy or enhanced conventional management, addressing the critical clinical issue of improving quality of life. This trial focused on whether the intervention reduced symptom severity for patients severely affected by post-thrombotic syndrome. Article number two. Cell Type-Specific Targeting of Different Smooth Muscle Cell Populations by Intersectional Genetics. This study developed a new strategy using intersectional genetics for cell type-specific targeting of smooth muscle cell populations. This refined approach effectively overcomes limitations of existing Cre/loxP recombination systems that previously showed off-target activity outside the smooth muscle cell lineage. The new method precisely distinguishes among arterial smooth muscle cells, venous smooth muscle cells, and non-vascular smooth muscle cells. This capability is essential for characterizing the distinct roles of smooth muscle cells in various organs and diseases. Article number three. Timing is everything: Using time-varying binary indicators for evaluating post-transplant risk factors. This study demonstrated that incorporating a time-varying binary indicator in a Cox model correctly analyzes post-transplant risk factors. Traditional methods, which treat risk factors as fixed at the time of transplantation, produce inaccurate effect estimates due to immortal time bias. Using infection-related hospitalizations after heart transplantation as an example, this refined approach properly aligns the timing of exposure with survival follow-up. This methodology yields more credible and accurate effect estimates for risk factors emerging after transplantation. Article number four. Subclinical atrial fibrillation and the risk of heart failure: insights from ARTESiA. The ARTESiA (Apixaban for the Reduction of Thromboembolism in Patients with Device-Detected Subclinical Atrial Fibrillation) trial, involving 3986 patients, compared apixaban with aspirin for reducing thromboembolism in individuals with device-detected subclinical atrial fibrillation. This study leveraged the ARTESiA patient cohort to investigate the connection between subclinical atrial fibrillation and the incidence of heart failure events. It established that while heart failure and clinical atrial fibrillation are closely related, the specific impact of device-detected subclinical atrial fibrillation on heart failure risk remained previously undefined. The research therefore identified a critical area for further clinical understanding regarding this patient population. Article number five. Dyssynchronous heart failure: mitochondrial distribution and functions mirror regional workload and energy demand in a large-animal model of ventricular desynchronization. This study in an ovine model of dyssynchronous heart failure with left bundle branch block demonstrated that mitochondrial distribution and functions mirror regional workload and energy demand. Researchers established left bundle branch block-like activation in 11 sheep, observing them over eight weeks, alongside six control animals. The findings showed inhomogeneous left ventricular workload and systolic dysfunction in the dyssynchronous heart failure group. This research specifically linked metabolic remodeling, including glucose metabolism assessed by 18F-fluorodeoxyglucose tracers, to regional energetic stress in the diseased myocardium. Thank you for listening. Don’t forget to subscribe. KEYWORDS aspirin, left bundle branch block, cell targeting, mitochondrial function, Cox model, endovascular therapy, iliac-vein stent, dyssynchronous heart failure, heart failure, smooth muscle cells, deep-vein thrombosis, myocardial remodeling, arterial smooth muscle cells, subclinical atrial fibrillation, heart transplantation, immortal time bias, ventricular desynchronization, risk factors, time-varying binary indicator, venous obstruction, post-thrombotic syndrome, ARTESiA trial, Cre-loxP system, apixaban, intersectional genetics, thromboembolism. ABOUT Concise summaries of cardiovascular research for professionals. Subscribe • Share • Follow The post Time-Varying Data Boosts Transplant Risk Accuracy 04/14/26 [https://podcast.explainheart.com/podcast/time-varying-data-boosts-transplant-risk-accuracy-04-14-26/] first appeared on Cardiology Today [https://podcast.explainheart.com].

Salusin-Alpha Restores Vessels in Pulmonary Hypertension 04/13/26

Welcome to Cardiology Today – Recorded April 13, 2026. This episode summarizes 5 key cardiology studies on topics like ischemic stroke and prehospital delay. Key takeaway: Salusin-Alpha Restores Vessels in Pulmonary Hypertension. Article Links: Article 1: Salusin-α Restores Vascular Relaxation and Remodeling in Pulmonary Hypertension. [https://pubmed.ncbi.nlm.nih.gov/41958393] (Hypertension (Dallas, Tex. : 1979)) Article 2: Endothelial Senescence Drives Deleterious Endothelial-Adipocyte Cross-Talk in Patients With Heart Failure and Type 2 Diabetes. [https://pubmed.ncbi.nlm.nih.gov/41967191] (JACC. Basic to translational science) Article 3: Kinetics of Technetium-Labeled Cardiac Amyloid Radionuclide Imaging. [https://pubmed.ncbi.nlm.nih.gov/41961986] (Circulation. Cardiovascular imaging) Article 4: Intracranial Hemorrhage Patterns and Outcomes in Minor Stroke: Analysis of the TEMPO-2 Trial. [https://pubmed.ncbi.nlm.nih.gov/41958392] (Stroke) Article 5: Cost-Effectiveness of Prehospital Delay Reduction Versus Primary Stroke Prevention in US Adults With Type 2 Diabetes. [https://pubmed.ncbi.nlm.nih.gov/41958382] (Stroke) Full episode page: https://podcast.explainheart.com/podcast/salusin-alpha-restores-vessels-in-pulmonary-hypertension-04-13-26/ [https://podcast.explainheart.com/podcast/salusin-alpha-restores-vessels-in-pulmonary-hypertension-04-13-26/] FEATURED ARTICLES ARTICLE 1: SALUSIN-Α RESTORES VASCULAR RELAXATION AND REMODELING IN PULMONARY HYPERTENSION. Journal: Hypertension (Dallas, Tex. : 1979) PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41958393 [https://pubmed.ncbi.nlm.nih.gov/41958393] Summary: This study demonstrated that salusin-alpha restored vascular relaxation and reversed vascular remodeling in pulmonary hypertension. Researchers found these effects by assessing pulmonary artery relaxation using isometric tension recording in isolated rat pulmonary arteries. They quantified reductions in pulmonary artery remodeling through histological morphometric analysis. The data indicated that salusin-alpha significantly alleviated the progressive increase in pulmonary arterial resistance characteristic of pulmonary hypertension. ARTICLE 2: ENDOTHELIAL SENESCENCE DRIVES DELETERIOUS ENDOTHELIAL-ADIPOCYTE CROSS-TALK IN PATIENTS WITH HEART FAILURE AND TYPE 2 DIABETES. Journal: JACC. Basic to translational science PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41967191 [https://pubmed.ncbi.nlm.nih.gov/41967191] Summary: Microvascular endothelial cells (MVECs) from subcutaneous adipose tissue of patients with type two diabetes mellitus and heart failure exhibited a senescent phenotype. These senescent cells displayed elevated senescence-associated secretory phenotype markers, reduced adenosine triphosphate production, and impaired angiogenic and proliferative capacities. When cocultured with healthy adipocytes, these senescent M. V. E. C. s drove adverse cross-talk, inducing a proinflammatory adipocyte phenotype with increased interleukin-6 expression. This research revealed how endothelial senescence contributes to chronic inflammation in this high-risk patient population. ARTICLE 3: KINETICS OF TECHNETIUM-LABELED CARDIAC AMYLOID RADIONUCLIDE IMAGING. Journal: Circulation. Cardiovascular imaging PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41961986 [https://pubmed.ncbi.nlm.nih.gov/41961986] Summary: This study characterized the tracer kinetics of technetium-labeled bone-avid tracers used for diagnosing transthyretin cardiac amyloidosis. Researchers defined these kinetics using quantitative single-photon emission computed tomography with computed tomography in 24 subjects evaluated for the condition. The findings established the kinetic profile of these diagnostic agents. The study also addressed the use of hydroxymethylene diphosphonate as an alternative to technetium-99m pyrophosphate due to supply shortages, noting the limited comparative kinetic data available. ARTICLE 4: INTRACRANIAL HEMORRHAGE PATTERNS AND OUTCOMES IN MINOR STROKE: ANALYSIS OF THE TEMPO-2 TRIAL. Journal: Stroke PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41958392 [https://pubmed.ncbi.nlm.nih.gov/41958392] Summary: This secondary analysis of the TEMPO-2 multicenter, randomized trial evaluated specific intracranial hemorrhage patterns and their impact on functional outcomes in patients with minor ischemic stroke. The study identified distinct predictors associated with intracranial hemorrhage within this patient population. It found that intracranial hemorrhage negatively impacts functional outcomes after ischemic stroke, with disproportionate effects observed in patients with minor stroke. The TEMPO-2 trial compared tenecteplase with nonthrombolytic standard care for patients within 12 hours of symptom onset. ARTICLE 5: COST-EFFECTIVENESS OF PREHOSPITAL DELAY REDUCTION VERSUS PRIMARY STROKE PREVENTION IN US ADULTS WITH TYPE 2 DIABETES. Journal: Stroke PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41958382 [https://pubmed.ncbi.nlm.nih.gov/41958382] Summary: This study determined the relative benefits and cost-effectiveness of reducing prehospital delay for acute ischemic stroke patients compared to implementing primary stroke prevention measures. The analysis focused on U. S. adults with type two diabetes, a population at high risk for acute ischemic stroke. Researchers utilized data from the National Health and Nutrition Examination Survey from 2015 to 2018. The findings established which intervention strategy offered greater cost-effectiveness in this specific high-risk group. TRANSCRIPT Today’s date is April 13, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Salusin-α Restores Vascular Relaxation and Remodeling in Pulmonary Hypertension. This study demonstrated that salusin-alpha restored vascular relaxation and reversed vascular remodeling in pulmonary hypertension. Researchers found these effects by assessing pulmonary artery relaxation using isometric tension recording in isolated rat pulmonary arteries. They quantified reductions in pulmonary artery remodeling through histological morphometric analysis. The data indicated that salusin-alpha significantly alleviated the progressive increase in pulmonary arterial resistance characteristic of pulmonary hypertension. Article number two. Endothelial Senescence Drives Deleterious Endothelial-Adipocyte Cross-Talk in Patients With Heart Failure and Type 2 Diabetes. Microvascular endothelial cells (MVECs) from subcutaneous adipose tissue of patients with type two diabetes mellitus and heart failure exhibited a senescent phenotype. These senescent cells displayed elevated senescence-associated secretory phenotype markers, reduced adenosine triphosphate production, and impaired angiogenic and proliferative capacities. When cocultured with healthy adipocytes, these senescent M. V. E. C. s drove adverse cross-talk, inducing a proinflammatory adipocyte phenotype with increased interleukin-6 expression. This research revealed how endothelial senescence contributes to chronic inflammation in this high-risk patient population. Article number three. Kinetics of Technetium-Labeled Cardiac Amyloid Radionuclide Imaging. This study characterized the tracer kinetics of technetium-labeled bone-avid tracers used for diagnosing transthyretin cardiac amyloidosis. Researchers defined these kinetics using quantitative single-photon emission computed tomography with computed tomography in 24 subjects evaluated for the condition. The findings established the kinetic profile of these diagnostic agents. The study also addressed the use of hydroxymethylene diphosphonate as an alternative to technetium-99m pyrophosphate due to supply shortages, noting the limited comparative kinetic data available. Article number four. Intracranial Hemorrhage Patterns and Outcomes in Minor Stroke: Analysis of the TEMPO-2 Trial. This secondary analysis of the TEMPO-2 multicenter, randomized trial evaluated specific intracranial hemorrhage patterns and their impact on functional outcomes in patients with minor ischemic stroke. The study identified distinct predictors associated with intracranial hemorrhage within this patient population. It found that intracranial hemorrhage negatively impacts functional outcomes after ischemic stroke, with disproportionate effects observed in patients with minor stroke. The TEMPO-2 trial compared tenecteplase with nonthrombolytic standard care for patients within 12 hours of symptom onset. Article number five. Cost-Effectiveness of Prehospital Delay Reduction Versus Primary Stroke Prevention in US Adults With Type 2 Diabetes. This study determined the relative benefits and cost-effectiveness of reducing prehospital delay for acute ischemic stroke patients compared to implementing primary stroke prevention measures. The analysis focused on U. S. adults with type two diabetes, a population at high risk for acute ischemic stroke. Researchers utilized data from the National Health and Nutrition Examination Survey from 2015 to 2018. The findings established which intervention strategy offered greater cost-effectiveness in this specific high-risk group. Thank you for listening. Don’t forget to subscribe. KEYWORDS ischemic stroke, prehospital delay, microvascular endothelial cells, technetium-labeled tracers, tenecteplase, endothelial senescence, pulmonary artery, single-photon emission computed tomography, adipocyte cross-talk, inflammation, minor stroke, acute ischemic stroke, type two diabetes mellitus, intracranial hemorrhage, heart failure, primary stroke prevention, functional outcomes, tracer kinetics, vascular remodeling, pulmonary hypertension, cost-effectiveness, TEMPO-2 trial, salusin-alpha, hydroxymethylene diphosphonate, National Health and Nutrition Examination Survey, cardiac imaging, transthyretin cardiac amyloidosis, vascular relaxation. ABOUT Concise summaries of cardiovascular research for professionals. Subscribe • Share • Follow The post Salusin-Alpha Restores Vessels in Pulmonary Hypertension 04/13/26 [https://podcast.explainheart.com/podcast/salusin-alpha-restores-vessels-in-pulmonary-hypertension-04-13-26/] first appeared on Cardiology Today [https://podcast.explainheart.com].

CKM Syndrome Shapes Atrial Fibrillation Outcomes 04/13/26

Welcome to Cardiology Today – Recorded April 13, 2026. This episode summarizes 5 key cardiology studies on topics like sex differences and adverse clinical outcomes. Key takeaway: CKM Syndrome Shapes Atrial Fibrillation Outcomes. Article Links: Article 1: Long-Term Outcomes of Stent-Based Pulmonary Angioplasty for Isolated Peripheral Pulmonary Artery Stenosis. [https://pubmed.ncbi.nlm.nih.gov/41967784] (The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation) Article 2: Plasma Protein Profiles in Different Heart Failure Phenotypes. [https://pubmed.ncbi.nlm.nih.gov/41967491] (ESC heart failure) Article 3: Cardiovascular-kidney-metabolic syndrome and atrial fibrillation: Insights from 2 real-world prospective registries across Europe and East Asia. [https://pubmed.ncbi.nlm.nih.gov/41966525] (Heart rhythm) Article 4: Sex difference in clinically suspected immune checkpoint inhibitor-related myocarditis: a single-institute retrospective study with seven-year follow-up. [https://pubmed.ncbi.nlm.nih.gov/41967772] (International journal of cardiology) Article 5: Plasma Protein Profiles in Different Heart Failure Phenotypes. [https://pubmed.ncbi.nlm.nih.gov/41967491] (ESC heart failure) Full episode page: https://podcast.explainheart.com/podcast/ckm-syndrome-shapes-atrial-fibrillation-outcomes-04-13-26/ [https://podcast.explainheart.com/podcast/ckm-syndrome-shapes-atrial-fibrillation-outcomes-04-13-26/] FEATURED ARTICLES ARTICLE 1: LONG-TERM OUTCOMES OF STENT-BASED PULMONARY ANGIOPLASTY FOR ISOLATED PERIPHERAL PULMONARY ARTERY STENOSIS. Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41967784 [https://pubmed.ncbi.nlm.nih.gov/41967784] Summary: This single-center retrospective study included 23 adults with isolated peripheral pulmonary artery stenosis who received stent-based angioplasty between 2007 and 2024. The study characterized the long-term durability and the incidence and determinants of in-stent restenosis. It also observed changes in patient hemodynamics and six-minute walk distance. This research provides insights into the outcomes of stent-based angioplasty for this rare condition. ARTICLE 2: PLASMA PROTEIN PROFILES IN DIFFERENT HEART FAILURE PHENOTYPES. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41967491 [https://pubmed.ncbi.nlm.nih.gov/41967491] Summary: This study analyzed data from 50765 U. K. Biobank participants to characterize plasma protein profiles. It examined three distinct heart failure phenotypes: heart failure with preceding myocardial infarction, heart failure with preceding atrial fibrillation, and heart failure without either preceding condition. The analysis was conducted to understand the unique protein signatures across these different heart failure presentations and potentially identify a common protein profile. ARTICLE 3: CARDIOVASCULAR-KIDNEY-METABOLIC SYNDROME AND ATRIAL FIBRILLATION: INSIGHTS FROM 2 REAL-WORLD PROSPECTIVE REGISTRIES ACROSS EUROPE AND EAST ASIA. Journal: Heart rhythm PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41966525 [https://pubmed.ncbi.nlm.nih.gov/41966525] Summary: This study evaluated the association between cardiovascular-kidney-metabolic syndrome stages and adverse clinical outcomes in patients with atrial fibrillation. It included patients from the E. U. R. O. bservational Research Programme Atrial Fibrillation General Long-Term Registry and the K. A. F. Registry, representing real-world populations across Europe and East Asia. The research characterized the clinical impact of cardiovascular-kidney-metabolic syndrome in atrial fibrillation patients by analyzing data from these prospective registries. ARTICLE 4: SEX DIFFERENCE IN CLINICALLY SUSPECTED IMMUNE CHECKPOINT INHIBITOR-RELATED MYOCARDITIS: A SINGLE-INSTITUTE RETROSPECTIVE STUDY WITH SEVEN-YEAR FOLLOW-UP. Journal: International journal of cardiology PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41967772 [https://pubmed.ncbi.nlm.nih.gov/41967772] Summary: This retrospective study characterized sex differences in clinically suspected immune checkpoint inhibitor-related myocarditis over a seven-year follow-up period. It included patients diagnosed at a single institute between 2018 and 2024. The research analyzed baseline characteristics, laboratory markers, and echocardiographic parameters to identify sex-specific risk factors and predictors. ARTICLE 5: PLASMA PROTEIN PROFILES IN DIFFERENT HEART FAILURE PHENOTYPES. Journal: ESC heart failure PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41967491 [https://pubmed.ncbi.nlm.nih.gov/41967491] Summary: This study analyzed data from 50765 U. K. Biobank participants to characterize plasma protein profiles. It examined three distinct heart failure phenotypes: heart failure with preceding myocardial infarction, heart failure with preceding atrial fibrillation, and heart failure without either preceding condition. The analysis was conducted to understand the unique protein signatures across these different heart failure presentations and potentially identify a common protein profile. TRANSCRIPT Today’s date is April 13, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Long-Term Outcomes of Stent-Based Pulmonary Angioplasty for Isolated Peripheral Pulmonary Artery Stenosis. This single-center retrospective study included 23 adults with isolated peripheral pulmonary artery stenosis who received stent-based angioplasty between 2007 and 2024. The study characterized the long-term durability and the incidence and determinants of in-stent restenosis. It also observed changes in patient hemodynamics and six-minute walk distance. This research provides insights into the outcomes of stent-based angioplasty for this rare condition. Article number two. Plasma Protein Profiles in Different Heart Failure Phenotypes. This study analyzed data from 50765 U. K. Biobank participants to characterize plasma protein profiles. It examined three distinct heart failure phenotypes: heart failure with preceding myocardial infarction, heart failure with preceding atrial fibrillation, and heart failure without either preceding condition. The analysis was conducted to understand the unique protein signatures across these different heart failure presentations and potentially identify a common protein profile. Article number three. Cardiovascular-kidney-metabolic syndrome and atrial fibrillation: Insights from 2 real-world prospective registries across Europe and East Asia. This study evaluated the association between cardiovascular-kidney-metabolic syndrome stages and adverse clinical outcomes in patients with atrial fibrillation. It included patients from the E. U. R. O. bservational Research Programme Atrial Fibrillation General Long-Term Registry and the K. A. F. Registry, representing real-world populations across Europe and East Asia. The research characterized the clinical impact of cardiovascular-kidney-metabolic syndrome in atrial fibrillation patients by analyzing data from these prospective registries. Article number four. Sex difference in clinically suspected immune checkpoint inhibitor-related myocarditis: a single-institute retrospective study with seven-year follow-up. This retrospective study characterized sex differences in clinically suspected immune checkpoint inhibitor-related myocarditis over a seven-year follow-up period. It included patients diagnosed at a single institute between 2018 and 2024. The research analyzed baseline characteristics, laboratory markers, and echocardiographic parameters to identify sex-specific risk factors and predictors. Article number five. Plasma Protein Profiles in Different Heart Failure Phenotypes. This study analyzed data from 50765 U. K. Biobank participants to characterize plasma protein profiles. It examined three distinct heart failure phenotypes: heart failure with preceding myocardial infarction, heart failure with preceding atrial fibrillation, and heart failure without either preceding condition. The analysis was conducted to understand the unique protein signatures across these different heart failure presentations and potentially identify a common protein profile. Thank you for listening. Don’t forget to subscribe. KEYWORDS sex differences, adverse clinical outcomes, plasma protein profiles, U. K. Biobank, stent-based angioplasty, immune checkpoint inhibitor-related myocarditis, six-minute walk distance, echocardiographic parameters, hemodynamics, heart failure, E. U. R. O. bservational Research Programme, atrial fibrillation, in-stent restenosis, risk factors, cardiovascular-kidney-metabolic syndrome, peripheral pulmonary artery stenosis, biomarkers, K. A. F. Registry, myocardial infarction. ABOUT Concise summaries of cardiovascular research for professionals. Subscribe • Share • Follow The post CKM Syndrome Shapes Atrial Fibrillation Outcomes 04/13/26 [https://podcast.explainheart.com/podcast/ckm-syndrome-shapes-atrial-fibrillation-outcomes-04-13-26/] first appeared on Cardiology Today [https://podcast.explainheart.com].

Mycn Promotes Heart Protection Post M.I. 04/12/26

Welcome to Cardiology Today – Recorded April 12, 2026. This episode summarizes 5 key cardiology studies on topics like pediatric cardiology and morbidity. Key takeaway: Mycn Promotes Heart Protection Post M.I.. Article Links: Article 1: Patient-Surgeon Sex Concordance and Clinical Outcomes After Adult Cardiac Surgery. [https://pubmed.ncbi.nlm.nih.gov/41954068] (Journal of the American Heart Association) Article 2: Increased Risk of Disabilities in Children and Adolescents With Congenital Heart Disease of Any Severity. [https://pubmed.ncbi.nlm.nih.gov/41954067] (Journal of the American Heart Association) Article 3: Correlates and Prognostic Value of Serial N-Terminal Pro-B-Type Natriuretic Peptide Assay in Congenitally Corrected Transposition of the Great Arteries. [https://pubmed.ncbi.nlm.nih.gov/41954066] (Journal of the American Heart Association) Article 4: Long-Term Outcomes With Class 1C Antiarrhythmic Drug Use in Atrial Fibrillation. [https://pubmed.ncbi.nlm.nih.gov/41954064] (Journal of the American Heart Association) Article 5: Mycn Reactivates the Cell Cycle in Adult Cardiomyocytes and Promotes Cardioprotection in Myocardial Infarction. [https://pubmed.ncbi.nlm.nih.gov/41954062] (Journal of the American Heart Association) Full episode page: https://podcast.explainheart.com/podcast/mycn-promotes-heart-protection-post-m-i-04-12-26/ [https://podcast.explainheart.com/podcast/mycn-promotes-heart-protection-post-m-i-04-12-26/] FEATURED ARTICLES ARTICLE 1: PATIENT-SURGEON SEX CONCORDANCE AND CLINICAL OUTCOMES AFTER ADULT CARDIAC SURGERY. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41954068 [https://pubmed.ncbi.nlm.nih.gov/41954068] Summary: This large cohort study provided a comprehensive characterization of patient-surgeon sex concordance in relation to clinical outcomes following adult cardiac surgery. The research documented data from 223065 Medicare beneficiaries who underwent coronary artery bypass grafting, surgical aortic valve replacement, or proximal aortic surgery. The study’s analysis focused on composite outcomes of mortality and morbidity, including myocardial infarction, stroke, and all-cause readmission, stratified by surgeon and patient sex. These findings contribute crucial information for understanding potential sex-based differences in cardiac surgical care. ARTICLE 2: INCREASED RISK OF DISABILITIES IN CHILDREN AND ADOLESCENTS WITH CONGENITAL HEART DISEASE OF ANY SEVERITY. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41954067 [https://pubmed.ncbi.nlm.nih.gov/41954067] Summary: This retrospective data-linkage study found an increased risk of disabilities in children and adolescents diagnosed with congenital heart disease of any severity. The research revealed a higher prevalence of overall and specific disability service use within this patient group compared to matched controls and siblings. These findings highlight a significant burden of disabilities across all severities of congenital heart disease in pediatric patients. The study provides crucial information for long-term care planning and resource allocation for this population. ARTICLE 3: CORRELATES AND PROGNOSTIC VALUE OF SERIAL N-TERMINAL PRO-B-TYPE NATRIURETIC PEPTIDE ASSAY IN CONGENITALLY CORRECTED TRANSPOSITION OF THE GREAT ARTERIES. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41954066 [https://pubmed.ncbi.nlm.nih.gov/41954066] Summary: This study established the correlates and confirmed the prognostic value of serial N-terminal pro-B-type natriuretic peptide assays in adults with congenitally corrected transposition of the great arteries. The research provided specific data on the role of these measurements for heart failure risk stratification in this distinct patient population. The findings confirm N-terminal pro-B-type natriuretic peptide as a relevant cardiovascular biomarker, addressing previously limited data for this group. This offers important insights for clinical monitoring and management of these adults. ARTICLE 4: LONG-TERM OUTCOMES WITH CLASS 1C ANTIARRHYTHMIC DRUG USE IN ATRIAL FIBRILLATION. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41954064 [https://pubmed.ncbi.nlm.nih.gov/41954064] Summary: This large study characterized the long-term outcomes associated with class one C antiarrhythmic drug use in 100748 adult patients with atrial fibrillation. The research documented the cardiovascular benefits and safety profile of class one C pharmacotherapy in comparison to rate control strategies over an extended period. The findings provide crucial information regarding the real-world efficacy and safety of these agents for rhythm control. This study contributes significantly to the understanding of optimal management strategies in atrial fibrillation patients. ARTICLE 5: MYCN REACTIVATES THE CELL CYCLE IN ADULT CARDIOMYOCYTES AND PROMOTES CARDIOPROTECTION IN MYOCARDIAL INFARCTION. Journal: Journal of the American Heart Association PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41954062 [https://pubmed.ncbi.nlm.nih.gov/41954062] Summary: This study found that Mycn reactivates the cell cycle in adult cardiomyocytes, a significant discovery given their typically limited capacity for cell cycle re-entry. The research demonstrated that Mycn promotes cardioprotection following myocardial infarction in preclinical models. These findings suggest a novel therapeutic avenue for enhancing cardiac repair after ischemic injury. The study contributes significantly to understanding the role of Myc family isoforms in cardiomyocyte plasticity and regeneration. TRANSCRIPT Today’s date is April 12, 2026. Welcome to Cardiology Today. Here are the latest research findings. Article number one. Patient-Surgeon Sex Concordance and Clinical Outcomes After Adult Cardiac Surgery. This large cohort study provided a comprehensive characterization of patient-surgeon sex concordance in relation to clinical outcomes following adult cardiac surgery. The research documented data from 223065 Medicare beneficiaries who underwent coronary artery bypass grafting, surgical aortic valve replacement, or proximal aortic surgery. The study’s analysis focused on composite outcomes of mortality and morbidity, including myocardial infarction, stroke, and all-cause readmission, stratified by surgeon and patient sex. These findings contribute crucial information for understanding potential sex-based differences in cardiac surgical care. Article number two. Increased Risk of Disabilities in Children and Adolescents With Congenital Heart Disease of Any Severity. This retrospective data-linkage study found an increased risk of disabilities in children and adolescents diagnosed with congenital heart disease of any severity. The research revealed a higher prevalence of overall and specific disability service use within this patient group compared to matched controls and siblings. These findings highlight a significant burden of disabilities across all severities of congenital heart disease in pediatric patients. The study provides crucial information for long-term care planning and resource allocation for this population. Article number three. Correlates and Prognostic Value of Serial N-Terminal Pro-B-Type Natriuretic Peptide Assay in Congenitally Corrected Transposition of the Great Arteries. This study established the correlates and confirmed the prognostic value of serial N-terminal pro-B-type natriuretic peptide assays in adults with congenitally corrected transposition of the great arteries. The research provided specific data on the role of these measurements for heart failure risk stratification in this distinct patient population. The findings confirm N-terminal pro-B-type natriuretic peptide as a relevant cardiovascular biomarker, addressing previously limited data for this group. This offers important insights for clinical monitoring and management of these adults. Article number four. Long-Term Outcomes With Class One C Antiarrhythmic Drug Use in Atrial Fibrillation. This large study characterized the long-term outcomes associated with class one C antiarrhythmic drug use in 100748 adult patients with atrial fibrillation. The research documented the cardiovascular benefits and safety profile of class one C pharmacotherapy in comparison to rate control strategies over an extended period. The findings provide crucial information regarding the real-world efficacy and safety of these agents for rhythm control. This study contributes significantly to the understanding of optimal management strategies in atrial fibrillation patients. Article number five. Mycn Reactivates the Cell Cycle in Adult Cardiomyocytes and Promotes Cardioprotection in Myocardial Infarction. This study found that Mycn reactivates the cell cycle in adult cardiomyocytes, a significant discovery given their typically limited capacity for cell cycle re-entry. The research demonstrated that Mycn promotes cardioprotection following myocardial infarction in preclinical models. These findings suggest a novel therapeutic avenue for enhancing cardiac repair after ischemic injury. The study contributes significantly to understanding the role of Myc family isoforms in cardiomyocyte plasticity and regeneration. Thank you for listening. Don’t forget to subscribe. KEYWORDS pediatric cardiology, morbidity, rate control, cell cycle reactivation, adult cardiac surgery, surgical aortic valve replacement, Mycn, risk stratification, cardiac repair, heart failure, coronary artery bypass grafting, rhythm control, myocardial infarction, N-terminal pro-B-type natriuretic peptide, Patient-surgeon sex concordance, Atrial fibrillation, long-term outcomes, Congenital heart disease, class one C antiarrhythmic drugs, cardiovascular biomarkers, adult cardiomyocytes, cardioprotection, mortality, disability service use, congenitally corrected transposition of the great arteries, disabilities. ABOUT Concise summaries of cardiovascular research for professionals. Subscribe • Share • Follow The post Mycn Promotes Heart Protection Post M.I. 04/12/26 [https://podcast.explainheart.com/podcast/mycn-promotes-heart-protection-post-m-i-04-12-26/] first appeared on Cardiology Today [https://podcast.explainheart.com].