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Fit For Science

Podcast by Stephan Reichl and Rob ter Horst

English

Health & personal development

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About Fit For Science

Two scientists discuss how they live their best life, using science, data, tech, wearables, and systems. Fit For Science is a deep-dive podcast hosted by two biological data scientists, Rob and Stephan, exploring the intersection of research, health tech, and data-driven lifestyle design. The hosts provide evidence-based systems, layered with practical "N=2" personal experimentation, to cut through the noise and enable everyone to become their best N-of-1. The Quantified Scientist (Rob): youtube.com/TheQuantifiedScientist Stephan's Website: http://polytechnist.me

All episodes

17 episodes

episode #17 The Three Dimensions of Wearables: Hardware, Algorithms and Apps (UI/UX) artwork

#17 The Three Dimensions of Wearables: Hardware, Algorithms and Apps (UI/UX)

Rob and Stephan break down the three critical dimensions of wearables—hardware, algorithms, and UI/UX—to explain what truly drives accurate health and sports tracking. 📝Summary Biological data scientists Rob and Stephan explore the three foundational pillars that determine the quality of health and sports tracking wearables: hardware, algorithms, and Apps (UI/UX). They begin by evaluating the maturity of physical sensors like PPG and accelerometers, noting that while hardware capabilities have largely plateaued in high-end devices, energy density and battery technology continue to improve. The conversation then shifts to the critical differentiating factor of algorithms, breaking them down into three levels of complexity: direct on-device processing of heart rate, second-order computations for metrics like sleep staging, and highly advanced long-term disease risk predictions. Finally, the hosts discuss how the user interface and user experience tie these elements together, highlighting the importance of data presentation and the emergence of pure data aggregators in the wearable market. ⏳Chapters 00:00:00 The Three Dimensions of Wearable Performance 00:02:26 Hardware: The Foundation of Wearable Sensors 00:06:15 Understanding Raw Signals and Sensor Interference 00:09:46 Battery Technology and Hardware Durability 00:15:41 Level 1 Algorithms: Direct On-Device Processing (e.g., Heart rate) 00:23:51 Level 2 Algorithms: Derived Metrics (e.g., Sleep Stages) 00:55:50 Level 3 Algorithms: High-Level Aggregations (e.g., Long-Term Disease Risk) 00:56:20 Apps (UI & UX): The Final Wearable App Experience 📚Resources Photoplethysmogram [https://en.wikipedia.org/wiki/Photoplethysmogram] (PPG) Accelerometer [https://en.wikipedia.org/wiki/Accelerometer] Global Positioning System (GPS) [https://en.wikipedia.org/wiki/Global_Positioning_System] Pulse oximetry (SpO2 Sensor) [https://en.wikipedia.org/wiki/Pulse_oximetry] Holter monitor [https://en.wikipedia.org/wiki/Holter_monitor] (ECG) Polysomnography (Sleep Study) [https://en.wikipedia.org/wiki/Polysomnography] Heart rate variability (HRV) [https://en.wikipedia.org/wiki/Heart_rate_variability] Dual carbon battery [https://en.wikipedia.org/wiki/Dual_carbon_battery]  Edge computing [https://en.wikipedia.org/wiki/Edge_computing]  Embedded system [https://en.wikipedia.org/wiki/Embedded_system] Pulse wave velocity (PWV) [https://en.wikipedia.org/wiki/Pulse_wave_velocity] Foundation model (AI) [https://en.wikipedia.org/wiki/Foundation_model] User experience (UI/UX) [https://en.wikipedia.org/wiki/User_experience] Garmin [https://en.wikipedia.org/wiki/Garmin] Oura Health [https://en.wikipedia.org/wiki/Oura_Health] Apple Watch [https://en.wikipedia.org/wiki/Apple_Watch] The accuracy of Apple Watch measurements: a living systematic review and meta-analysis [https://www.nature.com/articles/s41746-025-02238-1] Whoop [https://en.wikipedia.org/wiki/Whoop_(company)] Bevel [https://bevel.health/]  Athlytic [https://www.athlyticapp.com/]  Garbage in, garbage out (GIGO) [https://en.wikipedia.org/wiki/Garbage_in,_garbage_out] Introducing the new Google Fitbit Air [https://blog.google/products-and-platforms/devices/fitbit/fitbit-air/]  A Systematic Review of Chest-Worn Sensors in Cardiac Assessment: Technologies, Advantages, and Limitations [https://pmc.ncbi.nlm.nih.gov/articles/PMC12526813/]  …There is more: complete show notes here [https://docs.google.com/document/d/1LCIm780Aue5573FWVpyDve5Wm_DBTwDqfzoZ5zTqeyY/edit?usp=sharing] 🎙️About Fit For Science is a deep-dive podcast hosted by two biological data scientists, Rob and Stephan, exploring the intersection of research, health tech, and data-driven lifestyle design. The hosts provide evidence-based systems, layered with practical "N=2" personal experimentation, to cut through the noise and enable everyone to become their best N-of-1. Learn more [https://creators.spotify.com/pod/profile/fitforscience/] and subscribe on your favorite platforms: YouTube [https://www.youtube.com/@FitForScience] Spotify [https://open.spotify.com/show/56TjUxuMsPETb0kGEJ7nwf] Apple Podcasts [https://podcasts.apple.com/us/podcast/fit-for-science/id1863479802] Amazon Music [https://music.amazon.de/podcasts/c3e54ee7-4a2c-442e-a59f-553fbfb02b11/fit-for-science] Collection of all show notes [https://docs.google.com/document/d/1LCIm780Aue5573FWVpyDve5Wm_DBTwDqfzoZ5zTqeyY/edit?usp=sharing] ⚠️Disclaimer: This podcast represents our own opinions and is for informational purposes only. It does not constitute medical or financial advice or a professional relationship.

18 May 2026 - 56 min
episode The 1-Minute Exercise Myth, Exercise & Mortality, Athletes' Health Risks & Rob's 8-Watch Marathon (Fit For Science #16) artwork

The 1-Minute Exercise Myth, Exercise & Mortality, Athletes' Health Risks & Rob's 8-Watch Marathon (Fit For Science #16)

In this episode of Fit For Science, Rob and Stephan explore the complex relationship between various exercise types, intensity levels, and mortality, while also recounting Rob's intense DIY smartwatch-testing marathon. 📝Summary In this episode, Rob and Stephan dive into the nuanced impacts of physical activity on mortality and disease risk, emphasizing that while exercise is universally beneficial, its effects vary by type, intensity, and duration. The hosts unpack a 30-year cohort study involving over 111,000 participants, highlighting that 20 MET hours per week and a variety of activities optimally reduce mortality risk, with walking being highly effective. They critically examine recent wearable-based studies claiming that a few minutes of vigorous intermittent lifestyle physical activity (VILPA) can drastically substitute for longer low-intensity sessions, pointing out the limitations of substitution modeling. Furthermore, the discussion touches on "masters athletes," exploring how extreme, long-term exercise volumes can lead to unique cardiovascular adaptations and potential risks like atrial fibrillation or bradyarrhythmias, underscoring the need for specialized cardiological care. Finally, Rob shares his experience running a solo marathon fueled by a stationary bike feed station to test the GPS accuracy of eight different smartwatches simultaneously. ⏳Chapters 00:00:00 The DIY Marathon: Rob recounts his solo marathon to test eight smartwatches 00:13:48 Exercise and Mortality: A 30-year study on MET hours, activity types, and death risk 00:23:38 Walking vs. Swimming: Different mortality correlations between specific sports 00:28:46 The Power of Variety: How mixing exercise types significantly lowers mortality risk 00:32:49 VILPA and Vigorous Exercise: Analyzing studies on high intensity exercise 00:38:17 Critiquing claims that one minute of vigorous activity equals 54 minutes of low intensity activity 00:44:49 Masters Athletes: Defining high-performing athletes over 35 and their cardiovascular health 00:51:56 The Athlete's Heart: Exploring cardiovascular specific risks in endurance athletes 01:00:49 Final takeaways on balancing exercise intensity and seeking appropriate medical advice 📚Resources Physical activity types, variety, and mortality: results from two prospective cohort studies [https://bmjmedicine.bmj.com/content/5/1/e001513]  Mix of different types of physical activity may be best for longer life [https://medicalxpress.com/news/2026-01-physical-longer-life.html#google_vignette]  Metabolic equivalent of task (MET) [https://en.wikipedia.org/wiki/Metabolic_equivalent_of_task]  Association of wearable device-measured vigorous intermittent lifestyle physical activity (VILPA) with mortality [https://www.nature.com/articles/s41591-022-02100-x]  Wearable device-based health equivalence of different physical activity intensities against mortality, cardiometabolic disease, and cancer [https://www.nature.com/articles/s41467-025-63475-2]  Why Vigorous Exercise Is 4–10x More Effective Than Moderate (New Evidence) [https://www.youtube.com/watch?v=QnloZ45PVxQ]  The Best Type of Exercise for Longevity [https://www.foundmyfitness.com/episodes/exercise-intensity] 1 Minute of Vigorous Activity Same as 53 Minutes of Light Intensity? [https://www.youtube.com/watch?v=qBqMHSoTM8M] Masters Athletes With Abnormal Cardiovascular Findings [https://www.sciencedirect.com/science/article/pii/S073510972605730X]  The Recreational Athlete's Heart [https://pubmed.ncbi.nlm.nih.gov/41330412/]  Bradycardia [https://en.wikipedia.org/wiki/Bradycardia]  …There is more: complete show notes here [https://docs.google.com/document/d/1LCIm780Aue5573FWVpyDve5Wm_DBTwDqfzoZ5zTqeyY/edit?usp=sharing] 🎙️About Fit For Science is a deep-dive podcast hosted by two biological data scientists, Rob and Stephan, exploring the intersection of research, health tech, and data-driven lifestyle design. The hosts provide evidence-based systems, layered with practical "N=2" personal experimentation, to cut through the noise and enable everyone to become their best N-of-1. Learn more [https://creators.spotify.com/pod/profile/fitforscience/] and subscribe on your favorite platforms: YouTube [https://www.youtube.com/@FitForScience] Spotify [https://open.spotify.com/show/56TjUxuMsPETb0kGEJ7nwf] Apple Podcasts [https://podcasts.apple.com/us/podcast/fit-for-science/id1863479802] Amazon Music [https://music.amazon.de/podcasts/c3e54ee7-4a2c-442e-a59f-553fbfb02b11/fit-for-science] Collection of all show notes [https://docs.google.com/document/d/1LCIm780Aue5573FWVpyDve5Wm_DBTwDqfzoZ5zTqeyY/edit?usp=sharing] ⚠️Disclaimer: This podcast represents our own opinions and is for informational purposes only. It does not constitute medical or financial advice or a professional relationship.

9 May 2026 - 57 min
episode Stanford's Aging Fish, Tracking Wishlist, Placebo Blueberries & Measuring Body Composition - Q1’26 Updates (Fit For Science Episode 15) artwork

Stanford's Aging Fish, Tracking Wishlist, Placebo Blueberries & Measuring Body Composition - Q1’26 Updates (Fit For Science Episode 15)

In this episode, Rob and Stephan explore the intersection of lifespan research, the exposome, and daily health tracking, tackling everything from aging fish and AI stool analysis to passive exercise tracking and body composition scales. 📝Summary In episode 15 of Fit For Science, Rob and Stephan explore the intersection of lifespan research, the exposome, and daily health tracking, tackling everything from fish behavior to body composition. The hosts, both biological data scientists, dive into a recent Stanford study published in Science that tracked the lifetime behavior of short-lived fish to uncover insights into aging, connecting these methods to human wearable technology and exposome tracking. They transition into discussing the potential benefits and practical hurdles of tracking daily bowel movements using AI and the Bristol stool chart compared to infrequent microbiome testing. The conversation also highlights wishlist features for wearables, specifically the ability to quantify passive exercises like saunas and cold plunges. A personal anecdote about a sudden burst of energy and reduced sleep need following the consumption of freeze-dried blueberries sparks a debate on whether this was due to antioxidants reducing neuroinflammation or simply project-induced excitement. Finally, they compare at-home bioelectrical impedance smart scales to clinical measurements, detailing the nuances between lean mass, visceral fat, and the importance of long-term trend averaging. ⏳Chapters 00:00:00 Fish Aging Study: Discussing a Stanford study connecting fish with wearables 00:04:13 The Exposome: Exploring how environmental exposures are tracked 00:12:05 Stool Tracking vs. Microbiome Analysis 00:19:33 Quantifying Passive Exercise: A wishlist discussion 00:25:30 The Blueberry Effect and Sleep: Stephan's placebo experience 00:34:30 Body Composition and Smart Scales 00:43:03 Advanced Body Composition Measurement Techniques 00:46:07 Lean Mass vs. Visceral Fat 00:51:22 Data Averages and Trends 📚Resources LinkedIn post about Stanford's aging fish study [https://www.linkedin.com/posts/paulxmccarthy_a-breathtaking-new-study-published-in-science-activity-7440570851906990080-koQG]  Watching a lifetime in motion reveals the architecture of aging [https://news.stanford.edu/stories/2026/03/architecture-aging-behavior-animals-research]  Youthful antics predict lifespan — at least for these fish [https://www.nature.com/articles/d41586-026-00782-8]  Paper: Lifelong behavioral screen reveals an architecture of vertebrate aging [https://www.science.org/doi/10.1126/science.aea9795]  Amazon's failed body composition app: The science behind the Halo Body feature [https://www.amazon.science/latest-news/the-science-behind-the-amazon-halo-band-body-feature]  Academic publishing: Open Access vs Paywalls [https://en.wikipedia.org/wiki/Academic_publishing#Open_access_journals]  Actigraphy [https://en.wikipedia.org/wiki/Actigraphy]  An atlas of exposome–phenome associations in health and disease risk [https://www.nature.com/articles/s41591-026-04266-0]  Exposome [https://en.wikipedia.org/wiki/Exposome]  Snyder Lab - Exposome [https://med.stanford.edu/snyderlab/news/news-story-1.html]  A Network-Based Framework for Assessing the Pathobiological Impact of Environmental Exposures on Human Development & Health - Salvo D Lombardo [https://repositorium.meduniwien.ac.at/obvumwhs/content/titleinfo/12287727] CeMM - Research Center for Molecular Medicine (where we work) [https://cemm.at/]  Massive biomolecular shifts occur in our 40s and 60s [https://med.stanford.edu/news/all-news/2024/08/massive-biomolecular-shifts-occur-in-our-40s-and-60s--stanford-m.html]  Microbiome [https://en.wikipedia.org/wiki/Microbiome]  Bristol Stool Chart: Types & What They Mean [https://my.clevelandclinic.org/health/articles/bristol-stool-chart]  Zettelkasten system (Stephan uses his email inbox) [https://en.wikipedia.org/wiki/Zettelkasten] Body Scan | Withings Europe [https://www.withings.com/eu/en/body-scan]  The 10 Best Ways to Measure Your Body Fat Percentage [https://www.healthline.com/nutrition/ways-to-measure-body-fat]  The Evaluation of a Mass Media Campaign Aimed at Weight Gain Prevention Among Young Dutch Adults [https://onlinelibrary.wiley.com/doi/full/10.1038/oby.2007.330]  Sustained visceral fat loss is associated with attenuated brain atrophy and improved cognitive function in late midlife [https://www.nature.com/articles/s41467-026-71141-4] …There is more: complete show notes here [https://docs.google.com/document/d/1LCIm780Aue5573FWVpyDve5Wm_DBTwDqfzoZ5zTqeyY/edit?usp=sharing] 🎙️About Fit For Science is a deep-dive podcast hosted by two biological data scientists, Rob and Stephan, exploring the intersection of research, health tech, and data-driven lifestyle design. The hosts provide evidence-based systems, layered with practical "N=2" personal experimentation, to cut through the noise and enable everyone to become their best N-of-1. Learn more [https://creators.spotify.com/pod/profile/fitforscience/] and subscribe on your favorite platforms: YouTube [https://www.youtube.com/@FitForScience] Spotify [https://open.spotify.com/show/56TjUxuMsPETb0kGEJ7nwf] Apple Podcasts [https://podcasts.apple.com/us/podcast/fit-for-science/id1863479802] Amazon Music [https://music.amazon.de/podcasts/c3e54ee7-4a2c-442e-a59f-553fbfb02b11/fit-for-science] Collection of all show notes [https://docs.google.com/document/d/1LCIm780Aue5573FWVpyDve5Wm_DBTwDqfzoZ5zTqeyY/edit?usp=sharing] ⚠️Disclaimer: This podcast represents our own opinions and is for informational purposes only. It does not constitute medical or financial advice or a professional relationship.

27 Apr 2026 - 55 min
episode The Silicon Valley Peptide Craze: Trust the Science, Not the Influencer (+ Hierarchy of Evidence) (Fit For Science Episode 14) artwork

The Silicon Valley Peptide Craze: Trust the Science, Not the Influencer (+ Hierarchy of Evidence) (Fit For Science Episode 14)

In this episode of Fit for Science, Rob and Stephan use the recent Silicon Valley "peptide craze" as a case study to explore how to critically evaluate health claims and navigate the scientific hierarchy of evidence. 📝Summary In episode 14 of the Fit for Science podcast, biological data scientists Rob and Stephan delve into the growing trend of Silicon Valley tech elites self-injecting unregulated peptides, using this phenomenon as a launchpad to discuss how to critically assess health and lifestyle claims. They begin by demystifying what peptides actually are, providing examples ranging from life-saving insulin and GLP-1 agonists to harmful spider venom, while warning against the dangers of untested, gray-market substances. The core of the episode breaks down the hierarchy of scientific evidence, guiding listeners from the weakest forms, such as second-hand anecdotes and social media influencers, up through epidemiological observational studies, prospective studies, and rigorous randomized controlled trials, finally culminating at the pinnacle: meta-analyses. Furthermore, they offer practical advice on safely running personal health experiments using wearables, emphasizing the importance of systematic testing, understanding biological mechanisms versus actual tested outcomes, and relying on high-quality institutional guidelines over viral internet trends. ⏳Chapters 00:00:00 Unpacking the Silicon Valley peptide craze 00:04:50 Defining Peptides: Understanding small proteins 00:17:18 The Hierarchy of Evidence: Why anecdotes and personal experiences sit at the bottom 00:26:59 Epidemiological Studies: The value and limitations of observational data 00:32:45 Prospective Studies: Planning health research and utilizing wearable data 00:35:08 Randomized Controlled Trials: The gold standard for testing interventions and eliminating bias 00:43:24 Meta-Analyses: Combining data to form medical consensus and guidelines 00:46:29 Evaluating Sources: Disentangling the message from the messenger 00:52:17 AI in Health Research: Tips and pitfalls when using frontier models for scientific inquiries 00:58:10 Community Q&A: How to safely use wearables to run systematic self-experiments 01:07:11 Final thoughts on evaluating risks and a recap of the evidence hierarchy 📚Resources ‘Chinese Peptides’ Are the Latest Biohacking Trend in the Tech World - The New York Times [https://www.nytimes.com/2026/01/03/business/chinese-peptides-silicon-valley.html?unlocked_article_code=1.BlA.bSI-.5puwhP1yiF6B&smid=url-share%E2%80%A6] Silicon Valley's new miracle drug [https://www.youtube.com/watch?v=W0ltbBby9FU] Eric Topol - The Peptide Craze - Ground Truths [https://erictopol.substack.com/p/the-peptide-craze]  Economist - Want to hack your body with peptides? If only the science agreed [https://www.economist.com/science-and-technology/2026/03/11/want-to-hack-your-body-with-peptides-if-only-the-science-agreed]  ‘People are turning themselves into lab rats’: the injectable peptides craze sweeping the US | The Guardian [https://www.theguardian.com/wellness/2026/feb/05/injectable-peptides-trend] ProPublica - A Las Vegas Festival Promised Ways to Cheat Death. Two Attendees Left Fighting for Their Lives. [https://www.propublica.org/article/peptide-injections-raadfest-rfk-jr]   Hierarchy of evidence [https://en.wikipedia.org/wiki/Hierarchy_of_evidence]  Survivorship bias (incl. airplane bullet holes anecdote) [https://en.wikipedia.org/wiki/Survivorship_bias]  UK Biobank [https://www.ukbiobank.ac.uk/]  NHANES - National Health and Nutrition Examination Survey | CDC [https://www.cdc.gov/nchs/nhanes/index.html]  Meta-analysis - Examine [https://examine.com/glossary/meta-analysis/]  VIP medicine aka VIP syndrome aka VIP effect [https://en.wikipedia.org/wiki/VIP_medicine]  Edison Platform for science-based AI research [https://platform.edisonscientific.com/] Perplexity AI for research (you can select academic papers) [https://www.perplexity.ai/]   Eddy Burback - ChatGPT made me delusional [https://www.youtube.com/watch?v=VRjgNgJms3Q]  Principles from the episode * Proteins are the smallest functional unit of life and peptides are just small proteins. …There is more: complete show notes here [https://docs.google.com/document/d/1LCIm780Aue5573FWVpyDve5Wm_DBTwDqfzoZ5zTqeyY/edit?usp=sharing] 🎙️About Fit For Science is a deep-dive podcast hosted by two biological data scientists, Rob and Stephan, exploring the intersection of research, health tech, and data-driven lifestyle design. The hosts provide evidence-based systems, layered with practical "N=2" personal experimentation, to cut through the noise and enable everyone to become their best N-of-1. Learn more [https://creators.spotify.com/pod/profile/fitforscience/] and subscribe on your favorite platforms: YouTube [https://www.youtube.com/@FitForScience] Spotify [https://open.spotify.com/show/56TjUxuMsPETb0kGEJ7nwf] Apple Podcasts [https://podcasts.apple.com/us/podcast/fit-for-science/id1863479802] Amazon Music [https://music.amazon.de/podcasts/c3e54ee7-4a2c-442e-a59f-553fbfb02b11/fit-for-science] Collection of all show notes [https://docs.google.com/document/d/1LCIm780Aue5573FWVpyDve5Wm_DBTwDqfzoZ5zTqeyY/edit?usp=sharing] ⚠️Disclaimer: This podcast represents our own opinions and is for informational purposes only. It does not constitute medical or financial advice or a professional relationship.

21 Apr 2026 - 1 h 10 min
episode The $100 Genome: Genetic Risk Scores & Sequencing Babies (Fit For Science Episode 13) artwork

The $100 Genome: Genetic Risk Scores & Sequencing Babies (Fit For Science Episode 13)

Rob and Stephan explore the new reality of $100 whole genome sequencing, the actionable value of polygenic risk scores, and the ethical future of personalized genomic medicine. 📝Summary Biological data scientists Rob and Stephan discuss the implications of the newly achieved $100 whole genome sequencing milestone, comparing unbiased whole genome reads to popular genotyping consumer products like 23andMe. They delve into the mechanics of genome-wide association studies and polygenic risk scores, examining how genetics interact with lifestyle and environmental factors to influence disease probability. The hosts share their personal experiences with services like Nebula Genomics, 23andMe and Dante Labs, revealing how insights, such as a high genetic predisposition for elevated ApoB levels, can drive actionable dietary changes like reducing saturated fats. Finally, they explore the psychological barriers, data privacy concerns, and ethical considerations of integrating genomic sequencing into standard medical practice and newborn screening to create a proactive, Bayesian model of preventative healthcare. ⏳Chapters 00:00:00 The $100 Genome: Cost breakthroughs and historical perspective 00:07:41 Defining Sequencing: Genotyping consumer products vs. Whole Genome Sequencing 00:16:19 Polygenic Risk Scores: Predicting complex diseases using multiple genes 00:20:44 Nature vs. Nurture: How lifestyle pulls the trigger on genetic predispositions 00:23:17 Medical Implementation: Psychological anxiety and the actionability of genetic data 00:33:03 Personal Experiences: Reviews of Nebula Genomics, 23andMe, and Dante Labs 00:44:23 Actionable Insights: Modifying saturated fat intake based on ApoB percentiles 00:54:55 A Bayesian Healthcare Model: Combining genetics, demographics, and lifestyle 01:06:20 Ethical Explorations: The future of sequencing newborns and preventative screening 📚Resources Human Genome Project [https://en.wikipedia.org/wiki/Human_Genome_Project] cost ~$3 Billion and took ~13 years (1990-2003) How to sequence the human genome - TED-Ed Video [https://www.youtube.com/watch?v=MvuYATh7Y74]  Genetic disorder (monogenic i.e., single-gene cause) [https://en.wikipedia.org/wiki/Genetic_disorder#Single_gene_disorder]  Scrappy San Diego startup goes toe-to-toe with gene-sequencing giant Illumina [https://www.sandiegouniontribune.com/2026/02/19/scrappy-san-diego-startup-goes-toe-to-toe-with-gene-sequencing-giant-illumina/] Element Biosciences [https://www.elementbiosciences.com/] Eric Topol's X post about $100 Gneom [https://x.com/EricTopol/status/2025265560901292279]  The cost of sequencing human genome has fallen from $100M to under $100 in approximately 25 years [https://www.reddit.com/r/singularity/comments/1rbhtzc/the_cost_of_sequencing_human_genome_has_fallen/#:~:text=BuildwithVignesh-,The%20cost%20of%20sequencing%20human%20genome%20has%20fallen%20from%20$100,111%20Go%20to%20comments%20Share]   The $100 Genome: Where’s the Limit? [https://frontlinegenomics.com/the-100-genome-wheres-the-limit/]  Genome-wide association study (GWAS) [https://en.wikipedia.org/wiki/Genome-wide_association_study] Polygenic score (PRS) [https://en.wikipedia.org/wiki/Polygenic_score] What are Polygenic Risk Scores (PRS) and how can they be used in healthcare? [https://www.youtube.com/watch?v=BqR_G8DnPJw]  Systematic comparison of family history and polygenic risk across 24 common diseases [https://pmc.ncbi.nlm.nih.gov/articles/PMC9748261/]  > “In most diseases, including coronary artery disease, glaucoma, and type 2 diabetes, a positive family history with a high PRS was associated with a considerably elevated risk, whereas a low PRS compensated completely for the risk implied by positive family history.” > “In addition to capturing shared DNA, FH [family history] measures non-genetic exposures and behaviors shared by families” Nebula Genomics [https://nebula.org/] now DNA Complete [https://dnacomplete.com/] with subscription model George Church (geneticist) [https://en.wikipedia.org/wiki/George_Church_(geneticist)]  23andMe [https://www.23andme.com/] Dante Labs [https://www.dantelabs.com/] Promethease [https://promethease.com/] for DNA reporting Reference genome [https://en.wikipedia.org/wiki/Reference_genome]  Personalized genomics [https://en.wikipedia.org/wiki/Personalized_genomics]  Apolipoprotein B (ApoB) [https://en.wikipedia.org/wiki/Apolipoprotein_B]   The ‘thousand-dollar genome’: an ethical exploration | European Journal of Human Genetics [https://www.nature.com/articles/ejhg201373] (2013!) …There is more: complete show notes here [https://docs.google.com/document/d/1LCIm780Aue5573FWVpyDve5Wm_DBTwDqfzoZ5zTqeyY/edit?usp=sharing] 🎙️About Fit For Science is a deep-dive podcast hosted by two biological data scientists, Rob and Stephan, exploring the intersection of research, health tech, and data-driven lifestyle design. The hosts provide evidence-based systems, layered with practical "N=2" personal experimentation, to cut through the noise and enable everyone to become their best N-of-1. Learn more [https://creators.spotify.com/pod/profile/fitforscience/] and subscribe on your favorite platforms: YouTube [https://www.youtube.com/@FitForScience] Spotify [https://open.spotify.com/show/56TjUxuMsPETb0kGEJ7nwf] Apple Podcasts [https://podcasts.apple.com/us/podcast/fit-for-science/id1863479802] Amazon Music [https://music.amazon.de/podcasts/c3e54ee7-4a2c-442e-a59f-553fbfb02b11/fit-for-science] Collection of all show notes [https://docs.google.com/document/d/1LCIm780Aue5573FWVpyDve5Wm_DBTwDqfzoZ5zTqeyY/edit?usp=sharing] ⚠️Disclaimer: This podcast represents our own opinions and is for informational purposes only. It does not constitute medical or financial advice or a professional relationship.

19 Mar 2026 - 1 h 2 min
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