Signal and Symptoms Podcast

Healthcare AI: What To Know, What's Still Broken, and Where To Go Next

What does it actually cost when a diagnosis comes six months too late, a test gets ordered twice, or a treatment decision gets made without the best information available? In this special recap episode of Signal & Symptoms, we synthesize the strongest healthcare AI insights from previous episodes — moving from the promise of what AI can do, to the real patient stories that reveal what's at stake when we delay, to an honest look at the barriers still standing in the way, and finally to the path ahead for clinicians and leaders ready to act. This isn't a hype episode. It's a practical reckoning: AI is already changing how diagnoses get made, how patients advocate for themselves, and how the next generation of healthcare standards will be written. The only question is whether you'll help shape it — or watch it happen without you. What You Will Discover: - The Promise: The Tech Exists - The Patient Problem: The Real Cost of Delay - The Reality Check: What the Studies Don't Tell You - Clinician Leadership: Before Someone Else Writes the Rules - The Road Ahead: Act Now or Get Left Behind Tune in to the full episodes: 🎥https://youtu.be/Vj8JXBkD4OQ [https://youtu.be/Vj8JXBkD4OQ] (Microsoft AI & Clinical Context) 🎥https://youtu.be/yjqhF-coM_w [https://youtu.be/yjqhF-coM_w] (Patient Delay & Missed Diagnosis) 🎥https://youtu.be/vCBOSzMRk-s [https://youtu.be/vCBOSzMRk-s] (Clinician Leadership, Medicine & Dentistry) Referenced in the show: 🖇️Blog (2025): The Path to Medical Superintelligence - https://microsoft.ai/new/the-path-to-medical-superintelligence/ [https://microsoft.ai/new/the-path-to-medical-superintelligence/] Connect with us: Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™ 💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd [https://www.linkedin.com/in/junaidkaliamd] 🔗Website - https://www.junaidkalia.com/ [https://www.junaidkalia.com/] 📹YouTube - https://www.youtube.com/@junaidkaliamd [https://www.youtube.com/@junaidkaliamd] Dr. Harvey Castro, ER Physician, #DrGPT™ 💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ [https://www.linkedin.com/in/harveycastromd/] 🔗Website - https://www.harveycastromd.com/ [https://www.harveycastromd.com/] 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en [https://www.instagram.com/harveycastromd/?hl=en] 📑 Substack - https://harveycastromd.substack.com/ [https://harveycastromd.substack.com/] Edward Marx, CEO, Advisor 💼LinkedIn - https://www.linkedin.com/in/edwardmarx/ [https://www.linkedin.com/in/edwardmarx/] 🔗Website - https://www.marxadvisory.com/ [https://www.marxadvisory.com/] 📹YouTube - https://www.youtube.com/@EdwardMarx [https://www.youtube.com/@EdwardMarx] Visit our website: https://signalandsymptoms.com/ [https://signalandsymptoms.com/] Get advisory insights about Healthcare AI — at zero cost: https://junaidkaliamd.substack.com/ [https://junaidkaliamd.substack.com/]

What Hospitals Actually Need Before They'll Deploy Your AI

Will AI eliminate primary care — or finally give primary care physicians their time back? That's the central question driving this episode, as Dr. Junaid Kalia, Dr. Harvey Castro, and Ed Marx sit down with Dr. John Dayton — an ER physician who has evaluated healthcare startups as an angel investor, built pilots at Intermountain Ventures, and is now raising a $5M fund. He brings a rare view of what AI looks like from the bedside, the boardroom, and the cap table. Dr. Dayton maps how AI decisions actually get made inside health systems: why a technology has to align with the CEO's mission, the CFO's budget, the CTO's existing stack, and clinical staff's real workflow — and why losing any one of those four is where most implementations quietly stall. For physicians and healthcare enthusiasts who want to separate signal from noise — and understand whether the tools landing on their unit deserve to be there — this is the peer-to-peer analysis that conference keynotes never deliver. What You Will Discover: - Intro: John Dayton's origin story - Why He Never Really Left Medicine - How hospitals actually make AI decisions - Is an MBA worth it if it's not free? - The Decision Making Approach Inside Health Systems - The Two Questions Nobody Answers Directly It's not about whether AI is ready for clinical use. It's about whether clinicians are ready to guide patients who are already using it. Referenced in the show: 🖇️ "Professional Development and Upskilling Resources for Clinicians" – https://www.linkedin.com/pulse/professional-development-upskilling-resources-john-dayton-md-mba-xlpmc/ Connect with us: Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™ 💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd [https://www.linkedin.com/in/junaidkaliamd] 🔗Website - https://www.junaidkalia.com/ [https://www.junaidkalia.com/] 📹YouTube - https://www.youtube.com/@junaidkaliamd [https://www.youtube.com/@junaidkaliamd] Dr. Harvey Castro, ER Physician, #DrGPT™ 💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ [https://www.linkedin.com/in/harveycastromd/] 🔗Website - https://www.harveycastromd.com/ [https://www.harveycastromd.com/] 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en [https://www.instagram.com/harveycastromd/?hl=en] 📑 Substack - https://harveycastromd.substack.com/ [https://harveycastromd.substack.com/] Edward Marx, CEO, Advisor 💼LinkedIn - https://www.linkedin.com/in/edwardmarx/ [https://www.linkedin.com/in/edwardmarx/] 🔗Website - https://www.marxadvisory.com/ [https://www.marxadvisory.com/] 📹YouTube - https://www.youtube.com/@EdwardMarx [https://www.youtube.com/@EdwardMarx] Special Guest: John Dayton, MD, MBA 💼LinkedIn - linkedin.com/in/johndaytonmd [http://linkedin.com/in/johndaytonmd] Visit our website: https://signalandsymptoms.com/ [https://signalandsymptoms.com/] Get advisory insights about Healthcare AI — at zero cost: https://junaidkaliamd.substack.com/ [https://junaidkaliamd.substack.com/]

The Hidden Risk of AI-Powered Clinical Decisions

You already know not every AI tool belongs in your workflow. The real question is whether your filter is sharp enough to tell the difference. In this episode, Dr. Junaid Kalia and Dr. Harvey Castro sit down with Dr. Hansa Bhargava, Chief Innovation Officer at Healio and a physician who has spent her career building trust at scale, to examine what trustworthy clinical AI actually looks like from the inside. They trace how the content integrity crisis predates AI, why clinician-in-the-loop development is the clearest signal of a tool worth adopting, and how evidence-sourced curation is the only real defense against sophisticated noise at the point of care. The stakes go deeper than adoption. Who carries the legal weight when AI-assisted decisions go wrong? And are the physicians leaning into AI today quietly trading long-term clinical judgment for short-term efficiency? This episode doesn't evaluate the tools — it reframes what's actually at risk. What You Will Discover: - Intro: Building Trust in Medical Literature - Dr. Hansa’s Journey in Architecting Trust - Her North Star: Better Patient Outcomes - Is Clinical Research Already Compromised Before AI? - Why AI Is Built to Agree With You - Clinician-in-the-Loop is the #1 Trust Signal - The Biggest Risk & Opportunity in the Age of AI Connect with us: Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™ 💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd [https://www.linkedin.com/in/junaidkaliamd] 🔗Website - https://www.junaidkalia.com/ [https://www.junaidkalia.com/] 📹YouTube - https://www.youtube.com/@junaidkaliamd [https://www.youtube.com/@junaidkaliamd] Dr. Harvey Castro, ER Physician, #DrGPT™ 💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ [https://www.linkedin.com/in/harveycastromd/] 🔗Website - https://www.harveycastromd.com/ [https://www.harveycastromd.com/] 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en [https://www.instagram.com/harveycastromd/?hl=en] 📑 Substack - https://harveycastromd.substack.com/ [https://harveycastromd.substack.com/] Edward Marx, CEO, Advisor 💼LinkedIn - https://www.linkedin.com/in/edwardmarx/ [https://www.linkedin.com/in/edwardmarx/] 🔗Website - https://www.marxadvisory.com/ [https://www.marxadvisory.com/] 📹YouTube - https://www.youtube.com/@EdwardMarx [https://www.youtube.com/@EdwardMarx] Special Guest: Hansa Bhargava MD 💼LinkedIn - https://www.linkedin.com/in/hansa-bhargava-mdd-752a463a/ Visit our website: https://signalandsymptoms.com/ [https://signalandsymptoms.com/] Get advisory insights about Healthcare AI — at zero cost: https://junaidkaliamd.substack.com/ [https://junaidkaliamd.substack.com/]

Why Will Digital Twins Change the Way We Treat Patients?

What if the most powerful diagnostic tool wasn't a scan or a lab result — but a continuously learning model of your patient, built from their own data? In this episode, Dr. Junaid Kalia sits down with co-host Dr. Harvey Castro, this time in the guest seat, to unpack one of the most transformative concepts in modern medicine: the healthcare digital twin. They trace how the concept evolved from NASA simulations and factory floors into clinical reality, breaking it down clearly for those new to the idea while grounding it in real applications — predictive analytics, personalized pharmacogenomics, and Harvey's personal digital twin, which he built and uses today. They also don't shy away from the harder questions: data privacy, implementation costs, the global adoption gap, and the tension between rapid innovation and regulation that can barely keep pace. Whether you're a clinician thinking about what's next for patient care, or a healthcare enthusiast trying to make sense of where medicine is heading, this episode gives you a grounded, honest look at a technology that's closer than you think. What You Will Discover: - Intro: What Are Healthcare Digital Twins? - The Human + AI Concept: Harvey's Personal Digital Twin - Top 3 Applications for Digital Twin Transforming Patient Care - Data Privacy and Cybersecurity Risks - Why Culture Is the Real Rate-Limiting Step - Implementation Challenges in the US vs. Other Countries - Are Tokens Reliably Used in Healthcare? - Genetics, Epigenomics & the Future of Point-of-Care Treatment - The Future We're Building: A Final Word from Two Doctors Resources: 🔗 Ask Harvey a healthcare AI question –– https://harvey.deepfoundai.com/ [https://harvey.deepfoundai.com/] Connect with us: Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™ 💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd [https://www.linkedin.com/in/junaidkaliamd] 🔗Website - https://www.junaidkalia.com/ [https://www.junaidkalia.com/] 📹YouTube - https://www.youtube.com/@junaidkaliamd [https://www.youtube.com/@junaidkaliamd] Dr. Harvey Castro, ER Physician, #DrGPT™ 💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ [https://www.linkedin.com/in/harveycastromd/] 🔗Website - https://www.harveycastromd.com/ [https://www.harveycastromd.com/] 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en [https://www.instagram.com/harveycastromd/?hl=en] 📑 Substack - https://harveycastromd.substack.com/ [https://harveycastromd.substack.com/] Edward Marx, CEO, Advisor 💼LinkedIn - https://www.linkedin.com/in/edwardmarx/ [https://www.linkedin.com/in/edwardmarx/] 🔗Website - https://www.marxadvisory.com/ [https://www.marxadvisory.com/] 📹YouTube - https://www.youtube.com/@EdwardMarx [https://www.youtube.com/@EdwardMarx] Visit our website: https://signalandsymptoms.com/ [https://signalandsymptoms.com/] Get advisory insights about Healthcare AI — at zero cost: https://junaidkaliamd.substack.com/ [https://junaidkaliamd.substack.com/]

What Happens to Hospital Revenue When AI Replaces Primary Care?

Most healthcare conversations stop at disruption, but this one starts there. In this episode, three healthcare experts sit down to map what happens when AI doesn't just change clinical workflows — it rewires the economics behind them. From the slow-adoption trap crippling hospital governance, to the cultural lag quietly signaling a broken system, to a collapse of the referral pipeline impacting financial stability — the kind of conversation most boardrooms aren't having yet. The twin disruption isn't coming. It's already restructuring the room. Where do you stand? What You Will Discover: - Intro: The Twin Disruption No One's Naming - Slow Adoption Is Now a Liability - Culture Is the Real Bottleneck - Will Hospitals Need to Sell Off Physical Assets? - On Restructuring Value-Based Care - The Shift to 'Tokenized Economy’ in Healthcare Referenced in the show: 🖇️ "The Twin Disruption: How AI is Rewriting the Economics of Healthcare" – https://drive.google.com/file/d/1dGc9RXPlnpZTbs0VEvWJdrDH-0PCEttP/view?usp=sharing Connect with us: Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™ 💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd [https://www.linkedin.com/in/junaidkaliamd] 🔗Website - https://www.junaidkalia.com/ [https://www.junaidkalia.com/] 📹YouTube - https://www.youtube.com/@junaidkaliamd [https://www.youtube.com/@junaidkaliamd] Dr. Harvey Castro, ER Physician, #DrGPT™ 💼LinkedIn - https://www.linkedin.com/in/harveycastromd/ [https://www.linkedin.com/in/harveycastromd/] 🔗Website - https://www.harveycastromd.com/ [https://www.harveycastromd.com/] 📷Instagram - https://www.instagram.com/harveycastromd/?hl=en [https://www.instagram.com/harveycastromd/?hl=en] 📑 Substack - https://harveycastromd.substack.com/ [https://harveycastromd.substack.com/] Edward Marx, CEO, Advisor 💼LinkedIn - https://www.linkedin.com/in/edwardmarx/ [https://www.linkedin.com/in/edwardmarx/] 🔗Website - https://www.marxadvisory.com/ [https://www.marxadvisory.com/] 📹YouTube - https://www.youtube.com/@EdwardMarx [https://www.youtube.com/@EdwardMarx] Visit our website: https://signalandsymptoms.com/ [https://signalandsymptoms.com/] Get advisory insights about Healthcare AI — at zero cost: https://junaidkaliamd.substack.com/ [https://junaidkaliamd.substack.com/]