Pediheart: Pediatric Cardiology Today

Pediheart Podcast #388: The Proteomic Signature Of The Adult Fontan Patient

38 min · 10 de jul de 2026
Portada del episodio Pediheart Podcast #388: The Proteomic Signature Of The Adult Fontan Patient

Descripción

This week we delve again into the world of adult congenital heart disease and specifically the realm of biomarkers when we review a recent report of the proteomics of the adult Fontan patient. What is proteomics and how can this inform our understanding of the pathophysiology and adaptive pathways of the Fontan circulation? Are there meaningful differences in the patterns of protein expression between the adult Fontan patient and control 2 ventricle subjects? What might account for differences and how can we understand these differences to explain outcomes in the Fontan adult patient? We speak with the first and senior authors of this week's work, Professor Alexander Opotowsky of the University of Cincinnati and Mr. Ismael Assi who is a Sarnoff Fellow and soon to be 4th year medical student at the University of Cincinnati.  * DOI: 10.1016/j.jacadv.2026.102810 [https://doi.org/10.1016/j.jacadv.2026.102810]

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591 episodios

Portada del episodio Pediheart Podcast #391: The "Lone Pines" Of Congenital Cardiology - An Inspiring Tale Of Progress

Pediheart Podcast #391: The "Lone Pines" Of Congenital Cardiology - An Inspiring Tale Of Progress

This week we review a recent book entitled Reimagining a Child’s Heart: The Lone Pines of Congenital Cardiology which was recently published by Springer and which was authored by Dr. Thomas J. Kulik and Dr. Macdonald Dick. Drs. Kulik and Dick recount the innumerable steps in discovery that led to what the authors view as one of the pinnacles of achievement in our field, namely the palliation of children with HLHS and single ventricle disease. Dr. Kulik tragically passed suddenly in 2021 but his friend and colleague Dr. Dick completed the book that Dr. Kulik had spent over a decade toiling over. This week we sit down with Dr. Dick and also, briefly, Dr. Roberta Williams and Dr. Kulik's wife Ms. Linda Kulik to discuss the book, Dr. Kulik's legacy, mentorship and more. Dr. Dick also shares with us what he believes are the keys to a successful retirement. This is a rare opportunity to listen to some of the truest pioneers of our field, 'Lone Pines" themselves share their insights and warm stories.  For those interested, this is one of many sites to obtain the book: https://www.amazon.com/dp/3031886070?lv=shuf&channelId=500&plpRedirect=mhFallback Also mentioned in this episode are 2 prior episodes including our conversation with Dr. Michael Freed and our conversation with Ms. Patricia Meisol and links are below: https://podcasts.apple.com/us/podcast/pediheart-podcast-203-a-conversation-with-dr-michael-freed/id1341472214?i=1000556610155 https://podcasts.apple.com/us/podcast/pediheart-podcast-320-the-extraordinary-life/id1341472214?i=1000677938143

31 de jul de 20261 h 10 min
Portada del episodio Pediheart Podcast #390: Minimally Invasive Cardiac Surgery In Children

Pediheart Podcast #390: Minimally Invasive Cardiac Surgery In Children

This week we discuss a recent report from the team at SickKids in Toronto on minimally invasive cardiac surgery. What sorts of operations are most common for this approach? Why are length of ICU and length of hospitalization periods lower in this surgical cohort than more traditional midline sternotomy approaches? How does one train a surgeon to perform these operations if the surgical exposure is so small, allowing only the priimary surgeon to see the majority of the surgery? What are the limits of this sort of surgical approach? These are amongst the questions posed to the first author of this work, Associate Professor of Surgery at University of Toronto, Dr. Christoph Haller.  * DOI: 10.1016/j.jtcvs.2025.12.009 [https://doi.org/10.1016/j.jtcvs.2025.12.009]

24 de jul de 202637 min
Portada del episodio Pediheart Podcast #388: The Proteomic Signature Of The Adult Fontan Patient

Pediheart Podcast #388: The Proteomic Signature Of The Adult Fontan Patient

This week we delve again into the world of adult congenital heart disease and specifically the realm of biomarkers when we review a recent report of the proteomics of the adult Fontan patient. What is proteomics and how can this inform our understanding of the pathophysiology and adaptive pathways of the Fontan circulation? Are there meaningful differences in the patterns of protein expression between the adult Fontan patient and control 2 ventricle subjects? What might account for differences and how can we understand these differences to explain outcomes in the Fontan adult patient? We speak with the first and senior authors of this week's work, Professor Alexander Opotowsky of the University of Cincinnati and Mr. Ismael Assi who is a Sarnoff Fellow and soon to be 4th year medical student at the University of Cincinnati.  * DOI: 10.1016/j.jacadv.2026.102810 [https://doi.org/10.1016/j.jacadv.2026.102810]

10 de jul de 202638 min
Portada del episodio Pediheart Podcast #387: A Conversation With Professor Rica Arnon

Pediheart Podcast #387: A Conversation With Professor Rica Arnon

This week we speak with a true pioneer in pediatric cardiology, Professor Rica Arnon of Mount Sinai in NYC. Dr. Arnon's career has spanned from the mid 1970's right up to the present time where she is still working as a cardiology consultant and educator at Mount Sinai in Pediatrics after more than 50 years. In this episode we learn the travails of a pioneering women in medicine/cardiology as Dr. Arnon shares with us the challenges and triumphs of a career that balanced outstanding clinical excellence with a rich family life. Why did she travel from Israel to the US to train? How did she choose to become a pediatric cardiologist and who were her mentors? What makes a good teacher of cardiology for young learners? What advice can this master of cardiology provide regarding 'balance' in a clinically active life when one is also devoted to their family? What is better in our field today and what does Dr. Arnon believe may have been lost along the way? Dr. Arnon tells it to us 'straight' in a delightful conversation with a master clinician and teacher.  A conversation with Dr. Michael Freed: https://podcasts.apple.com/us/podcast/pediheart-podcast-replay-of-203-a-conversation/id1341472214?i=1000681074493 [https://tel] A conversation with Dr. Welton Gersony: https://podcasts.apple.com/us/podcast/pediheart-podcast-247-a-conversation-with-living/id1341472214?i=1000607813461 [https://tel]

3 de jul de 202646 min