The IVF Test That Could Finally Explain Your Failed Transfers with Jeremy Grushcow of Juniper Genomics

The IVF Test That Could Finally Explain Your Failed Transfers with Jeremy Grushcow of Juniper Genomics

If you've ever gone through a failed embryo transfer and wondered why , this episode is for you. Dr. Sasha sits down with Jeremy Grushcow, co-founder and CEO of Juniper Genomics, to break down a groundbreaking advancement in IVF: whole genome and transcriptome embryo testing. Jeremy holds a PhD in molecular genetics and cell biology from the University of Chicago, along with a law degree, and has published research in DNA repair, cancer, gene therapy, bioethics, and patent law. He's building the technology that could change the odds for IVF patients everywhere. In this episode, we cover: * What whole genome sequencing actually is — and why IVF has lagged behind every other field of clinical medicine in adopting it * The brilliant "books on a shelf" analogy that finally makes PGT-A vs. whole genome sequencing click * Why failed embryo transfers are not your fault, your doctor's fault, or your lab's fault — and what the embryo's genetics have to do with it * What the transcriptome tells us that the genome alone can't * The difference between PGT-A, PGT-M, and Juniper's PGT-G testing * How Juniper looks at both the embryo and the parents' DNA to identify where variants are coming from (egg or sperm?) * The 6,000+ known genetic diseases — and why 10–15% of embryos being transferred today carry a detectable single-gene disorder that standard carrier screening missed * Why "reduced viability variants" matter and how they impact IVF success rates * The emotional and financial cost of failed transfers — and how more information can reduce both * Pricing breakdown: what Juniper's PGT-A and PGT-G costs, how to make it more affordable, and how it stacks up against the cost of a failed transfer cycle * Why patient autonomy in the US and Canada is driving better IVF outcomes globally Follow Dr Sasha! TikTok: @sashahakmanmd Instagram: @sashahakmanmd @tryingwithdrhakman YouTube: @sashahakmanmd Resources & Links: Juniper Genomics website: junipergenomics.com [http://junipergenomics.com] Instagram: ⁠@junipergenomics⁠ [https://www.instagram.com/junipergenomics] Want to receive my weekly newsletter? Sign up at sashahakmanmd.com/newsletter [https://sashahakmanmd.com/newsletter] to receive updates, answers to Q&A and more !If you haven't already, please rate, review, and follow the podcast to be notified of new episodes every 2 weeks. If you're interested in becoming a patient go to sashahakmanmd.com [https://sashahakmanmd.com] to learn more! If this episode helped you, the best thing you can do is subscribe, rate, review, and share it with a friend. So many women deserve this information, help get it to them. Episodes drop every Wednesday. Learn more about your ad choices. Visit megaphone.fm/adchoices [https://megaphone.fm/adchoices]

Trying with Dr. Sasha Hakman Trailer

Trying with Dr. Sasha Hakman is a women's health podcast hosted by a reproductive endocrinologist, covering everything from fertility and IVF to perimenopause, endometriosis, and hormonal health, all in plain, evidence-based language. No jargon, no shame, just the answers you've been searching for. Learn more about your ad choices. Visit megaphone.fm/adchoices [https://megaphone.fm/adchoices]

Your Doctor Is Wrong About Exercise: What a Doctor of Physical Therapy Wants You to Know

Are you being told to stop exercising while trying to conceive or going through IVF? You're not alone and according to today's guest, you're also likely being given advice that isn't backed by science. In this episode, Dr. Shannon joins us for a conversation that is equal parts empowering and eye-opening. As both a physical therapist and a patient who exercised throughout her own fertility journey, she brings a rare dual perspective to the table. She and host Dr. Sasha take on the pervasive fear around exercise during fertility treatment, break down why the "rest and raise your legs" mentality is outdated (and potentially harmful), and share a practical, research-backed framework for building and maintaining muscle at every stage of the journey. Whether you're in the thick of fertility treatments, newly pregnant, postpartum, or just trying to understand your body better, this episode is packed with actionable guidance and a refreshing dose of truth. In This Episode, You'll Learn: * Why most doctors tell patients to stop exercising during IVF — and why there's no evidence behind it * How months of exercise restriction can harm your long-term recovery and postpartum body * The REPS Framework: the four principles that actually build muscle while TTC or pregnant * What "training to failure" really means — and why it's safe even during fertility treatment * Why you need to train near failure just to maintain the muscle you already have * How to choose exercises that actually target the right muscles (and why combo moves fall short) * Protein targets for TTC and pregnancy, and how to realistically hit them * When HIIT is okay to keep during TTC — and when it may be hurting your chances * How to safely return to exercise postpartum without setting yourself back * One simple trick to improve your form without a personal trainer Follow Dr. Shannon@dr.shannon.dpt @evlofitness  Follow Dr Sasha!TikTok: @sashahakmanmdInstagram: @sashahakmanmd @tryingtoconceivepodYouTube: @tryingtoconceivepod Resources Mentioned: Evlo App (Dr. Shannon's fitness app) — Use code DRSASHA for 6 weeks free (first 2-week trial + 1 month at $0) American College of Obstetricians and Gynecologists (ACOG) — exercise contraindications list available on their website Want to receive my weekly newsletter? Sign up at sashahakmanmd.com/newsletter [sashahakmanmd.com/newsletter%20]to receive updates, answers to Q&A and more!If you haven't already, please rate, review, and follow the podcast to be notified of new episodes every 2 weeks. If you're interested in becoming a patient go to sashahakmanmd.com [sashahakmanmd.com] to learn more! New episodes of Trying to Conceive with Dr. Sasha Hakman drop weekly. If this episode resonated with you, leave a review and share it with someone on their fertility journey. Learn more about your ad choices. Visit megaphone.fm/adchoices [https://megaphone.fm/adchoices]

The Truth About Women's Health, Medical Misinformation, and Advocating for Yourself

What does it actually mean to try as a woman, as a patient, as a person navigating a healthcare system that wasn't built with you in mind? In this first solo episode of the newly rebranded Trying with Dr. Sasha Hakman, Dr. Sasha shares why she changed the name, what this podcast is really about, and who it's for. She opens up about the conversation that sparked the rebrand, the reality of practicing medicine in a field driven by IVF incentives, and why she started a podcast in the first place. She also shares a personal update (18 weeks pregnant with baby #3!) and answers one of the most frequently asked questions from her community: how do you know if you can actually trust your doctor? In This Episode, You'll Learn: * Why Dr. Sasha rebranded from Trying to Conceive to Trying with Dr. Sasha Hakman * What a Reproductive Endocrinologist actually specializes in beyond IVF * How to know if your doctor's IVF recommendation is truly evidence-based or financially motivated * The green flags to look for when choosing a fertility doctor or clinic * How to read online reviews and pregnancy success rates without being misled * What actually makes an exceptional doctor Follow Dr. Sasha!  TikTok: @sashahakmanmd  Instagram: @sashahakmanmd @tryingpod  YouTube: @sashahakmanmd Want to receive my weekly newsletter? Sign up at sashahakmanmd.com/newsletter for updates, Q&A answers and more! If you haven't already, please rate, review, and follow the podcast to be notified of new episodes every week. If you're interested in becoming a patient go to sashahakmanmd.com to learn more! Thank you to our sponsors! head to http://www.bioptimizers.com/DRSASHA [http://www.bioptimizers.com/DRSASHA] and use my exclusive code DRSASHA to get 15% off any order Use our exclusive link to save 20% off Honeylove at honeylove.com/DRSASHA [honeylove.com/DRSASHA] Go to ogee.com/DRSASHA [ogee.com/DRSASHA] and use code DRSASHA for 20% off. New episodes of Trying with Dr. Sasha Hakman drop weekly. If this episode resonated with you, leave a review and share it with someone who needs a doctor they can trust in their corner. Learn more about your ad choices. Visit megaphone.fm/adchoices [https://megaphone.fm/adchoices]

A Reproductive Endocrinologist's Guide to Protecting Your Hormones

In this solo episode, Dr. Sasha goes deep on one of her most-requested topics: endocrine disrupting chemicals (EDCs). What they are, where they're hiding, how they affect your hormones and fertility, and exactly what you can do about it. As a reproductive endocrinologist and infertility specialist, she brings both clinical expertise and personal practice to this conversation. This episode is grounded in evidence-based research, including a 136-page scientific statement from the Endocrine Society, and is designed to inform, not alarm. In This Episode, You'll Learn: * What the endocrine system is and why hormones are the body's "keys and locks" * The definition of EDCs and why exposure is considered a global public health crisis * Why even tiny exposures can have outsized health impacts (it's not always dose-dependent) * The major classes of EDCs to know: BPA/bisphenols, phthalates, PFAS (forever chemicals), parabens, glyphosate, heavy metals, and triclosan and where each one hides * The 4 mechanisms EDCs use to disrupt your hormones - including epigenetic modification that can be passed down through generations * Why in utero exposure is the most critical window, and what effects have been linked to fetal EDC exposure (including hypospadias, cryptorchidism, diminished egg reserve, and premature ovarian insufficiency) * How EDC exposure impacts puberty, fertility, and the TTC window specifically - including the finding that phthalate metabolites were detected in the follicular fluid of 99% of women undergoing egg retrieval * The link between EDC exposure and sperm count decline (down 50% in 50 years, per Dr. Shanna Swan's research) * Health risks in adulthood: endometriosis, PCOS/PEMOS, diminished ovarian reserve, thyroid dysfunction, breast cancer, prostate cancer, and more * The Tier 1 vs. Tier 2 framework for prioritizing what to eliminate first * Why "BPA-free" is a marketing gimmick and what to look for instead * Why "unscented" ≠ fragrance-free - and what that means for your products * Why fragrance is banned entirely in IVF embryology labs (and what that tells us) * A study showing BPA urinary levels drop significantly after just 3 days of cutting out heated plastic Follow Dr Sasha! TikTok: @sashahakmanmd Instagram: @sashahakmanmd @tryingtoconceivepodYouTube: @tryingtoconceivepod Want to receive my weekly newsletter? Sign up at sashahakmanmd.com/newsletter to receive updates, answers to Q&A and more! If you haven't already, please rate, review, and follow the podcast to be notified of new episodes every 2 weeks. Thank you to our sponsors!  Head to AirDoctorPro.com [AirDoctorPro.com] and use promo code DRSASHA to get $250 off select AirDoctor air purifiers. Head to cozyearth.com [http://cozyearth.com] and use my code DRSASHA for an exclusive 20% discount. New episodes of Trying to Conceive with Dr. Sasha Hakman drop weekly. If this episode resonated with you, leave a review and share it with someone on their fertility journey. Learn more about your ad choices. Visit megaphone.fm/adchoices [https://megaphone.fm/adchoices]