The Zero100 Podcast

Is SynBio Manufacturing's Next Frontier?

Synthetic biology promises to revolutionize manufacturing, growing materials in fermentation tanks instead of relying on traditional industrial or agricultural sources. But can it scale? Zero100 Chief Content Officer Matt Davis sits down with Mathias Cousin, Managing Director at Monitor Deloitte and a SynBio veteran, to find out. Mathias reveals why manufacturing economics, not science, determines who survives, how AI is compressing design cycles from years to months, and why the biggest breakthroughs may come from replacing cows, not crude oil. With real-world examples, he shows what supply chain leaders need to understand as biological manufacturing moves from the lab to industrial reality.

What Will Humans Do When 60% of Work Is Automated?

Zero100 predicts that by 2030, 60% of supply chain’s functional activities will shift to automated or autonomous execution. But what happens to the workers in that equation? This week on the podcast, Zero100’s Matt Davis, Caroline Chumakov, and Lauren Acoba deliver the honest answer. Drawing from analyses of 413 solution providers and over a million job descriptions, they reveal how the division of labor is already shifting, explore and what work will remain distinctly human as data tasks move to automation and strategic judgment, supplier relationships, and systems thinking become the competitive advantage. With examples from BMW’s frontline upskilling programs and Fortune 100 adoption strategies, they show how winning companies bring entire workforces along this journey.

Breaking Free from AI Pilot Purgatory with PowerThreads

“If one more person brings me another pilot, they're getting fired," one C-level supply chain executive told Zero100 — and they’re far from alone in their frustration. Most companies are drowning in AI projects that never scale because they’re optimizing functions in isolation while ignoring how decisions actually flow across the business. The solution? PowerThreads: end-to-end AI-enabled workflows that connect sensing, deciding, and acting across organizational silos. This week, VPs, Research & Advisory Lauren Acoba, Jenna Fink, and Geraint John break down the five core PowerThreads driving 95% of enterprise value, share a $300M sourcing transformation that required five years of unglamorous foundation-building, and explain why optimizing one bottleneck without understanding the full system often just moves the problem downstream.

The Great Planning-Sourcing Standoff (And How to End It)

Planning and sourcing should be natural partners. So why does it so often feel like they’re working out of sync? This week, VPs, Research Kelly Coutinho and Geraint John dissect the disconnect – and, more importantly, how to bridge it. They share how leading companies are turning functional friction into competitive advantage by using AI to translate demand signals into sourcing actions, creating continuous planning rhythms that keep both teams aligned, and building cross-functional crisis protocols built to survive disruption.

Global Capability Centers: What to Move, Where to Invest, and How to Build Trust

Target's running a quarter of HQ operations remotely. Unilever's outsourcing demand planning to seven global hubs. Lowe's manages North American inventory from thousands of miles away. Today's Global Capability Centers have evolved far beyond back-office support – they're making the calls that drive your business. But without trust, governance, and the right talent strategy, they'll never live up to their potential. This week, Caroline Chumakov and Geraint John (VPs, Research & Advisory) and Justin Gillebo (Senior Director, Research & Advisory) break down what actually belongs in a GCC, why India isn't the only answer, and how to avoid the “us vs them" trap that hinders most implementations.