The Critical Role of Clinical Evidence and Primary Care – with Special Guest Dr. Lisa Rosenbaum

The Critical Role of Clinical Evidence and Primary Care – with Special Guest Dr. Lisa Rosenbaum

Join host Dr. Roy Ziegelstein as he speaks with Dr. Lisa Rosenbaum, cardiologist at Brigham and Women's Hospital, assistant professor at Harvard Medical School and national correspondent for The New England Journal of Medicine. Lisa, who also hosts the NEJM podcast Not Otherwise Specified, joins the conversation to explore how patient trust is formed and tested in today's technology-driven healthcare system. Together, they examine why trust remains central to care, how it is being reshaped by modern clinical practice and what it takes for physicians to maintain meaningful connections with patients amid growing complexity. Roy reflects on the growing importance of stronger evidence standards and human oversight as AI becomes more deeply integrated into healthcare decision-making. He emphasizes the need for transparent, rigorously validated clinical tools before they are deployed at scale. The episode also explores emerging research in cardiovascular care, including advances in GLP-1 therapies, as well as studies investigating whether the brain continues to process language and sound during unconscious states. Thank you for taking the time to listen. If you enjoyed this episode, please like and subscribe to be notified when new episodes release the first Tuesday of every month. Resources: * CHAI Governance Playbook [https://www.chai.org/news/coalition-for-health-ai-chai-releases-comprehensive-governance-playbooks-to] [1:49] * NEJM: Rosiglitazone — Continued Uncertainty about Safety [https://www.nejm.org/doi/full/10.1056/NEJMe078118] [3:24] * ASCO: GLP-1s May Reduce Metastatic Progression of Certain Obesity-Related Cancers [https://www.asco.org/about-asco/press-center/glp-may-reduce-metastatic-progression] [4:30] * Nature: Even the unconscious brain can learn — and predict what you'll say next [https://www.nature.com/articles/d41586-026-01465-0] [7:51] * NEJM: Is a Long-Simmering Crisis Boiling Over? U.S. Primary Care Today [https://www.nejm.org/doi/full/10.1056/NEJMms2510425] [15:45] * NEJM: Can AI Solve Primary Care? [https://not-otherwise-specified-podcast.nejm.org/e/can-ai-solve-primary-care/] [23:49] * Follow Dr. Roy Ziegelstein on LinkedIn [https://www.linkedin.com/in/roy-ziegelstein-md-macp-703ba238b/]. * Follow Dr. Lisa Rosenbaum on LinkedIn [https://www.linkedin.com/in/lisa-rosenbaum-08886911/]. Host: Dr. Roy Ziegelstein Guest: Dr. Lisa Rosenbaum Original music: Dr. Brian Garibaldi

Staying Human in Modern Medicine – with Special Guest Dr. Danielle Ofri

Join host Dr. Roy Ziegelstein as he welcomes Dr. Danielle Ofri, physician, author and professor, to discuss the evolving relationship between patients and physicians in an increasingly technology-driven healthcare system. Danielle is a primary care internist at Bellevue Hospital, clinical professor of medicine at NYU and an acclaimed writer whose work explores empathy, trust and humanism in medicine. Their conversation dives into how technology can both support and complicate patient care, as well as the importance of preserving compassion and connection in modern medicine. The episode covers Roy's point of view on recent research surrounding the growing role of AI and technology in healthcare, including a Lancet report that uncovered thousands of fabricated references in scientific papers and COVID-19 research published in The New England Journal of Medicine. Roy also introduces a new "Hot Takes" segment exploring AI's expanding role in everyday life and education. Thank you for taking the time to listen. If you enjoyed this episode, please like and subscribe to be notified when new episodes release the first Tuesday of every month. Resources: * The Lancet Article on Fabricated Citations [https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(26)00603-3/fulltext] [1:23] * NEJM Covid-19 Prophylaxis Study [https://www.nejm.org/doi/full/10.1056/NEJMoa2509306] [5:25] * Empathy in the age of the electronic medical record [https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)32036-7/abstract] by Dr. Danielle Ofri [27:06] * Bellevue Literary Review [https://blreview.org/] [33:34] * Follow Dr. Roy Ziegelstein on LinkedIn [https://www.linkedin.com/in/roy-ziegelstein-md-macp-703ba238b/]. * Follow Dr. Danielle Ofri on LinkedIn [https://www.linkedin.com/in/danielle-ofri/]. Host: Dr. Roy Ziegelstein Guest: Dr. Danielle Ofri Original music: Dr. Brian Garibaldi

Medicine as Public Trust - with Special Guest Dr. David Hellmann

On this episode, host Dr. Roy Ziegelstein welcomes Dr. David Hellmann, a prominent clinician and medical educator, to discuss innovation in medicine, the evolution of medical education, and patient trust. David is a rheumatologist at Johns Hopkins, distinguished teacher, and director of Johns Hopkins Center for Innovative Medicine, which promotes patient-centered care through the creative collaboration of research, teaching, and patient care programs. Their conversation dives into how technology affects medicine as a public trust and knowing the patient as a person. In the episode, Roy shares recent research that underscores the importance of expertly validated content in the medical field as well as the impact of AI scribes on healthcare costs and care delivery in the long run. Roy also explores the role nutrition plays in medical education – a topic he is particularly passionate about. Thank you for taking the time to listen. If you enjoyed this episode, please like and subscribe to be notified when new episodes release the first Tuesday of every month. Resources: * British Medical Journal Retraction Notice [https://jmg.bmj.com/content/early/2026/04/12/jmg-2026-56-1-2019ret] [1:10] * Ambient AI Scribe Article [https://www.statnews.com/2026/04/08/insurers-providers-agree-ai-scribes-raise-health-care-costs/] [4:05] * Follow Dr. Roy Ziegelstein on LinkedIn [https://www.linkedin.com/in/roy-ziegelstein-md-macp-703ba238b/]. Host: Dr. Roy Ziegelstein Guest: Dr. David Hellmann Original music: Dr. Brian Garibaldi

The Role of Clinicians Before & After AI - with Special Guest Dr. Steven Lin

In this episode, host Dr. Roy Ziegelstein is joined by globally renowned expert, Dr. Steven Lin, for a conversation about how AI is impacting clinical practice. Steve is a practicing family physician, a Clinical Professor of Medicine and Chief of General Primary Care at Stanford University School of Medicine, and the Founding Director of the Stanford Healthcare AI Applied Research Team. Together, Roy and Steve discuss the role of physicians before AI, the role of physicians with AI, as well as AI and trust. In the episode, Roy continues the theme of AI, sharing recent research about how it's being used by physicians and other clinicians, warnings about the potential for misdiagnosis and overuse, the public perception of AI and its impact on patient trust. He also shares a personal example of how he uses AI clinical decision support as a cardiologist. Thank you for taking the time to listen. If you enjoyed this episode, please like and subscribe to be notified when new episodes release the first Tuesday of every month. Resources: * AMA 2026 Physician Survey on Augmented Intelligence [https://www.ama-assn.org/system/files/physician-ai-sentiment-report.pdf] [01:09] * EBSCO Clinical Decisions Report: The Clinician-Patient Trust Dynamic in the Era of AI-Powered Clinical Decision Support (AI-CDS) [https://more.ebsco.com/2026-AI-CDS-Report.html] [1:30] * AHA & ACC Guideline on the Management of Blood Cholesterol [https://www.ahajournals.org/doi/10.1161/CIR.0000000000001423] [04:10] * ECRI Top 10 Patient Safety Concerns 2026 [https://home.ecri.org/blogs/ecri-thought-leadership-resources/top-10-patient-safety-concerns-2026] [05:56] * Follow Dr. Roy Ziegelstein on LinkedIn [https://www.linkedin.com/in/roy-ziegelstein-md-macp-703ba238b/]. * Follow Dr. Steven Lin on LinkedIn [https://www.linkedin.com/in/steven-lin-md/]. Host: Dr. Roy Ziegelstein Guest: Dr. Steven Lin Original music: Dr. Brian Garibaldi

Technology and the Future of Bedside Medicine - with Special Guest Dr. Brian Garibaldi

In the inaugural episode of Coeur de Roy - the Heart of Clinical Care, host Dr. Roy Ziegelstein is joined by special guest, Dr. Brian Garibaldi, Professor of Medicine at Northwestern University's Feinberg School of Medicine and Director of the Northwestern Center for Bedside Medicine, for a conversation about technology and the future of bedside medicine. Roy also spends time discussing recent studies and reports that caught his eye, outlines the implications of technology (specifically AI) in clinical practice, and provides perspective on the delicate nature of patient trust. Thank you for taking the time to listen. If you enjoyed this episode, please like and subscribe to be notified when new episodes release the first week of every month. Resources: Journal of the American Medical Association (JAMA): Coffee and Tea Intake, Dementia Risk, and Cognitive Function [https://jamanetwork.com/journals/jama/article-abstract/2844764] [02:05] The American Heart Association's 2026 Heart Disease and Stroke Statistics Report [https://www.ahajournals.org/doi/10.1161/CIR.0000000000001412] [03:24] JAMA study: Impact of a Smartwatch Hypertension Notification Feature for Population Screening [https://jamanetwork.com/journals/jama/article-abstract/2844767] [04:49] From the Desk of Dr. Z: What's the "Walter Cronkite" of Clinical Decision Support? [https://about.ebsco.com/blogs/health-notes/whats-walter-cronkite-clinical-decision-support] Follow Dr. Roy Ziegelstein on LinkedIn [https://www.linkedin.com/in/roy-ziegelstein-md-macp-703ba238b/]. Follow Dr. Brian Garibaldi on LinkedIn [https://www.linkedin.com/in/brian-garibaldi-3b9619164/]. Host: Dr. Roy Ziegelstein Guest: Dr. Brian Garibaldi Original music: Dr. Brian Garibaldi