Finding Strength: The Spaulding Rehabilitation Podcast
Featuring expert perspectives from Drs. Fabrisia Ambrosio and Gabrielle Gilmer, together with Elise Sargent’s first-hand account, this episode integrates current research on menopause biology and knee osteoarthritis with the tangible effects of joint pain in women. This episode examines the often-overlooked relationship between menopause and joint discomfort, highlighting the intersection of biological mechanisms, scientific inquiry, and lived experience in the context of women's osteoarthritis. Fabrisia Ambrosio, PhD is the Atlantic Charter Director of the Discovery Center for Musculoskeletal Recovery at the Schoen Adams Research Institute and an associate professor in the Department of Physical Medicine & Rehabilitation at Harvard Medical School. Her translational research focuses on developing innovative strategies to improve tissue healing and functional recovery by leveraging mechanical signals to enhance endogenous and donor stem cell function following injury or disease. An international leader in regenerative rehabilitation, she directs the NIH-funded Alliance for Regenerative Rehabilitation Research & Training (AR3T) and founded the International Consortium and Annual Symposium on Regenerative Rehabilitation. Gabrielle Gilmer, PhD is a trainee in the MD/PhD program at the University of Pittsburgh School of Medicine with a research focus at the intersection of women’s health and orthopedic surgery. She completed her PhD in 2024 in Dr. Fabrisia Ambrosio’s lab at Spaulding Rehabilitation Hospital, where her doctoral thesis focused on examining how menopause impacts knee osteoarthritis. Her work spans preclinical models to human clinical trials, with a particular emphasis on how sex and gender influence musculoskeletal pathology and outcomes. She has published in high-impact journals on aging, osteoarthritis, and musculoskeletal health and is planning to pursue orthopedic surgery residency this upcoming year. Elise Sargent is a longtime advocate for osteoarthritis, having spent more than three decades navigating life with the condition while remaining highly active as a dancer, golfer, and fitness enthusiast. She brings a patient-centered perspective shaped by her journey of adaptation, self-advocacy, and engagement with the healthcare system, as well as her volunteer leadership with the Arthritis Foundation, including organizing and fundraising for the Boston Walk to Cure Arthritis. Professionally, Elise is a retired software developer and senior engineering leader who now mentors and teaches leadership skills and project management to graduate and PhD students at Northeastern University. Episode Resources Episode Articles & Related Research Menopause-induced 17β-estradiol and progesterone loss increases senescence markers, matrix disassembly and degeneration in mouse cartilage [https://pubmed.ncbi.nlm.nih.gov/39820791/] Advocacy, Education, & Community Organizations * Arthritis Foundation [https://www.arthritis.org/] * Walk [https://events.arthritis.org/wtcabostonma] to Cure Arthritis 2026 – Boston, MA News & Services MGB News Release https://spauldingrehab.org/about/news/study-identifies-mechanism-underlying-increased-osteoarthritis-risk-in-postmenopausal-females [https://spauldingrehab.org/about/news/study-identifies-mechanism-underlying-increased-osteoarthritis-risk-in-postmenopausal-females] If you are interested in one of the articles highlighted on the show, but are having trouble accessing it, please reach out to us at SRNOutcomesCenter@partners.org [SRNOutcomesCenter@partners.org]. Subscribe to Finding Strength Spotify [https://open.spotify.com/show/19uf6qxbqoAZKoqguy9gQ9?si=itVSivxFQzCU2OAaojKe2Q] | iHeartRadio [https://iheart.com/podcast/109124377/] | Apple Podcasts [https://podcasts.apple.com/us/podcast/finding-strength-the-spaulding-rehabilitation-podcast/id1672657817] | Google Podcasts [https://podcasts.google.com/feed/aHR0cHM6Ly9hbmNob3IuZm0vcy9jNjc0ZmI2NC9wb2RjYXN0L3Jzcw] Credits Shonali Gaudino, OT, Host, Producer, Co-Creator Ellyn Pier, MPH, Producer, Co-Host Chuck Clough, Editor Mary Slavin, Executive Producer This production is a collaboration between, and partially funded by, the Rehabilitation Outcomes Center at Spaulding [https://spauldingrehab.org/research/programs-labs/rehabilitation-outcomes-center] and our Model Systems: the Boston-Harvard Burn Injury Model System [https://www.bhbims.org/] (NIDILRR Award #90DPBU0008), the Spaulding-Harvard Traumatic Brain Injury Model System [https://spauldingrehab.org/research/programs-labs/traumatic-brain-injury] (NIDILRR Award #90DPTB0027-01-01), and the Spaulding New England Regional Spinal Cord Injury Model System Center [https://www.snerscic.org/] (NIDILRR Award #90SIM0017-01-00).
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