Irish Thoracic Society Podcast Productions
In this episode, with Professor Edward McKone, we dive deep into the essentials of cystic fibrosis, exploring its underlying mechanisms, diagnostic challenges, and the revolutionary impact of CFTR modulators. Led by expert insights, this discussion highlights how evolving treatments are transforming patient outcomes and what lies ahead in CF care. In this episode - The genetics and pathophysiology of CF, including CFTR function and the impact on lungs and other organs - Advances in diagnosis, especially the role of newborn screening, sweat tests, and genetic sequencing - How CFTR modulators are changing the management landscape and their long-term effects - The future of CF treatment: reducing treatment burden and personalised medicine - The importance of holistic, multidisciplinary care and transition from paediatric to adult services Guest Professor Edward McKone is a leading respiratory physician and clinical professor based in Dublin, specialising in cystic fibrosis and respiratory disease. As a Consultant at St. Vincent’s University Hospital, he works at Ireland’s National Referral Centre for Adult Cystic Fibrosis, combining frontline care with clinical trials research. He has played a pivotal role in advancing cystic fibrosis treatment both in Ireland and internationally, including leadership roles with the Cystic Fibrosis Registry of Ireland and the European CF Registry. Alongside his clinical and research work, Professor McKone is deeply committed to medical education, currently serving as Dean of the Institute of Medicine and Co-Director of the Irish Clinician Educator Track. Hosts Email: edofficer@irishthoracicsociety.com Dr Barry Harnedy is a respiratory specialist trainee in Ireland. He graduated from National University of Ireland Galway. He is the current Irish Thoracic Society co Educational Officer. He is passionate about digital innovation and airways assessment. Sandra Green is an Irish-trained respiratory fellow with a strong track record in climate advocacy and multidisciplinary sustainable initiatives, as co-founder of Irish Doctors for the Environment. She has an MSc in Leadership and Innovation in Healthcare at the Royal College of Surgeons Ireland (2023–2025). With Marisssa, she co-founded the Irish Thoracic Society Podcast Productions, launching the platform in 2024 to share knowledge, insights, and innovations in respiratory care. LinkdIn - linkedin.com/in/dr-sandra-green-2a9536199 [linkedin.com/in/dr-sandra-green-2a9536199] Chapters 0:00 - Introduction 0:30 - Rapid Fire Round on cystic fibrosis. 6:02 - Cystic Fibrosis Pathophysiology 9:20 - Discussion on newborn screening and diagnostic steps. 11: 42 - Sweat test procedure 13:37 - Milder cases in adulthood and associated symptoms. 15:29 - CF in non-Caucasian populations and genetic testing. 17:25 - Referral to CF Centres 18.25 – Transition from Paediatric to Adult Care 22:13 - Overview of the mainstays of management and treatment within CF. 26:16 - Impact of CFTR Modulators 31:28 - The future challenges and management of aging CF patients. 38:57 - How socioeconomic status impacts CF outcomes in the era of modulators. 41:43 - Key message for clinicians and patients. 42:56 - Episode wrap-up and acknowledgments. Resource Links 1. Irish Cystic Fibrosis Society Website [https://www.cfireland.ie/] 2. Newborn Screening Information 3. Cystic Fibrosis Foundation [https://www.cff.org/] 4. European Cystic Fibrosis Society [https://www.ecfs.eu/] 5. Genetic Testing for CF [https://www.ncbi.nlm.nih.gov/gtr/] 6. CFTR Modulators Information [https://www.cff.org/managing-cf/cftr-modulators] 7. Transitioning from Pediatric to Adult Care
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