PCOS: The Hidden Hormone Disorder Affecting More Women Than You Think

Ozone Therapy Explained: Immune Support, Infections, Pain, Wound Healing & Biohacking

In this episode, Dr. Gentry is joined again by physician assistant Alexis Clark from Rejuvenated Medical Spa and Maverick Male Medical for a deep dive into one of the more science-heavy topics in functional and regenerative medicine: ozone therapy. They start by explaining why ozone can be confusing. Most people hear “ozone” and think about the ozone layer or pollution, but medical ozone is used differently and has a long history in medicine, wound care, water purification, and disinfection. Dr. Gentry walks through the history of ozone, including its discovery in the 1700s, its use in water treatment, Nikola Tesla’s patented ozone generator, and its early use in wound care during wartime. The conversation then breaks down the three major ways ozone may work in the body: direct antimicrobial effects, immune modulation, and hormetic stress. Dr. Gentry and Alexis compare ozone to other controlled stressors like exercise, sauna, cold therapy, and high-dose vitamin C. The idea is that a controlled oxidative stress may stimulate the body’s own repair, immune, and antioxidant systems. They also discuss how ozone is used clinically, especially through major autohemotherapy, where blood is drawn, mixed with ozone, and infused back into the patient. Other forms mentioned include ozonated water, ear insufflation, rectal ozone, vaginal ozone, and potential joint applications. A major safety point in the episode: ozone should never be inhaled directly into the lungs. Dr. Gentry and Alexis make it clear that while ozone can have clinical applications when used properly, breathing ozone can be toxic and may cause symptoms like headaches or lung irritation. This is especially important for people considering at-home ozone generators. The episode also explores the potential use of ozone therapy for acute infections, mold toxicity, chronic Epstein-Barr virus, long COVID-type symptoms, wound healing, arthritis, back pain, myofascial pain, insomnia, and general biohacking or anti-aging support. Dr. Gentry shares his own experience using IV ozone after testing positive for COVID and discusses patient cases where ozone was used during lingering respiratory illness. They close by talking through possible treatment protocols, including more frequent sessions for acute illness, weekly sessions for chronic issues, and monthly sessions for people using ozone more as a hormetic stressor or wellness tool. * What ozone therapy is and why it is misunderstood * The difference between environmental ozone and medical ozone * Why ozone is more common in some countries outside the United States * The history of ozone in medicine, water purification, and wound care * Why ozone therapy is difficult to advertise and research * The role of Nikola Tesla in ozone generator development * Ozone as an antimicrobial tool * How ozone may affect bacteria, viruses, and fungi * Immune modulation and immune activation * Ozone as a hormetic stressor * Similarities between ozone, sauna, cold exposure, exercise, and high-dose vitamin C * Glutathione, antioxidants, and heat shock proteins * Major autohemotherapy explained * Ozonated saline, ozonated water, ear ozone, rectal ozone, and joint applications * Why ozone should not be inhaled * Potential applications for acute infections * Ozone and chronic Epstein-Barr virus * Mold toxicity and ozone therapy * Pain, arthritis, back pain, and wound healing discussions * Potential use in skin ulcers and diabetic wound support * Suggested protocols for acute vs. chronic concerns * At-home ozone cautions and the importance of medical guidance

Weight Loss FAQs: Diet, GLP-1s, Protein, Strength Training & Sustainable Results

In this episode, Dr. Gentry is joined by co-host Alexis Clark, physician assistant from Rejuvenated Medical Spa and Maverick Men’s Health, for a rapid-fire FAQ episode focused on weight loss, GLP-1 medications, nutrition, exercise, and long-term metabolic health. They start with one of the biggest questions patients ask: is diet or exercise more important for weight loss? The answer is both, but diet takes the lead. You can’t outwork a bad diet, and weight loss is not just about eating less. It is about eating better, getting enough protein, fiber, healthy fats, and building habits that actually last. The conversation also covers the role of cheat meals and why an 80/20 or 85% consistency approach is often more realistic than trying to be perfect. Dr. Gentry and Alexis explain that one off-plan meal does not ruin progress, but letting a cheat meal become a cheat day or cheat weekend can. Sleep gets a major spotlight as a missing piece in weight loss. They discuss how poor sleep can increase cravings, raise cortisol, affect blood sugar, and lead people to eat significantly more during the day. For most people, seven to nine hours of quality sleep is the target. The episode also breaks down realistic weight loss goals. For most patients, they recommend aiming for roughly three to five pounds per month, though someone with a larger amount of weight to lose may safely lose more. They stress that weight loss is not linear and that body composition matters more than the number on the scale. Dr. Gentry and Alexis also tackle common nutrition myths, including whether carbs make you fat and whether you should cut fat to lose fat. Their answer: carbs and fats are not the enemy. The real issue is the quality, quantity, and context. Whole-food carbs like potatoes, rice, fruits, and vegetables can absolutely fit into a healthy plan, while healthy fats are important for hormones, satiety, brain function, and overall health. Protein and strength training become a major focus, especially for patients using GLP-1 medications. They recommend shooting for around one gram of protein per pound of ideal body weight, especially when strength training. They also warn that GLP-1s can contribute to muscle loss if patients are not eating enough protein and lifting weights. A major concern throughout the episode is the long-term risk of chasing “skinny” without protecting muscle and bone health. Dr. Gentry and Alexis warn that poor GLP-1 management, low protein, and lack of strength training could lead to more muscle loss and osteoporosis issues years down the road. They also discuss cardio, supplements, maintenance dosing for GLP-1s, hormone optimization, peptides, stress management, and what an ideal weight loss plan might look like for a 50-year-old woman wanting to lose 30 pounds over a year. * Diet vs. exercise for weight loss * Why GLP-1s are not a magic wand * Cheat meals and sustainable consistency * Sleep, cortisol, cravings, and weight loss * Realistic monthly weight loss goals * Why daily weighing can mess with your head * Carbs, fats, and common nutrition myths * Protein targets for fat loss and muscle retention * Why strength training is non-negotiable * Muscle loss and osteoporosis concerns with GLP-1 misuse * Cardio vs. strength training * Helpful supplements like protein powder, creatine, berberine, vitamin D, and B vitamins * GLP-1 maintenance and microdosing * Hormone replacement, peptides, and metabolic optimization * Building a realistic one-year weight loss plan Weight loss is not just “eat less and move more.” In this episode, Dr. Gentry and Alexis Clark break down the real foundations of sustainable fat loss: protein, strength training, sleep, hormones, GLP-1s, stress, supplements, and why protecting muscle matters just as much as losing weight.

Low-Dose Naltrexone: The $50 Drug That Could Change Everything

What if a decades-old drug—originally used for addiction—could help with chronic pain, autoimmune disease, and even long COVID? In this episode, we break down low-dose naltrexone (LDN)—a lesser-known treatment gaining traction for its ability to support the immune system, reduce inflammation, and improve overall quality of life. We cover: * The surprising history of naltrexone and how it evolved * How low-dose naltrexone works differently in the body * Conditions it may help with (fibromyalgia, Crohn’s, autoimmune issues, and more) * Why it’s becoming a go-to option for chronic inflammation * Real-world clinical insights, benefits, and limitations With a low cost and minimal side effects, LDN is one of the most interesting tools in modern medicine—and one more people should know about.

Retatrutide Explained: Hype, Risks, and the Truth About the Next Weight Loss Drug

In this episode, Alexis Clark, PA-C, sits down with Dr. Nick to break down one of the most talked-about weight loss drugs right now: Retatrutide. With growing buzz—especially in fitness and bodybuilding circles—they unpack what this “triple agonist” actually is, how it compares to medications like semaglutide and tirzepatide, and whether it lives up to the hype. They cover: * What makes Retatrutide different (and why it’s getting so much attention) * The science behind fat loss, appetite control, and metabolism * Early study results showing up to 24% body weight reduction * Why it’s not FDA-approved yet—and what that means for safety * The real risks of using research peptides or unregulated sources * Common mistakes people make with weight loss medications * Why muscle loss, poor nutrition, and lack of strength training can backfire long-term * How to properly approach fat loss for sustainable, healthy results They also dive into who might benefit from Retatrutide, when it could make sense to switch medications, and why a holistic approach (nutrition, training, hormones) is critical for success. Bottom line: this drug shows serious promise—but it’s not a magic shortcut, and using it incorrectly could do more harm than good.

PCOS: The Hidden Hormone Disorder Affecting More Women Than You Think

PCOS (Polycystic Ovarian Syndrome) is one of the most common—and most overlooked—hormonal conditions affecting women today. In this episode, we break down what PCOS really is, why it’s often missed, and how it impacts everything from fertility to weight, skin, and overall health. You’ll learn: * What’s actually happening in the body with PCOS * Why so many women go undiagnosed * The connection between hormones, insulin resistance, and symptoms * How PCOS affects fertility (and why it’s not hopeless) * Practical ways to manage symptoms and improve health If you’ve ever struggled with irregular cycles, stubborn weight gain, acne, or hormone issues—this episode might connect some dots.