Out of Network Podcast
Psychedelics are everywhere right now - and most physicians still feel uneasy even saying the words out loud. In this episode of Out of Network, Dr. Ryon Parker and Dr. Rishi Seth have a no-hype conversation about psychedelics in medicine: ketamine, psilocybin, MDMA, and what these therapies could mean for patients with refractory depression, anxiety, and PTSD who feel like they’ve run out of options. You’ll hear: * A real clinical case where a patient had tried “everything,” including multiple meds and therapy, and still wasn’t okay * Why Dr. Seth is skeptical (FDA approval, data quality, who these therapies are NOT for) * Dr. Parker’s decision to refer to a guided retreat option after clinical trials weren’t available * A personal story from Dr. Parker that adds a completely different layer to the conversation * Ketamine’s role today (anesthesia, pediatrics, refractory pain) and why “ketamine clinics” raise real questions Timestamps 00:00 – Why psychedelics in medicine makes doctors uncomfortable 01:26 – Clinical scenario: “nothing is working” for severe depression/anxiety 03:44 – The lineup: ketamine, MDMA, LSD, psilocybin 04:07 – Skepticism: “not FDA approved,” limited robust data 05:23 – A Colorado retreat enters the conversation 09:20 – The hard part: tapering off meds safely, risks, close follow-up 10:10 – Outcome: “first time I feel better” after the retreat 13:16 – Who psychedelics are NOT for (bipolar/psychotic disorders risk) 14:07 – What the research hints at (and what we still don’t know) 16:20 – Dr. Parker shares his personal experience and why this topic matters 28:40 – Ketamine: what it’s used for, what’s legit, what’s questionable 34:21 – Takeaways: hope, ambiguity, and why this deserves a real conversation Connect with Out of Network: 🌐 Website: https://www.outofnetworkpod.com/ 📱 Instagram: https://www.instagram.com/outofnetworkpodcast/ ▶️ YouTube: https://www.youtube.com/@OutofNetworkPodcast 🎵 TikTok: https://www.tiktok.com/@outofnetworkpodcast Connect with the Hosts: Dr. Ryon Parker → https://www.instagram.com/dr.ryonparker/ Parker Medical: https://parkermedical.org/ Dr. Rishi Seth → https://www.instagram.com/drrishiseth/ Seth Premiere Medical: https://sethmedical.com/ Enjoyed the Episode? If this conversation resonated with you, please like, comment, and subscribe. Share it with someone who cares about the future of healthcare. 🎙 About Out of Network Out of Network is a bold, physician-led podcast hosted by Dr. Ryon Parker and Dr. Rishi Seth. Each week, they challenge the broken healthcare system and explore how medicine can be reimagined—through patient-first care, prevention, and real human stories. Enjoyed the Episode? If you liked this conversation, please subscribe, leave us a review, and share this podcast with a friend—it helps more people discover a new vision for healthcare.
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