Genomics of the Psychedelic Frontier: Inside Tryptomics with Chris Pauli

Genomics of the Psychedelic Frontier: Inside Tryptomics with Chris Pauli

In this episode of Inside the Revival on Healthcare NOW Radio, host Jim Tate sits down with Chris Pauli, Co-Founder and Molecular Biologist at Tryptomics, a Colorado-based biotech laboratory pioneering testing and research services for psychoactive plants and fungi. From his early work sequencing the cannabis genome to building one of the first dedicated psychedelic testing labs, Pauli brings a rigorous scientific lens to a field that urgently needs one. The conversation covers the extraordinary variability in psilocybin potency across mushroom strains and flush cycles; the case for full-spectrum "ensemble" medicine over single-compound isolates; the emerging science of pharmacogenomics and what it could mean for personalized psychedelic therapy; Colorado's landmark Natural Medicine Health Act (Proposition 122) and the regulatory challenges ahead for ibogaine and DMT; and the troubling proliferation of synthetic tryptamines in the unregulated market. Pauli also introduces a critical reframe: replacing the borrowed cannabis concept of the "entourage effect" with what Tryptomics colleague Ian Bollinger calls the ensemble effect, a metaphor that recognizes every alkaloid as an integral part of the orchestra, not merely support for a VIP molecule. Candid, technically grounded, and forward-looking, this episode is essential listening for clinicians, policymakers, researchers, and anyone navigating the rapidly evolving landscape of natural medicine.

Ontological Shock & the Healing Threshold with Peter Addy, PhD.

S1E18: Ontological Shock and the Healing Threshold: A Psychedelic Clinician’s Field Guide with Peter Addy, PhD. Join host Jim Tate sits and his guest psychedelic researcher and psychotherapist Peter Addy, PhD for an honest, nuanced, and scientifically grounded survey of the current psychedelic landscape. From the mechanics of harm reduction and integration therapy to the politics of federal scheduling, the conversation moves fluidly between clinical science, cultural history, and personal experience. He addresses the promise and peril of the commercial psychedelic industry, reflects on Oregon’s pioneering psilocybin services framework, examines the FDA’s rejection of MDMA-assisted psychotherapy, and shares first-hand accounts from his clinical work with chronic pain patients. He also draws on deep field experience studying Salvia divinorum, including travel to Oaxaca, Mexico and years of postdoctoral research at Yale. Equal parts scholar, clinician, and thoughtful advocate, Dr. Addy offers a rare combination of scientific rigor and compassionate practice.

Healing From the Inside Out with Bénédicte Mannix

S1E17: Healing From the Inside Out: Bénédicte Mannix on Psilocybin, Mental Homeostasis, and the Art of the Private Retreat Join host Jim Tate and his guest Bénédicte (Ben) Mannix , holistic psilocybin therapist, sophrotherapist, and founder of Sophrodelic in Kingston, Jamaica for a candid and illuminating conversation about what truly personalized psychedelic-assisted therapy looks and feels like in practice.

Clearing the Plaque with Adam Butler

S1E16: Clearing the Plaque: How DMT Saved One Man's Life and What Science Is Beginning to Confirm Join host Jim Tate and his guest DMT Field Guide author Adam Butler, psychedelic philosopher, prolific author, and passionate DMT advocate , for a candid, deeply personal conversation at the intersection of mental health, neuroplasticity, and the emerging science of psychedelic medicine. Butler, author of Butler's DMT Field Guide: A Brief History, Step-by-Step Recipes, and Personal Experiences From a DMT Saturated Consciousness, shares how N,N-dimethyltryptamine pulled him back from the edge of suicide and addiction, and why he believes, with growing scientific backing that this endogenous molecule may hold keys to treating everything from depression and PTSD to stroke and dementia. From harm reduction and ontological risk to extended-state DMT research, microdosing philosophy, and the urgent need for philanthropic investment in psychedelic science, this episode maps the terrain for anyone curious about the revival happening at the frontier of mind, medicine, and healing.

The People's Mushroom with Anna Ross, PhD

S1E15: The People's Mushroom: Psychedelics, Policy, and the Push to Reclaim Scotland's Indigenous Apothecary with Anna Ross, PhD Join host Jim Tate travels north of the border to speak with Dr. Anna Ross, lecturer at the University of Edinburgh, co-founder of the Scottish Psychedelic Research Group (SPRG), and self-described "lived and living experience researcher" who came up through Scotland's 1990s rave scene. Dr. Ross traces the founding of SPRG, Scotland's rich but under-documented relationship with indigenous psychoactive plants, the conspicuous absence of clinical psychedelic trials north of England, the thorny politics of Compass Pathways and IP enclosure in the psychedelic space, and the underground scene that has quietly thrived for decades. She also opens up about her own encounters with DMT and her ongoing research focus: ontological shock, the profound and sometimes destabilizing worldview ruptures that psychedelics can produce, and which mainstream psychiatry still struggles to name, let alone treat. A rich, candid, and highly informed conversation from the northern edge of the psychedelic renaissance.