smenor/tangents
Image: Popularity of the first name Coral correlates with The number of biological technicians in Missouri Spurious correlation #3,596 https://www.tylervigen.com/spurious/correlation/3596_popularity-of-the-first-name-coral_correlates-with_the-number-of-biological-technicians-in-missouri Note: « every sequence has equal probability » is true but things are a little more complicated when you factor in entropy and the fact that some sequences are more « special » than others which matters when you consider say the probability of getting N heads and M tails after N+M tosses Note: I did not create the section / chapter labels; I need to figure out some way to turn that off because I don't care for them; I'm also not responsible for the captions which Apple is auto-generating ( and ignoring any that I put in so I stopped bothering to try with those ) Transcript Hey there I'm Scott and this is Tangents. Well it is the 7th of December 2025 as I record this. Not quite sure when my last one was but it's been a while. I'm I'm in Phoenix and just the last day when I have a little bit of opportunity to record something. Usually I'm back at my mom and sister's place at least recently and I've talked about this before but very happy that I have a place to stay all those kind of stuff but I will say very difficult to do stuff like this. I don't have a lot of time and space and all that kind of stuff. It's interesting to see what the things that I really miss are and like the the big ones from having my own place. Obviously you know controlling the temperature, controlling little basic things like that. Not having yeah not having somebody always there kind of nice. It is nice to be able to spend time with my mom and those. But the big ones that I miss the most more than anything like that are just having a place to work. Like I don't have I don't really have a comfortable chair there which I there are a bunch of chairs. There is that one that I can sit in that doesn't hurt me. I don't have a place to stand. I don't have my standing desk. I miss that really badly. And then I don't have my whiteboard and having like a little space, little desk. Nice cheer that I can sit in if I want to and push away and stand if I don't and then having that whiteboard where I can just offload short-term memories onto the board. It's it's all really nice and I have really miss it. But anyway I have this opportunity I'm going to record a couple today or at least that's my plan. It's already 1842. I've been working on some stuff and I'm really getting close to releasing something but I have a couple things that are just just frustratedly. It's one of these things. It always feels like you're 90% of the way there and then you keep chipping away at a chip away chip away chip away at a week later it's like you're 85% of the way there. That's that's kind of where I am. I think I'm going to make it converge soon-ish but it's it's been frustrating. Anyway anyway the thing I wanted to talk about today is something that it's something I talk about a decent amount. I've spoken a couple of times on it. I don't think I've made a specific episode at least in this iteration on this but this is particularly anti-vaxxers and I'm calling this one the jab and the reason I'm calling it the jab is I don't know what happened with language why people use this term when they're anti-vaxxers but for some reason they do and you know if you're from the UK okay jab that's what you call it. Any US calling an injection calling a vaccination a jab it's weird it's just weird and this is coming from somebody who like this room is you know the climate control I've set to the Celsius set to grid. I do that. I set the speed and a car to kilometers per hour. I do 24 hour time and things like that. I'm not saying that you can't do things that are not typical but why are you doing it? And the fact that this is so correlated I need I've talked about this before. I need to make one of these on literacy and when I say literacy it's not just the ability to directly like read and write that's a factor of literacy and end of numeracy as well you know understanding basic things in math and things like this but to be really literate doesn't just include being able to directly read the words on a piece of paper it involves being able to critically analyze them being able to understand what's behind them and there's a lot more to that than just literally directly reading word by word what's there. One of the things that I think I've talked about this many times as well but I have been online for so long and especially like in forums and things like that there are a lot of things that are extremely extremely obvious to me that you see somebody's somebody says something I just immediately glaringly and I'm not saying that I have some special power ability here it's not you know it's very developable and a lot of people have this too but I've spent enough time that I really can recognize tone in text you can see a lot of the authorship like whoever says something you could feel it you really can and it's something like I had a good in an argument with somebody I don't know a week or two ago and it was a white woman it's relevant here but I shared something that was about the sort of Malcolm and you know the whole idea of the sort of white liberal being a bigger impediment than air quotes conservatives to progress and I shared that and I'm explaining some stuff and then you get the almost as though you needed an example white woman comes in and talks about how you know well I think this is also power imbalance and yeah like there are a lot of factors in public a you don't need to be centering yourself like this was not this was not a space for you to come in and do that but also this whole idea and I am not an expert in this domain but I know enough to know just simply saying oh you know these other factors there are these other explanations or it's this thing that affects us all and you're trying to pull race out of the equation it doesn't it's actively harmful it really is and the thing about this is like what she said was just such an archetype of a pattern that you know it's like you're glaring with sunburn right I look at you and you're just glowing and condessantly it's obvious right and she is insisting like oh you don't know me you don't you know how can you jump to and I was I will say I was being extremely I would say diplomatic and trying to be helpful and I kind of I said you know like maybe go check out Rebecca the the white woman whisperer who I recommend to anyone I think she's got a lot of good stuff especially if you're your skin color looks like mine in your you don't say you totally don't think that your racist at all I kind of stuff you're probably doing a lot of harm that you don't realize and there are places you can go so I'm just saying go there you know maybe look maybe think about it but anyway she was extremely not having that and got really upset and weirdly you know unfriended me this was unfaithful unfriended me and then I said something we we we did some back but she says something I said something about you know how it's odd the you know this obviously offended you enough the you unfriended me and then she said she didn't unfriended me and then we went back and forth and then a couple of steps later she's like well I unfriended you because and why don't you just fucking tell the truth why don't you just accurately I don't understand this thing that people feel compelled to especially when something is just obvious why why are you lying about it like it's just weird but yeah and then she was explaining oh we met and we talked so many years ago when you were running for office and you seemed really intelligent and a lot of complimentary stuff and then she's like oh but I must have misjudged you and no you didn't misjudge you didn't I mean I'm not trying to suck my own dick here but you know I have a certain amount of insight and a certain amount of intelligence and awareness on in this domain and you know the the fact that you don't like what I'm saying doesn't necessarily invalidate what I'm saying but anyway I don't want to talk about that that's not the the point of this episode what I want to talk about here is anti-vaxxers and I'm not even gonna talk specifically about yeah because this is a subject that you could go you could write full dissertations on you could do your long research projects or multi-year research projects and it still wouldn't be complete but I want to talk about some things that I think are relevant there and the end up being a problem in other areas and these are these are things not not coincidentally this also has something to do with politics and with people's inability to just recognize and accept basic I would argue obvious things and instead they're trying to come up with just ridiculous epicycles on epicycles non-persononious answers for things because they won't accept what is obviously the case but anyway coming in focusing on this I got a message and it may have very well been sock puppet or I don't think it was a pot but you know it was not somebody actually using their own government name it was not somebody who's you know like representing themselves directly so somebody using a fake account or an account with you know just some random pseudonym or whatever and they come in they pop up and I should have it pulled up so that I could give you the full context doesn't matter too much but I said something and then they said something about how you know I should look it up just to remember exactly okay I should have actually obviously just done this yeah at the beginning but I I posted something or ski did I should say waiting for the doctor there's an antivax or that this was Monday last week on time flies it's almost a week ago today is Sunday I was at the I doctor getting a retinal file or follow up and while I was waiting which took a very long time I'm waiting and the doctors in the next room and I'm sitting there listening overhearing and there's a woman in the other room not that that's relevant but yeah or or someone with a femme voice I should say I don't know if it was a woman but in the next room somebody is sitting there and they're blaming vision loss and then they're talking about it in the way that it's like oh that thing that we're not supposed to talk about the yeah and she's obviously talking about the the COVID vaccines and it's just like this thing that was pissing me off so much because she's explaining I like I don't you can't read necessarily what somebody's intentions are but the doctor was letting her roll with a lot of stuff that was just out there and I I don't know maybe he's an antivax or or you know you just didn't want to accept the yeah and I don't think that to be clear I don't know what her situation was I have no idea but it sounded like it was some kind of idiopathic vision loss and you know so like no real explanation there's obviously some underlying something that caused it but it didn't sound like something that was like you did this and then that happened and I don't think it was his fault but he's sitting there and I think letting her roll with this idea which is actively harmful for everybody because it's you know fostering and fomenting antivax notions but he's letting her think and be convinced and then go off and tell her friends all the doctor kind of agreed with me that you know like maybe getting this vaccination was part of what precipitated her vision loss and I will say you know first of all and this whole discussion I'm going to be I'm going to try to be as deliberate and nuanced about it as possible it's it's a very complicated subject and it touches on you know medical ethics bodily autonomy capitalism statistics a bunch of different domains and I definitely absolutely I'm not going to be covering everything exhaustively and you know like I'm going to touch on a few things and there's no way I can I can do it full justice but I'm going to try to do as decent of a job as I can and so first of all it is true absolutely nothing that we do is free of risk there's nothing that we can do there's no choice we can make including the choice not to make a choice you know not choosing is also a choice everything has a risk associated with it and that risk may be you know like a one in a quadrillion chance of you know you stand up in the morning and something happens in a localea like anything you do there could be an extremely extremely rare unlikely event or series of events that causes that to end in all kinds of different ways and that that's important to acknowledge I think you don't want to say something is risk free because nothing is risk free absolutely nothing and then this is of course true because it's true for everything is true for any kind of medical intervention or treatment vaccination procedure whatever people people die from you know drinking water like literally drink water aspirated and you could die there are more you know is that the most rare most ridiculous kind of thing in the world you can die from just sun exposure you can die from pretty much anything that you do on a daily basis you cross the street you can very easily die you can you could just be sitting in bed and immediately right could just fall from the heavens and kill you there's there's nothing again that you can do that is not got some risk attached to it and those risks could be mortal risks for everything again and so it's certainly possible absolutely possible that somebody gets a vaccine and then that causes some kind of adverse reactions and and I will even go so far as to say we know there are certain things that will happen for sure add to some you know it's some rate low rate but you know you can be assured that there are certain risks one of those risks that is very well known and understood is that for people who have immune issues immunological issues such as autoimmunity the things like the hedge events in a vaccine can cause some kind of a flare-up or reaction so those are things that can happen and this is also just a little editorial aside this is one of the reasons why it's so important that as many people who can be effectively vaccinated get vaccinated because there are people who genuinely have reasons like actual medical reasons where either they can't get vaccinated because it could cause a flare-up in their autoimmune disease or they're on some kind of immune suppressant therapy or they just have some other immune suppressive state or immune suppressate and so they can't be effectively vaccinated the only way that they can be protected is if the rest of us are vaccinated and if enough of us are vaccinated and enough of us take precautions and do these kinds of things now you have this thing where all of those chains of infection get broken and you know things stop propagating and this is herd immunity is basic but I'm trying to describe without actually calling it that but annoyingly people have sort of stolen this term and twisted it into something else but what herd immunity is is basically even if you're not effectively vaccinated or immune to something if enough people around you are immune to it then you could get infected and then you can't give it to somebody else or if somebody else gets infected they're not surrounded by enough people who are susceptible and it sort of fizzles out and so that can protect other people you know you're not able to give it to somebody and so they're not able to give it to somebody else and then that other person which it can be you is protected by everybody else being protected this is one of the reasons why even not great vaccines where they're only giving like 60 70% protection if you get enough people vaccinated in the population you can actually use those to eradicate diseases because what really happens ultimately is based on the number of people who are vaccinated have current they are completely the vaccinations and in fact if they are all kind of stuff based on all of those kinds of things you are adjusting the basic multiplication factor so you're adjusting like I'm using things a little bit sloppy here because this is this is a very deep I put it being a logical in a area that for the lay person when you get sick there's some number which is like how many people you are likely to infect and if that number is above one then that means that each person that gets sick gets more on average than the replacement number of people to get sick and that means that you get amplification and that means that you get exponential growth if you in fact you get sick you infect two or three people now you have an exponential thing where every time you get sick you infect two or three people every one of them infects two or three people and so on and so forth and very quickly you get massive massive growth if you understand anything about exponential growth you know it doesn't take that many steps to get the huge numbers so that is this this replication factor and as you're getting more and more of the population vaccinated you're lowering that as you're doing other interventions you're lowering that and at a certain point if you do enough interventions you've got it below one and as long as that you know like each infected person is infecting on average less than one person and it's something that you can actually combat less from so if it's something like HIV where you get it and you're not going to recover or in enough time yeah you're not going to get rid of it you can to have this this work but for something where you actually get sick and then recover and then ideally you have convalesced and you're no longer sick no longer infectious now if it's below one that means you're not replacing yourself which means that you get exponential decay and if you get exponential decay then things will very quickly fizzle out it's the same kind of property of exponential growth into decay so basically the the thrust of all of that is you adjust that number we do interventions which generally are public health interventions and enough of those give you the ability to eradicate or at least greatly reduced diseases and even you know even if you're still above one and you have exponential growth there are good reasons to dial that down like for example if something is going to use a lot of medical resources the care for people if you dial that down even if it's still a problem it's under a more controlled kind of regulated growth to be useful but you especially would like to have things actually be below one anyway rambling on that's not what I want to talk about here but it is a thing that I think people have to understand that just because vaccines are not perfect doesn't mean that they're not extremely useful and I think also like I'm going to get back on track in a second though one thing I really constantly have to say and I blame Biden for a lot of this because you know you had this idea at a certain point well it's it's a very complicated thing in general but it's very simple to understand a certain aspect of this which is Swiss cheese this is to say if you have any kind of intervention any kind of layer of protection and it's not perfect it has holes if you have one of those then you have holes and things can get through if you have two of them and you stack them some of those holes are not going to overlap which means even though you have two imperfect layers of protection you get better protection then you might expect because some of those holes are not overlapping that's that perfect again but you get you know it's improving and you can do three or four multiple layers of Swiss cheese and you get fewer and fewer of these passageways that things can get through and this is also you know in other domains they call it defense and depth or you know this Swiss cheese model is extremely extremely simple extremely well understood and I think you can explain it to a little kid so that is how vaccines and masks and all these other things work you have a vaccine that's not perfect but it does a good job that's one layer of Swiss cheese you wear a respirator that's another layer of Swiss cheese you avoid situations where you're going to be in you know places that are like closed and you're going to have like a lot of people with them that's another layer of Swiss cheese you improve ventilation you improve their filtration you add in other public health interventions or or say rapid early detection and then when somebody's you know you detect somebody's infected add-in contact tracing add-in the ability to quarantine people yeah do a quarantine for a little while and tell people come for us and you add all this kind of stuff and then you get your contact traces you get quarantine if you've been exposed to somebody and then you get tested after whatever the incubation period is and you're negative now you're free to go if not you get to be quarantined yourself until you recover you know you do these kinds of things and each one of these layers of Swiss cheese adds more and more protection you don't need that many layers of imperfect protection to get pretty good protection also so the problem is of course Biden just like Trump is an extremely lazy student doesn't understand stuff doesn't really care the sort of philosophically is a big cheater I would say the kind of person I mean obviously know he literally cheated on stuff and undergrad in law school and then it was a big plagiarist got drummed out of the 1998 presidential pride primary for plagiarism yeah he's not a great guy but because of that sort of underlying ethos and way of looking at things he saw this problem like you have this pandemic and wanted to address it in the sense that he wanted to get credit for it didn't want to actually talk to people who know what the fuck they're doing and figure out how to actually address it which incidentally would not have taken that long like if you if you had a test trace isolate program and especially you know you did like a six to eight week paid sort of pause you know you can make it voluntary you don't have to like lock people down so to you know you have a pause preferably you stay home preferably you don't do this but you don't even have to make it perfect you do that and then you add to that ideally vaccinate people improve and improve filtration improve ventilation all of these kinds of things very quickly you could reduce this stuff to essentially just a trickle it would be very difficult to fully eradicate it because there are reservoirs and nonhumans like other animals but you you could get it down to very low levels and when it does crop up you could detect it very easily isolate and then prevent it from spreading those are things that you could very easily do which is frustrating because yeah if you if you've taken epidemiology like this is not some ridiculous complex unsolved problem we understand how to deal with this stuff and you could within again six to eight weeks basically be done with it you know you'd still have again these outbreaks and you'd still have surveillance but you'd basically be done and instead of doing that um he took kind of the shortcut which was okay well we're not gonna actually do this and instead we're going to say you get vaccinated and now you're magically protected and the vaccine is a magical personal shield that's completely effective and blah blah blah blah the problem is vaccines are not magical personal shields they are a component in a comprehensive public health plan and again at best at best they will protect you from getting infected like eighty ninety percent of the time is a really good vaccine there are some that are better than that but you know but it's not like a magical personal shield again it works mostly from herd immunity it does protect you it made you know it's it's always good to be vaccinated now well I guess unless you're talking about uh I something like say dengue fever where if you if you're infected one time it's not that bad it's not great but it's not that bad but then you get infected again and uh it's a much worse much worse disease uh dengue fever if you get vaccinated against it and then you get infected is actually not a thing that you want to do. The only time that it makes sense to the really get vaccinated is if you've been infected once now you've already got some immunity and then you get vaccinated and that protects you a little bit from subsequent infection but for most other diseases that's not the case most diseases getting vaccinated will make the course better don't get the outcomes better and again all of these things are statistical on average just so on and so forth so again I would like I I am somebody who looks at vaccines is kind of modern miracles and there are things that if you can get them very generally as long as they are protective I think it's ridiculous not to now and then they're I guess as long as I'm talking about this our immune systems have very broadly two different ways of approaching things so we have something called the Nate immunity and an adaptive immunity and innate immunity is stuff that just works in general it's not necessarily specific to anything but it's sort of a shield and it could be literally like in Tagument your skin it's a big part of the innate immune system just keeping stuff out of your body we have a lot of mechanisms for detecting viral viral replication in ourselves so a lot of viruses end up producing double stranded RNA and so we have things that detect double stranded RNA which our bodies don't generally produce and then there's this whole series of innate anti viral things and these kinds of things that that's not the only mechanism that that's one these kinds of things give you kind of non-specific protection and then we have adaptive immunity which is sort of a learned immune response and the way this works it's complicated but the general gist of it is that your immune system has the ability to recognize things called antigens and these antigens are they're usually proteins it doesn't matter what they are but they're parts of infectious agents that have a specific shape to them you could think of it it's a little more complicated than that basically now when you've seen that thing first you have that innate immune response that's very non-specific this brings up a whole slew of immune cells they get exposed and then the ones that happen through this process it's actually evolution of real time in your body but basically you produce this huge set of completely random abilities to recognize things and then some of those are going to just by chance be better at recognizing any kind of antigen so you get exposed to that antigen the ones that can recognize it get in there they get angry they multiply and then they you know fine tune and they get better and better at recognizing it and now you have this population of memory cells that will be kind of at some places in your body and then if you get exposed to that same infectious agent again those memory cells get you know get recruited they get the tech you're able to detect this again and then they're ready to respond so you have a much faster immune response and much more specific immune response much more effective immune response if you've been exposed and this is again Danny fever it's a little bit different there are other things that are immune invasive that there are complications that get added to this but that's the general way of work so vaccinations just expose your body to a specific antigen or a set of antigen and now they've gone through this process of doing the adaptive immunity and now you're no longer naïve you're able to muster a response that is specific to whatever that antigen is very quickly that's the whole point of vaccination that's literally all it is and it's it's one of these things it's it's not complicated again just like just like Swiss cheese is not complicated you can explain these things to little kids and I see this as a massive it's an educational feeling but it's a public health failing that we don't teach people these kinds of things we don't teach people what mRNA is for example like mRNA messenger RNA is just single stranded RNA ribospolyc acid doesn't matter what that is but it's basically a string of bases a string of little pieces and each one of these things is like a letter and you've without getting into the chemistry these will be AUG and C and the way it works is in your DNA so in the nucleus of yourselves or your mitochondria and various places you have these double stranded sequences of paired letters these will be ATG and C and the T and the U are sort of swapped in the DNA and RNA but don't worry about that out but basically you have this long sequence of letters and a sequence of complementary letters and then those find to each other and then you have this double stranded letter that's your your genome and there are ways that that can replicate itself you can imagine you unzip it you make a copy now you've got two copies you fill in the other you make the complementary strand basically now you've got two copies but you can also unzip it and turn DNA and RNA and when you do that you've expressed the mRNA for a gene there's more stuff to it like you can do editing after this and like change things a little bit basically comes out of your DNA and you've got mRNA and then that gets that's called the transcription that gets translated into protein and again you don't need to know what protein is you don't need to know it's like a sequence of amino acids and three letters of the mRNA code for each single mall or single I'm trying to train that to get too much into the chemistry video each three letter sequence codes for a specific amino acid just think of it as like a building block at the protein and the particular string of amino acids that you make determines the structure of the protein and then that in turn determines the function of the protein and things can be structural proteins they could just be like collagen or last and they're adding like stiffness or flexibility or rigidity that kind of stuff they can often be enzymes so they're like specifically speeding up certain chemical reactions or lowering the activation energy for them um a little more complicated in that but um yeah those are common things and so if you you go DNA mRNA protein for most things that's how genes are expressed and so you know to say keep saying mRNA and they're I haven't touched viruses or vaccines or anything like that mRNA is just how your body makes protein it's how your body does basically you know the vast fast majority of things that it does and viruses also make proteins and turns out some viruses there are lots of different I'm I'm going to go off on a little tangent of a tangent I'm sorry that's what I do viruses for their genomes can have single or double stranded DNA genomes or RNA genomes there are some that are double stranded RNA there are some that are single stranded RNA there are some that are plus-sense single stranded RNA and a plus-sense means the coding RNA which means they're basically mRNA as their genome happens to include the COVID coronavirus is there are ones that are minus-sense and these have to be first uh you have the non-coding version replicated the coding and then that codes for proteins there are others that don't go through proteins they're just uh yeah and then there are things where they're like double stranded or single stranded DNA then you have to go through RNA or sometimes there are even things like retro viruses where have there's the where the genome will be RNA and then it has to go back into DNA gets encoded or incorporated into the host genome there are lots of complications but in the case of coronavirus is the genome itself is essentially mRNA if you get infected by a coronavirus you're replicating that viruses genome which means you're replicating massive amounts of the mRNA that comprises the genome so it's kind of weird that people get strange about this because it's just like if you understand what I just described which which again is stuff that you know like is like biology 101 level stuff or molecular biology no one but it's stuff that anyone could understand again and if we would teach people this kind of stuff then all of this nonsense about mRNA being somehow like a big deal or you know like something horrible or shocking or whatever which is go away like it wouldn't get traction because there's nothing to have traction it's just simply you know like it's like obsessing about a bolt you know like somehow a bolt is a bad thing there are bolts and everything yeah bolts are just kind of an essential component of how things are put together and you know it's not like there's something magical or evil about a bolt at similar way mRNA it's just mRNA and when I would when I took a virology the first time and going to date myself here a little bit but it was in the 90s it was I think about 20 years before mRNA vaccines became a practical reality and the professor incidentally Dr. Brooke Jacobs who I really like one of my best professors when I'm probably my favorite professor ever when I took a class certainly up there annoyingly he was also a good researcher and got yeah that did decent job with the funding so he was able to escape teaching and then now yeah because he was so good at research they pulled out of that and they let's somebody also it was not that very good at it teach the class but don't worry about that it's just it's kind of annoying the way the academia really like looks at teaching is the secondary thing this kind of annoyance nuisance that you're trying to like you have to do it but you don't really want to and it's kind of punishment if you're not successful and the other stuff so it's it did totally irrelevant but the thing is when we're when I was taking this class he was explaining you know like one day maybe if we're really lucky and we really work hard we'll figure out how to make an mRNA vaccine that was the goal and the reason that you want to do it is because if you know most vaccines if you're using some kind of a organism to to vaccinate people you either use a live attenuated organism which is to say it's a weaker version of the original and sometimes those attenuations are not great but you know it's less bad or you take the original one and you kill it and then you use a dead slash inactivated version and that is the way that we've vaccinated people for the longest time you know like up for for the first vaccinations for smallpox we're basically just taking post-struals drying them out grinding them up and then like blowing that shit up somebody's nose and because of how it was inoculated and on a bunch of other things people would end up getting a different kind of infection and sometimes getting some protection out of it but you'd still also kill people with it you know it's not a it's not great to get exposed to live virus especially when that is something that kills you so then you try to either kill it deactivated and sometimes when you deactivate it it doesn't all work like you'll get some leaks through or there's some process issue there was with a lot of air with a killed polio vaccine this happened actually it wasn't properly deactivated and then some people got polio from it that was you know but again like one thing I want to say is every time I talk about something like this that happened one time got detected got fixed and then it was not it was it was not like an ongoing thing and also also this is true with all this kind of stuff once it happened got fixed but even even with it happening at some low rate the protection that the vaccines gave was far far better than the risk of getting an actual infection from getting vaccinated it's one of these situations where you just end again I understand were terrible at understanding relative risks were terrible at understanding like you know some things like I said everything has risk associated with it but even if you have a vaccination that could cause you know it's like bad it could even kill you at a low rate if the rate at which that is killing you is less than the rate of getting killed by an actual infection then it still makes sense to be vaccinated and by far even in that worst case scenario with the polio virus where there is that one fuck up even then it actually was more protective than harmful you know that the relative risk was in no veriner like complete no veriner now so anyway that the thing that's cool about mRNA vaccines and the reason that we're working on them for so long is that you don't need to have the whole organism you can just take the part of the organism that is going to elicit protective immunity and you can just replicate that really quickly and not only that you could say okay here's this new organism I've never seen before and part of this is also you know 20 years ago it was a much bigger deal to get sequences but now you can get sequences for almost nothing like it's 100 bucks easily yeah most things probably like 50 bucks or significantly less it's not a big deal getting there are certain things that cost a little bit of money like building a genetic library and you but to get a sequence for an awful organism is not that hard today and not that expensive and once you have that sequence you can actually depending on how novel it is but if it's like a coronavirus you know because these are all related and you have a bunch of other examples of them you can kind of look and you don't you're not going to see like exactly the same parts of the genome and everything but you'll see sort of in the same sense that you have you know similar bones and you know the digits you have phalangees you have parcels and metotarsals and femurs and phobias and phobias and all of these kinds of things they're conserved so if you look at those in an orangutan and you look at those in a human they might not be exactly the same but you can kind of tell what they are you can look at the genomes of these viruses and kind of tell okay this is the spike protein that's going to be involved in recognizing you know like binding to the target cells and performing an infection this is going to be the DNA polymerase or RNA dependent RNA polymerase or whatever you know you can kind of look at these things and understand from the sequences what they do and this actually ends up being a really cool thing because if you have developed a mRNA vaccine against any kind of organism that's even closely related you can know what the targets are and this is how we were able to get such yeah for a novel vaccine every novel virus get these vaccines so quickly because we already had coronavirus vaccines that were mRNA based we already had targets once you have those targets you get the new sequence you put that in and printing up mRNA is is that quite the same as putting a thing into a printer and then printing it but it's so close now we have things that are literally called the DNA printers and you can just make whatever the sequence says that you that you want to you can make that and you can update it really quickly so you're able to go from something that we've never seen before you get the sequence takes almost no time and then you can say okay well these are the targets you can make the you can make several different vaccine candidates for different targets and then you know just go into testing test for safety and efficacy all is kind of stuff and you're there you're basically there and this is you know it's magical because you don't have the full organism you don't have anything that could revert you don't have to develop and attenuated version you don't have to spend a long time figuring out how to make an effective vaccine against whatever whatever you're trying to make it vaccine against you just sort of take the cookbook of this is how we make or at least a certain kind of immunity from mRNA to a protein to an immune response and this will be an effective immune response for whatever this agent is and so you can go from something that might be a many decades long process to something that you could do realistically in six months to a year potentially significantly faster and you know just it's hard to explain it's hard to convey just how amazing that is versus what we used to do but it is a ridiculous improvement orders of magnitude better so anyway of course the the main thing like I'm trying to explain enough there to get you to understand there's not like a reason to be particularly nervous about these things and also it is a just scientific and medical miracle that we were able to develop them as quickly as we were and similarly also all the all of the standard vaccinations that we have all of these are against diseases which are necessarily massively lethal but they definitely have a lot of morbidity and mortality associated some of them killed like if you look at not that distant of past before the era of vaccines and antibiotics most kids used to die like if you had a kid the odds were strongly in favor of them dying like they would be the die of what is now a preventable disease or you know often like you get an injury or something and oh you have an injury which leads to an infection which kills you now take some antibiotics and you survive oh you have a appendicitis that would have killed you and you can get a pretty easy medical procedure that saves you and again all these things have risk associated with them but they you know if you look at the relative risk it's massively better to to have these interventions than not so anyway the thing that I really want to focus on here is just that humans are in a lethal at perceiving or understanding relative risks are intuition against sort of what is dangerous and what is safe is terrible absolutely terrible yeah and you always hear the example of air travel is the safest or flying is the safest way to travel and driving is much more dangerous and yet people when they're driving and especially when they're driving themselves they feel like they're at much lower risk and you know this is just one example of what you think is the reality being completely opposite from the actual reality and similarly you're getting and an occupation you're getting jabbed to use the word with a sharp scary needle and not only that but it has you know who knows what kind of chemicals are inside just probably die hydrogen and oxide in that needle that's getting injected into you that's kind of scary right your perception of what that risk is associated with that is one thing and then the reality of that risk is another and you have to consider like what is the actual risk which is again very very low not zero nothing is zero risk as I said a couple of times here but it's a very low risk of a few things versus a very real and much larger risk of getting an infection and not being protected from it and you also have to factor in you know it's you're not here alone like there's the chance of you getting that infection and not being protected but there's also the chance of you getting an infection and transmitting that to other people and whether something is going to kill you or not whether it's going to permanently injure you or not if you go out and you're part of a chain of infection it might not kill you but is it going to kill one of the people that you infect or is it going to kill one of the people that they infect and if you look at the the case mortality rate for COVID because obviously that's one of their things I'm talking about here it is in the low single digits of percentage and the basic replication factor again depends on the variant and the bunch of other stuff but it could be as high as a 18 so you get infected it's very contagious you're infecting a bunch of people but even if it's say you know imagine it was something that's not that infectious and you're infecting like a handful of people you infect five people let's just say this is an abstract virus or something like this is not a specific one but you infect five people you get infected each one of those five people infect five people so one hop out five people are infected two hops out 25 people are infected and then 25 times five and then so on and so forth and very quickly you've gone from one to five to 25 to 125 to 125 to 625 and it just keeps going and going and going if the case mortality rate is one percent that is the same one percent of infections kill somebody then all you have to do is go out three hops and now you are like even if you were fine even if the people you infect that are fine now you've at least killed one person and if you wouldn't have infected people if you would have broken the chain of transmission at yourself that person would still be alive you go out one more step it's going to be five times that and so on and so forth so to me and I know this is controversial but we live in a society and we have a responsibility to each other and so you have your own personal protection and you also have to think about like what is the contribution of you taking measures to keep from getting infected and keep from infecting people and it is I mean I'm not going to say it's quite the same as like taking a gun and pointing it at a crowd closing your eyes and shooting it but it's not that different you know if you are letting people get infected then and they're going to let people get infected a couple of hops out somebody's dead now if you point to a crowd and pull the trigger versus you sneeze one seems much more proximal one is much easier to understand the causation but both of them you as surely lead to somebody's and of course also because everybody who gets infected in fact more people it's not just one death it's tens or hundreds or thousands of deaths a few hops out so you couldn't I don't know to me it seems like a no-brainer especially when the the cost is extremely enough or low and it has a benefit to you and you're also protecting other people so anyway I guess I wanted to say we're also terrible just in general and it really fits in here as well but we're terrible at understanding causal relationships with things it's not just that we're bad at understanding relative risk but it's very difficult for us to actually know a cause to be and there are a number of things that I think complicate this but fundamentally a lot of it is sort of the way that our brains work and we have a tendency to kind of overlearn and I would say it's sort of a tendency towards superstition so it's not to say that you're not learning things that are actually happening but I think I'm speculating a little bit here and why this is but I think probably for ancestors if you did something and then that almost killed you you don't want to do it again or if you saw somebody died from something you don't want to do that so it was probably better to see something and then notice something happens afterwards and just avoid that behavior and think that that might be the the thing that caused it probably more important than actually delving into what actually was the causal agent or what was the the causal chain so you know if there are three things you see somebody does somebody sneezes and then they die and somebody takes a walk over here and then they die or somebody flips a coin and then they die it might be well I didn't use good examples and then somebody runs toward a cliff and falls off the cliff you see those four things three of those four things there's nothing you could do about that they're not they're not actually causing somebody to die one of them they are but the problem is you want to have a learning model that catches the one where you know it is actually going to kill you and it's probably better to have false positives there like you learn things that are not really the case than to not learn things and then be killed by them or you know something else that's going to cause you know not necessarily your death but you know consequences that keep you from being able to reproduce or keep you from being able to reproduce as effectively or whatever so that is I think why we're bad at perceiving causation but ultimately the the consequence of that is we're very very prone to superstition and especially you know when something happens I mean this is true just in general if you notice patterns your brain will associate you know this happened and then that happened and you can go I always I was I was always liked this but there's a Tyler Viggin VHEN Tango Yankee Lima Echo Romeo Victor India Gulf Echo November TylerViggin dot com go there and there's this thing called spurious correlations and what this is is basically it's something called data dredging or p hacking which is you're looking this is an interesting thing I think and it gets to one of the reasons why like we don't we don't understand statistics as a general rule like even if you've taken statistics epidemiology is full of things where they're very counterintuitive or there's something that is very easy to misunderstand or draw the wrong conclusions from I've taken epidemiology a few times and that was the biggest takeaway I had which was it's just fraught there's I don't have a good example offhand but there are so many things that you learn about where you'll see it and there's something that seems like obviously this is you know obviously this is the conclusion you would draw obviously this is how stuff works and then you actually look at the statistics and it's something that's much more complicated or it's misleading or anything like this it's it's fraught I would just say so understanding that is one reason why I generally don't I don't wait too much into epidemiology other than the things that I'm pretty confident about and I'm much more of an expert at the topic than a lot of people who you know tended to say a lot of stuff about it and then even if you don't condemn epidemiology statistics is fraught and and again like you know you could be very strong in statistics and you're going to fuck up a epidemiology similarly you could be pretty good into which they're at intuition but you're gonna have terrible intuition about statistics there are lots of things yeah and you can just go through they're not really paradoxes but things that are surprising of often be called paradoxes that are things that are just very simple statistical things that are very easy to prove or demonstrate and they're just really really counterintuitive like the birthday paradox if you have more than not even that many people the odds are that you're going to have two people that have the same birthday you don't know what the birthday is going to be but you have 20 people in the room it's very very likely that two people have the same birthday shockingly likely even though each birthday is going to be one day out of 365 days of the year another one that's is the Matty Hall problem you have the three different doors two of them have nothing and then one of them has you know some big prize if you have somebody open the door at random and your choice is to take whatever is there or to reject it the odds of you succeeding in the next round are much better if you reject it that's very counterintuitive like it's very it's one of these things I don't want to get like deep into it but you can go through and do a lot of research on these things and there are shockingly many of them and there are just things that you know you will think they work a certain way and they just don't or or someone will really like coin tosses if you have a perfect fair coin and every time you toss it there's a 50 50 shot of it being heads or tails you would expect it in and I don't mean like maybe you have enough intuition that you don't expect that to go heads tails heads tails but you kind of kind of still do you kind of think oh it's going to be like half the time heads it has the time tails which means it sort of alternates or balances out the odds that you'll have any particular sequence are all equal which means that getting a hundred heads in a row seems very unlikely but there's nothing magical or special but you know keeps that from happening there's nothing like that's a perfectly reasonable sequence that is just as likely as heads tails heads tails tails or any other you know low and drop or any any other sequence that doesn't just look sort of random so to speak there there are a lot of things like this that again are just not intuitive and if you go to this site that I sort of mentioned before Tyler bigan.com and look at these various correlations you can find that if you look at one measure of fitness which is fitness and the sense of sort of how you're measuring I guess you could you'd call it a figure of merit but how you're measuring like two things are connected and this is the correlation coefficient so basically if two things are changing in a way that one goes up the other goes up one goes down the other goes down and so on if you guess a pattern and then you see it and you see a strong correlation that tells you one thing but if you pick a correlation and you have a large collection of patterns it's very easy to just sift through and find things that will be spurious correlations and those two things sound very similar but the difference is monumental this is one of the reasons why you know like you can almost be guaranteed that if you have enough patterns you'll find correlations of any level like if you if you have you in fact you can do some statistical analysis and figure out how many things you have to find in order to get some level of correlation so if you want like a 90% correlation you need this many samples you need 95% 99% correlation you just need this many and so on and so forth and it's a large number but it's not that large and if you get enough you can pick any level of correlation and find it you can also figure out any kind of p value I don't want to do what that is but it's a figure of what the odds are that something happened by chance and if you misapply this statistic then this is called p hacking if you misapply it by judging through data and looking for something then you can get something that looks like it's very good by that statistic but the problem is you're sort of circularly applying that statistic the find the thing that fits the statistic you're not using the statistic as it was meant to be used if that makes sense so this kind of stuff this is also actually why and I see this one all the time but for like audible air quotes AI bullshit somebody also say oh this has a 90% success rate or 90% accuracy or something like this what does that actually mean I mean if you're the way that these things are trained and the way that the things are are working here you're kind of misapplying a figure of merit in such a way that you're going to find something that looks like it's much better than it is also 90% is not great but you can find something that is going to fit 90% of the time especially especially if you're not careful about how you put in the data and how you do the analysis and you're not overfitting or overtraining or anything like this you can find something that works 90 or 95% of the time but it's completely wrong and it's just that it happens to work in the data corpus that you have that you're looking at similar what you can find something that doesn't look great and it's actually pretty pretty good it's just there's a lot of noise or there's some other but you have to I think the general thing that I would take away is your intuition is terrible at epidemiology even if you're really good at statistics and your intuition at statistics is really terrible guaranteed even if you're you've spent a lot of time studying these things and especially if you never have and it's very easy to to mislead yourself to to come to bad conclusions with things like this and especially like when something is a very simple explanation or answer especially to something that is really horrible like somebody dies you want an explanation for that you don't want to just oh they just like shit happens you want to go like what caused this or or your kid gets injured gets leukemia gets whatever any kind of thing like this you really want an answer and you know it's it's not only do you want an answer you want that answer to be something like so and so did something and it was somebody's fault it's not oh this cosmic rage just happened to land here and then this other one happened to land here and you know you had this weird free oxygen radical that happened to do this thing and the combination of those things caused this problem or you know you had just a random congenital heart defect and then something happened and you had heart attack that a very young age you want there to be a LA this was caused by a person who did something foolishly and I think I don't know if that's a cultural thing or if it's just an in a human thing but it definitely is a common thing and so the problem is you have a brain that is sitting there sitting there basically designed to be a superstition machine did just designed to look for patterns whether or not they're real and you have some kind of a correlation and though that correlation could be by chance it could be not by chance but you know it could seem really good but especially you know you filter out all the thousands or millions of things that something could be and you filter out all the things that have either complex causations or multifactorial causations or yeah and you come up with something where something happened that was easy to identify and then at some point in the future something all happened and you want there to be a simple explanation a causal explanation and so you come up with that and I think this is how you get to a lot of people with these sort of anti-vax beliefs because kids get a lot of vaccines that's just how it works that's the normal thing and that's not I'm not saying that that's you know like that's just how it should be frankly you have and you could just say like let's take something that's less charged kids are going to be exposed to the sun many many times you know you get exposed to the sun every day for your life probably just about and so there's something like you're going to get exposed to this thing many many times which means that if something else happens if something bad happens it's very easy to say well you know every kid that died of a bike crash was exposed to sunlight like isn't that interesting every single kid who has ever you know died from from bicycling was exposed to sunlight and if you had somebody sitting there trying to give you a bullshit answer and pointing a finger at you know it's like big sunlight is causing your kids to get these bike racks and you should avoid have your kids avoid that sunlight because yeah you don't want your kids to die it sounds ridiculous but that is where you are with these vaccinations because you have this thing this treatment that a lot of kids most kids almost all kids are getting a lot of and then something happens which a lot you know things like childhood leukemias or injuries or you know different things happen a lot during childhood enduring development also you have a lot of things where you might not have noticed something and independent of anything else that was going to come but because your brain is looking for these patterns you see oh this happened and then days or weeks or months or whatever later this happened they must be correlated they must be not only correlated but causal the the thing caused this other thing and especially you know you take that that's your kind of innate leaning and then you have somebody who's whatever reason maybe they have a financial interest or maybe whatever but for whatever reason they're pushing the narrative that a causes b now you get that and you're in that situation and you get really convinced that a causes b and this is one of these things like I'm not it's certainly possible obviously that a did cause b I'm not throwing that out I'm not dismissing it out of hand but the odds are that it didn't and how do you know if a caused b well it actually for an individual is very difficult to like the tease out causation they there are certain things where you know if if somebody shoots you and then you get killed you could probably probably connect those two things somebody takes a knife and chops off your finger and then you don't have a finger it's pretty easy to come up with the causation there but when it comes to something like getting vaccinated even the efficacy of a vaccine you are a single data point you're not something that you can't take a million copies of you and take half of them and randomly not apply the treatment and half of them and apply the treatment and then see what happens you can't control you can't conduct a control experiment you're just one path through reality and because of that it's actually fundamentally kind of impossible for things that are subtle the detect and determine causation and an individual basis now what you can do is look at populations and there are some very powerful statistical methods that are that are common in epidemiology that will help you tease out causation from correlation and detect these kinds of things and then there are also like the the gold standard would be sort of what I described you just like create a controlled experiment and you have two different populations which are as similar as we can make them half of them we apply a treatment half of them we don't and then you see what is the difference in outcomes that that would be something that is not necessarily ethical when it comes to medical or medical stuff but that's sort of the gold standard you can do it without that too but it gets more big it's heavier it's more complicated and then I don't even want to get into like we for for vaccinations we generally don't do that anymore because what we discovered for most of these is that it's not ethical to do that kind of a controlled experiment because we know going in for most of these things being vaccinated is actually going to be very protective and if it's something that you know it's something that you don't want somebody to get in the consequences of getting it really bad it's just not ethical not the treat them and we also know that the risk is very low and we know the probability of efficacy probably decent and just from past experience like this is not like we just decided it so there are reasons why we don't do that but that is the gold standard and so you know like even in yourself like the the kind of example that I would give here because it's something that I hear people jump to a lot but somebody that say say even you got a vaccine you were vaccinated and then something happens and because I'm kind of on topic here let's let's say you got a rash now did the vaccine cause the rash that's a complicated question and it's going to be you know I would argue it's actually almost impossible to know definitively now you can say like okay well it's focused around wherever you were vaccinated well is that from an immune that like an allergic reaction or is it an infection is it that there was some kind of chemical contamination and it's just an irritation and this is another thing also like people do not have a great training in what an allergic reaction looks like this is this is one of these things I wish you know we should teach people early and often obviously like CPR or basic first aid stop the bleed kind of stuff but you should definitely also teach people to know the difference between say food poisoning and infection you know food poisoning rapid onset you eat and then 30 minutes 60 90 minutes later you're vomiting you have diarrhea it's very fast versus an infection usually more than 24 hours often 48 72 hours kind of incubation period and then it's growing and then you get sick after you've been exposed. Understanding the difference and those kinds of things understanding the difference in course understanding the you know like influenza generally speaking is like a two week hellish kind of course you get exposed 48 72 hours later you present with symptoms and then for like 14 days you'll feel like complete shit you'll have a high fever and you'll have like phone and muscle aches and you have a bunch of stuff and it's fairly characteristics stuff although flu like symptoms are going to be common for pretty much any viral in fact most infections just in general because innate immunity is the cause of a lot of these things and adaptive immunity is also but you know like understanding that kind of stuff understanding that you know like if you get a cold or what you would call a cold not the same as the flu and if you haven't had a definitive test for influenza you probably didn't have the flu and if you had the flu you probably would know because again hellish two wee
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