The Healthspan Podcast
In this highlight episode, Dr. Robert Todd Hurst, MD, FACC, FASE sits down with neurologist Jeremy Pruzin, MD to unpack one of the most common and most misunderstood topics in brain health: the difference between dementia and Alzheimer’s disease. They explore how vascular health, protein buildup like amyloid and tau, and lifestyle factors all intersect to influence cognitive decline. The conversation also dives into the concept of “mixed dementia,” why prevention strategies overlap with heart disease, and what actionable steps can significantly reduce risk, especially for those with genetic predispositions like APOE4. Watch the full podcast episode here: https://youtu.be/5hIKmiPNGjA Dr. Pruzin is a Behavioral Neurologist, Dementia Specialist, Alzheimer's Disease Researcher - specializing in cognitive disorders and dementia. He brings deep clinical insight into how brain pathology develops over time, helping patients understand risk, early symptoms, and the evolving landscape of treatment. His approach emphasizes both cutting-edge science and practical, personalized strategies for prevention and care. Connect With Jeremy Pruzin, MD - Behavioral Neurologist, Dementia Specialist, Alzheimer's Disease Researcher Website: https://pacocommunity.com/ Instagram: https://www.instagram.com/jeremypruzinmd/ Linkedin: https://www.linkedin.com/in/jeremy-pruzin-82867615/ Key Timestamps 00:00 Introduction to HealthspanMD Heart Longevity Program 00:40 Overview of episode topics: dementia vs Alzheimer’s 01:10 Prevention strategies and link to heart health 02:19 APOE4 explained and what it means for risk 03:00 Practical lifestyle changes to lower dementia risk 04:30 Life’s Simple 7 and its impact on dementia 05:45 Why heart health and brain health are deeply connected 06:40 Risk-based prevention and treatment strategies 08:00 Medications and emerging therapies for brain health 08:58 Understanding dementia pathology: vascular vs protein causes 09:40 Difference between dementia and Alzheimer’s disease 10:30 What is mixed dementia and why it’s most common 11:20 Rethinking how dementia is categorized 12:30 APOE4 risk levels and implications 13:20 Final thoughts and how to take action with HealthspanMD Connect with HealthspanMD : 👉 https://www.linkedin.com/company/healthspanmd/ 👉 https://www.facebook.com/healthspanmd 👉 https://www.instagram.com/healthspanmd/ 👉 https://open.spotify.com/show/5KQuoWqKP2vTBu05ci6EQB?si=fdb033a52b674909 👉 https://podcasts.apple.com/us/podcast/the-healthspan-podcast/id1680270608 🏆 Become a Member / 🤝 Partner With Dr. Hurst and His Expert Team To Add a Decade or More Of Healthy Life At HealthspanMD, we combine cutting-edge medicine, advanced technology, and concierge care to help high-achievers avoid heart attacks, strokes, and dementia. 🔍 Learn how patients add years to their lives by going to 👉 [https://www.healthspanmd.com](https://www.healthspanmd.com/) . 📅 Or Schedule a Call Directly with a HealthspanMD Dedicated Patient Advisor by clicking 👉 https://join.healthspanmd.com/call
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