The Incubator At The Bench

#025 - Can We Predict Which Pregnancies Will Fail Before They Do?

44 min · 30 de mar de 2026
Portada del episodio #025 - Can We Predict Which Pregnancies Will Fail Before They Do?

Descripción

What is actually happening inside the uterus during a threatened pregnancy — and does the timing of infection change everything? In this episode of At the Bench, hosts Ben Fensterheim and Betsy Crouch sit down with Dr. Kristen Noble, assistant professor at Indiana University, to explore her work building a transcriptomic and proteomic atlas of intrauterine immune responses across gestation. Dr. Noble shares how clinical uncertainty at the bedside — that impossible question of deliver now or wait — drove her into the lab. She also opens up about navigating doubt early in training, finding the right mentors, and what it looks like to rebuild a research program from scratch at a new institution.

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episode #024 - Navigating the Neonatal Immune Landscape: Insights from Dr. Bunmi Olaloye artwork

#024 - Navigating the Neonatal Immune Landscape: Insights from Dr. Bunmi Olaloye

In this episode of At the Bench, hosts Misty Good and Betsy Crouch welcome Dr. Bunmi Olaloye, a neonatologist and physician scientist at Yale School of Medicine. Dr. Olaloye shares her path from an early interest in engineering to focusing on necrotizing enterocolitis and spontaneous intestinal perforation in preterm infants. She discusses her research into early life immune development using mass cytometry and single-cell RNA sequencing, revealing distinct immune signatures that could shape future treatments.  The conversation also explores the challenges of building an independent research career, the importance of mentorship and team science, and the limitations of current animal models. Dr. Olaloye highlights the potential of organoid systems for studying human-specific questions and the protective role of breast milk in modulating immune responses in NEC. Her story offers both scientific insight and genuine inspiration for anyone navigating the path from clinical training to independent research.

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