Cellular and Molecular Mechanisms of Chemotherapy Induced Peripheral Neuropathy Pathophysiology

Neurotoxicity and Chemotherapy - An Oncology Perspective

In this episode of the Peripheral Nerve Podcast, hosts Susanna Park and Paola Alberti are joined by Maryam Lustberg to explore the real-world impact of chemotherapy-induced peripheral neuropathy (CIPN). Together, they examine why CIPN remains such a persistent challenge in oncology care and discuss evolving approaches to assessment, management, and research. The conversation also looks ahead to emerging innovations and the growing importance of collaborative, patient-centered care. Resources: * Mitigating long-term and delayed adverse events associated with cancer treatment: implications for survivorship - https://pnsociety.com/wp-content/uploads/Ep.2-CIDP-Paper1-1May2026.pdf [https://pnsociety.com/wp-content/uploads/Ep.2-CIDP-Paper1-1May2026.pdf] * Evolution of predictive risk factor analysis for chemotherapy‑related toxicity - https://pnsociety.com/wp-content/uploads/Ep.2-CIDP-Podcast-Paper2-1May2026.pdf [https://pnsociety.com/wp-content/uploads/Ep.2-CIDP-Podcast-Paper2-1May2026.pdf]

Cellular and Molecular Mechanisms of Chemotherapy Induced Peripheral Neuropathy Pathophysiology

In this episode of the Peripheral Nerve Podcast, hosts Dr. Paola Alberti (University of Milano-Bicocca, Italy) and Professor Susanna Park (University of Sydney, Australia) are joined by Professor Guido Cavaletti (University of Milano-Bicocca, Italy), a global leader in chemotherapy-induced peripheral neuropathy (CIPN) research. This discussion explores the current understanding and ongoing uncertainties surrounding the cellular and molecular mechanisms that drive CIPN. Drawing on decades of research, Professor Cavaletti provides critical insights into pathophysiology, translational challenges, and emerging therapeutic strategies. Links for show notes: journals.lww.com/pain/fulltext/2024/11000/translation_of_paclitaxel_induced_peripheral.11.aspx Transcript: https://pnsociety.com/wp-content/uploads/Ep1-CIPN-Podcast-Transcript-23March2026.docx

Treatment, Prognosis, Prevention

In this concluding episode of the Peripheral Nerve Society's Leprosy Awareness Podcast series, global experts examine the critical reality that microbiologic cure does not equal patient recovery. The discussion focuses on practical, real-world priorities: * Treating Hansen's disease effectively * Predicting neurologic and functional outcomes * Preventing disability, stigma, and ongoing transmission The panel emphasizes that while multidrug therapy (MDT) reliably cures infection, nerve damage, disability, and social consequences remain the central unmet needs in leprosy care. Transcript: https://pnsociety.com/wp-content/uploads/PNS-Podcast_Ep7_Treatment-and-prognosis-of-leprosy-neuropathy_19Feb2026.pdf [https://pnsociety.com/wp-content/uploads/PNS-Podcast_Ep7_Treatment-and-prognosis-of-leprosy-neuropathy_19Feb2026.pdf]

Pathology and imaging methods in leprosy neuropathy

In this episode of the Leprosy Awareness Podcast, we tackle one of the most complex challenges in clinical practice: accurate and timely diagnosis of leprosy neuropathy. This episode explores how neurologists, dermatologists, and imaging specialists can integrate clinical examination, neurophysiology, ultrasound, Doppler, elastography, and MRI neurography to improve diagnostic accuracy—while minimizing misdiagnosis and false positives. Through expert discussion, we examine leprosy as a spectral neuroinflammatory disease, the limitations of single-modality testing, and the importance of multidisciplinary collaboration in both endemic and non-endemic settings. Featured Guests * Prof. Marcello Nogueira-Barbosa, MD, PhD Associate Professor of Radiology, University of São Paulo - Ribeirão Preto, Brazil * Prof. Diogo Fernandes dos Santos, MD, PhD Associate Professor of Neurology, Universidade Federal de Uberlândia, Brazil

Electrophysiology, Schwann Cell Biology, and the Neurophysiological Mechanisms of Leprosy Neuropathy

Hosts: * Camila Pupe – Professor of Neurology, Universidade Federal Fluminense, Brazil * Wilson Marques Jr. – Professor of Neurology, University of São Paulo School of Medicine – Ribeirão Preto Guests: * Einar Wilder-Smith – Professor of Neurology, University of Bern, Switzerland * Pedro Jose Tomaselli – Neurology Department, University of São Paulo, Ribeirão Preto This episode explores the neurophysiological mechanisms underlying leprosy neuropathy, emphasizing how interactions between Mycobacterium leprae, Schwann cell biology, and host immune responses manifest in electrophysiology. The discussion highlights the distinctive neurophysiological "fingerprint" of leprosy neuropathy and the evolution of diagnostic approaches—from standard nerve conduction studies to multisite protocols and advanced ultrasound techniques. This episode brings together leading experts in the field, offering rich insights that integrate basic science, clinical neurology, and emerging diagnostic tools.