Heavily Meditated: How Dave Asprey Turns Off the PKD Cell-Danger Response

Cancer’s Hidden Trigger: How Fungi Ignite ALL Tumors & What It Could Mean for PKD - Mark Lintern

In this episode, Felix welcomes Author and citizen scientist Mark Lintern—the man who might finally have nailed what actually flips healthy cells into the Warburg Effect metabolism that Professor Thomas Seyfried made famous— and explained on the Reversing PKD Podcast. Mark lays out his “Cell Suppression Theory,” showing how fungi seize control of cells, and create the glucose-dependent breakdown of respiration that Seyfried’s metabolic theory describes by keeping cells stuck in the „Cell Danger Response“ (CDR). Not in error, but it an attempt to rescue the cell. The two swap notes on the parallels between malignant tumors and expanding kidney cysts: a terrain drenched in toxic triggers and suppressed E-cadherin, mirroring the endotoxin fingerprints Felix had already traced in Polycystic Kidney Disease prior. They explore how viewing both diseases as slow-motion reactions to infections and/or toxins reframes everything—from a ketogenic “first line of defense" to antifungals and antiparasitic tactics that could stop tumors and cysts at their microbial root. 🎙️ Guest & Core Material • Mark Lintern – Cell Suppression Theory website https://www.cellsuppression.com/ [https://www.cellsuppression.com/] • Free 13-page synopsis (PDF) https://www.cellsuppression.com/marks-theory-synopsis-free-download [https://www.cellsuppression.com/marks-theory-synopsis-free-download] • Book — The Cancer Resolution ? (Amazon) https://amzn.to/4jOnZhI [https://amzn.to/4jOnZhI] • Facebook discussion group https://www.facebook.com/groups/marklinterncancertheory/ [https://www.facebook.com/groups/marklinterncancertheory/] ________________________________________ 💊 Supplements Mentioned • Salvestrols (Example, standard 2000 pt dosage): https://amzn.to/45gal3d [https://amzn.to/45gal3d] • Glutamine https://amzn.to/43Z3gBV [https://amzn.to/43Z3gBV] or https://de.iherb.com/pr/doctor-s-best-pure-l-glutamine-powder-10-6-oz-300-g/85597?utm_source=chatgpt.com&rcode=HLH837 [https://de.iherb.com/pr/doctor-s-best-pure-l-glutamine-powder-10-6-oz-300-g/85597?utm_source=chatgpt.com&rcode=HLH837] • Colloidal Silver https://amzn.to/4l7YE3j [https://amzn.to/4l7YE3j] or https://de.iherb.com/pr/sovereign-silver-bio-active-silver-hydrosol-10-ppm-16-fl-oz-473-ml/16056?utm_source=chatgpt.com&rcode=HLH837 [https://de.iherb.com/pr/sovereign-silver-bio-active-silver-hydrosol-10-ppm-16-fl-oz-473-ml/16056?utm_source=chatgpt.com&rcode=HLH837] ________________________________________ 📚 Theories, Books & Foundational Papers • Thomas N. Seyfried/Wiley e-text version https://onlinelibrary.wiley.com/doi/book/10.1002/9781118310311 [https://onlinelibrary.wiley.com/doi/book/10.1002/9781118310311] • Thomas N. Seyfried on the ReversingPKD Podcast: https://www.youtube.com/watch?v=xQhIJxatT1M [https://www.youtube.com/watch?v=xQhIJxatT1M] • Robert K. Naviaux – Cell Danger Response overview (PDF) https://naviauxlab.ucsd.edu/wp-content/uploads/2020/02/Naviaux-CDR-Environmental-Health_2019.pdf [https://naviauxlab.ucsd.edu/wp-content/uploads/2020/02/Naviaux-CDR-Environmental-Health_2019.pdf] ________________________________________ 🦠 Fungal & Microbiome-Cancer Links • Malassezia 3 000-fold enrichment in pancreatic cancer (Nature 2019) https://pubmed.ncbi.nlm.nih.gov/31578522/ [https://pubmed.ncbi.nlm.nih.gov/31578522/] pubmed.ncbi.nlm.nih.gov • Nature editorial – “Fungi promote pancreatic cancer” https://www.nature.com/articles/s41575-019-0231-x [https://www.nature.com/articles/s41575-019-0231-x] nature.com • Itraconazole case report — pancreatic tumor down-staging https://pubmed.ncbi.nlm.nih.gov/25670260/ [https://pubmed.ncbi.nlm.nih.gov/25670260/] pubmed.ncbi.nlm.nih.gov • ReDO review: itraconazole as an anti-cancer agent https://ecancer.org/en/journal/article/521-repurposing-drugs-in-oncology-redo-itraconazole-as-an-anti-cancer-agent [https://ecancer.org/en/journal/article/521-repurposing-drugs-in-oncology-redo-itraconazole-as-an-anti-cancer-agent] ecancer.org • Candida → PD-L1 up-regulation (2022 study) https://pubmed.ncbi.nlm.nih.gov/35362187/ [https://pubmed.ncbi.nlm.nih.gov/35362187/] pubmed.ncbi.nlm.nih.gov • Vomocytosis – macrophage expulsion of fungi https://onlinelibrary.wiley.com/doi/10.1111/cmi.13145 [https://onlinelibrary.wiley.com/doi/10.1111/cmi.13145] onlinelibrary.wiley.com ________________________________________ 🧑‍🔬 Organisations Mentioned • Yes to Life (UK integrative cancer charity) – https://yestolife.org.uk/ [https://yestolife.org.uk/] ________________________________________ 🧑‍⚕️ Key Definitions / Background • Warburg Effect (overview) – https://pmc.ncbi.nlm.nih.gov/articles/PMC4783224/ [https://pmc.ncbi.nlm.nih.gov/articles/PMC4783224/] pmc.ncbi.nlm.nih.gov • Cell Danger Response explainer – https://aonm.org/wp-content/uploads/2021/07/Cell-Danger-Response-IHCAN.pdf [https://aonm.org/wp-content/uploads/2021/07/Cell-Danger-Response-IHCAN.pdf] aonm.org • E-cadherin / CDH1 gene factsheet – https://www.ncbi.nlm.nih.gov/gene/999 [https://www.ncbi.nlm.nih.gov/gene/999] ncbi.nlm.nih.gov

I Listened To The PKD Foundation's New Podcast So You Don't Have To

Felix checked out the PKD Foundation’s brand-new podcast "PKD Chronicles", sat through every sponsor tag and heartfelt story, and is coming back with questions no one on the show seems to be willing to ask. In this episode he talks about what really drives the conversation, why some topics stay off-limits, and how that silence impacts anyone taking their kidney health into their own hands. Stick around to the end for a preview of next week’s interview on the Cell Suppression Theory, actual info that moves the needle and adds to the metabolic understanding of uncontrolled growth - which might just matter for PKD.Ready to hear what Felix heard—and what he didn’t? Press play.---Go tohttps://www.reversingpkd.com to find more learning resources and get on the PKD health coaching program.

Heavily Meditated: How Dave Asprey Turns Off the PKD Cell-Danger Response

In this episode, Felix finally welcomes bio-hacking pioneer Dave Asprey—the man whose Bulletproof ideas we quote in almost every show—to the Reversing PKD Podcast. Dave explains why his new book Heavily Meditated puts mindset first, showing how switching off the “cell danger response” can unlock the healing potential of ketogenic eating, smart supplements and targeted fasting for people with Polycystic Kidney Disease. They dig into kidney-protective tactics—from boosting Klotho and strengthening cell membranes with Calcium AEP to tightening the gut barrier against endotoxin—and explore whether fungi or LPS keep cysts growing in some patients.________________________________________Viewers will learn• How calming the nervous system lowers the cell-danger response that blocks kidney repair• Practical ways to raise Klotho for kidney protection now and in the future• How Calcium AEP and targeted probiotics & fiber help seal cell membranes and the gut lining• Importance of cutting fungal toxins and endotoxin load, including when an antifungal trial makes sense• The BICEP method of brief, controlled stress to reset dopamine and cortisol📚 Resources & Mentions from the Episode with Dave AspreySupport the show by using the links below—some are affiliate links with no extra cost to you.________________________________________🧠 Dave Asprey's New Book – Heavily Meditated📘 Amazon: https://www.amazon.com/dp/0063204762?tag=pkdprotocol-20🧬 Viome Gut Intelligence Test🔬 Amazon: https://www.amazon.com/dp/B07HBFM8LS?tag=pkdprotocol-20🌐 Official Viome store (10% off): https://www.viome.com — use code 10DAVE at checkout💊 Calcium AEP (Ca-2-AEP)Amazon: https://www.amazon.com/dp/B003VLENHQ?tag=pkdprotocol-20 🦠 OMNi-BiOTiC® HETOX ProbioticAmazon: https://www.amazon.com/dp/B08PMY3973?tag=pkdprotocol-20Official Store: https://shop.omni-biotic.com/en-eu/products/omni-biotic-hetox-int-99107⚖️ Potassium BicarbonateAmazon: https://www.amazon.com/dp/B07YNXRM76?tag=pkdprotocol-20iHerb: https://www.iherb.com/pr/nutricost-potassium-bicarbonate-unflavored-16-oz-454-g/132299?rcode=HLH837🌿 Boswellia Serrata Extract (with 5-LOXIN – Swanson)40mg AKBA per capsule, so 4-5 capsules/day would be efficient for humans as per study to double Klotho, extrapolated via HED calculation from mouse models.Amazon: https://www.amazon.com/dp/B00A8FCFEQ?tag=pkdprotocol-20iHerb: https://www.iherb.com/pr/swanson-boswellia-serrata-extract-125-mg-60-veggie-caps/118170?rcode=HLH837🎧 Don’t forget to like, comment, and subscribe if this episode brought value to your PKD journey.🧬 This is not medical advice.---Go tohttps://www.reversingpkd.com to find more learning resources and get on the PKD health coaching program.

Mitochondria, Gut, and Detox: A Deep Dive into PKD Healing | Chris Shade, PhD

Use Code REVERSINGPKD at https://www.quicksilverscientific.com/ (I don't make commission on this, it is just for your benefit.) In this episode, Felix interviews detoxification expert Dr. Chris Shade on the pivotal role of endotoxins and mitochondrial function in reversing Polycystic Kidney Disease (PKD). Learn how endotoxins drive chronic inflammation and cyst growth and explore the connection between mitochondrial health, autophagy and kidney function. Learn how activating AMPK and sirtuins can enhance cellular repair mechanisms, and discover actionable strategies involving ketogenic dieting, fasting and supplements to reduce endotoxin load. Dr. Shade also delves into optimizing detox pathways through improved bile flow and liver support to protect your kidneys. Viewers will learn: - How endotoxins contribute to PKD progression and cyst formation. - The importance of mitochondrial health and autophagy in reversing PKD. - How activating AMPK and sirtuins enhances cellular repair and function. - The benefits of ketogenic diets and fasting in reducing endotoxin levels. - Strategies to improve bile flow and liver detoxification pathways. - Ways to strengthen gut barriers to minimize endotoxin absorption. --- Go to https://www.reversingpkd.com to find more learning resources and get on the PKD health coaching program.

The Fiber Fix: Is Something in Your Gut Secretly Worsening Your PKD?

Order my book "Reversing Polycystic Kidney Disease" here: https://reversingpkd.com/booklinks – send your receipt to bonus@reversingpkd.com to receive the free infographic to get started right away! -- In this episode, Felix interviews world-renowned Author and gut biome specialist Dr. William Davis on the role of gut health in improving PKD outcomes. Learn how fiber plays a critical role in reducing endotoxin that damages kidneys and how a balanced microbiome can lower inflammation and improve overall health. Discover the fascinating connection between SIBO, Leaky gut and fiber, and how it impacts PKD on the molecular level. You will get actionable strategies to fix your gut and protect your kidneys, including the importance of prebiotics, fermented foods, and Davis' special SIBO-fighting yogurt recipe. Viewers will learn: How endotoxins from the gut affect PKD progression. The role of fiber and prebiotics in maintaining a strong gut lining. How Dr. Davis's yogurt recipe combats SIBO and endotoxemia. Why carnivore and low-fiber keto can worsen blood glucose and endotoxemia. - Starters for Yogurt fermentation: Dr. Davis' brand for L.reuteri: https://www.oxiceutics.com/products/myreuteri Generic options: L.reuteri tablets Amazon US: https://amzn.to/3UWvEkr L.reuteri tablets iHerb US & Worldwide: https://www.iherb.com/pr/biogaia-gastrus-for-optimal-gut-health-mandarin-30-tablets/80974?rcode=HLH837 L.Gasseri Capsules Amazon US: https://amzn.to/4fvn2t3 L.Gasseri Capsules iHerb US & Worldwide: https://www.iherb.com/pr/swanson-lactobacillus-gasseri-3-billion-cfu-60-veggie-drcaps/109008?rcode=HLH837 B.Coagulans Capsules Amazon US: https://amzn.to/3UT1PBi B.Coagulans Capsules iHerb US & Worldwide: https://www.iherb.com/pr/swanson-bacillus-coagulans-6-billion-cfu-60-veggie-caps/118477?rcode=HLH837 W. Davis' Blog post on making L. reuteri yogurt: https://drdavisinfinitehealth.com/2019/07/how-to-make-l-reuteri-yogurt-step-by-step/ W. Davis' Video on making L. reuteri yogurt: https://youtu.be/la9yODLZizo