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The BioDisruptors Podcast

Podcast door The BioDisruptors

Engels

Technologie en Wetenschap

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The BioDisruptors Podcast – Making Biotech Make Sense 🧬 Biotech is evolving fast, but keeping up shouldn’t feel like reading a textbook. We break down dense white papers and complex science into clear, engaging discussions—so you stay informed without the headache. Whether you're a biotech professional or just curious about the latest breakthroughs, we’ve got you covered. No fluff, no unnecessary jargon—just biotech made simple. 🔬 Follow us to stay ahead of the latest biotech innovations! 🎧 Listen now and turn biotech complexity into clarity.

Alle afleveringen

30 afleveringen

aflevering Ep. 29 Inside the Plant Powered Pharmaceutical Factory artwork

Ep. 29 Inside the Plant Powered Pharmaceutical Factory

What if the factory of the future looks more like a greenhouse than a clean room full of steel tanks? In this episode, we explore a surprising shift in biotechnology where scientists use living plants to make vaccines, antibodies, and other critical medicines. You will learn why a humble tobacco relative has become one of the most important tools in modern biotech, how genes can be delivered into leaves in a matter of minutes, and why this approach could dramatically speed up responses to future pandemics and supply chain disruptions. Featured Article: Harnessing Transient Expression Systems with Plant Viral Vectors for the Production of Biopharmaceuticals in Nicotiana benthamiana (https://doi.org/10.3390/ijms26125510 [https://doi.org/10.3390/ijms26125510])

22 jan 2026 - 14 min
aflevering Ep. 27 Astronaut Food to mRNA: The Radical Evolution of Lyophilization artwork

Ep. 27 Astronaut Food to mRNA: The Radical Evolution of Lyophilization

This week, we explore the critical yet often overlooked world of lyophilization, better known as freeze drying. While you might associate it with astronaut food, it is actually the backbone of the modern pharmaceutical supply chain, stabilizing everything from mRNA vaccines to life saving biologics. We break down how the industry is ditching inefficient, decades old batch processing for a revolutionary suspended vial continuous system. By suspending vials individually, manufacturers can eliminate the effect of uneven heating, ensuring every single dose experiences identical physics. Featured Article:  Mechanistic Modeling of Continuous Lyophilization for Biopharmaceutical Manufacturing (https://doi.org/10.1002/advs.202511693 [https://doi.org/10.1002/advs.202511693])

16 dec 2025 - 11 min
aflevering Ep. 26 DMSO in Cell Therapy: Separating Fact from Fiction artwork

Ep. 26 DMSO in Cell Therapy: Separating Fact from Fiction

In this episode, we break down the truth about DMSO in cell therapy, how it works, why it is used, and what the data really says about its safety. Drawing from a comprehensive review of more than 1100 patients, we explore infusion reactions, dose thresholds, and common misconceptions around DMSO toxicity. We also discuss pharmacokinetics, including the half life of DMSO, urinary elimination, and its metabolism into dimethyl sulfide. Whether you are in biotech, manufacturing, or clinical development, this episode offers a clear and evidence based look at one of the most misunderstood ingredients in regenerative medicine. Featured Article:  Dimethyl Sulfoxide in Cryopreserved Mesenchymal Stromal Cell Therapy Products: Is there a Safety Risk to Patients? (https://doi.org/10.1186/s12967-025-06807-6 [https://doi.org/10.1186/s12967-025-06807-6])

2 dec 2025 - 13 min
aflevering Ep. 25 The Organoid Revolution: Ending Animal Testing with Better Science artwork

Ep. 25 The Organoid Revolution: Ending Animal Testing with Better Science

What if we could test new drugs and study diseases without using animals? In this episode, we dive into the world of organoids, mini organs grown from human cells that are reshaping biomedical research. We unpack how these tiny living systems mimic real human tissue, offering scientists a more accurate and ethical way to study biology and develop new treatments. From breakthroughs in drug testing to the promise of personalized medicine, this episode explores how organoids are driving a revolution in science that is both smarter and more humane. Featured Article:  Replacing Animal Testing with Stem Cell-Organoids : Advantages and Limitations (https://doi.org/10.1007/s12015-024-10723-5 [https://doi.org/10.1007/s12015-024-10723-5])

12 nov 2025 - 14 min
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