Saturday Morning Coffee Talk 5/16/26

Retatrutide Masterclass | Dosing, Side Effects, and the Framework Most People Get Wrong

All links here: https://hunterwilliamshealth.com/links [https://hunterwilliamshealth.com/links] 00:00 — Intro and why I'm doing these masterclasses 02:42 — What we're covering and the regulatory timeline 04:04 — The two users: weight loss vs longevity 05:30 — What Retatrutide actually does (the three receptors) 06:50 — Why the glucagon receptor makes Retatrutide different 07:54 — Weight loss trial data (1mg to 12mg) 10:50 — The longevity data: liver fat, ApoB, blood pressure 13:14 — Who the lean biohacker user is 13:50 — The titration playbook 15:32 — Once weekly vs split dosing 19:50 — Morning vs night injections 21:02 — How far to push the dose (why 8mg is the ceiling) 22:50 — How long to stay on and the regain problem 25:44 — Longevity maintenance protocol 26:34 — Lean user protocol 27:24 — Protein and training are non-negotiable 29:06 — Side effects and how to manage them 30:20 — The heart rate question and why I use taurine 32:00 — The weird skin sensitivity issue 33:48 — Pairing Retatrutide with testosterone 35:56 — Drug interactions (blood pressure, thyroid, insulin) 37:02 — Metrics that matter 38:42 — How to cycle off correctly 39:54 — The most common mistakes 40:42 — How to start, what to do if you plateau 43:04 — Should you switch from Tirzepatide? 45:28 — Combining Retatrutide with other peptides 46:50 — The Ten Commandments of Retatrutide use 47:50 — The bottom line Today's episode is the first in a new format I'm rolling out. I'm working on a book where I cover one peptide at a time, one chapter at a time. Alongside that, I wanted to do a masterclass on each peptide and condense down everything I know into one place. First up is Retatrutide. I cover what it actually does in your body, the two very different users that should be on it, and the dosing strategies that get debated to death online. We go through the weight loss data, the longevity data, and why I think 8 milligrams is the real ceiling for most people. I also break down once weekly versus split dosing, the heart rate question, the skin sensitivity issue, and why testosterone optimization has to come first. If you want a definitive guide on Retatrutide, this is it. My goal is that you walk away with a framework you can actually use, whether it's on yourself, your coaching clients, or your patients. Let me know what you think. I plan on doing many more of these on every peptide that matters. ⚠️ For research and entertainment purposes only. ⚠️

Saturday Morning Coffee Talk 5/16/26

All Links Here: https://hunterwilliamshealth.com/links [https://hunterwilliamshealth.com/links]

Episode 4 — Why the 49ers Can't Stay Healthy | Peter Cowan on EMF, Substations, and Your Hormones

If you do everything right and still feel off, this episode is for you. I sat down with Peter Cowan, a quantum biology practitioner and environmental health investigator who got chronically sick from EMF exposure, walked away from Silicon Valley, and spent years figuring out why on his own. Peter's Substack series on the San Francisco 49ers, who practice and play right next to a power substation, is some of the most compelling EMF research I've seen anywhere. We covered the EMF checklist anyone can run at home, the mitochondrial mechanism behind oxidative stress from magnetic fields, how EMF disrupts the cortisol and melatonin cycle that drives your testosterone, why pre-sunrise workouts under fluorescent lights are doing more damage than most people realize, and the three-pronged light protocol that took Peter's testosterone from 437 to over 800. Follow Peter: https://peteranthonycowan.substack.com/ [https://peteranthonycowan.substack.com/] For research and entertainment purposes only. 👇 ALL MY LINKS IN ONE PLACE https://hunterwilliamshealth.com/links [https://hunterwilliamshealth.com/links]

This Peptide Works 10X Faster Than SSRIs (Here's How)

👇 ALL MY LINKS IN ONE PLACE https://hunterwilliamshealth.com/links PE-22-28 is one of those peptides almost nobody is talking about, and I think that's a shame. In this episode I walk you through what it is, how it works, and why I'd put it in the antidepressant category before I'd call it a true nootropic. I get into the background as an optimized analogue of spadin, the TREK-1 channel inhibition that drives the effect, and the downstream impact on BDNF, synaptogenesis, and neuroinflammation. I also cover the part most people care about: the rapid antidepressant onset, usually around four days, versus the three to four weeks you wait on a typical SSRI. From there I share the dosing protocol I've been using on myself, including a four-on, three-off cycle to keep tolerance low, plus what I've noticed in terms of mood, mental energy, and the lack of any real come-down or withdrawal. I'm not saying this is a cure for depression. Depression is multifaceted and deserves a multifaceted approach. But if you need something to help get you out of the hole and back into the habits that actually move the needle, PE-22-28 is worth knowing about.

Reader Mailbag 3 — Traveling, Glutathione, Sleep & More | Hunter & Taylor Williams

Hunter and Taylor are back for another deep dive Reader Mailbag. Real questions, real answers, no shortcuts. This week: traveling with peptides and TRT through customs, fixing glutathione injection pain, melanatan 1 vs 2 and skin cancer risk, severe female insomnia and perimenopause sleep protocols, retatrutide plateaus and GLP-1 desensitization, and how to actually build a peptide stack using the bleeding neck framework. Whether you're new to peptides or deep in your optimization journey this one has something for everyone. Submit your questions for the next episode at the link below. For research and entertainment purposes only. 👇 EVERYTHING IN ONE PLACEhttps://hunterwilliamshealth.com/links [https://hunterwilliamshealth.com/links]