What can an organoid teach us about the human menstrual cycle: Conversation with Dr. Margherita Turco, Part II

What triggers Spontaneous Labor? A research based theory: conversation with Dr. Todd Rosen (Encore)

Today I'm gonna share an episode that was originally aired about a year and a half ago about what might be the trigger for starting spontaneous labor. It's kind of amazing that this fundamental experience that all of us have starts with an event that arrives by surprise. In fact, we accept that , labor, if it starts when it starts, will be a surprise. Every popular depiction of a woman in labor that you've seen on TV or in movies or experienced yourself contains at least one real truth. The start of labor is a surprise. It's a surprise because despite the many things we know about labor, we don't know how or why it's initiated, what series of things have to happen to get labor to turn on, and why. In 1 in 10 births in the U. S., does it turn on too early? This is the topic my guest, Dr. Todd Rosen, talks about today. Collaborator, Bingbing Wang, have developed a compelling theory about the conversation between the placenta and the fetus. That may explain what these triggers are.

Looking for Patterns in your Menstrual Cycle as Keys to Overall Health: Conversation with Dr. Gombert-Labedens, Part II

We are at the cusp of understanding more about the complicated conversation going on between your brain, ovaries, and pituitary. Your menstrual cycle contains within it information about your overall health, and the work we'll talk about today gets us one step closer to deciphering important elements of this conversation.  In particular, by organizing data according to the rhythm of menstrual cycles, we are looking not only at a level change, for example, is temperature going up or down in different parts of the cycle, but at the daily context in which temperature changes, which allows us to look for patterns in this change over time. In the future, we may be able to use these patterns to diagnose not only issues with reproductive health (ie, PMDD, endometriosis, etc.), but with health overall. Identifying Menstrual Metrics as Personal Health Markers: Age Trends and Individual Footprints in Temperature across 5674 cycles: https://www.science.org/doi/10.1126/sciadv.aeb1175 [https://www.science.org/doi/10.1126/sciadv.aeb1175] Nanotechnology looking at measuring hormones: https://www.nature.com/articles/s41565-023-01513-0 [https://www.nature.com/articles/s41565-023-01513-0]

What Can we learn about overall health by examining features of the menstrual cycle?: Conversation with Dr. Gombert-Labedens, Part I

Your menstrual cycle is the engine of reproduction and a window into your overall health.  It's critical both for a successful pregnancy, and can tell us things about your endocrine, metabolic, immune, and cardiac systems.  We have tended to look at things like how heavy or light the flow of your period is, or the length of the cycle as signs of wellness or distress in your system. But some researchers, like the one I speak with today, are trying to mine different aspects of the cycle for information about overall health.  What Dr. Gombert-Labedens  and her colleagues are looking at is menstrual cycle linked temperature patterns, which change systemically with age and are surprisingly consistent within each person, so that they may be useful to track aging and detect deviations from a person's usual physiological state. We'll talk today about the state of this research and where it may be going Using activity trackers in pregnancy, conversation with Dr. Benjamin Smarr (part I): https://podcasts.apple.com/us/podcast/can-an-activity-tracker-tell-you-if-you-are-pregnant/id1779600854?i=1000719761885 [https://podcasts.apple.com/us/podcast/can-an-activity-tracker-tell-you-if-you-are-pregnant/id1779600854?i=1000719761885] Science Advances paper: Identifying Menstrual Metrics as Personal Health Markers: Age Trends and individual footprints in temperature across 5675 cycles: https://www.science.org/doi/10.1126/sciadv.aeb1175 [https://www.science.org/doi/10.1126/sciadv.aeb1175]

What can an organoid teach us about the human menstrual cycle: Conversation with Dr. Margherita Turco, Part II

This is a glimpse of our future through the lens of the menstrual cycle. Women, on average, experience about 400 cycles in their lives, and the process is integrally connected to many other features of your overall health and, of course, is critically important to a successful pregnancy. Using 3-D human organoids, Dr. Turco and her team test different facets of the cells of the uterine lining to learn more about what in the world is going on in your uterus during your cycle.   In most studies of the human body, there's one particular market served by the research, but this one's a doozy. If you are a human with a uterus, this work is for you, and if you are planning to be born from a human with a uterus, this work is also for you.

Inside the Black Box of your Menstrual Cycle: Conversation with Dr. Margherita Turco, Part I

For all recorded time, the human menstrual cycle has been kind of a mystery. Is your period too long? Is your period too short? Are you bleeding too much? Is there too much pain?  It's hard to answer these questions because I'm not sure it makes sense to compare yourself to some, quote, "average woman," because the menstrual cycle is so integrally involved in so many different systems in your body. It makes more sense to look at how your cycle is changing over time, but we don't even have very much data about that.  Can we experiment with mice? Sure. But our system is different from the system of a mouse.  Can we look at samples of the uterine linings of different women over time? Sure. But that approach tells a story that's not the same as whatever is going on in one person's uterus over time.  Today's guest is ushering in a new era of uterine lining exploration that will allow for a much more dynamic, human-centered examination of this amazing tissue that's critical for both a successful pregnancy and integral to women's health. She is opening up the black box of the human menstrual cycle.  AN IN VITRO MENSTRUAL CYCLE USING ORGANOIDS CAPTURES EPITHELIAL CELL TRANSITIONS DURING MENSTRUATION AND REGENERATION OF THE HUMAN ENDOMETRIUM: HTTPS://WWW.CELL.COM/CELL-STEM-CELL/FULLTEXT/S1934-5909(26)00145-1?_RETURNURL=HTTPS%3A%2F%2FLINKINGHUB.ELSEVIER.COM%2FRETRIEVE%2FPII%2FS1934590926001451%3FSHOWALL%3DTRUE [https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(26)00145-1?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1934590926001451%3Fshowall%3Dtrue]