Popp Talk with Mary Jane Popp
Popp Talk with Mary Jane Popp Biotech Breakthroughs, Hidden Pain, and the Truth We Struggle to Tell Guests, Tim Harris and Michelle May A Potpourri of Health, Science, and Self-Understanding In this episode of Popp Talk, host Mary Jane Popp introduces a wide-ranging “potpourri” show covering biotechnology, health, therapy, and the hidden struggles people sometimes carry beneath the surface. She begins by setting up an interview with Tim Harris, author of In Pursuit of Unicorns: A Journey Through 50 Years of Biotechnology, and later introduces Michelle May, psychotherapist and author of What I Couldn’t Tell My Therapist. The episode moves from the evolution of biotech and medical innovation to emotional repression, chronic pain, social media misinformation, and the importance of personal responsibility. Tim Harris on Biotechnology and the Pursuit of Unicorns Mary Jane’s first guest, Tim Harris, defines biotechnology as the combination of biology and technology, beginning with recombinant DNA and monoclonal antibodies. He explains that his book title uses the word “unicorns” because biotech companies can become billion-dollar enterprises, though some valuations may prove more mythical than real. Harris presents biotechnology not only as a scientific field but also as a business story shaped by companies, capital, invention, risk, and the long effort to turn scientific tools into useful products. Recombinant DNA, Monoclonal Antibodies, and Gene Editing Harris walks listeners through the development of recombinant DNA, explaining how scientists learned to combine pieces of DNA and use bacteria such as E. coli to produce important proteins like insulin and growth hormone. He also explains monoclonal antibodies as single antibodies made by cloned cells, first useful for diagnostics and later for therapies. The conversation then turns to gene editing, including CRISPR-Cas9 and its use in sickle cell disease, which Harris describes as life-changing for patients whose lives revolve around managing pain and disease. Cancer, mRNA Vaccines, AI, and the Risks of Innovation Mary Jane and Harris discuss why cancer remains difficult to treat, with Harris explaining CAR T-cell therapy, its success in certain leukemias and lymphomas, and the continuing challenge of solid tumors such as breast, prostate, and colon cancer. He also connects nanotechnology to COVID-19 mRNA vaccines, describing lipid nanoparticles as the delivery system for messenger RNA. The conversation expands into new COVID strains, vaccine updates, artificial intelligence, risk assessment, and the limits of prediction in biology. Harris emphasizes that while AI can help analyze data and predict viral changes, drug discovery and development remain experimental sciences. Michelle May’s Story of Chronic Pain and Repressed Emotion The second major interview features Michelle May, who shares that she woke up in 2007 with a headache that lasted six years. Doctors eventually found a Chiari malformation, and after two brain surgeries, her head pain improved dramatically. Still, some headaches remained, and May says she later learned through intensive dynamic therapy that repressed emotions also contributed to her pain. She explains that anger, grief, guilt, and love can be pushed out of awareness when people grow up in environments where certain feelings do not feel safe, but those emotions may still remain in the body. What People Cannot Tell Their Therapist May explains that the title What I Couldn’t Tell My Therapist has two meanings: the painful family stories she feared would feel like betrayal, and the truths she had not yet admitted to herself. She describes how patients may minimize or filter their experiences, especially when they love the people who hurt them. Mary Jane presses her on how therapy helps uncover those hidden barriers, and May explains that she watches for avoidance patterns, such as looking away, intellectualizing, minimizing pain, or struggling to stay connected while discussing intimacy and emotion. Pain, Anxiety, Opioids, Social Media, and Responsibility The interview broadens into the overlap between physical pain and emotional pain, with May stressing that medical causes should always be ruled out first before exploring emotional processes. She distinguishes between feelings and actions, explaining that anger is a bodily experience while harmful behavior is a choice. The conversation also covers chronic pain, opioid dependence, the mind-body connection, social media misinformation, fact-checking, political and cultural falsehoods, and the difficulty people have admitting they were wrong. The episode closes with May encouraging people to find a therapist they trust, while Mary Jane emphasizes comfort, accountability, and the need to stop blaming others when personal responsibility is required.
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