Dr. Robert Califf on the Future of Public Health

Isaac Barchas Sees The Next Biotech Boom

For decades, the biotech industry has been concentrated in a handful of coastal hubs. But according to Isaac Barchas, one of the most significant opportunities in medicine may be hiding in plain sight.In this episode of Get Real, Jim Weiss sits down with Isaac Barchas, co-founder of Arsenal Bridge Ventures, to discuss why world-class scientific research is happening far beyond Boston and Silicon Valley, and why investors have been overlooking it for years.Isaac shares Arsenal Bridge's mission to identify breakthrough discoveries emerging from universities and research institutions across America's heartland, provide the capital and leadership needed to commercialize them, and help transform promising science into life-changing therapies.Together, Jim and Isaac explore the future of biotech innovation, the challenges of building companies outside traditional venture capital hubs, and why investing in overlooked regions could be good for patients, good for business, and good for America.

Dr. Cheri Mah: Why Sleep Is the Ultimate Performance Drug

Dr. Cheri Mah has spent her career proving what elite athletes are finally starting to take seriously: sleep is not optional — it’s medicine. In this episode of Get Real, the internationally recognized sleep physician and researcher joins Jim to break down how sleep drives performance, recovery, injury prevention, and mental health, both in sports and in life. They explore why chronic sleep deprivation is quietly undermining health outcomes, how teams use sleep data to gain a competitive edge, and what everyday people can learn from the way professional athletes prioritize rest. From circadian rhythm to behavior change, this conversation reframes sleep not as a luxury, but as one of the most powerful and underestimated tools we have for human performance and well‑being.

Vern Glenn: How Sports Build Communities and Change Lives

Few voices are as woven into Bay Area sports as Vern Glenn’s. In this episode of Get Real, the longtime broadcaster sits down with Jim to trace his journey to becoming one of the most recognizable storytellers in local television. Vern reflects on breaking into the business, making mistakes on air, and building a career defined by curiosity, humor, and hands‑on reporting — earning the nickname “Mr. Involvement.” They talk about the pressures facing athletes, the power of sports for mental health and community, and why giving back through the Vern Glenn Invitational has become one of his proudest chapters. A warm, candid conversation about craft, longevity, and loving the work enough to keep showing up.

Founder Len Kozhukh on The Oral Microbiome and Writing a New Playbook for Longevity

Founder Len Kozhukh sees a new horizon of health - using a quick assessment of your oral microbiome to PREVENT THE EVENT, one of the pillars of this show. In a special in-person episode, Jim and Len discuss Len's company nihl and how Len hopes it can be the start of a longevity revolution. We need to free everyone's health data so you can be in the driver's seat - can our saliva be the key? Let's find out!

Sean Khozin, MD: From Revolution to Precision Oncology

Sean Khozin has lived through revolution, rebuilt from scratch, and gone on to help reshape modern oncology. In this episode of Get Real, Sean shares his journey from fleeing Iran as a child to leading at the highest levels of cancer research, regulation, and innovation at the NCI, FDA, Johnson & Johnson, and now as CEO of the CEO Roundtable on Cancer. We explore why cancer is always personal, how AI can restore the doctor‑patient relationship, and why data must become liquid to unlock precision medicine. This is a wide‑ranging chat about science, freedom, music, and why the future of healthcare only works if it starts with the patient.