Symptoms Spotlight: Melanie's Updates on Sleep Apnea and Constipation

Developing Story: CureWise Goes Live - The AI Platform Built by Cancer Patients, for Cancer Patients

Last time, we had a front row seat to a vision. This time, that vision has a launch date. On June 20th, CureWise officially launched, and for every cancer patient who walks into an oncologist's office with ten minutes and no idea what to ask, it couldn't come at a better time. In this episode of Live From Stage 4, Victoria Goldberg sits down with Steve Brown (founder & CEO of CureWise) and Lisa Booth (metastatic breast cancer advocate and CureWise's patient #2) to talk about what it actually means to have an AI platform that knows your full medical history, speaks your language, and helps you show up to your appointments prepared and empowered. Also joining us: Beta users Lynda Weatherby (MBC patient and Live From Stage 4  team memberr) and her husband Todd Weatherby (CEO of Siemens Advanta, former VP at AWS), bringing the real-world patient and caregiver perspective to the conversation. In this episode: * How CureWise pulls your medical records from multiple institutions automatically * The Cross-Check feature: asking ChatGPT, Claude, and Gemini the same question simultaneously * Why 60% of cancer patients have an actionable mutation, but only 15% are being treated for it * How to prepare for your oncology appointment using AI * The caregiver experience and what's coming next on the roadmap * Pricing, the 7-day free trial, and how to get started Important note: CureWise is not a doctor. It is a powerful tool to help you understand your medical records and have better conversations with your care team. All medical decisions should be made with your physician. 🔗 Sign up at www.curewise.com [http://www.curewise.com/] Thanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org [http://www.livefromstage4.org/] for show notes and links.  Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer. Until next time, take care and keep pushing for progress.

Developing Story: Beyond Camizestrant — The Evolving Landscape of ER+/HER2- MBC with Dr. Sarah Premji

The field of hormone receptor-positive, HER2-negative metastatic breast cancer is moving faster than ever, and in this episode, we go beyond SERENA-6 to map the full picture of what's changing. Joining hosts Victoria Goldberg and Abigail Johnston is Dr. Sarah Premji, Assistant Director of Breast Cancer Research at Sarah Cannon in Nashville, for a comprehensive deep dive into the new wave of endocrine therapies reshaping treatment for the most common subtype of breast cancer. Together, they cover the evolution from CDK4/6 inhibitors to the era of oral SERDs, FDA approvals of elacestrant, imlunestrant, and vepdegestrant and what makes each unique, the emerging mechanisms of PROTACs and CERANs, and how ESR1 mutations drive treatment decisions at progression. Dr. Premji also shares her real-world approach to sequencing therapy, weighing tumor profiling, prior treatment history, sites of disease, and each patient's individual lifestyle and priorities. The conversation closes with a look at the growing role of AI in oncology, from clinical trial matching to pathology and imaging. Whether you are a community oncologist navigating an increasingly complex algorithm or a patient advocate trying to stay current, this episode is your guide to where ER+ breast cancer treatment stands today and where it is headed. Thanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org [http://www.livefromstage4.org/] for show notes and links.  Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer. Until next time, take care and keep pushing for progress.

Symptoms Spotlight: Neutropenia with Abigail Johnston and Melanie Sisk

In this episode of the Symptom Spotlight Series, hosts Abigail Johnston and Melanie Sisk are joined by Dr. Jill Tirabassi, this podcast's team member, to break down neutropenia. It is one of the most common and important side effects of cancer treatment. Dr. Tirabassi explains what neutropenia actually means, why neutrophils matter, and how chemotherapy and CDK 4/6 inhibitors can deprive your body of these critical infection-fighting white blood cells. The conversation covers what happens when your absolute neutrophil count (ANC) drops too low, when your oncology team might delay or reduce your dose, and what medications like bone marrow stimulators (and the auto-injectors that deliver them) can do to help. The hosts also share their own personal experiences: from managing bone pain with loratadine (Claritin), to navigating a hospital admission with a dangerously low ANC, to learning what questions to ask your doctor before a fever or infection hits on a weekend. Topics covered: * What neutropenia is and why it's a concern during cancer treatment * The ANC number your care team watches and what happens when it's too low * Bone marrow-stimulating drugs: how they work, timing, and side effects * Lifestyle tips (diet, masking, sleep) when your counts are low * CDK 4/6 inhibitors and dose reductions * When to call your doctor vs. go to the ER, and why that conversation matters Thanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org [http://www.livefromstage4.org/] for show notes and links.  Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer. Until next time, take care and keep pushing for progress.

Developing Story: The Camizestrant Vote, Doctors Weigh In with Dr. Sarah Sammons & Dr. Neil Vasan

Two weeks ago, we broke down the ODAC vote on camizestrant and SERENA-6 with seven patient advocates. This week, we go deeper — bringing in the clinical and regulatory perspectives from two of the most qualified voices in the field. We're joined by Dr. Sarah Sammons, newly appointed Co-Leader of Breast Oncology at the University of Maryland Greenebaum Comprehensive Cancer Center and former faculty at Dana-Farber Cancer Institute and Harvard Medical School, and Dr. Neil Vasan, Director of Translational Research in Breast Cancer at NYU Langone Health — and the Acting Chair of the FDA's Oncologic Drugs Advisory Committee who sat in that room and cast a vote. Plus, patient advocates Janice Cowden and Abigail Johnston are back to ask the questions the rest of us are thinking. We cover: * What SERENA-6 actually proved — and what it didn't * Why the ODAC voted 6–3 against the ctDNA-guided switching strategy * The four FDA critiques that drove the vote * What the quality of life data showed — and why regulators couldn't act on it * The persevERA trial and where oral SERDs actually fit right now * What the vote means for the future of biomarker-driven trials * The HERizon-Breast trial and ctDNA-guided scanning on the horizon Breaking news: The FDA has extended the camizestrant review deadline to August 14, 2026, after AstraZeneca submitted a Major Amendment with additional SERENA-6 data. This story isn't over. Show notes and resources at livefromstage4.org This episode is for informational purposes only and does not constitute medical advice. Please consult your oncologist about your individual situation Thanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org [http://www.livefromstage4.org/] for show notes and links.  Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer. Until next time, take care and keep pushing for progress.

Symptoms Spotlight: Melanie's Updates on Sleep Apnea and Constipation

After recording our earlier Symptoms Spotlight episodes on sleep and constipation, Melanie Sisk comes back with real-life updates that prove these topics hit closer to home than she expected. First, Melanie shares her surprising new diagnosis of obstructive sleep apnea, discovered thanks to a sharp-eyed friend at a cancer conference. She breaks down the symptoms to watch for, why they're so easy to confuse with cancer treatment side effects, and how simple the at-home sleep test really is. Then, Melanie reveals what happened after we recorded the constipation episode: her CT scan showed she was significantly constipated, leading to a gastroenterologist visit and a diagnosis of chronic constipation with diarrhea breakthrough, something she never saw coming, even as a nurse. Her takeaway? Don't automatically chalk every symptom up to cancer treatment. There may be something else going on that's very treatable. Both updates are a powerful reminder of the importance of primary care physicians and specialists who can see the full picture of your health beyond cancer. Thanks for listening. If you enjoyed the episode, subscribe and leave a review — it really helps. Follow us on social media @livefromstage4 and visit our website at www.livefromstage4.org [http://www.livefromstage4.org/] for show notes and links.  Your support helps us continue to share important stories and advocate for those living with metastatic breast cancer. Until next time, take care and keep pushing for progress.