SHTG Digest — Friday July 10, 2026

SHTG Digest — Friday July 10, 2026

No top-tier journal papers cleared the bar this cycle so Part A drops down a tier to three directly relevant clinical items on hypertriglyceridemia and LPL biology, while Part B is dominated by a single but consequential Ionis story — the surprise Phase 3 failure of Wainua in ATTR-CM, which isn't a lipid-program readout but is reshaping the competitive and investor picture for Ionis and Alnylam.

SHTG Digest — Tuesday July 7, 2026

A thin cycle on both sides — the only new top-tier hit is a review on residual lipid risk beyond LDL (ANGPTL/apoC-III/FGF21 pathways get a mention), and there's no fresh industry news in the last 5 days beyond last week's Tryngolza sHTG approval, which was already covered.

SHTG Digest — Friday July 3, 2026

A quiet cycle overall — no top-tier journal papers on our core targets cleared the bar and no genuinely new industry news broke in the last five days, so this episode leans on two next-best-tier papers (an ANGPTL3-inhibitor phase 3 extension and a pediatric SHTG risk-prediction study) while the Arrowhead/Ionis/Alnylam news front stayed silent beyond what's already been covered.

SHTG Digest — Tuesday June 30, 2026

A quiet science week surfaces a novel APOC3 role in diabetic retinal angiogenesis and a diagnostic yield study for monogenic HTG, while the industry story remains Ionis' Tryngolza commercial launch into the 3.6-million-patient sHTG market following last week's FDA approval.

SHTG Digest — Friday June 26, 2026

The week's dominant story is the FDA's June 24 approval of Ionis' Tryngolza (olezarsen) as the first-ever treatment for severe hypertriglyceridemia with a pancreatitis risk reduction claim; on the science side, three next-best-tier papers examine plozasiran's pharmacology, ApoC3's biphasic role across the MASLD spectrum, and urinary ANGPTL3 as a novel biomarker for podocyte injury.