When Will We Go Beyond Morphine? | Prof. Allan Basbaum

Spinoza: God, Nature, Free Will & The Good Life | Prof. Steven Nadler

In this episode, Professor Steven Nadler and I explore the philosophy of Baruch Spinoza: his views on God, nature, free will, religion, and the good life. We discuss why Spinoza identified God with Nature, why this made him such a controversial figure, and whether he should be considered an atheist. Professor Nadler explains why Spinoza denied free will, yet still believed that human beings can become freer through reason and understanding. We also explore Spinoza’s account of happiness, virtue, death, immortality, and what it means to live well. Finally, we discuss his critique of organised religion, miracles, and the political importance of freedom of thought.

How Does The Brain Process Language? | Prof. David Poeppel

In this episode, Prof. David Poeppel and I discuss the Dual Stream Model of Language and how the brain processes speech. We explore the roles of the dorsal and ventral language pathways, the concept of efference copy, neural oscillations, and brain-stimulation techniques such as TMS. We also discuss neural sampling rates and neuroimaging methods such as EEG and MEG. Prof. Poeppel explains spatial, spectral, and temporal resolution, asymmetric oscillatory sampling, and how language processing may differ in neurodivergent individuals. Finally, we explore how the brain processes music, what it means to store words in our heads, and how babies learn language.

How Do You Transcend Nihilism? | Dr Nolen Gertz

In this episode, Dr. Nolen Gertz and I discuss nihilism, technology, meaning, and the modern human condition. We explore the difference between passive and active nihilism, and how technology can make distraction and escapism easier, pushing us away from confronting reality and deeper questions of meaning. We also discuss Heidegger’s philosophy of technology, existentialism, AI, religion, and the search for meaning in an increasingly technological world.

Evidence-based Medicine | Dr Gordon Guyatt

In this episode, Gordon Guyatt & I discuss evidence-based medicine, a term and movement he helped create and develop. We explore what evidence-based medicine actually means, the hierarchy of evidence, randomised controlled trials, bias in research, and how evidence can be systematically summarised to improve clinical decision-making. We also discuss the origins and evolution of evidence-based medicine, communicating risks and benefits effectively to patients, making decisions consistent with patient values and preferences, balancing research with clinical work, building intellectually stimulating teams, and what determines success in research.

When Will We Go Beyond Morphine? | Prof. Allan Basbaum

In this episode, Prof. Allan Basbaum and I discuss the neuroscience of pain and humanity’s attempts to discover a drug beyond morphine that is effective but with minimal side effects. We talk about nociceptors, pain pathways, and different types of pain, alongside recent developments in drug design and emerging imaging technologies. We end the podcast with Prof. Allan’s advice for young aspiring scientists, including why research that appears less clinically relevant can still lead to major breakthroughs.