APS Publications Podcast

Interorgan Insights: Sprouting and splitting - rethinking angiogenesis in biomaterials

In this podcast, author Kuihua Zhan discusses the recently published article, ‘Vascularization Is Driven by Sprouting and Subsequent Splitting: Mechanisms of Physiological Angiogenesis in a Porous Biomaterial Scaffold and Intervention Insights’. The article describes engineering interventions to support the physiological vascularization of large-scale tissue scaffolds.  Vascularization Is Driven by Sprouting and Subsequent Splitting: Mechanisms of Physiological Angiogenesis in a Porous Biomaterial Scaffold and Intervention Insights Kuihua Zhan [https://onlinelibrary.wiley.com/authored-by/Zhan/Kuihua], Lun Bai [https://onlinelibrary.wiley.com/authored-by/Bai/Lun] Comprehensive Physiology 2026 16:3, e70170 https://doi.org/10.1002/cph4.70170 [https://doi.org/10.1002/cph4.70170]

Time-Restricted Feeding Improves Metabolic Rhythms and Liver Bioenergetics

In this AI generated episode of The APS Publications Podcast featuring Function, we will dive into exciting new research that is shaping our understanding of how the body works at its most fundamental level. We spotlight the article “Short-term time-restricted feeding improves metabolic rhythms and liver mitochondrial bioenergetic function in high-fat diet-fed mice,” by Valcin et al. published recently in Function. Across the U.S. and the world, more people are developing fatty liver disease—now often called metabolic dysfunction–associated steatotic liver disease. About one in three adults are affected. What causes it? Often, long-term high-fat diets and disrupted metabolism. Inside the liver, tiny structures called mitochondria—the cell’s power plants—stop working efficiently. When that happens, the liver struggles to burn fat, energy levels drop, inflammation rises, and damage spreads to other organs. But here’s the surprising part: It’s not just what we eat that hurts these mitochondria. It’s when we eat. Ready to learn more? Listen now.   Jennifer A. Valcin, Telisha Millender-Swain, Jodi R. Paul, Brandon K. Collins, Fatme Ghandour, Sameer Al Diffalha, Jennifer S. Pollock, David M. Pollock, Scott W. Ballinger, Karen L. Gamble, Shannon M. Bailey Short-term time-restricted feeding improves metabolic rhythms and liver mitochondrial bioenergetic function in high-fat diet-fed mice [https://doi.org/10.1152/function.082.2025] Function, published February 25, 2026. DOI: 10.1152/function.082.2025

Interorgan Insights: Role of the gut microbiome in predicting PAH severity

In this podcast, author Arun Jose discusses the recently published article, ‘Lactobacillus Is Associated With Disease in Pulmonary Arterial Hypertension: A Prospective Cohort Study.' The prospective cohort study linked the gut microbiome, gut-derived metabolites, and disease severity in patents with pulmonary arterial hypertension undergoing right heart catheterization. Authors found that the presence of Lactobacillus was associated with less severe disease.  Lactobacillus Is Associated With Disease in Pulmonary Arterial Hypertension: A Prospective Cohort Study Arun Jose [https://onlinelibrary.wiley.com/authored-by/Jose/Arun], Senu Apewokin [https://onlinelibrary.wiley.com/authored-by/Apewokin/Senu], Nicholas J. Ollberding [https://onlinelibrary.wiley.com/authored-by/Ollberding/Nicholas+J.], Qing Duan [https://onlinelibrary.wiley.com/authored-by/Duan/Qing], Jennifer Trannguyen [https://onlinelibrary.wiley.com/authored-by/Trannguyen/Jennifer], Sasha Z. Prisco [https://onlinelibrary.wiley.com/authored-by/Prisco/Sasha+Z.], Thenappan Thenappan [https://onlinelibrary.wiley.com/authored-by/Thenappan/Thenappan], Anna R. Hemnes [https://onlinelibrary.wiley.com/authored-by/Hemnes/Anna+R.], Jean M. Elwing [https://onlinelibrary.wiley.com/authored-by/Elwing/Jean+M.] Comprehensive Physiology 2026 16:3, e70161 https://doi.org/10.1002/cph4.70161 [https://doi.org/10.1002/cph4.70161]

Interorgan Insights: MASLD through the lens of the mitochondrial-autophagy axis

In this podcast, coauthors Gaurab Bhaduri and Anchin Kalia discuss their recently published review, ‘The Mitochondrial–Autophagy Axis in MASLD: Mechanisms, Crosstalk, and Therapeutic Targets’. The review integrates contemporary evidence regarding mitochondrial dysfunction and autophagic regulation in metabolic dysfunction–associated steatotic liver disease (MASLD).  The Mitochondrial–Autophagy Axis in MASLD: Mechanisms, Crosstalk, and Therapeutic Targets Gaurab Bhaduri, Anchin Kalia, Banshi Saboo, Sanjay Bandyopadhyay Comprehensive Physiology 2026 16:3, e70155 https://doi.org/10.1002/cph4.70155 [https://doi.org/10.1002/cph4.70155]

Interorgan Insights: Highlighting the crucial role of the vascular lymphatic system

In this podcast, author Daniela Negrini discusses the recently published review, ‘The Thoracic Lymphatic Vasculature: Inter-Organ Strategies to Achieve an Optimal Tissue Function’. The article highlights the important but often overlooked role of vascular lymphatic system and the contribution of lymphatic vasculature to the control of extracellular fluid volume and composition as it applies to the majority of the body tissues.    The Thoracic Lymphatic Vasculature: Inter-Organ Strategies to Achieve an Optimal Tissue Function Daniela Negrini, Eleonora Solari, Cristiana Marcozzi, Andrea Moriondo Comprehensive Physiology 2026 16:2, e70143 https://doi.org/https://doi.org/10.1002/cph4.70143