Founders and Empanadas

The 2x YC-Backed PhD Founder Who Learned Why Great Technology Is NOT Enough | Andrea Mazzocchi

Andrea Mazzocchi defended her PhD, applied to Y Combinator, and watched the country shut down for COVID all on the same weekend. That was May 2020. By the end of the year, she had a wet lab running, a seed round closing, and a company called Known Medicine using 3D tumor organoids to predict which cancer drugs would actually work for individual patients. Three years later, she sold it. Then started over. In this episode, Joshua sits down with Andrea, Co-Founder and CEO of Play Health (YC F25), to talk about what it really took to build two YC-backed companies from scratch, what she learned selling the first one, and the single most uncomfortable thing a technical founder has to face: great technology is not a business strategy. In this episode: * Starting a company the weekend COVID shut everything down * What it actually feels like to go from founder to babysitter after an acquisition, and why she left * The mistake technical founders keep making at the intersection of science and business * Why founder-led is almost always better than bringing in the resume * Radical prioritization: why if ten things are a priority, nothing is * Her hot take on wearables and personal health data (you're probably not using 70% of it either) * Building a 4-person team that punches above its weight Subscribe and listen to this episode of Founders & Empanadas with Andrea everywhere you get your podcasts!

10,000 Hours of Play: Stop Grinding, Start Playing | Yu-kai Chou

Starting in 2003, years before anyone was using the term, Yu-kai Chou began developing what would become the Octalysis Framework: a model of human motivation built around 8 core drives that influence every decision we make. He gamified his own life first. Then his companies. Then Fortune 500s. Then governments. Now he's one of the most sought-after behavioral designers on the planet. He's been to Ukraine (during the war) to advise on gamification strategies for the country. He's the author of Actionable Gamification and 10,000 Hours of Play, his reframe of Malcolm Gladwell's famous concept. His clients include Google, Duolingo, and national governments. In this episode of Founders & Empanadas, we get into: * Why he tells founders to "optimize for failure" and why it might be the most counterintuitive success strategy you'll hear * The VC pattern he experienced 4-5 times: being called "crazy" and "stupid" before the world finally caught up * Why older generations actually respond better to gamification than younger ones, and what that means for product design * The dark side of gamification: how Black Hat mechanics tap into your survival instincts and trap users into addiction * What 10,000 Hours of Play really means and how to apply it to your work and life right now * What happens every time a big company acquires a startup and why it ends the same way almost every time * How he went from a kid struggling in a Taiwanese school to advising the president of a country at war Yu-kai is sharp, funny, and genuinely one of the most interesting people I've sat down with. This one will change how you think about your time. 🎙️ Listen on Spotify, Apple Podcasts, or wherever you get your podcasts. 📺 Watch on YouTube.

What Conflict Zones Taught This Founder About Building a Gaming Startup with Jessica Murrey

Jessica Murrey won a Regional Emmy at 24 for an anti-child abuse campaign, then spent seven years training young activists and former extremists in countries recovering from genocide and civil war: Myanmar, Burundi, Nigeria, Colombia. She came home asking: how do you scale this? The answer was a video game. Jessica co-founded Wicked Saints Studios with a behavioral scientist and a former senior Pokémon GO engineer. They raised $5M+ from Riot Games, Precursor Ventures, and Reid Hoffman, putting Jessica among fewer than 100 Black women in history to cross the $1M venture threshold. Their game, World Reborn, runs on one mechanic no other game uses: you can't buy progress. You earn it by doing real things in the real world. Brands like e.l.f. Beauty and Discord are integrated not as ads, but as quests. In an industry where brand click-through rates average under 1%, World Reborn is hitting 31%. In this episode: * Why peacebuilding in conflict zones and mobile gaming for Gen Z are solving the same problem * What the "Tattoo Method" is and why it works when traditional behavior change doesn't * The fundraising reality of being a Black woman founder (0.3% of VC went to Black women in 2023) * How World Reborn broke the brand ROI model that's stumped the rest of the gaming industry * The question about startup culture she never gets asked: does "more money and more power" actually make your life better? * A three-step conflict framework from the warzones, built for co-founder disputes, fractured teams, and difficult investors One of the most unusual founder backgrounds Joshua has ever encountered on this show. Worth every minute. 🎙️ Listen on Spotify, Apple Podcasts, or wherever you get your podcasts. 📺 Watch on YouTube.

Two Exits, 180 Angel Investments, and Why 90% of Jobs Are Gone with Serial Entrepreneur Sahin Boydas

Sahin Boydas moved from Turkey to San Francisco in 2012 with no network, no warm intros, and a conviction that remote work was going to change everything, about a decade before COVID made it unavoidable. What followed was four companies, two exits (MovieLaLa to Gfycat, RemoteTeam.com [http://RemoteTeam.com] to Gusto in 2021), 180+ angel investments including Anthropic and OpenAI, and a ranking as the #1 Most Active Angel Investor in 2024. He's now building Levy, an AI-native neobank for startups and he has zero interest in giving you soft takes. What we covered: * How he sold RemoteTeam.com [http://RemoteTeam.com] to Gusto and what actually kept him there for 3.5 years after the deal closed * Why post-exit founders are the single most reliable predictor of building a unicorn (the Super Founders data is wild) * Why he thinks 90% of desk jobs are gone and why he's weirdly optimistic about it * His rule: if an employee says AI doesn't give them good results, fire them immediately * Why empathy (not hustle, not grit) is the #1 skill every founder actually needs * How AI just handed every founder outside Silicon Valley access to the knowledge the Valley spent decades hoarding * Why founders who ask for permission to go to the dentist have already missed the point If you're building something, this episode of Founders & Empanadas is worth your full attention. Subscribe wherever you get your podcasts!

Why Your Authenticity Is Your Best Marketing Asset with Renee Gittins

Renee Gittins didn't take the conventional path. She built her own. She started as a biomedical engineer, then walked away from biotech at 21 to teach herself game development from scratch: moonlighting on her own game while working day jobs to pay the bills. That game, Potions: A Curious Tale, ended up on Steam, Switch, Xbox, and PS5 with 90%+ positive reviews. Along the way, she became Executive Director of the IGDA, representing 10,000+ game developers worldwide and advocating for them in front of the FTC. Now she's running Stumbling Cat full-time, building her next game, and writing The Bad Boss Witch Guide to Rule Your World: a book on Stoic leadership for people who actually need it. In this episode of Founders & Empanadas, we get into: * Why she spends one hour every day doing absolutely nothing and why it's her best creative tool * How walking away from biotech at 21 set her up for everything that came after * The Kickstarter mistake she'd fix if she did it over * Why taking personal blame for every team failure completely changed her culture * The one move that boosted her game's Steam conversion rate by 500% (it costs nothing) * What running a $300K/year org for 10,000+ developers taught her about doing more with less * How her dad, who was an Olympic 400m hurdler, wired her for grit, reflection, and daily growth * Why tying your identity to your work is a trap and how she's actively undoing it Renee is sharp, honest, and surprisingly funny. This one's for any founder who wants to build something real without losing themselves in the process. 🎙️ Listen on Spotify, Apple Podcasts, or wherever you get your podcasts. 📺 Watch on YouTube. Subscribe to Founders & Empanadas for new episodes every week.