Healthy Longevity

How to Keep Your Brain Young

If you've ever misplaced your keys or cell phone or forgotten the name of a friend you've known for decades, you've probably wondered, "is it early dementia?" Fear of cognitive decline is at an all-time high. A few years back, an AARP survey found that nearly half of adults over age 40 believe they will likely develop dementia. And Alzheimer's Disease International reports nearly 80% of the public is worried about the disease. Are you? Brain fog, memory loss, and dementia are among the seven common patterns of aging I write about in my new book, Invincible: Defy Your Genetic Destiny to Live Better, Longer, because so many people are concerned, and there are steps you can take today to minimize risk. On today's podcast, I'm delighted to welcome one of the leading experts in the field of brain longevity--board-certified neurologist, Dr. Sheldon Jordan, who is visiting us from Santa Monica, California where he has the private practice—Neurological Associates, The Interventional Group. Dr. Jordan is also the founder of The Regenesis Project, a clinical research initiative focused on advancing brain health, neurological regeneration, and interventions that target the biology of aging and neurodegeneration. Disclaimer: This podcast has not been approved by the FDA. The information in this presentation is for educational and informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition.

How to Keep your Brain Young, Part 2

We return to Healthy Longevity for Part 2 of our discussion about brain health with special guest neurologist Shelly Jordan, MD. In this segment, Drs. Comite and Jordan talk about inflammation in the brain, natural killer cells, the APOE4 gene variant, and advanced imaging techniques for predicting cognitive decline. Dr. Jordan also summarizes the practical steps you can take to optimize your brain power, including building muscle through resistance training, improving your sleep, managing your environment, even controlling the air you breathe, and avoiding ingesting microplastics that can make their way to the brain.

Dr. Drew Taylor: Regrow Hair with Your Own Stem Cells

Imagine taking your own stem cells from your hair follicles, preserving and banking them to rejuvenate your hair and skin when you start to notice those annoying signs of aging in the mirror. This is not science fiction; it's happening right now, and you will learn all about it in today's episode of Healthy Longevity from my guest biomedical engineer Drew Taylor, PhD, CEO of the regenerative medicine company Acorn Biolabs.

Sahil Chopra, MD: How to Sleep Well for Better Health Tonight

Want to perform better tomorrow at anything you do? Then get a good night's sleep tonight. "Sleep plays a critical role in restoration for humans; it is the housekeeping process for our physiology that allows us to restore and start the next day," says sleep expert Sahil Chopra, MD, today's guest on Healthy Longevity with Florence Comite MD. Dr. Chopra is co-founder and chief medical officer for Empower Sleep, a virtual sleep care program that makes personalized multi-night sleep analysis and treatment accessible from home. Nearly 40% of adults report falling asleep during the day without meaning to at least once a month. Also, an estimated 50 to 70 million Americans have chronic, or ongoing, sleep disorders, according to the Centers for Disease Control and Prevention. "If people don't sleep well, the likelihood of having cardiovascular disease … is higher, the possibility of cancer is six-fold higher," says Chopra. "Growth hormone levels are lower; cortisol dysregulation is higher. Circadian rhythms, if they are misaligned, result in a compromised metabolic state. REM sleep plays a critical role in emotional stability." If you're suffering from brain fog or nodding off at your desk after lunch, you'll want to tune in to discover how to dramatically improve your health and health trajectory by improving your sleep habits. You'll learn: * Sleep debt builds slowly, so you may not recognize what it's doing to you. * Why a one-night sleep study is not an effective way to diagnose a sleep disorder. * Sleep trackers like Empower Sleep's medical-grade ring and consumer models like the Oura Ring provide patients with real-time analysis of their sleep quality in their own bed without spending a restless night in a sleep lab wired to a machine. * Poor sleep is a gut punch, affecting the gut microbiome by disrupting the GI tract's normal nightly slow-down, which allows its epithelial lining to repair and recover. * Lack of sleep compromises the immune system. Studies show that sleep-deprived people (getting four to six hours of sleep) don't respond to vaccines as well as people who get adequate sleep (seven to eight hours). * During deep sleep stages, blood flow to the brain peaks through the glymphatic system, which clears the beta amyloid and tau proteins that are believed to play a role in Alzheimer's dementia. * What to do an hour before bedtime and within 15 minutes of waking to reset a healthy circadian rhythm. * Remedies for restless leg syndrome, including new technology that stimulates nerves in the legs to make the brain think that your lower limbs are moving. * And much more! About Florence Comite, MD Dr. Comite began her medical journey at Yale University School of Medicine and continued at Yale with a residency in medicine. She completed a fellowship in Reproductive Endocrinology (multidisciplinary training incorporating pediatrics, gynecology, and andrology) at the National Institute of Child Health and Human Development. She remained at the National Institutes of Health as a senior clinical research associate before joining the Yale faculty as an associate professor in endocrinology. During her 25-year faculty tenure, Dr. Comite founded and directed Women's Health at Yale. In 2005, she launched her bespoke medical practice, Comite Center for Precision Medicine & Healthy Longevity, in New York City and subsequently expanded offices to Palo Alto and Miami Beach. Through her medical practice and decades of clinical research, Dr. Comite recognized that all humans have inherited a disorder of carbohydrate metabolism (a glucose disorder leading toward diabetes), which is accelerated by aging and the natural decline of the hormones testosterone and estrogen, which begins around age 30. Dr. Comite's podcast delivers the truth about your health—that age-related disease begins early in life at the cellular level. By slowing and even reversing the biological aging process, we can stay active and in great health for life. She interviews renowned physicians, researchers, and thought leaders offering surprising insights and practical tips that listeners can use to improve their own health trajectory.

Delphine Le Grand: Know Your Body to Lengthen Your Healthspan

Longevity isn't just a roll of the genetic dice; it's something you can actively shape. By building a plan to expand your healthspan, you're investing in your future self, ensuring that as you age, you continue to feel strong, keep your brain sharp, and live life to the fullest. Being proactive is the point of longevity medicine, which takes the best parts of conventional healthcare and wellness and helps you play an active role in your health like never before, says Delphine Le Grand, an entrepreneur in the booming longevity space. Delphine is a bridge builder, fostering partnerships with early-stage companies and longevity physicians to bring personalized, preventative care models to market. Join my conversation with Delphine as we explore this "cultural moment" that longevity medicine is currently enjoying and how it will impact you. You'll learn: · The longevity medicine ecosystem is still in its infancy, but hang on for an explosion of technology, bioscience breakthrough, and more that will make living well beyond 100 years common. · The first step in building a plan to lengthen your healthspan to match your lifespan is to know your body and understand what it's telling you at the cellular level. · Bio data is important but knowing what to do with that information to improve your health is essential. And that's the piece of the puzzle that's missing—unless you know where to look. · The biggest breakthrough in reducing chronic cardiometabolic disease will come from reversing the carbohydrate metabolism disorder that affects 99 percent of human beings. · To improve your health tomorrow, discover what's holding you back from living in optimal health today. Is it poor sleep, unhealthy eating, insufficient exercise, or stress? Identify your nemesis and overcome it. About Florence Comite, MD Dr. Comite began her medical journey at Yale University School of Medicine and continued her training there with a residency in medicine. She completed a fellowship in Reproductive Endocrinology (multidisciplinary training incorporating pediatrics, gynecology, and andrology) at the National Institute of Child Health and Human Development. She remained at the National Institutes of Health as a senior clinical research associate before joining the Yale faculty as an associate professor in endocrinology. During her 25-year faculty tenure, Dr. Comite founded and directed Women's Health at Yale. In 2005, she launched her bespoke medical practice, Comite Center for Precision Medicine & Healthy Longevity, in New York City and, subsequently expanded offices to Palo Alto and Miami Beach. Through her medical practice and decades of clinical research, Dr. Comite recognized that all humans have inherited a disorder of carbohydrate metabolism (a glucose disorder leading toward diabetes), which is accelerated by aging and the natural decline of the hormones testosterone and estrogen, which begins around age 30. Dr. Comite's podcast delivers the truth about your health—that age-related disease begins early in life at the cellular level. By slowing and even reversing the biological aging process, we can stay active and in great health for life. She interviews renowned physicians, researchers, and thought leaders, offering surprising insights and practical tips that listeners can use to improve their own health trajectory. Next on Healthy Longevity with Florence Comite Aug. 19: Dean Ornish, MD, world-renowned pioneer of lifestyle medicine, on practical steps to reverse chronic disease.