Rotations 2.0

Rotations 2.0 Episode 67 Urticaria

Send us Fan Mail [https://www.buzzsprout.com/2428578/fan_mail/new] Episode 67 Urticaria Shoot me any comments or questions @Rotation2ptoh  on X Intro Music: KI Instrumental (Rock Celtic) by Lyrium-2025 Outro Music: Pure Energy by Alex Grohl Courtesy of Pixabay under Creative Commons non-commercial use. Produced by: Todd Fredricks DO MSS  Edited by: Todd Fredricks DO MSS Answers for Episode 66  Contact Dermatitis Question 1 A 34‑year‑old hairdresser reports intensely pruritic, erythematous, and edematous lesions with vesiculation at the dorsal hands that begin within a few hours after she contacts a known workplace chemical at sites previously affected in the past. Which immunologic mechanism best explains the rapid onset of her local reaction? C. Activation of epidermal CD8+ tissue‑resident memory (TRM) cells that rapidly produce IFN‑γ and IL‑17 and drive neutrophil recruitment.  Question 2 Which of the following experimental findings would most directly support a pathogenic role for neutrophils in rapid‑onset allergic contact dermatitis in a mouse model? A.    Depletion of neutrophils prior to allergen challenge markedly reduces the early (<24 h) skin swelling and histologic neutrophil infiltrate.  Question 3 A researcher proposes a clinical trial to prevent rapid‑onset ACD flares by blocking neutrophil chemotaxis. Which therapeutic target discussed in the article is most appropriate for this strategy, and what practical limitation did the authors highlight for its use in real‑world rapid flares? A. Target CXCR2 to inhibit neutrophil recruitment; limitation — need for near‑immediate administration after allergen re‑exposure to prevent extravasation.  Paper for Next Week: Brazel, Morgan, Anand Desai, Abhirup Are, and Kiran Motaparthi. “Staphylococcal Scalded Skin Syndrome and Bullous Impetigo.” Medicina 57, no. 11 (2021): 1157. Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS. Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency. Listeners interested in specifics from the paper authors should contact them directly through their respective institutions. Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

Rotations 2.0 Episode 66 Contact Dermatitis

Send us Fan Mail [https://www.buzzsprout.com/2428578/fan_mail/new] Episode 66 Contact Dermatitis Shoot me any comments or questions @Rotation2ptoh  on X Intro Music: KI Instrumental (Rock Celtic) by Lyrium-2025 Outro Music: Sport Rock by Alex Grohl Courtesy of Pixabay under Creative Commons non-commercial use. Produced by: Todd Fredricks DO MSS  Edited by: Todd Fredricks DO MSS Answers for Episode 65  Eczema (Atopic Dermatitis) Question 1 — Systemic Therapy Selection A 32‑year‑old woman with moderate‑to‑severe atopic eczema has failed optimized topical corticosteroids, topical calcineurin inhibitors, and UVB therapy. She has no significant medical history and is not pregnant. She asks about the most evidence‑supported systemic therapy with the best long‑term safety profile and minimal laboratory monitoring. Which of the following is the most appropriate next‑line therapy? C. Dupilumab 600 mg loading dose, then 300 mg every 2 weeks Question 2 — Pediatric Treatment Decision A 10‑year‑old boy (weight 28 kg) has severe atopic eczema poorly controlled with optimized topical therapy and narrow‑band UVB. His parents prefer a systemic option that is FDA/EMA‑approved for his age group and does not require routine blood monitoring. Which treatment is most appropriate? B. Dupilumab 300 mg every 4 weeks Question 3 — Contraindicated Therapy in Pregnancy A 29‑year‑old woman with severe atopic eczema presents for follow‑up. She tells you she is 8 weeks pregnant and her disease is worsening despite appropriate topical corticosteroids and emollient therapy. Which of the following systemic therapies is contraindicated during pregnancy? C. Upadacitinib Paper for Next Week: Bizjak, Mojca, Olivier Aerts, David Pesqué, Melba Muñoz, Riccardo Asero, Margarida Gonçalo, Thomas Rustemeyer, Mitja Košnik, Mark Kačar, An Goossens, Jose Hernán Alfonso, Charlotte G. Mortz, Maryam Ali Al‑Nesf, Joachim W. Fluhr, Howard I. Maibach, and Ana Maria Giménez‑Arnau. “Contact Urticaria and Related Conditions: Clinical Review.” Contact Dermatitis 93 (2025): 87–107.   Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS. Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency. Listeners interested in specifics from the paper authors should contact them directly through their respective institutions Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

Rotations 2.0 point Episode 65.1 Ibogaine and Executive Orders

Send us Fan Mail [https://www.buzzsprout.com/2428578/fan_mail/new] Episode 65.1  Ibogaine and Executive Order  Shoot me any comments or questions @Rotations2ptoh  on X Intro/Outro: Night Detective by Amaksi Courtesy of Pixabay under Creative Commons for non-Commercial Educational use only. Produced by: Todd Fredricks DO MSS  Edited by: Todd Fredricks DO MSS Papers referenced Mosca, Alessio, Stefania Chiappini, Andrea Miuli, Gianluca Mancusi, Maria Chiara Santovito, Francesco Di Carlo, Mauro Pettorruso, John M. Corkery, Carlos Canessa, Giovanni Martinotti, and Massimo Di Giannantonio. “Ibogaine/Noribogaine in the Treatment of Substance Use Disorders: A Systematic Review of the Current Literature.” Current Neuropharmacology 21, no. 11 (2023): 2178–2194.  Mackey, Katherine M., Johanna K. Anderson, Beth E. Williams, Rachel M. Ward, and Nicholas J. Parr. Evidence Brief: Psychedelic Medications for Mental Health and Substance Use Disorders. Washington, DC: Evidence Synthesis Program, Health Services Research and Development Service, Office of Research and Development, U.S. Department of Veterans Affairs, 2022. PRESIDENTIAL ACTIONS: ACCELERATING MEDICAL TREATMENTS FOR SERIOUS MENTAL ILLNESS Executive Orders April 18, 2026 Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency. Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

Rotations 2.0 Episode 65 Eczema: Atopic Dermatitis

Send us Fan Mail [https://www.buzzsprout.com/2428578/fan_mail/new] Episode 65 Atopic Dermatitis Shoot me any comments or questions @Rotation2ptoh  on X Intro Music: KI Instrumental (Rock Celtic) by Lyrium-2025 Outro Music: Christmas by Alex Grohl Courtesy of Pixabay under Creative Commons non-commercial use.  Produced by: Todd Fredricks DO MSS  Edited by: Todd Fredricks DO MSS  Answers for Episode 64 Psoriasis  Question 1 — Psoriasis Comorbidities and Early Detection A 36‑year‑old man with a 10‑year history of chronic plaque psoriasis presents for evaluation. He reports new-onset morning stiffness in his lower back lasting more than an hour and improving with activity. His exam shows limited lumbar flexion but no peripheral joint swelling. Radiographs of the sacroiliac joints are unremarkable. Which of the following is the most important reason to screen this patient promptly for psoriatic arthritis? D. Early diagnosis reduces the risk of irreversible joint damage Question 2 — Systemic Therapy Safety Considerations A 29‑year‑old woman with erythrodermic psoriasis is prescribed a systemic retinoid. After one month of treatment, she reports dry lips, hair thinning, and peeling skin. She asks when she can safely become pregnant after stopping therapy. Laboratory studies show mild hyperlipidemia. Which medication is she most likely taking? C. Acitretin Question 3 — Treatment Escalation and Contraindications A 45‑year‑old woman with moderate to severe plaque psoriasis has failed topical therapy and methotrexate. She is being evaluated for biologic therapy. Her past medical history is significant for Crohn’s disease. Which biologic agent should be avoided in this patient? B. Secukinumab Paper for Next Week:  Anders Boutrup Funch, Carsten Geisler, and Charlotte Menné Bonefeld. “Allergic Contact Dermatitis: Immunopathology and Potential Therapeutic Strategies.” Journal of Clinical Medicine 14, no. 20 (2025): 7175. https://doi.org/10.3390/jcm14207175. Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS. Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency. Listeners interested in specifics from the paper authors should contact them directly through their respective institutions. Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.

Rotations 2.0 Episode 64 Psoriasis

Send us Fan Mail [https://www.buzzsprout.com/2428578/fan_mail/new] Episode 64 Psorasis Shoot me any comments or questions @Rotation2ptoh  on X Intro Music: KI Instrumental (Rock Celtic) by Lyrium-2025 Outro Music: Ambient Tension by Alex Grohl Courtesy of Pixabay under Creative Commons non-commercial use. Produced by: Todd Fredricks DO MSS  Edited by: Todd Fredricks DO MSS Answers for Episode 63 AcneQuestion 1 A 17‑year‑old adolescent presents with moderate inflammatory acne on the face and back. Microbiome analysis of her lesions shows decreased alpha diversity and an overrepresentation of Enterococcaceae on both the face and back. Which of the following best explains these findings? D. Dysbiosis characterized by decreased microbial diversity and overgrowth of specific taxa Question 2 A 19‑year‑old woman with moderate acne begins treatment with 2% supramolecular salicylic acid (SSA) for 8 weeks. At follow‑up, she reports clinical improvement. Microbiome analysis shows increased alpha and beta diversity and reductions in Staphylococcus, Ralstonia, and Streptococcus species. Which mechanism best explains these findings? B. Anti‑inflammatory effects with stabilization of microbial communities Question 3 A researcher evaluates the impact of different acne treatments on the cutaneous microbiome. She notes that only one standard therapy consistently produced a statistically significant change in alpha diversity across multiple studies included in a meta‑analysis. Which treatment is she referring to? D. Topical benzoyl peroxide (BPO) Paper for Next Week: Wollenberg, A., M. Kinberger, B. Arents, N. Aszodi, S. Barbarot, T. Bieber, H. A. Brough, et al. 2025. “European Guideline (EuroGuiDerm) on Atopic Eczema: Living Update.” Journal of the European Academy of Dermatology and Venereology 39: 1537–1566. https://doi.org/10.1111/jdv.20639. Rotations  2.0 is copyrighted. But you can use any content from the podcast for non-commercial purposes under Creative Commons….BUT, BUT, BUT, you must cite Rotations 2.0 and Todd Fredricks DO MSS as the source of the material AND AND AND you cannot alter or edit the content in any manner without expressed permission of Todd Fredricks DO MSS. Rotations 2.0 is made possible by the generous understanding and accommodation of my beloved institution, Ohio University. The comments and ideas expressed on Rotations 2.0 are that of the content creators alone and may not reflect official policy or the opinion of the Ohio University, the State of Ohio, or the US Government or any other state, person or governmental agency. Listeners interested in specifics from the paper authors should contact them directly through their respective institutions. Any therapeutic ideas discussed should not be taken as any kind of medical advice or recommendations by the content creators and the content creators are not offering medical advice but discussing topics from an academic perspective. Listeners seeking advice about any medical care or decision-making should consult their own physician or medical provider and the content creators of Rotations 2.0 assume no liability for any listener's care or decision-making stemming from the topics discussed on Rotations 2.0.