This Week in Cardiology

Jul 31 2026 This Week in Cardiology

Another failure of LA posterior wall isolation, first-line AF ablation, a revelation on EAST-AFNET 4 trial, an LAAC meta-analysis, and preventing AKI post-cardiac surgery are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback * DAPT-MVD Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2517588 II Another Failure of Posterior Wall Isolation * CORNERSTONE-AF Trial https://doi.org/10.1093/eurheartj/ehag486 * CAPLA Trial https://jamanetwork.com/journals/jama/fullarticle/2800186 * PVIOTAL IDE Trial 10.1016/j.hrthm.2025.08.018 External Link III First Line AF ablation – One new study and a discovery about a second one * Catheter Ablation vs AAD for First-line Treatment of AF 10.1016/j.hrthm.2025.07.061 External Link * EAST-AFNET 4 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2019422 * Cardiology Trials Substack https://cardiologytrials.substack.com/p/summary-and-discussion-of-east-afnet IV Left Atrial Appendage Closure Meta-analysis * Long-Term Efficacy and Safety of LAAC vs OAC -- Meta-analysis https://academic.oup.com/europace/article/28/7/euag159/8739567 V Prevention of AKI after Cardiac Surgery: MERCURI-2 * MERCURI-2 Study https://jamanetwork.com/journals/jama/fullarticle/2852324 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

July 24 2026 This Week in Cardiology

The first oral PCSK9 inhibitor, another study finding safe MRI scanning in patients with nonconditional CIEDs, the PFA-SHAM trial, and the curious case of orthopedic injuries in cardiology are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Enlicitide Approved First Oral PCSK9 Inhibitor Welcomed for Potential Primary Care Impact https://www.medscape.com/viewarticle/first-oral-pcsk9-inhibitor-welcomed-potential-primary-care-2026a1000own * Dr Gregory Katz Substack https://gregorykatz.substack.com/p/are-we-sure-mercks-new-cholesterol * CORALreef Lipids Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2511002 * CORALreef HeFH Trial https://jamanetwork.com/journals/jama/fullarticle/2841258 * CORALreef Outcomes Trial https://clinicaltrials.gov/study/NCT06008756 II MRI Scans in Non-conditional CIEDs Specialized Nurse Practitioners Safely Manage MRI in Patients With Cardiac Implantable Devices https://www.medscape.com/viewarticle/specialized-nurse-practitioners-safely-manage-mri-patients-2026a1000ozt * Nurse Practitioner-Led CIED Monitoring During MRI 10.1016/j.hroo.2026.04.031 External Link * MRI in Nonconditional Pacemakers and ICDs https://academic.oup.com/europace/article/22/2/288/5717383 * Heart Rhythm Society Consensus Document 10.1016/j.hrthm.2017.04.025 External Link III PFA-SHAM trial * PFA-SHAM Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079484 * SHAM-PVI Trial https://jamanetwork.com/journals/jama/fullarticle/2823283 IV Orthopedic Injuries in Cardiology What Will It Take to Make Fluoroscopy Labs Safer? https://www.medscape.com/viewarticle/what-will-it-take-make-fluoroscopy-labs-safer-2026a1000ox6 * Expert Consensus Statement on Enhanced Radiation Protection https://www.jacc.org/doi/10.1016/j.jcin.2026.06.011 * 'Shed the Lead' and the Injuries. Should Cath Labs Go Lead-Free? https://www.medscape.com/viewarticle/shed-lead-and-injuries-should-cath-labs-go-lead-free-2024a1000hnb * Health Hazards of Working in the Interventional Laboratory https://doi.org/10.1016/j.jacc.2014.11.056 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Jul 17 2026 This Week in Cardiology Podcast

DAPT back in the news, a practice-changing trial in VTE therapy, new knowledge in sudden cardiac death, heart failure definitions updated, and a dumb decision by NICE in the UK are the topics discussed by John Mandrola, MD, in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Antiplatelet Therapy After Stenting * DAPT-MVD Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2517588 * HOST-EXAM Trial at 2 years https://pubmed.ncbi.nlm.nih.gov/34010616/ * HOST-EXAM Trial at 10 years 10.1016/S0140-6736(26)00422-8 External Link * Nick Kurzen on X https://x.com/ncurzen/status/2077676739463922151 II Aspirin Proves Its Mettle After Hip and Knee Replacement * EPCAT III Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2603649 * CRISTAL Trial https://jamanetwork.com/journals/jama/fullarticle/2795528 III New (and old) Knowledge in Sudden Cardiac Death * Sudden Cardiac Death and its Relation to Cardiac Disease at Autopsy https://doi.org/10.1016/j.jacc.2026.01.029 * Sudden Cardiac Death Due to MI With Obstructive and Nonobstructive Coronary Arteries https://doi.org/10.1016/j.jacc.2026.01.030 * Frequency of Sudden Cardiac Death and Profiles of Risk https://www.ajconline.org/article/S0002-9149(97)00477-3/fulltext IV Heart Failure Diagnosis * AHA/ACC/ESC/WHF Expert Consensus Document http://jacc.org/doi/10.1016/j.jacc.2026.05.036 V NICE Makes a Dumb Decision * NICE Recommends New Nonsteroidal MRA for Heart Failure https://www.medscape.com/viewarticle/nice-recommends-new-nonsteroidal-mra-heart-failure-2026a1000nzv You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Jul 10 2026 This Week in Cardiology

Listener feedback on ICE vs TEE in AF ablation, fractional flow reserve without a wire or catheter, more bad news for ticagrelor, the POLY-HF trial, and oxygen targets after cardiac arrest are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback Oct 10, 2025 This Week in Cardiology Podcast https://www.medscape.com/viewarticle/1002990 * ICE vs TEE in Atrial Fibrillation Ablation https://jamanetwork.com/journals/jamacardiology/fullarticle/2839370 II FFR Without the Wire – Angiography-Derived FFR to Guide PCI * ALL-RISE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2600949 * FAST III Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2601841 * FAVOR III Trial 10.1016/S0140-6736(24)02175-5 External Link * FAME 2 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1205361 * Venk Murthy on X https://x.com/venkmurthy/status/2074849421452329456?s=20 III More Bad News for Ticagrelor Jul 11, 2025 This Week in Cardiology Podcast https://www.medscape.com/viewarticle/1002704 * Prasugel, Ticagrelor, or Clopidogrel After PCI https://jamanetwork.com/journals/jamacardiology/fullarticle/2849614 IV The Polypill in Heart Failure * POLY-HF trial https://www.nature.com/articles/s41591-026-04504-5 V Oxygen Targets After Cardiac Arrest * LOGICAL Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2513814 * ICU-ROX Trial https://link.springer.com/article/10.1007/s00134-020-06196-y * Secondary Analysis of the PILOT Trial https://journal.chestnet.org/article/S0012-3692(25)00553-7/fulltext * Oxygen Targets in Comatose Survivors of Cardiac Arrest https://www.nejm.org/doi/10.1056/NEJMoa2208686 You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net

Jun 26 2026 This Week in Cardiology

Listener feedback on valvular heart disease, statins and frailty, left atrial posterior wall ablation fails again, interpreting medical tests and AI ECG reading are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intended for healthcare professionals only. To read a partial transcript or to comment, visit: https://www.medscape.com/twic I Listener Feedback * PREVUE-VALVE Study https://www.jacc.org/doi/10.1016/j.jacc.2026.02.5137 II Statins and Frailty Statin Initiation Tied to Lower Frailty Risk in Older Adults https://www.medscape.com/viewarticle/statin-initiation-tied-lower-frailty-risk-older-adults-2026a1000lec * Statins and Survival Free of Incident Frailty https://doi.org/10.1093/eurheartj/ehag451 III LA Posterior Wall Isolation Fails Again * CORNERSTONE Trial https://doi.org/10.1093/eurheartj/ehag486 * CAPLA Trial https://jamanetwork.com/journals/jama/fullarticle/2800186 IV Does the Display of Test Results Improve Clinical Decisions? * Interval Likelihood Ratios for Clinical Decsion-Making https://evidence.nejm.org/doi/full/10.1056/EVIDoa2500249 * Making Sense of Health Statistics https://journals.sagepub.com/doi/full/10.1111/j.1539-6053.2008.00033.x V AI and the ECG and Saving Doctors * Case Report — AI-Enhanced Diagnostics https://www.nature.com/articles/s41591-026-04454-y * The New York Times article https://www.nytimes.com/2026/06/22/health/artificial-intelligence-heart-damage.html You may also like: The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington Questions or feedback, please contact news@medscape.net