GeneInCell

siRNAs: Programmable Drugs for Silencing Genetic Disease | GeneInCell

siRNAs are transforming medicine by acting as programmable drugs that selectively silence disease-causing genes. In this episode, we explore how small interfering RNAs work through the RNA interference pathway, why they are so powerful for precision therapeutics, and how they are being developed to treat genetic, metabolic, liver, and rare diseases. We also discuss delivery challenges, clinical progress, and what makes siRNA one of the most promising platforms in modern drug development.

Prime editing: Search and replace for human DNA | GeneInCell | 2026

Prime editing is a next-generation gene editing tool designed to precisely rewrite DNA—like a search-and-replace function for the human genome. In this episode, we break down how prime editing works, the chemistry behind it, and why it offers a powerful alternative to traditional CRISPR by making targeted changes without creating double-strand breaks. We also explore its applications in disease correction, its growing path toward the clinic, and the key challenges that still stand in the way.

New Approach Methodologies (NAMs) for Replacing Animal Models in Drug Discovery | GeneInCell | 2026

NAMs are changing how new drugs are developed. We discuss organoids, tissue chips, and AI-based tools, along with the growing FDA and NIH push toward more human-relevant methods that can improve prediction, reduce reliance on animal models, and help bring safer treatments forward faster.

Growing replacement kidneys from stem cells | GeneInCell | 2026

Can we grow new kidneys from stem cells? In this episode, we explore how scientists are using pluripotent stem cells to create kidney organoids that mimic early kidney development. We discuss how these mini-organs help study kidney disease, test new drugs, and move us closer to future regenerative therapies for kidney failure.

Is Space Travel Safe For You? | GeneInCell | 2026

What really happens to your cells under stress, in space, and during space travel? In this episode, we zoom in on the physiological, cellular, and molecular levels to uncover how zero gravity affects them.