Just Now Possible
Guests * Arzu Sandıkçı, Co-founder & CEO, Rhea's Factory * Mert Topcu, Co-founder, Rhea's Factory In this episode: * Why only 10% of plastic gets recycled—and why mechanical and chemical methods hit a ceiling * How enzymatic recycling breaks plastic all the way back to its original monomers, unlike traditional methods that just shorten polymer chains * Why enzymes are selective: they can target specific plastic types even in mixed waste streams * The discovery of a plastic-eating bacteria in Japan that opened the door to enzymatic recycling * How AlphaFold and the Nobel Prize in Chemistry transformed what's possible in enzyme engineering * How Rhea's Factory uses protein language models (PLMs) and multi-step AI pipelines to design novel enzymes computationally * The evolution from a human-orchestrated pipeline to an agentic AI scientist * How guardrails at each pipeline step keep the AI pointed in the right direction without limiting exploration * Why wet lab data—even just hundreds of proprietary data points—can be enough to train a powerful domain-specific prediction model * Why Mert sometimes wants the model to hallucinate (and how high temperature settings help explore the full enzyme design space) * The business constraint: enzymatic recycling must compete economically with cheap, oil-based plastic production * What's next: a process agent, a 5,000-ton demo plant in California, and enzymes for new plastic types Resources & Links * Rhea's Factory [https://rheasfactory.com/?ref=producttalk.org] — Enzymatic plastic recycling technology * AlphaFold [https://alphafold.ebi.ac.uk/?ref=producttalk.org] — DeepMind's AI system for protein structure prediction (inspiration for the Nobel Prize in Chemistry) * Maven AI Evals Course [https://maven.com/parlance-labs/evals?promoCode=torres-35&ref=producttalk.org] — The course Teresa took to learn about evals (35% off with Teresa's affiliate link) Chapters 00:00 Meet the Founders 01:50 Why Plastic Circularity 03:19 Mechanical vs True Recycling 04:52 Biology as the New Tool 07:20 Necklace and Pearls Analogy 13:22 Low Energy Reactor Process 17:33 Origin Story and PET Enzyme 22:52 Protein Folding and AlphaFold 28:32 AI Designed Enzymes 34:28 Protein Language Models Stack 37:14 Multi Step Protein Generation 39:00 Building on Foundation Models 40:50 Lab First Success Metrics 43:10 From Human to Agentic Orchestration 43:59 Problem Statements as Inputs 46:18 Guardrails at Every Stage 47:48 Prediction Models and Data Limits 50:03 Industrial Reality and Cost 52:30 Agentic Parallels and Orchestrators 57:45 Impact on Timelines and Diversity 01:03:23 When Hallucination Helps 01:04:09 Scaling Up and Process Agents 01:06:56 Enzyme Blends for Mixed Plastics 01:07:49 Why Clamshells Aren't Recyclable 01:09:34 Closing Thoughts and Thanks
26 episodios
Comentarios
0Sé la primera persona en comentar
¡Regístrate ahora y únete a la comunidad de Just Now Possible!