Episode 114: Dr. Jennifer Kulp-Makarov Revolutionizing IVF for Women Over 40
In this episode of Dismantling You, I sit down with Dr. Jennifer Kulp-Makarov, a Board-Certified Reproductive Endocrinologist and founder of Fleura Fertility, trained at Johns Hopkins and Yale. We dig into how traditional fertility clinics often rely on a one size fits all approach to IVF, and why that can actually backfire for women with low AMH or those trying to conceive over 40. Dr. Jennifer shares the patient experience that changed everything for her: a woman who gave up on growing her family because she thought aggressive, high dose IVF was her only option. That moment became the catalyst for her to build a practice centered on personalized protocols and her signature Goldilocks approach to stimulation, finding the just right dose of medication rather than defaulting to the highest one.
We also explore cutting edge fertility innovations including ovarian PRP, which is showing promise in improving markers like AMH and antifollicle count, and rapamycin, an emerging treatment that may help protect egg reserves and delay menopause. Dr. Jennifer breaks down how FSH dosing plays a critical role in egg competence and why monitoring it throughout the cycle, not just at baseline, makes a real difference. We talk about how fertility care is evolving to better support LGBTQ individuals through inclusive language and treatment design, and how AI could soon help standardize ultrasound data and embryo analysis. We wrap up with Dr. Jennifer's rapid fire answers on the most underrated factor in fertility, the biggest mistake patients make when choosing a clinic, and the one belief she had to dismantle in her own career.
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Key Highlights
💊 Dr. Jennifer developed a middle ground between high dose IVF and mini IVF called the Goldilocks approach. By adjusting medications through the cycle based on real time hormone levels, she optimizes egg growth without overwhelming the body.
🔬 For women over 40 or with low AMH, pushing more medication can actually cause eggs to stop growing altogether. Many patients labeled as poor responders simply needed a more nuanced, individualized approach rather than aggressive stimulation.
🩸 Ovarian PRP is showing improvements in AMH and antifollicle count, though large studies on pregnancy outcomes are still needed. Dr. Jennifer has seen clinical promise in her own patients, particularly those with low egg reserve.
💡 Early research suggests rapamycin may help protect egg reserves and delay menopause. A promising study also showed improved IVF outcomes for patients with endometriosis, though the data is still limited.
🧬 After 35, egg quality declines sharply, becoming more dramatic past 40. Dr. Jennifer monitors FSH levels throughout the cycle, not just at baseline, treating it like fertilizer that needs careful dosing.
🏳️🌈 Fertility care is moving beyond a heteronormative infertility model, and Dr. Jennifer emphasizes the importance of inclusive intake forms, vocabulary, and recognizing that LGBTQ patients may be perfectly fertile and seeking family building support rather than treatment for infertility.
🤖 AI shows promise in standardizing ultrasound measurements and analyzing embryo time lapse videos, reducing operator dependency, though the final clinical decisions should still rest with the reproductive endocrinologist.
Bio
Dr. Makarov is a fellowship-trained reproductive endocrinologist with training from Johns Hopkins Hospital and Yale University School of Medicine. With extensive experience treating complex cases including decreased ovarian reserve, recurrent pregnancy loss, and multiple failed IVF cycles, Dr. Makarov is committed to providing personalized, patient-centered care. She works closely with individuals, couples, and LGBTQ+ families, helping them achieve their dream of parenthood.
Resources & Next Steps
🌐 Visit Fleura Fertility
📸 Follow Dr. Jenn Fertility on Instagram @drjennfertilityfriend, TikTok, and YouTube