BTRC Conversations: The Fight Against Brain Tumours

Episode 1: Targeting Brain Tumour Stem Cells

The lab of Peter Dirks investigates how medulloblastoma stem cells transition from a dormant state to an active, proliferative state, a process regulated by the transcription factor Olig2. The scientists found that inactivating Olig2 prevents stem cell activation, thereby blocking tumour growth. Targeting Olig2 with a small molecule inhibitor, CT-179, significantly slowed early tumour formation and regrowth after therapy in a mouse model. Further analysis revealed the drug effectively limits the ability of the quiescent stem cells to transition to a proliferative state. The study suggests that therapies targeting this stem cell fate transition could improve medulloblastoma treatment outcomes, especially in high-risk cases. The findings provide a basis for developing new treatments targeting cancer stem cell activation and limiting patient tumour progression. Research funding for pediatric brain tumours is at an all-time low. Please consider donating to the Brain Tumour Research Centre at SickKids (be sure to select "For a specific area or purpose" when prompted at this link: https://www.sickkids.ca/en/care-services/centres/brain-tumour-research-centre/#support [https://www.sickkids.ca/en/care-services/centres/brain-tumour-research-centre/#support] Dr Christian Smith: https://www.scientistandthepsychic.com/ [https://www.scientistandthepsychic.com/]